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Lymph node xanthomatosis

MedGen UID:
1841856
•Concept ID:
C5826538
•
Disease or Syndrome
Synonym: Lymph node xanthomas
 
HPO: HP:0034628

Definition

Lipid deposits localized within one or more lymph nodes. Xanthomas are benign but are often an important visible sign of systemic conditions such as familial hypercholesterolemia. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLymph node xanthomatosis

Professional guidelines

PubMed

Noninvasive preoperative differential diagnosis of gallbladder carcinoma and xanthogranulomatous cholecystitis: A retrospective cohort study of 240 patients.
Xiao J, Zhou R, Zhang B, Li B
Cancer Med 2022 Jan;11(1):176-182. Epub 2021 Nov 27 doi: 10.1002/cam4.4442. PMID: 34837350Free PMC Article
Differential diagnosis and treatment options for xanthogranulomatous cholecystitis.
Cui Y, Zhang H, Zhao E, Cui N, Li Z
Med Princ Pract 2013;22(1):18-23. Epub 2012 Jul 14 doi: 10.1159/000339659. PMID: 22814128Free PMC Article

Recent clinical studies

Etiology

Noninvasive preoperative differential diagnosis of gallbladder carcinoma and xanthogranulomatous cholecystitis: A retrospective cohort study of 240 patients.
Xiao J, Zhou R, Zhang B, Li B
Cancer Med 2022 Jan;11(1):176-182. Epub 2021 Nov 27 doi: 10.1002/cam4.4442. PMID: 34837350Free PMC Article
Diagnostic accuracy of MDCT in differentiating gallbladder cancer from acute and xanthogranulomatous cholecystitis.
Wasnik AP, Davenport MS, Kaza RK, Weadock WJ, Udager A, Keshavarzi N, Nan B, Maturen KE
Clin Imaging 2018 Jul-Aug;50:223-228. Epub 2018 Apr 14 doi: 10.1016/j.clinimag.2018.04.010. PMID: 29679780
New scoring system for differentiating xanthogranulomatous cholecystitis from gall bladder carcinoma: a tertiary care centre experience.
Rajaguru K, Mehrotra S, Lalwani S, Mangla V, Mehta N, Nundy S
ANZ J Surg 2018 Jan;88(1-2):E34-E39. Epub 2016 Sep 6 doi: 10.1111/ans.13733. PMID: 27599003
Expression of stabilin-1 in M2 macrophages in human granulomatous disease and melanocytic lesions.
Schönhaar K, Schledzewski K, Michel J, Dollt C, Gkaniatsou C, Géraud C, Kzhyshkowska J, Goerdt S, Schmieder A
Int J Clin Exp Pathol 2014;7(4):1625-34. Epub 2014 Mar 15 PMID: 24817959Free PMC Article
Primary histiocytic dermatoses.
Ringel E, Moschella S
Arch Dermatol 1985 Dec;121(12):1531-41. PMID: 2998286

Diagnosis

Noninvasive preoperative differential diagnosis of gallbladder carcinoma and xanthogranulomatous cholecystitis: A retrospective cohort study of 240 patients.
Xiao J, Zhou R, Zhang B, Li B
Cancer Med 2022 Jan;11(1):176-182. Epub 2021 Nov 27 doi: 10.1002/cam4.4442. PMID: 34837350Free PMC Article
A unique kind of Cholecystitis.
Aslam A, Khan NA
J Pak Med Assoc 2020 Apr;70(4):780-782. doi: 10.5455/JPMA.292823. PMID: 32296239
Differential diagnosis and treatment options for xanthogranulomatous cholecystitis.
Cui Y, Zhang H, Zhao E, Cui N, Li Z
Med Princ Pract 2013;22(1):18-23. Epub 2012 Jul 14 doi: 10.1159/000339659. PMID: 22814128Free PMC Article
Xanthogranulomatous sialadenitis.
Padfield CJ, Choyce MQ, Eveson JW
Histopathology 1993 Nov;23(5):488-91. doi: 10.1111/j.1365-2559.1993.tb00504.x. PMID: 8314229
Primary histiocytic dermatoses.
Ringel E, Moschella S
Arch Dermatol 1985 Dec;121(12):1531-41. PMID: 2998286

