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Short N2 sleep

MedGen UID:
1853173
•Concept ID:
C5872995
•
Finding
Synonym: Short subdued state of NREM
 
HPO: HP:5200307

Definition

Decreased duration of phase N2 of nonrapid eye movement (NREM) sleep. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVShort N2 sleep

Professional guidelines

PubMed

Intensive Sleep Retraining Treatment of Insomnia.
Lack L, Scott H, Lovato N
Sleep Med Clin 2019 Jun;14(2):245-252. Epub 2019 Apr 2 doi: 10.1016/j.jsmc.2019.01.005. PMID: 31029190
Sensor-based evaluation and treatment of nocturnal hypokinesia in Parkinson's disease: An evidence-based review.
Bhidayasiri R, Sringean J, Thanawattano C
Parkinsonism Relat Disord 2016 Jan;22 Suppl 1:S127-33. Epub 2015 Sep 30 doi: 10.1016/j.parkreldis.2015.09.049. PMID: 26453387
Sleep apnoea in end-stage renal disease: a short review of mechanisms and potential benefit from its treatment.
Chakravorty I, Shastry M, Farrington K
Nephrol Dial Transplant 2007 Jan;22(1):28-31. Epub 2006 Oct 5 doi: 10.1093/ndt/gfl582. PMID: 17023494

Recent clinical studies

Etiology

Dysautonomia: A Forgotten Condition - Part 1.
Rocha EA, Mehta N, Távora-Mehta MZP, Roncari CF, Cidrão AAL, Elias Neto J
Arq Bras Cardiol 2021 Apr;116(4):814-835. doi: 10.36660/abc.20200420. PMID: 33886735Free PMC Article
Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes.
Wang H, Lane JM, Jones SE, Dashti HS, Ollila HM, Wood AR, van Hees VT, Brumpton B, Winsvold BS, Kantojärvi K, Palviainen T, Cade BE, Sofer T, Song Y, Patel K, Anderson SG, Bechtold DA, Bowden J, Emsley R, Kyle SD, Little MA, Loudon AS, Scheer FAJL, Purcell SM, Richmond RC, Spiegelhalder K, Tyrrell J, Zhu X, Hublin C, Kaprio JA, Kristiansson K, Sulkava S, Paunio T, Hveem K, Nielsen JB, Willer CJ, Zwart JA, Strand LB, Frayling TM, Ray D, Lawlor DA, Rutter MK, Weedon MN, Redline S, Saxena R
Nat Commun 2019 Aug 13;10(1):3503. doi: 10.1038/s41467-019-11456-7. PMID: 31409809Free PMC Article
Cognitive Performance, Sleepiness, and Mood in Partially Sleep Deprived Adolescents: The Need for Sleep Study.
Lo JC, Ong JL, Leong RL, Gooley JJ, Chee MW
Sleep 2016 Mar 1;39(3):687-98. doi: 10.5665/sleep.5552. PMID: 26612392Free PMC Article
Biomarkers of Parkinson's disease: present and future.
Miller DB, O'Callaghan JP
Metabolism 2015 Mar;64(3 Suppl 1):S40-6. Epub 2014 Oct 31 doi: 10.1016/j.metabol.2014.10.030. PMID: 25510818Free PMC Article
REM and dreaming.
Glaubman H, Lewin I
Percept Mot Skills 1977 Jun;44(3 Pt 1):929-30. doi: 10.2466/pms.1977.44.3.929. PMID: 195268

