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Peripheral primitive neuroectodermal tumor of soft tissues

MedGen UID:
205115
•Concept ID:
C1112437
•
Neoplastic Process
Synonyms: Peripheral Neuroectodermal Tumor of Soft Tissues; peripheral neuroectodermal tumor of soft tissues; Peripheral Neuroectodermal Tumor of the Soft Tissues; peripheral neuroectodermal tumor of the soft tissues; peripheral neuroectodermal tumour of soft tissues; peripheral neuroectodermal tumour of the soft tissues; Peripheral Neuroepithelioma of Soft Tissues; peripheral neuroepithelioma of soft tissues; Peripheral Neuroepithelioma of the Soft Tissues; peripheral neuroepithelioma of the soft tissues; Peripheral Primitive Neuroectodermal Tumor of Soft Tissues; peripheral primitive neuroectodermal tumor of soft tissues; soft tissue peripheral neuroepithelioma
 
Monarch Initiative: MONDO:0002982

Definition

A small round cell tumor with neural differentiation arising from the soft tissues. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPeripheral primitive neuroectodermal tumor of soft tissues

Professional guidelines

PubMed

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Cancer Radiother 2022 Feb-Apr;26(1-2):356-367. Epub 2021 Dec 27 doi: 10.1016/j.canrad.2021.11.018. PMID: 34969622
The new international neuroblastoma response criteria.
Orr KE, McHugh K
Pediatr Radiol 2019 Oct;49(11):1433-1440. Epub 2019 Oct 16 doi: 10.1007/s00247-019-04397-2. PMID: 31620844
Revisions to the International Neuroblastoma Response Criteria: A Consensus Statement From the National Cancer Institute Clinical Trials Planning Meeting.
Park JR, Bagatell R, Cohn SL, Pearson AD, Villablanca JG, Berthold F, Burchill S, Boubaker A, McHugh K, Nuchtern JG, London WB, Seibel NL, Lindwasser OW, Maris JM, Brock P, Schleiermacher G, Ladenstein R, Matthay KK, Valteau-Couanet D
J Clin Oncol 2017 Aug 1;35(22):2580-2587. Epub 2017 May 4 doi: 10.1200/JCO.2016.72.0177. PMID: 28471719Free PMC Article

Recent clinical studies

Etiology

Prognostic factors of sarcomas occurring in bone and joint: A SEER based study.
Zhou H, He S, Zhang D, Wang J, Yang X, Jiao J, Xu W, Yang J, Xiao J
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Revisions to the International Neuroblastoma Response Criteria: A Consensus Statement From the National Cancer Institute Clinical Trials Planning Meeting.
Park JR, Bagatell R, Cohn SL, Pearson AD, Villablanca JG, Berthold F, Burchill S, Boubaker A, McHugh K, Nuchtern JG, London WB, Seibel NL, Lindwasser OW, Maris JM, Brock P, Schleiermacher G, Ladenstein R, Matthay KK, Valteau-Couanet D
J Clin Oncol 2017 Aug 1;35(22):2580-2587. Epub 2017 May 4 doi: 10.1200/JCO.2016.72.0177. PMID: 28471719Free PMC Article
¹³¹I-Metaiodobenzylguanidine Theranostics in Neuroblastoma: Historical Perspectives; Practical Applications.
Parisi MT, Eslamy H, Park JR, Shulkin BL, Yanik GA
Semin Nucl Med 2016 May;46(3):184-202. doi: 10.1053/j.semnuclmed.2016.02.002. PMID: 27067500
Pediatrics: diagnosis of neuroblastoma.
Sharp SE, Gelfand MJ, Shulkin BL
Semin Nucl Med 2011 Sep;41(5):345-53. doi: 10.1053/j.semnuclmed.2011.05.001. PMID: 21803184
Pesticides and childhood cancer.
Zahm SH, Ward MH
Environ Health Perspect 1998 Jun;106 Suppl 3(Suppl 3):893-908. doi: 10.1289/ehp.98106893. PMID: 9646054Free PMC Article

