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Metastatic malignant neoplasm to vertebral column

MedGen UID:
195773
•Concept ID:
C0684550
•
Neoplastic Process
Synonyms: CA - Secondary cancer of spine; Metastases to Spine; Metastases to the Spine; Metastasis to spine; Metastasis to Spine; Metastasis to the Spine; Metastasis to vertebral column; Metastatic Cancer to the Spine; Metastatic Cancer to the Vertebral Column; Metastatic Malignant Neoplasm in the Spine; Metastatic malignant neoplasm of vertebral column; Metastatic malignant neoplasm to spine; Metastatic Malignant Neoplasm to the Spine; Metastatic Neoplasm to the Spine; Metastatic Neoplasm to the Vertebral Column; Metastatic Tumor to the Spine; Metastatic Tumor to the Vertebral Column; Secondary cancer of spine; Secondary malignant neoplasm of spine; Secondary malignant neoplasm of vertebral column; Secondary tumor of spine; Spinal metastases
SNOMED CT: Secondary malignant neoplasm of vertebral column (94602001); Secondary malignant neoplasm of spine (94602001); Metastatic malignant neoplasm to spine (94602001); Metastatic malignant neoplasm to vertebral column (94602001); Metastatic malignant neoplasm of vertebral column (94602001); Secondary tumor of spine (94602001); Metastasis to vertebral column (94602001); Metastasis to spine (94602001); Secondary cancer of spine (94602001); CA - Secondary cancer of spine (94602001); Spinal metastases (94602001)

Definition

The spread of a malignant neoplasm to the spine. This may be from a primary spinal malignant neoplasm, or from a malignant neoplasm at a distant site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic malignant neoplasm to vertebral column

Professional guidelines

PubMed

Current Overview of Treatment for Metastatic Bone Disease.
Tsukamoto S, Kido A, Tanaka Y, Facchini G, Peta G, Rossi G, Mavrogenis AF
Curr Oncol 2021 Aug 29;28(5):3347-3372. doi: 10.3390/curroncol28050290. PMID: 34590591Free PMC Article
Assessment and Management of Patients With Metastatic Spinal Cord Compression: A Multidisciplinary Review.
Lawton AJ, Lee KA, Cheville AL, Ferrone ML, Rades D, Balboni TA, Abrahm JL
J Clin Oncol 2019 Jan 1;37(1):61-71. Epub 2018 Nov 5 doi: 10.1200/JCO.2018.78.1211. PMID: 30395488
International Spine Radiosurgery Consortium consensus guidelines for target volume definition in spinal stereotactic radiosurgery.
Cox BW, Spratt DE, Lovelock M, Bilsky MH, Lis E, Ryu S, Sheehan J, Gerszten PC, Chang E, Gibbs I, Soltys S, Sahgal A, Deasy J, Flickinger J, Quader M, Mindea S, Yamada Y
Int J Radiat Oncol Biol Phys 2012 Aug 1;83(5):e597-605. Epub 2012 May 19 doi: 10.1016/j.ijrobp.2012.03.009. PMID: 22608954

Curated

UK NICE Guideline (NG234), Spinal metastases and metastatic spinal cord compression, 2023

Recent clinical studies

Etiology

Complication Avoidance in Surgical Management of Vertebral Column Tumors.
Feler J, Sun F, Bajaj A, Hagan M, Kanekar S, Sullivan PLZ, Fridley JS, Gokaslan ZL
Curr Oncol 2022 Feb 25;29(3):1442-1454. doi: 10.3390/curroncol29030121. PMID: 35323321Free PMC Article
Evolution of surgical treatment of metastatic spine tumors.
Sullivan PZ, Niu T, Abinader JF, Syed S, Sampath P, Telfeian A, Fridley J, Klinge P, Camara J, Oyelese A, Gokaslan ZL
J Neurooncol 2022 Apr;157(2):277-283. Epub 2022 Mar 20 doi: 10.1007/s11060-022-03982-0. PMID: 35306618
Minimally Invasive Surgery for Spinal Metastasis: A Review.
Flynn SC, Eli IM, Ghogawala Z, Yew AY
World Neurosurg 2022 Mar;159:e32-e39. Epub 2021 Nov 30 doi: 10.1016/j.wneu.2021.11.097. PMID: 34861449
Consensus Contouring Guidelines for Postoperative Stereotactic Body Radiation Therapy for Metastatic Solid Tumor Malignancies to the Spine.
Redmond KJ, Robertson S, Lo SS, Soltys SG, Ryu S, McNutt T, Chao ST, Yamada Y, Ghia A, Chang EL, Sheehan J, Sahgal A
Int J Radiat Oncol Biol Phys 2017 Jan 1;97(1):64-74. Epub 2016 Sep 17 doi: 10.1016/j.ijrobp.2016.09.014. PMID: 27843035Free PMC Article
Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: a randomised trial.
Patchell RA, Tibbs PA, Regine WF, Payne R, Saris S, Kryscio RJ, Mohiuddin M, Young B
Lancet 2005 Aug 20-26;366(9486):643-8. doi: 10.1016/S0140-6736(05)66954-1. PMID: 16112300