Diagnosis

Dysautonomia: A Forgotten Condition - Part 1.
Rocha EA, Mehta N, Távora-Mehta MZP, Roncari CF, Cidrão AAL, Elias Neto J
Arq Bras Cardiol 2021 Apr;116(4):814-835. doi: 10.36660/abc.20200420. PMID: 33886735Free PMC Article
Behavioural and psychological symptoms of dementia in patients with Alzheimer's disease and family caregiver burden: a path analysis.
Kim B, Noh GO, Kim K
BMC Geriatr 2021 Mar 5;21(1):160. doi: 10.1186/s12877-021-02109-w. PMID: 33663416Free PMC Article
Short or Long Sleep Duration and CKD: A Mendelian Randomization Study.
Park S, Lee S, Kim Y, Lee Y, Kang MW, Kim K, Kim YC, Han SS, Lee H, Lee JP, Joo KW, Lim CS, Kim YS, Kim DK
J Am Soc Nephrol 2020 Dec;31(12):2937-2947. Epub 2020 Oct 1 doi: 10.1681/ASN.2020050666. PMID: 33004418Free PMC Article
Biomarkers of Parkinson's disease: present and future.
Miller DB, O'Callaghan JP
Metabolism 2015 Mar;64(3 Suppl 1):S40-6. Epub 2014 Oct 31 doi: 10.1016/j.metabol.2014.10.030. PMID: 25510818Free PMC Article
Agrypnia excitata.
Provini F
Curr Neurol Neurosci Rep 2013 Apr;13(4):341. doi: 10.1007/s11910-013-0341-8. PMID: 23423537

Therapy

Short or Long Sleep Duration and CKD: A Mendelian Randomization Study.
Park S, Lee S, Kim Y, Lee Y, Kang MW, Kim K, Kim YC, Han SS, Lee H, Lee JP, Joo KW, Lim CS, Kim YS, Kim DK
J Am Soc Nephrol 2020 Dec;31(12):2937-2947. Epub 2020 Oct 1 doi: 10.1681/ASN.2020050666. PMID: 33004418Free PMC Article
Cognitive Performance, Sleepiness, and Mood in Partially Sleep Deprived Adolescents: The Need for Sleep Study.
Lo JC, Ong JL, Leong RL, Gooley JJ, Chee MW
Sleep 2016 Mar 1;39(3):687-98. doi: 10.5665/sleep.5552. PMID: 26612392Free PMC Article
Cannabinoids for Medical Use: A Systematic Review and Meta-analysis.
Whiting PF, Wolff RF, Deshpande S, Di Nisio M, Duffy S, Hernandez AV, Keurentjes JC, Lang S, Misso K, Ryder S, Schmidlkofer S, Westwood M, Kleijnen J
JAMA 2015 Jun 23-30;313(24):2456-73. doi: 10.1001/jama.2015.6358. PMID: 26103030
Biomarkers of Parkinson's disease: present and future.
Miller DB, O'Callaghan JP
Metabolism 2015 Mar;64(3 Suppl 1):S40-6. Epub 2014 Oct 31 doi: 10.1016/j.metabol.2014.10.030. PMID: 25510818Free PMC Article
Neuroleptic drugs in dementia: benefits and harm.
Ballard C, Howard R
Nat Rev Neurosci 2006 Jun;7(6):492-500. doi: 10.1038/nrn1926. PMID: 16715057

Prognosis

Dysautonomia: A Forgotten Condition - Part 1.
Rocha EA, Mehta N, Távora-Mehta MZP, Roncari CF, Cidrão AAL, Elias Neto J
Arq Bras Cardiol 2021 Apr;116(4):814-835. doi: 10.36660/abc.20200420. PMID: 33886735Free PMC Article
Biomarkers of Parkinson's disease: present and future.
Miller DB, O'Callaghan JP
Metabolism 2015 Mar;64(3 Suppl 1):S40-6. Epub 2014 Oct 31 doi: 10.1016/j.metabol.2014.10.030. PMID: 25510818Free PMC Article
Long-term safety and efficacy of radiofrequency ablation in the treatment of sleep disordered breathing: a meta-analysis.
Veer V, Yang WY, Green R, Kotecha B
Eur Arch Otorhinolaryngol 2014 Nov;271(11):2863-70. Epub 2014 Feb 8 doi: 10.1007/s00405-014-2909-6. PMID: 24510179
Migraine in women.
Brandes JL
Continuum (Minneap Minn) 2012 Aug;18(4):835-52. doi: 10.1212/01.CON.0000418646.70149.71. PMID: 22868545
Gamma-vinyl GABA (vigabatrin): clinical experience in adult and adolescent patients with intractable epilepsy.
Reynolds EH
Epilepsia 1992;33 Suppl 5:S30-4; discussion S34-5. PMID: 1425498