Diagnosis

Prognostic factors of sarcomas occurring in bone and joint: A SEER based study.
Zhou H, He S, Zhang D, Wang J, Yang X, Jiao J, Xu W, Yang J, Xiao J
Medicine (Baltimore) 2023 Oct 27;102(43):e34231. doi: 10.1097/MD.0000000000034231. PMID: 37904412Free PMC Article
Non-chemotherapy adjuvant agents in TP53 mutant Ewing sarcoma.
Kim JA, Crawford KA, Spada PA, Martin LR, Zhang J, Wong R, Reid JM, Stewart CF, Frank TM, Liu Q, Michalek JE, Keller C
Sci Rep 2023 Sep 1;13(1):14360. doi: 10.1038/s41598-023-40751-z. PMID: 37658148Free PMC Article
Revisions to the International Neuroblastoma Response Criteria: A Consensus Statement From the National Cancer Institute Clinical Trials Planning Meeting.
Park JR, Bagatell R, Cohn SL, Pearson AD, Villablanca JG, Berthold F, Burchill S, Boubaker A, McHugh K, Nuchtern JG, London WB, Seibel NL, Lindwasser OW, Maris JM, Brock P, Schleiermacher G, Ladenstein R, Matthay KK, Valteau-Couanet D
J Clin Oncol 2017 Aug 1;35(22):2580-2587. Epub 2017 May 4 doi: 10.1200/JCO.2016.72.0177. PMID: 28471719Free PMC Article
Pesticides and childhood cancer.
Zahm SH, Ward MH
Environ Health Perspect 1998 Jun;106 Suppl 3(Suppl 3):893-908. doi: 10.1289/ehp.98106893. PMID: 9646054Free PMC Article
Neuroblastoma-like neurilemoma.
Goldblum JR, Beals TF, Weiss SW
Am J Surg Pathol 1994 Mar;18(3):266-73. doi: 10.1097/00000478-199403000-00006. PMID: 8116794

Therapy

Immune landscape and in vivo immunogenicity of NY-ESO-1 tumor antigen in advanced neuroblastoma patients.
Camisaschi C, Renne SL, Beretta V, Rini F, Spagnuolo RD, Tuccitto A, Podda MG, Parmiani G, Rivoltini L, Collini P, Castelli C, Luksch R
BMC Cancer 2018 Oct 16;18(1):983. doi: 10.1186/s12885-018-4910-8. PMID: 30326856Free PMC Article
Treatment and outcome of adult-onset neuroblastoma.
Suzuki M, Kushner BH, Kramer K, Basu EM, Roberts SS, Hammond WJ, LaQuaglia MP, Wolden SL, Cheung NV, Modak S
Int J Cancer 2018 Sep 1;143(5):1249-1258. Epub 2018 Apr 6 doi: 10.1002/ijc.31399. PMID: 29574715Free PMC Article
Revisions to the International Neuroblastoma Response Criteria: A Consensus Statement From the National Cancer Institute Clinical Trials Planning Meeting.
Park JR, Bagatell R, Cohn SL, Pearson AD, Villablanca JG, Berthold F, Burchill S, Boubaker A, McHugh K, Nuchtern JG, London WB, Seibel NL, Lindwasser OW, Maris JM, Brock P, Schleiermacher G, Ladenstein R, Matthay KK, Valteau-Couanet D
J Clin Oncol 2017 Aug 1;35(22):2580-2587. Epub 2017 May 4 doi: 10.1200/JCO.2016.72.0177. PMID: 28471719Free PMC Article
Efficacy of trabectedin in advanced soft tissue sarcoma: beyond lipo- and leiomyosarcoma.
De Sanctis R, Marrari A, Marchetti S, Mussi C, Balzarini L, Lutman FR, Daolio P, Bastoni S, Bertuzzi AF, Quagliuolo V, Santoro A
Drug Des Devel Ther 2015;9:5785-91. Epub 2015 Oct 27 doi: 10.2147/DDDT.S92395. PMID: 26604682Free PMC Article
Pesticides and childhood cancer.
Zahm SH, Ward MH
Environ Health Perspect 1998 Jun;106 Suppl 3(Suppl 3):893-908. doi: 10.1289/ehp.98106893. PMID: 9646054Free PMC Article

