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Prolonged N3 sleep

MedGen UID:
1853185
•Concept ID:
C5873014
•
Finding
HPO: HP:5200359

Definition

Increased duration of phase N3 of nonrapid eye movement (NREM) sleep. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProlonged N3 sleep

Professional guidelines

PubMed

European Academy of Neurology guideline on the diagnosis of coma and other disorders of consciousness.
Kondziella D, Bender A, Diserens K, van Erp W, Estraneo A, Formisano R, Laureys S, Naccache L, Ozturk S, Rohaut B, Sitt JD, Stender J, Tiainen M, Rossetti AO, Gosseries O, Chatelle C; EAN Panel on Coma, Disorders of Consciousness
Eur J Neurol 2020 May;27(5):741-756. Epub 2020 Feb 23 doi: 10.1111/ene.14151. PMID: 32090418
Sedentary time in older men and women: an international consensus statement and research priorities.
Dogra S, Ashe MC, Biddle SJH, Brown WJ, Buman MP, Chastin S, Gardiner PA, Inoue S, Jefferis BJ, Oka K, Owen N, Sardinha LB, Skelton DA, Sugiyama T, Copeland JL
Br J Sports Med 2017 Nov;51(21):1526-1532. Epub 2017 Jul 19 doi: 10.1136/bjsports-2016-097209. PMID: 28724710Free PMC Article
Management of imported cutaneous larva migrans: A case series and mini-review.
Kincaid L, Klowak M, Klowak S, Boggild AK
Travel Med Infect Dis 2015 Sep-Oct;13(5):382-7. Epub 2015 Jul 29 doi: 10.1016/j.tmaid.2015.07.007. PMID: 26243366

Recent clinical studies

Etiology

Acupuncture for primary insomnia: Effectiveness, safety, mechanisms and recommendations for clinical practice.
Zhao FY, Spencer SJ, Kennedy GA, Zheng Z, Conduit R, Zhang WJ, Xu P, Yue LP, Wang YM, Xu Y, Fu QQ, Ho YS
Sleep Med Rev 2024 Apr;74:101892. Epub 2023 Dec 11 doi: 10.1016/j.smrv.2023.101892. PMID: 38232645
Clinical observation of dexmedetomidine nasal spray in the treatment of sleep disorders on the first night after undergoing maxillofacial surgery: a single-center double-blind randomized controlled study.
Wang Y, Jin Z, Xu W, Chen K, Wei L, Yang D, Deng X, Tong S
J Pharm Pharm Sci 2023;26:11699. Epub 2023 Oct 3 doi: 10.3389/jpps.2023.11699. PMID: 37854323Free PMC Article
Developmental changes in obstructive sleep apnea and sleep architecture in Down syndrome.
Kahanowitch R, Aguilar H, Weiss M, Lew J, Pan Q, Ortiz-Vergara MC, Rodriguez O, Nino G
Pediatr Pulmonol 2023 Jul;58(7):1882-1888. Epub 2023 Apr 14 doi: 10.1002/ppul.26405. PMID: 37057861
SPECT and epilepsy with continuous spike waves during slow-wave sleep.
Gaggero R, Caputo M, Fiorio P, Pessagno A, Baglietto MG, Muttini P, De Negri M
Childs Nerv Syst 1995 Mar;11(3):154-60. doi: 10.1007/BF00570256. PMID: 7773975
Sleep-terror disorder in children: the role of self-hypnosis in management.
Kohen DP, Mahowald MW, Rosen GM
Am J Clin Hypn 1992 Apr;34(4):233-44. doi: 10.1080/00029157.1992.10402853. PMID: 1580230

