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Pulmonary sarcoidosis

MedGen UID:
19873
•Concept ID:
C0036205
•
Disease or Syndrome
Synonyms: Pulmonary Sarcoidoses; Pulmonary Sarcoidosis; Sarcoidoses, Pulmonary; Sarcoidosis, Pulmonary
SNOMED CT: Sarcoidosis of lung (24369008); Pulmonary sarcoidosis (24369008)
 
Monarch Initiative: MONDO:0001708

Definition

Sarcoidosis affecting the lung parenchyma. It is characterized by the presence of non-necrotizing granulomas in the lung tissues. It is manifested with dyspnea, cough, fever, night sweats, fatigue, and weight loss. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPulmonary sarcoidosis

Professional guidelines

PubMed

Diagnosis and Treatment of Pulmonary Sarcoidosis: A Review.
Belperio JA, Shaikh F, Abtin FG, Fishbein MC, Weigt SS, Saggar R, Lynch JP 3rd
JAMA 2022 Mar 1;327(9):856-867. doi: 10.1001/jama.2022.1570. PMID: 35230389
Clinical management of pulmonary sarcoidosis.
Zhou Y, Lower EE, Li H, Baughman RP
Expert Rev Respir Med 2016;10(5):577-91. Epub 2016 Mar 28 doi: 10.1586/17476348.2016.1164602. PMID: 26959110
Treatment of sarcoidosis.
Baughman RP
Panminerva Med 2013 Jun;55(2):175-89. PMID: 23676958

Recent clinical studies

Etiology

Monitoring of Sarcoidosis.
Kouranos V, Wells AU
Clin Chest Med 2024 Mar;45(1):45-57. Epub 2023 Sep 4 doi: 10.1016/j.ccm.2023.08.002. PMID: 38245370
Fibrotic Pulmonary Sarcoidosis.
Nunes H, Brillet PY, Bernaudin JF, Gille T, Valeyre D, Jeny F
Clin Chest Med 2024 Mar;45(1):199-212. Epub 2023 Sep 4 doi: 10.1016/j.ccm.2023.08.011. PMID: 38245367
High-dose (40 mg) versus low-dose (20 mg) prednisolone for treating sarcoidosis: a randomised trial (SARCORT trial).
Dhooria S, Sehgal IS, Agarwal R, Muthu V, Prasad KT, Dogra P, Debi U, Garg M, Bal A, Gupta N, Aggarwal AN
Eur Respir J 2023 Sep;62(3) Epub 2023 Sep 9 doi: 10.1183/13993003.00198-2023. PMID: 37690784
Efzofitimod for the Treatment of Pulmonary Sarcoidosis.
Culver DA, Aryal S, Barney J, Hsia CCW, James WE, Maier LA, Marts LT, Obi ON, Sporn PHS, Sweiss NJ, Shukla S, Kinnersley N, Walker G, Baughman R
Chest 2023 Apr;163(4):881-890. Epub 2022 Nov 8 doi: 10.1016/j.chest.2022.10.037. PMID: 36356657Free PMC Article
Pulmonary Sarcoidosis.
Valeyre D, Bernaudin JF, Jeny F, Duchemann B, Freynet O, Planès C, Kambouchner M, Nunes H
Clin Chest Med 2015 Dec;36(4):631-41. doi: 10.1016/j.ccm.2015.08.006. PMID: 26593138