Clinical prediction guides

Short or Long Sleep Duration and CKD: A Mendelian Randomization Study.
Park S, Lee S, Kim Y, Lee Y, Kang MW, Kim K, Kim YC, Han SS, Lee H, Lee JP, Joo KW, Lim CS, Kim YS, Kim DK
J Am Soc Nephrol 2020 Dec;31(12):2937-2947. Epub 2020 Oct 1 doi: 10.1681/ASN.2020050666. PMID: 33004418Free PMC Article
Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes.
Wang H, Lane JM, Jones SE, Dashti HS, Ollila HM, Wood AR, van Hees VT, Brumpton B, Winsvold BS, Kantojärvi K, Palviainen T, Cade BE, Sofer T, Song Y, Patel K, Anderson SG, Bechtold DA, Bowden J, Emsley R, Kyle SD, Little MA, Loudon AS, Scheer FAJL, Purcell SM, Richmond RC, Spiegelhalder K, Tyrrell J, Zhu X, Hublin C, Kaprio JA, Kristiansson K, Sulkava S, Paunio T, Hveem K, Nielsen JB, Willer CJ, Zwart JA, Strand LB, Frayling TM, Ray D, Lawlor DA, Rutter MK, Weedon MN, Redline S, Saxena R
Nat Commun 2019 Aug 13;10(1):3503. doi: 10.1038/s41467-019-11456-7. PMID: 31409809Free PMC Article
Cognitive Performance, Sleepiness, and Mood in Partially Sleep Deprived Adolescents: The Need for Sleep Study.
Lo JC, Ong JL, Leong RL, Gooley JJ, Chee MW
Sleep 2016 Mar 1;39(3):687-98. doi: 10.5665/sleep.5552. PMID: 26612392Free PMC Article
Biomarkers of Parkinson's disease: present and future.
Miller DB, O'Callaghan JP
Metabolism 2015 Mar;64(3 Suppl 1):S40-6. Epub 2014 Oct 31 doi: 10.1016/j.metabol.2014.10.030. PMID: 25510818Free PMC Article
Long-term safety and efficacy of radiofrequency ablation in the treatment of sleep disordered breathing: a meta-analysis.
Veer V, Yang WY, Green R, Kotecha B
Eur Arch Otorhinolaryngol 2014 Nov;271(11):2863-70. Epub 2014 Feb 8 doi: 10.1007/s00405-014-2909-6. PMID: 24510179

Recent systematic reviews

Lamentations in the night: A systematic review on catathrenia.
Martel Q, Maranci JB, Philippe C, Arnulf I
Sleep Med Rev 2024 Jun;75:101944. Epub 2024 May 6 doi: 10.1016/j.smrv.2024.101944. PMID: 38718707
Automatic sleep staging by cardiorespiratory signals: a systematic review.
Ebrahimi F, Alizadeh I
Sleep Breath 2022 Jun;26(2):965-981. Epub 2021 Jul 29 doi: 10.1007/s11325-021-02435-8. PMID: 34322822
Systematic review of light exposure impact on human circadian rhythm.
Tähkämö L, Partonen T, Pesonen AK
Chronobiol Int 2019 Feb;36(2):151-170. Epub 2018 Oct 12 doi: 10.1080/07420528.2018.1527773. PMID: 30311830
Poor Sleep and Risk of Falls in Community-Dwelling Older Adults: A Systematic Review.
Min Y, Slattum PW
J Appl Gerontol 2018 Sep;37(9):1059-1084. Epub 2016 Dec 20 doi: 10.1177/0733464816681149. PMID: 28380704
Cannabinoids for Medical Use: A Systematic Review and Meta-analysis.
Whiting PF, Wolff RF, Deshpande S, Di Nisio M, Duffy S, Hernandez AV, Keurentjes JC, Lang S, Misso K, Ryder S, Schmidlkofer S, Westwood M, Kleijnen J
JAMA 2015 Jun 23-30;313(24):2456-73. doi: 10.1001/jama.2015.6358. PMID: 26103030

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