Therapy

Successful treatment with rituximab of IgG4-related disease coexisting with adult-onset asthma and periocular xanthogranuloma.
Asproudis I, Kanari M, Ntountas I, Ragos V, Goussia A, Batistatou A, Voulgari PV
Rheumatol Int 2020 Apr;40(4):671-677. Epub 2019 Aug 7 doi: 10.1007/s00296-019-04409-2. PMID: 31392499
Metastatic melanoma with balloon/histiocytoid cytomorphology after treatment with immunotherapy: A histologic mimic and diagnostic pitfall.
Farah M, Nagarajan P, Torres-Cabala CA, Curry JL, Amaria RN, Wargo J, Tawbi H, Ivan D, Prieto VG, Tetzlaff MT, Aung PP
J Cutan Pathol 2018 Jul;45(7):545-549. Epub 2018 May 18 doi: 10.1111/cup.13263. PMID: 29672900
Necrobiotic xanthogranuloma associated with paraproteinemia and non-Hodgkin's lymphoma developing into chronic lymphocytic leukemia: the first case reported in the literature and review of the literature.
Oumeish OY, Oumeish I, Tarawneh M, Salman T, Sharaiha A
Int J Dermatol 2006 Mar;45(3):306-10. doi: 10.1111/j.1365-4632.2006.02575.x. PMID: 16533236
Extensive xanthelasma associated with anaplastic large cell lymphoma and hyperimmunoglobulin E syndrome.
Lee MW, Choi JH, Sung KJ, Moon KC, Koh JK
Int J Dermatol 2003 Dec;42(12):944-6. doi: 10.1111/j.1365-4632.2003.01829.x. PMID: 14636188
Florid xanthomatous pelvic lymph node reaction to metastatic prostatic adenocarcinoma. A sequela of preoperative androgen deprivation therapy.
Schned AR, Gormley EA
Arch Pathol Lab Med 1996 Jan;120(1):96-100. PMID: 8554456

Prognosis

Noninvasive preoperative differential diagnosis of gallbladder carcinoma and xanthogranulomatous cholecystitis: A retrospective cohort study of 240 patients.
Xiao J, Zhou R, Zhang B, Li B
Cancer Med 2022 Jan;11(1):176-182. Epub 2021 Nov 27 doi: 10.1002/cam4.4442. PMID: 34837350Free PMC Article
Diagnostic accuracy of MDCT in differentiating gallbladder cancer from acute and xanthogranulomatous cholecystitis.
Wasnik AP, Davenport MS, Kaza RK, Weadock WJ, Udager A, Keshavarzi N, Nan B, Maturen KE
Clin Imaging 2018 Jul-Aug;50:223-228. Epub 2018 Apr 14 doi: 10.1016/j.clinimag.2018.04.010. PMID: 29679780
Acute abdomen: rare and unusual presentation of right colic xanthogranulomatosis.
Addario Chieco P, Antolino L, Giaccaglia V, Centanini F, Cunsolo GV, Sparagna A, Uccini S, Ziparo V
World J Gastroenterol 2014 Jul 14;20(26):8717-21. doi: 10.3748/wjg.v20.i26.8717. PMID: 25024630Free PMC Article
Primary histiocytic dermatoses.
Ringel E, Moschella S
Arch Dermatol 1985 Dec;121(12):1531-41. PMID: 2998286
Sex differences in incidence and severity of lymph node lipogranulomatosis; a similarity to atherosclerosis.
SPAIN DM
AMA Arch Pathol 1957 Jul;64(1):54-7. PMID: 13434569

Clinical prediction guides

Noninvasive preoperative differential diagnosis of gallbladder carcinoma and xanthogranulomatous cholecystitis: A retrospective cohort study of 240 patients.
Xiao J, Zhou R, Zhang B, Li B
Cancer Med 2022 Jan;11(1):176-182. Epub 2021 Nov 27 doi: 10.1002/cam4.4442. PMID: 34837350Free PMC Article
Diagnostic accuracy of MDCT in differentiating gallbladder cancer from acute and xanthogranulomatous cholecystitis.
Wasnik AP, Davenport MS, Kaza RK, Weadock WJ, Udager A, Keshavarzi N, Nan B, Maturen KE
Clin Imaging 2018 Jul-Aug;50:223-228. Epub 2018 Apr 14 doi: 10.1016/j.clinimag.2018.04.010. PMID: 29679780
New scoring system for differentiating xanthogranulomatous cholecystitis from gall bladder carcinoma: a tertiary care centre experience.
Rajaguru K, Mehrotra S, Lalwani S, Mangla V, Mehta N, Nundy S
ANZ J Surg 2018 Jan;88(1-2):E34-E39. Epub 2016 Sep 6 doi: 10.1111/ans.13733. PMID: 27599003
Acute abdomen: rare and unusual presentation of right colic xanthogranulomatosis.
Addario Chieco P, Antolino L, Giaccaglia V, Centanini F, Cunsolo GV, Sparagna A, Uccini S, Ziparo V
World J Gastroenterol 2014 Jul 14;20(26):8717-21. doi: 10.3748/wjg.v20.i26.8717. PMID: 25024630Free PMC Article
Differential diagnosis and treatment options for xanthogranulomatous cholecystitis.
Cui Y, Zhang H, Zhao E, Cui N, Li Z
Med Princ Pract 2013;22(1):18-23. Epub 2012 Jul 14 doi: 10.1159/000339659. PMID: 22814128Free PMC Article

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