U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Trisomy 15

MedGen UID:
208642
•Concept ID:
C0795856
•
Disease or Syndrome

Definition

A chromosomal abnormality consisting of the presence of a third copy of chromosome 15 in somatic cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTrisomy 15

Professional guidelines

PubMed

Cytogenetics in the management of clonal chromosomal abnormalities of undetermined significance and persistent polyclonal B-cell lymphocytosis: Guidelines from the Groupe Francophone de Cytogénétique Hématologique (GFCH).
Nadal N, Auger N, Bidet A, Nguyen-Khac F
Curr Res Transl Med 2023 Oct-Dec;71(4):103426. Epub 2023 Oct 26 doi: 10.1016/j.retram.2023.103426. PMID: 38016423
Trisomy 15 mosaicism: Challenges in prenatal diagnosis.
Silva M, Alves C, Pedro S, Marques B, Ferreira C, Furtado J, Martins AT, Fernandes R, Correia J, Correia H
Am J Med Genet A 2015 Nov;167A(11):2847-50. Epub 2015 Jun 30 doi: 10.1002/ajmg.a.37229. PMID: 26126738
Retrospective diagnosis of trisomy 15 in formalin-fixed, paraffin-embedded placental tissue in a newborn girl with Prader-Willi syndrome.
Walczak C, Enders H, Grissinger K, Dufke A
Prenat Diagn 2000 Nov;20(11):914-6. doi: 10.1002/1097-0223(200011)20:11<914::aid-pd939>3.0.co;2-6. PMID: 11113895

Recent clinical studies

Etiology

Frequency of Chromosomal Abnormalities in Products of Conception.
Teles TM, Paula CM, Ramos MG, Costa HB, Andrade CR, Coxir SA, Penna ML
Rev Bras Ginecol Obstet 2017 Mar;39(3):110-114. Epub 2017 Mar 15 doi: 10.1055/s-0037-1600521. PMID: 28297732Free PMC Article
Association between increased yolk sac diameter and abnormal karyotypes.
Gersak K, Veble A, Mulla ZD, Plavsic SK
J Perinat Med 2012 Jan 10;40(3):251-4. doi: 10.1515/jpm.2011.140. PMID: 22505502
Chromosomal abnormalities associated with neural tube defects (I): full aneuploidy.
Chen CP
Taiwan J Obstet Gynecol 2007 Dec;46(4):325-35. doi: 10.1016/S1028-4559(08)60002-9. PMID: 18182338
X-chromosome inactivation patterns in females with Prader-Willi syndrome.
Butler MG, Theodoro MF, Bittel DC, Kuipers PJ, Driscoll DJ, Talebizadeh Z
Am J Med Genet A 2007 Mar 1;143A(5):469-75. doi: 10.1002/ajmg.a.31506. PMID: 17036338Free PMC Article
Cytogenetic and age-dependent risk factors associated with uniparental disomy 15.
Robinson WP, Langlois S, Schuffenhauer S, Horsthemke B, Michaelis RC, Christian S, Ledbetter DH, Schinzel A
Prenat Diagn 1996 Sep;16(9):837-44. doi: 10.1002/(SICI)1097-0223(199609)16:9<837::AID-PD956>3.0.CO;2-7. PMID: 8905898

Diagnosis

Hystero-embryoscopy: evaluation and evacuation of spontaneous missed abortions.
Hincapie M, McGrail K, Nezhat C
Fertil Steril 2023 Feb;119(2):331-332. Epub 2022 Nov 17 doi: 10.1016/j.fertnstert.2022.11.015. PMID: 36402428
Association between increased yolk sac diameter and abnormal karyotypes.
Gersak K, Veble A, Mulla ZD, Plavsic SK
J Perinat Med 2012 Jan 10;40(3):251-4. doi: 10.1515/jpm.2011.140. PMID: 22505502
Chromosomal abnormalities associated with neural tube defects (I): full aneuploidy.
Chen CP
Taiwan J Obstet Gynecol 2007 Dec;46(4):325-35. doi: 10.1016/S1028-4559(08)60002-9. PMID: 18182338
Severe intrauterine growth restriction and trisomy 15 confined placental mosaicism: a case report and review of literature.
Redaelli S, Sala E, Roncaglia N, Colombo C, Crosti F, Villa N, Tagliabue P, Cappellini A, Dalprà L
Prenat Diagn 2005 Feb;25(2):140-7. doi: 10.1002/pd.1093. PMID: 15712378
Prenatal diagnosis of low level trisomy 15 mosaicism: review of the literature.
Zaslav AL, Fallet S, Brown S, Ebert R, Fleischer A, Valderama E, Fox JE
Clin Genet 1998 Apr;53(4):286-92. doi: 10.1111/j.1399-0004.1998.tb02698.x. PMID: 9650767