Diagnosis

Diagnosis and Treatment of Pulmonary Sarcoidosis: A Review.
Belperio JA, Shaikh F, Abtin FG, Fishbein MC, Weigt SS, Saggar R, Lynch JP 3rd
JAMA 2022 Mar 1;327(9):856-867. doi: 10.1001/jama.2022.1570. PMID: 35230389
BTS Clinical Statement on pulmonary sarcoidosis.
Thillai M, Atkins CP, Crawshaw A, Hart SP, Ho LP, Kouranos V, Patterson K, Screaton NJ, Whight J, Wells AU
Thorax 2021 Jan;76(1):4-20. Epub 2020 Dec 2 doi: 10.1136/thoraxjnl-2019-214348. PMID: 33268456
Challenges in Cardiac and Pulmonary Sarcoidosis: JACC State-of-the-Art Review.
Trivieri MG, Spagnolo P, Birnie D, Liu P, Drake W, Kovacic JC, Baughman R, Fayad ZA, Judson MA
J Am Coll Cardiol 2020 Oct 20;76(16):1878-1901. doi: 10.1016/j.jacc.2020.08.042. PMID: 33059834Free PMC Article
Pulmonary sarcoidosis.
Spagnolo P, Rossi G, Trisolini R, Sverzellati N, Baughman RP, Wells AU
Lancet Respir Med 2018 May;6(5):389-402. Epub 2018 Apr 3 doi: 10.1016/S2213-2600(18)30064-X. PMID: 29625772
Pulmonary Sarcoidosis.
Valeyre D, Bernaudin JF, Jeny F, Duchemann B, Freynet O, Planès C, Kambouchner M, Nunes H
Clin Chest Med 2015 Dec;36(4):631-41. doi: 10.1016/j.ccm.2015.08.006. PMID: 26593138

Therapy

High-dose (40 mg) versus low-dose (20 mg) prednisolone for treating sarcoidosis: a randomised trial (SARCORT trial).
Dhooria S, Sehgal IS, Agarwal R, Muthu V, Prasad KT, Dogra P, Debi U, Garg M, Bal A, Gupta N, Aggarwal AN
Eur Respir J 2023 Sep;62(3) Epub 2023 Sep 9 doi: 10.1183/13993003.00198-2023. PMID: 37690784
Efzofitimod for the Treatment of Pulmonary Sarcoidosis.
Culver DA, Aryal S, Barney J, Hsia CCW, James WE, Maier LA, Marts LT, Obi ON, Sporn PHS, Sweiss NJ, Shukla S, Kinnersley N, Walker G, Baughman R
Chest 2023 Apr;163(4):881-890. Epub 2022 Nov 8 doi: 10.1016/j.chest.2022.10.037. PMID: 36356657Free PMC Article
Challenges in Cardiac and Pulmonary Sarcoidosis: JACC State-of-the-Art Review.
Trivieri MG, Spagnolo P, Birnie D, Liu P, Drake W, Kovacic JC, Baughman R, Fayad ZA, Judson MA
J Am Coll Cardiol 2020 Oct 20;76(16):1878-1901. doi: 10.1016/j.jacc.2020.08.042. PMID: 33059834Free PMC Article
Advanced Pulmonary Sarcoidosis.
Gupta R, Baughman RP
Semin Respir Crit Care Med 2020 Oct;41(5):700-715. Epub 2020 Aug 10 doi: 10.1055/s-0040-1709495. PMID: 32777853
Sarcoidosis-Associated Pulmonary Hypertension.
Shlobin OA, Baughman RP
Semin Respir Crit Care Med 2017 Aug;38(4):450-462. Epub 2017 Jul 27 doi: 10.1055/s-0037-1603767. PMID: 28750460

Prognosis

Advanced pulmonary sarcoidosis.
Patel DC, Valeyre D
Curr Opin Pulm Med 2020 Sep;26(5):574-581. doi: 10.1097/MCP.0000000000000705. PMID: 32740378
Advanced sarcoidosis.
Baughman RP, Wells A
Curr Opin Pulm Med 2019 Sep;25(5):497-504. doi: 10.1097/MCP.0000000000000612. PMID: 31365384
Interstitial Lung Diseases in Developing Countries.
Rivera-Ortega P, Molina-Molina M
Ann Glob Health 2019 Jan 22;85(1) doi: 10.5334/aogh.2414. PMID: 30741505Free PMC Article
Pulmonary sarcoidosis.
Spagnolo P, Rossi G, Trisolini R, Sverzellati N, Baughman RP, Wells AU
Lancet Respir Med 2018 May;6(5):389-402. Epub 2018 Apr 3 doi: 10.1016/S2213-2600(18)30064-X. PMID: 29625772
Pulmonary sarcoidosis.
Lynch JP 3rd, Ma YL, Koss MN, White ES
Semin Respir Crit Care Med 2007 Feb;28(1):53-74. doi: 10.1055/s-2007-970333. PMID: 17330192