Diagnosis

A Systematic Review, Meta-Analysis and Meta-Regression on the Effects of Carbohydrates on Sleep.
Vlahoyiannis A, Giannaki CD, Sakkas GK, Aphamis G, Andreou E
Nutrients 2021 Apr 14;13(4) doi: 10.3390/nu13041283. PMID: 33919698Free PMC Article
European Academy of Neurology guideline on the diagnosis of coma and other disorders of consciousness.
Kondziella D, Bender A, Diserens K, van Erp W, Estraneo A, Formisano R, Laureys S, Naccache L, Ozturk S, Rohaut B, Sitt JD, Stender J, Tiainen M, Rossetti AO, Gosseries O, Chatelle C; EAN Panel on Coma, Disorders of Consciousness
Eur J Neurol 2020 May;27(5):741-756. Epub 2020 Feb 23 doi: 10.1111/ene.14151. PMID: 32090418
Sleep, insomnia, and depression.
Riemann D, Krone LB, Wulff K, Nissen C
Neuropsychopharmacology 2020 Jan;45(1):74-89. Epub 2019 May 9 doi: 10.1038/s41386-019-0411-y. PMID: 31071719Free PMC Article
Coffee, caffeine, and sleep: A systematic review of epidemiological studies and randomized controlled trials.
Clark I, Landolt HP
Sleep Med Rev 2017 Feb;31:70-78. Epub 2016 Jan 30 doi: 10.1016/j.smrv.2016.01.006. PMID: 26899133
Infantile spasms.
Hrachovy RA, Frost JD Jr
Handb Clin Neurol 2013;111:611-8. doi: 10.1016/B978-0-444-52891-9.00063-4. PMID: 23622208

Therapy

Clinical observation of dexmedetomidine nasal spray in the treatment of sleep disorders on the first night after undergoing maxillofacial surgery: a single-center double-blind randomized controlled study.
Wang Y, Jin Z, Xu W, Chen K, Wei L, Yang D, Deng X, Tong S
J Pharm Pharm Sci 2023;26:11699. Epub 2023 Oct 3 doi: 10.3389/jpps.2023.11699. PMID: 37854323Free PMC Article
A Systematic Review, Meta-Analysis and Meta-Regression on the Effects of Carbohydrates on Sleep.
Vlahoyiannis A, Giannaki CD, Sakkas GK, Aphamis G, Andreou E
Nutrients 2021 Apr 14;13(4) doi: 10.3390/nu13041283. PMID: 33919698Free PMC Article
Encoding, Consolidation, and Renormalization in Depression: Synaptic Homeostasis, Plasticity, and Sleep Integrate Rapid Antidepressant Effects.
Rantamäki T, Kohtala S
Pharmacol Rev 2020 Apr;72(2):439-465. doi: 10.1124/pr.119.018697. PMID: 32139613
Coffee, caffeine, and sleep: A systematic review of epidemiological studies and randomized controlled trials.
Clark I, Landolt HP
Sleep Med Rev 2017 Feb;31:70-78. Epub 2016 Jan 30 doi: 10.1016/j.smrv.2016.01.006. PMID: 26899133
Acquired epileptiform opercular syndrome: a second case report, review of the literature, and comparison to the Landau-Kleffner syndrome.
Shafrir Y, Prensky AL
Epilepsia 1995 Oct;36(10):1050-7. doi: 10.1111/j.1528-1157.1995.tb00965.x. PMID: 7555956

Prognosis

Slow-wave sleep and REM sleep without atonia predict motor progression in Parkinson's disease.
Tao MX, Meng L, Xie WY, Li HX, Zhang JR, Yan JH, Cheng XY, Wang F, Mao CJ, Shen Y, Liu CF
Sleep Med 2024 Mar;115:155-161. Epub 2024 Feb 8 doi: 10.1016/j.sleep.2024.02.003. PMID: 38367357
Perseverative Cognition as a Mediator Between Perceived Stress and Sleep Disturbance: A Structural Equation Modeling Meta-analysis (meta-SEM).
Zagaria A, Ottaviani C, Lombardo C, Ballesio A
Ann Behav Med 2023 May 23;57(6):463-471. doi: 10.1093/abm/kaac064. PMID: 36409327
Inter-sleep stage variations in corrected QT interval differ between obstructive sleep apnea patients with and without stroke history.
Ebrahimian S, Sillanmäki S, Hietakoste S, Duce B, Kulkas A, Töyräs J, Leppänen T, Lipponen JA, Kainulainen S
PLoS One 2022;17(12):e0278520. Epub 2022 Dec 1 doi: 10.1371/journal.pone.0278520. PMID: 36454997Free PMC Article
Epileptic encephalopathy of late childhood: Landau-Kleffner syndrome and the syndrome of continuous spikes and waves during slow-wave sleep.
Smith MC, Hoeppner TJ
J Clin Neurophysiol 2003 Nov-Dec;20(6):462-72. doi: 10.1097/00004691-200311000-00008. PMID: 14734935
Sleep-terror disorder in children: the role of self-hypnosis in management.
Kohen DP, Mahowald MW, Rosen GM
Am J Clin Hypn 1992 Apr;34(4):233-44. doi: 10.1080/00029157.1992.10402853. PMID: 1580230