Diagnosis

Spinal Metastases.
Chiu RG, Mehta AI
JAMA 2020 Jun 16;323(23):2438. doi: 10.1001/jama.2020.0716. PMID: 32543685
Spine Oncology: Imaging and Intervention.
Gibbs WN, Nael K, Doshi AH, Tanenbaum LN
Radiol Clin North Am 2019 Mar;57(2):377-395. Epub 2018 Dec 10 doi: 10.1016/j.rcl.2018.10.002. PMID: 30709476
Consensus Contouring Guidelines for Postoperative Stereotactic Body Radiation Therapy for Metastatic Solid Tumor Malignancies to the Spine.
Redmond KJ, Robertson S, Lo SS, Soltys SG, Ryu S, McNutt T, Chao ST, Yamada Y, Ghia A, Chang EL, Sheehan J, Sahgal A
Int J Radiat Oncol Biol Phys 2017 Jan 1;97(1):64-74. Epub 2016 Sep 17 doi: 10.1016/j.ijrobp.2016.09.014. PMID: 27843035Free PMC Article
Metastatic saccrococcygeal chordoma.
Fatehi Hassanabad M, Mansouri A, Alotaibi NM, Hazrati LN, Bernstein M
J Clin Neurosci 2016 Jan;23:149-152. Epub 2015 Nov 18 doi: 10.1016/j.jocn.2015.05.036. PMID: 26602601
International Spine Radiosurgery Consortium consensus guidelines for target volume definition in spinal stereotactic radiosurgery.
Cox BW, Spratt DE, Lovelock M, Bilsky MH, Lis E, Ryu S, Sheehan J, Gerszten PC, Chang E, Gibbs I, Soltys S, Sahgal A, Deasy J, Flickinger J, Quader M, Mindea S, Yamada Y
Int J Radiat Oncol Biol Phys 2012 Aug 1;83(5):e597-605. Epub 2012 May 19 doi: 10.1016/j.ijrobp.2012.03.009. PMID: 22608954

Therapy

Assessment and Management of Patients With Metastatic Spinal Cord Compression: A Multidisciplinary Review.
Lawton AJ, Lee KA, Cheville AL, Ferrone ML, Rades D, Balboni TA, Abrahm JL
J Clin Oncol 2019 Jan 1;37(1):61-71. Epub 2018 Nov 5 doi: 10.1200/JCO.2018.78.1211. PMID: 30395488
Medical treatment of advanced chordomas.
Colia V, Stacchiotti S
Eur J Cancer 2017 Sep;83:220-228. Epub 2017 Jul 25 doi: 10.1016/j.ejca.2017.06.038. PMID: 28750274
Association Between BMP-2 and Carcinogenicity.
Skovrlj B, Koehler SM, Anderson PA, Qureshi SA, Hecht AC, Iatridis JC, Cho SK
Spine (Phila Pa 1976) 2015 Dec;40(23):1862-71. doi: 10.1097/BRS.0000000000001126. PMID: 26274524Free PMC Article
Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: a randomised trial.
Patchell RA, Tibbs PA, Regine WF, Payne R, Saris S, Kryscio RJ, Mohiuddin M, Young B
Lancet 2005 Aug 20-26;366(9486):643-8. doi: 10.1016/S0140-6736(05)66954-1. PMID: 16112300
Vertebral body resection.
Martin LW, Walsh GL
Thorac Surg Clin 2004 May;14(2):241-54. doi: 10.1016/S1547-4127(04)00009-X. PMID: 15382300

Prognosis

Sacral Dimple.
Khairy S, Azzubi M
World Neurosurg 2017 May;101:811.e7-811.e8. Epub 2017 Feb 27 doi: 10.1016/j.wneu.2017.02.074. PMID: 28245993
Neuroimaging of spine tumors.
Pinter NK, Pfiffner TJ, Mechtler LL
Handb Clin Neurol 2016;136:689-706. doi: 10.1016/B978-0-444-53486-6.00033-8. PMID: 27430436
Metastatic saccrococcygeal chordoma.
Fatehi Hassanabad M, Mansouri A, Alotaibi NM, Hazrati LN, Bernstein M
J Clin Neurosci 2016 Jan;23:149-152. Epub 2015 Nov 18 doi: 10.1016/j.jocn.2015.05.036. PMID: 26602601
Neoplastic meningitis.
Chamberlain MC
J Clin Oncol 2005 May 20;23(15):3605-13. doi: 10.1200/JCO.2005.01.131. PMID: 15908671
Vertebral chondroblastoma.
Ilaslan H, Sundaram M, Unni KK
Skeletal Radiol 2003 Feb;32(2):66-71. Epub 2002 Nov 21 doi: 10.1007/s00256-002-0599-4. PMID: 12589483