Clinical prediction guides

High-dose (40 mg) versus low-dose (20 mg) prednisolone for treating sarcoidosis: a randomised trial (SARCORT trial).
Dhooria S, Sehgal IS, Agarwal R, Muthu V, Prasad KT, Dogra P, Debi U, Garg M, Bal A, Gupta N, Aggarwal AN
Eur Respir J 2023 Sep;62(3) Epub 2023 Sep 9 doi: 10.1183/13993003.00198-2023. PMID: 37690784
Efzofitimod for the Treatment of Pulmonary Sarcoidosis.
Culver DA, Aryal S, Barney J, Hsia CCW, James WE, Maier LA, Marts LT, Obi ON, Sporn PHS, Sweiss NJ, Shukla S, Kinnersley N, Walker G, Baughman R
Chest 2023 Apr;163(4):881-890. Epub 2022 Nov 8 doi: 10.1016/j.chest.2022.10.037. PMID: 36356657Free PMC Article
Diagnosis and Treatment of Pulmonary Sarcoidosis: A Review.
Belperio JA, Shaikh F, Abtin FG, Fishbein MC, Weigt SS, Saggar R, Lynch JP 3rd
JAMA 2022 Mar 1;327(9):856-867. doi: 10.1001/jama.2022.1570. PMID: 35230389
Pulmonary sarcoidosis.
Spagnolo P, Rossi G, Trisolini R, Sverzellati N, Baughman RP, Wells AU
Lancet Respir Med 2018 May;6(5):389-402. Epub 2018 Apr 3 doi: 10.1016/S2213-2600(18)30064-X. PMID: 29625772
Chest Imaging.
Keijsers RG, Veltkamp M, Grutters JC
Clin Chest Med 2015 Dec;36(4):603-19. doi: 10.1016/j.ccm.2015.08.004. PMID: 26593136

Recent systematic reviews

MicroRNAs in pulmonary sarcoidosis: A systematic review.
Pattnaik B, Sryma PB, Mittal S, Agrawal A, Guleria R, Madan K
Respir Investig 2020 Jul;58(4):232-238. Epub 2020 Apr 15 doi: 10.1016/j.resinv.2020.02.008. PMID: 32305227
Sarcoidosis and cancer risk: systematic review and meta-analysis of observational studies.
Bonifazi M, Bravi F, Gasparini S, La Vecchia C, Gabrielli A, Wells AU, Renzoni EA
Chest 2015 Mar;147(3):778-791. doi: 10.1378/chest.14-1475. PMID: 25340385
Efficacy and safety of conventional transbronchial needle aspiration in sarcoidosis: a systematic review and meta-analysis.
Agarwal R, Aggarwal AN, Gupta D
Respir Care 2013 Apr;58(4):683-93. doi: 10.4187/respcare.02101. PMID: 23050747
Corticosteroids for pulmonary sarcoidosis.
Paramothayan NS, Lasserson TJ, Jones PW
Cochrane Database Syst Rev 2005 Apr 18;2005(2):CD001114. doi: 10.1002/14651858.CD001114.pub2. PMID: 15846612Free PMC Article
Corticosteroid therapy in pulmonary sarcoidosis: a systematic review.
Paramothayan S, Jones PW
JAMA 2002 Mar 13;287(10):1301-7. doi: 10.1001/jama.287.10.1301. PMID: 11886322

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