Prognosis

Prognostic factors of sarcomas occurring in bone and joint: A SEER based study.
Zhou H, He S, Zhang D, Wang J, Yang X, Jiao J, Xu W, Yang J, Xiao J
Medicine (Baltimore) 2023 Oct 27;102(43):e34231. doi: 10.1097/MD.0000000000034231. PMID: 37904412Free PMC Article
Treatment and outcome of adult-onset neuroblastoma.
Suzuki M, Kushner BH, Kramer K, Basu EM, Roberts SS, Hammond WJ, LaQuaglia MP, Wolden SL, Cheung NV, Modak S
Int J Cancer 2018 Sep 1;143(5):1249-1258. Epub 2018 Apr 6 doi: 10.1002/ijc.31399. PMID: 29574715Free PMC Article
¹³¹I-Metaiodobenzylguanidine Theranostics in Neuroblastoma: Historical Perspectives; Practical Applications.
Parisi MT, Eslamy H, Park JR, Shulkin BL, Yanik GA
Semin Nucl Med 2016 May;46(3):184-202. doi: 10.1053/j.semnuclmed.2016.02.002. PMID: 27067500
Pediatrics: diagnosis of neuroblastoma.
Sharp SE, Gelfand MJ, Shulkin BL
Semin Nucl Med 2011 Sep;41(5):345-53. doi: 10.1053/j.semnuclmed.2011.05.001. PMID: 21803184
Ophthalmic striated muscle neoplasms.
Knowles DM, Jakobiec FA, Potter GD, Jones IS
Surv Ophthalmol 1976 Nov-Dec;21(3):219-61. doi: 10.1016/0039-6257(76)90123-5. PMID: 797029

Clinical prediction guides

Prognostic factors of sarcomas occurring in bone and joint: A SEER based study.
Zhou H, He S, Zhang D, Wang J, Yang X, Jiao J, Xu W, Yang J, Xiao J
Medicine (Baltimore) 2023 Oct 27;102(43):e34231. doi: 10.1097/MD.0000000000034231. PMID: 37904412Free PMC Article
Is high-risk neuroblastoma induction chemotherapy possible without G-CSF? A pilot study of safety and treatment delays in the absence of primary prophylactic hematopoietic growth factors.
Whittle SB, Smith V, Silverstein A, Parmeter M, Minard CG, Bernhardt MB, Zage PE, Venkatramani R, Nuchtern JG, Heczey A, Russell HV, Shohet JM, Foster JH
Pediatr Blood Cancer 2020 Oct;67(10):e28417. Epub 2020 Jul 30 doi: 10.1002/pbc.28417. PMID: 32729196Free PMC Article
¹³¹I-Metaiodobenzylguanidine Theranostics in Neuroblastoma: Historical Perspectives; Practical Applications.
Parisi MT, Eslamy H, Park JR, Shulkin BL, Yanik GA
Semin Nucl Med 2016 May;46(3):184-202. doi: 10.1053/j.semnuclmed.2016.02.002. PMID: 27067500
Clinical features and outcomes in patients with Ewing sarcoma and regional lymph node involvement.
Applebaum MA, Goldsby R, Neuhaus J, DuBois SG
Pediatr Blood Cancer 2012 Oct;59(4):617-20. Epub 2011 Dec 19 doi: 10.1002/pbc.24053. PMID: 22184129Free PMC Article
Pesticides and childhood cancer.
Zahm SH, Ward MH
Environ Health Perspect 1998 Jun;106 Suppl 3(Suppl 3):893-908. doi: 10.1289/ehp.98106893. PMID: 9646054Free PMC Article

Recent systematic reviews

Malignant spinal cord compression in the paediatric population-a systematic review, meta-analysis.
Quraishi NA, Palliyil N, Hassanin MA, D'Aquino D, Shetaiwi A, Walker D
Eur Spine J 2023 Dec;32(12):4306-4313. Epub 2023 Jun 20 doi: 10.1007/s00586-023-07820-3. PMID: 37338630

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