Clinical prediction guides

A vertebral skeletal stem cell lineage driving metastasis.
Sun J, Hu L, Bok S, Yallowitz AR, Cung M, McCormick J, Zheng LJ, Debnath S, Niu Y, Tan AY, Lalani S, Morse KW, Shinn D, Pajak A, Hammad M, Suhardi VJ, Li Z, Li N, Wang L, Zou W, Mittal V, Bostrom MPG, Xu R, Iyer S, Greenblatt MB
Nature 2023 Sep;621(7979):602-609. Epub 2023 Sep 13 doi: 10.1038/s41586-023-06519-1. PMID: 37704733Free PMC Article
Clinical features and prognostic factors of spinal metastatic pancreatic cancer: A retrospective observational study.
Yun JH, Cho PG, Kim KT, Shin DA, Kim KN, Kim SH, Noh SH
Medicine (Baltimore) 2023 Jul 14;102(28):e34264. doi: 10.1097/MD.0000000000034264. PMID: 37443474Free PMC Article
Spine Oncology: Imaging and Intervention.
Gibbs WN, Nael K, Doshi AH, Tanenbaum LN
Radiol Clin North Am 2019 Mar;57(2):377-395. Epub 2018 Dec 10 doi: 10.1016/j.rcl.2018.10.002. PMID: 30709476
Management and retrospective analysis of primary and metastatic sacral tumors and infections: evaluation with 73 cases.
Arıkan M, Togral G, Hastürk AE, Aktaş E, Güngör S
Eklem Hastalik Cerrahisi 2014;25(3):126-32. doi: 10.5606/ehc.2014.28. PMID: 25413456
Atraumatic vertebral compression fractures: differential diagnosis between benign osteoporotic and malignant fractures by MRI.
Cicala D, Briganti F, Casale L, Rossi C, Cagini L, Cesarano E, Brunese L, Giganti M
Musculoskelet Surg 2013 Aug;97 Suppl 2:S169-79. Epub 2013 Aug 15 doi: 10.1007/s12306-013-0277-9. PMID: 23949939

Recent systematic reviews

ESTRO clinical practice guideline: Stereotactic body radiotherapy for spine metastases.
Guckenberger M, Andratschke N, Belka C, Bellut D, Cuccia F, Dahele M, Guninski RS, Josipovic M, Mancosu P, Minniti G, Niyazi M, Ricardi U, Munck Af Rosenschold P, Sahgal A, Tsang Y, Verbakel W, Alongi F
Radiother Oncol 2024 Jan;190:109966. Epub 2023 Nov 2 doi: 10.1016/j.radonc.2023.109966. PMID: 37925107
Efficacy and safety of SBRT for spine metastases: A systematic review and meta-analysis for preparation of an ESTRO practice guideline.
Guninski RS, Cuccia F, Alongi F, Andratschke N, Belka C, Bellut D, Dahele M, Josipovic M, Kroese TE, Mancosu P, Minniti G, Niyazi M, Ricardi U, Munck Af Rosenschold P, Sahgal A, Tsang Y, Verbakel WFAR, Guckenberger M
Radiother Oncol 2024 Jan;190:109969. Epub 2023 Nov 2 doi: 10.1016/j.radonc.2023.109969. PMID: 37922993
Stereotactic radiosurgery versus whole brain radiotherapy in patients with intracranial metastatic disease and small-cell lung cancer: a systematic review and meta-analysis.
Gaebe K, Li AY, Park A, Parmar A, Lok BH, Sahgal A, Chan KKW, Erickson AW, Das S
Lancet Oncol 2022 Jul;23(7):931-939. Epub 2022 May 26 doi: 10.1016/S1470-2045(22)00271-6. PMID: 35644163
Metastatic Spinal Cord Compression and Steroid Treatment: A Systematic Review.
Kumar A, Weber MH, Gokaslan Z, Wolinsky JP, Schmidt M, Rhines L, Fehlings MG, Laufer I, Sciubba DM, Clarke MJ, Sundaresan N, Verlaan JJ, Sahgal A, Chou D, Fisher CG
Clin Spine Surg 2017 May;30(4):156-163. doi: 10.1097/BSD.0000000000000528. PMID: 28437329
A novel classification system for spinal instability in neoplastic disease: an evidence-based approach and expert consensus from the Spine Oncology Study Group.
Fisher CG, DiPaola CP, Ryken TC, Bilsky MH, Shaffrey CI, Berven SH, Harrop JS, Fehlings MG, Boriani S, Chou D, Schmidt MH, Polly DW, Biagini R, Burch S, Dekutoski MB, Ganju A, Gerszten PC, Gokaslan ZL, Groff MW, Liebsch NJ, Mendel E, Okuno SH, Patel S, Rhines LD, Rose PS, Sciubba DM, Sundaresan N, Tomita K, Varga PP, Vialle LR, Vrionis FD, Yamada Y, Fourney DR
Spine (Phila Pa 1976) 2010 Oct 15;35(22):E1221-9. doi: 10.1097/BRS.0b013e3181e16ae2. PMID: 20562730

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2023
      UK NICE Guideline (NG234), Spinal metastases and metastatic spinal cord compression, 2023

    Consumer resources

    Reviews

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    • PMC Articles
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