Clinical prediction guides

Slow-wave sleep and REM sleep without atonia predict motor progression in Parkinson's disease.
Tao MX, Meng L, Xie WY, Li HX, Zhang JR, Yan JH, Cheng XY, Wang F, Mao CJ, Shen Y, Liu CF
Sleep Med 2024 Mar;115:155-161. Epub 2024 Feb 8 doi: 10.1016/j.sleep.2024.02.003. PMID: 38367357
Clinical observation of dexmedetomidine nasal spray in the treatment of sleep disorders on the first night after undergoing maxillofacial surgery: a single-center double-blind randomized controlled study.
Wang Y, Jin Z, Xu W, Chen K, Wei L, Yang D, Deng X, Tong S
J Pharm Pharm Sci 2023;26:11699. Epub 2023 Oct 3 doi: 10.3389/jpps.2023.11699. PMID: 37854323Free PMC Article
Are intrinsic neural timescales related to sensory processing? Evidence from abnormal behavioral states.
Zilio F, Gomez-Pilar J, Cao S, Zhang J, Zang D, Qi Z, Tan J, Hiromi T, Wu X, Fogel S, Huang Z, Hohmann MR, Fomina T, Synofzik M, Grosse-Wentrup M, Owen AM, Northoff G
Neuroimage 2021 Feb 1;226:117579. Epub 2020 Nov 20 doi: 10.1016/j.neuroimage.2020.117579. PMID: 33221441
European Academy of Neurology guideline on the diagnosis of coma and other disorders of consciousness.
Kondziella D, Bender A, Diserens K, van Erp W, Estraneo A, Formisano R, Laureys S, Naccache L, Ozturk S, Rohaut B, Sitt JD, Stender J, Tiainen M, Rossetti AO, Gosseries O, Chatelle C; EAN Panel on Coma, Disorders of Consciousness
Eur J Neurol 2020 May;27(5):741-756. Epub 2020 Feb 23 doi: 10.1111/ene.14151. PMID: 32090418
Insomnia, alcoholism and relapse.
Brower KJ
Sleep Med Rev 2003 Dec;7(6):523-39. doi: 10.1016/s1087-0792(03)90005-0. PMID: 15018094

Recent systematic reviews

Perseverative Cognition as a Mediator Between Perceived Stress and Sleep Disturbance: A Structural Equation Modeling Meta-analysis (meta-SEM).
Zagaria A, Ottaviani C, Lombardo C, Ballesio A
Ann Behav Med 2023 May 23;57(6):463-471. doi: 10.1093/abm/kaac064. PMID: 36409327
A Systematic Review, Meta-Analysis and Meta-Regression on the Effects of Carbohydrates on Sleep.
Vlahoyiannis A, Giannaki CD, Sakkas GK, Aphamis G, Andreou E
Nutrients 2021 Apr 14;13(4) doi: 10.3390/nu13041283. PMID: 33919698Free PMC Article
Coffee, caffeine, and sleep: A systematic review of epidemiological studies and randomized controlled trials.
Clark I, Landolt HP
Sleep Med Rev 2017 Feb;31:70-78. Epub 2016 Jan 30 doi: 10.1016/j.smrv.2016.01.006. PMID: 26899133

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