Therapy

Cytogenetic analysis of early pregnancy loss after assisted reproduction treatment using intracytoplasmic sperm injection.
Kamar A, Turktekin N, Ozyurt R, Karakus C, Saribal D, Hocaoglu-Emre FS
Ginekol Pol 2021;92(7):475-480. Epub 2021 Apr 12 doi: 10.5603/GP.a2020.0147. PMID: 33844246
A randomized and blinded comparison of qPCR and NGS-based detection of aneuploidy in a cell line mixture model of blastocyst biopsy mosaicism.
Goodrich D, Tao X, Bohrer C, Lonczak A, Xing T, Zimmerman R, Zhan Y, Scott RT Jr, Treff NR
J Assist Reprod Genet 2016 Nov;33(11):1473-1480. Epub 2016 Aug 6 doi: 10.1007/s10815-016-0784-3. PMID: 27497716Free PMC Article
Isolated +15 in bone marrow: disease-associated or a benign finding?
Goswami RS, Liang CS, Bueso-Ramos CE, Hu S, Goswami M, Yin CC, Lu G, Medeiros LJ, Tang G
Leuk Res 2015 Jan;39(1):72-6. Epub 2014 Nov 15 doi: 10.1016/j.leukres.2014.11.005. PMID: 25435027
X-chromosome inactivation patterns in females with Prader-Willi syndrome.
Butler MG, Theodoro MF, Bittel DC, Kuipers PJ, Driscoll DJ, Talebizadeh Z
Am J Med Genet A 2007 Mar 1;143A(5):469-75. doi: 10.1002/ajmg.a.31506. PMID: 17036338Free PMC Article
Trisomy 15 as the sole abnormality in myelodysplastic syndromes: case report and review of the literature.
Morel F, Le Bris MJ, Herry A, Morice P, De Braekeleer M
Leuk Lymphoma 2003 Mar;44(3):549-51. doi: 10.1080/1042819021000055084. PMID: 12688332

Prognosis

Mosaic trisomy 15 in a liveborn infant.
McPadden J, Helm BM, Spangler BB, Ross LP, Boles DB, Schrier Vergano SA
Am J Med Genet A 2015 Apr;167A(4):821-5. Epub 2015 Mar 3 doi: 10.1002/ajmg.a.36958. PMID: 25736076
Role of additional chromosomal changes in the prognostic value of t(4;14) and del(17p) in multiple myeloma: the IFM experience.
Hebraud B, Magrangeas F, Cleynen A, Lauwers-Cances V, Chretien ML, Hulin C, Leleu X, Yon E, Marit G, Karlin L, Roussel M, Stoppa AM, Belhadj K, Voillat L, Garderet L, Macro M, Caillot D, Mohty M, Facon T, Moreau P, Attal M, Munshi N, Corre J, Minvielle S, Avet-Loiseau H
Blood 2015 Mar 26;125(13):2095-100. Epub 2015 Jan 30 doi: 10.1182/blood-2014-07-587964. PMID: 25636340Free PMC Article
Candidate genes for congenital diaphragmatic hernia from animal models: sequencing of FOG2 and PDGFRalpha reveals rare variants in diaphragmatic hernia patients.
Bleyl SB, Moshrefi A, Shaw GM, Saijoh Y, Schoenwolf GC, Pennacchio LA, Slavotinek AM
Eur J Hum Genet 2007 Sep;15(9):950-8. Epub 2007 Jun 13 doi: 10.1038/sj.ejhg.5201872. PMID: 17568391
Trisomy 15 as the sole abnormality in myelodysplastic syndromes: case report and review of the literature.
Morel F, Le Bris MJ, Herry A, Morice P, De Braekeleer M
Leuk Lymphoma 2003 Mar;44(3):549-51. doi: 10.1080/1042819021000055084. PMID: 12688332
Frequency of trisomy 15 and loss of the Y chromosome in adult leukemia.
Smith A, Watson N, Sharma P
Cancer Genet Cytogenet 1999 Oct 15;114(2):108-11. doi: 10.1016/s0165-4608(99)00042-4. PMID: 10549265

Clinical prediction guides

Frequency of Chromosomal Abnormalities in Products of Conception.
Teles TM, Paula CM, Ramos MG, Costa HB, Andrade CR, Coxir SA, Penna ML
Rev Bras Ginecol Obstet 2017 Mar;39(3):110-114. Epub 2017 Mar 15 doi: 10.1055/s-0037-1600521. PMID: 28297732Free PMC Article
Detection of aneuploidy from single fetal nucleated red blood cells using whole genome sequencing.
Hua R, Barrett AN, Tan TZ, Huang Z, Mahyuddin AP, Ponnusamy S, Sandhu JS, Ho SS, Chan JK, Chong S, Quan S, Choolani M
Prenat Diagn 2015 Jul;35(7):637-44. Epub 2014 Oct 16 doi: 10.1002/pd.4491. PMID: 25178640
X-chromosome inactivation patterns in females with Prader-Willi syndrome.
Butler MG, Theodoro MF, Bittel DC, Kuipers PJ, Driscoll DJ, Talebizadeh Z
Am J Med Genet A 2007 Mar 1;143A(5):469-75. doi: 10.1002/ajmg.a.31506. PMID: 17036338Free PMC Article
Prenatal diagnosis of low level trisomy 15 mosaicism: review of the literature.
Zaslav AL, Fallet S, Brown S, Ebert R, Fleischer A, Valderama E, Fox JE
Clin Genet 1998 Apr;53(4):286-92. doi: 10.1111/j.1399-0004.1998.tb02698.x. PMID: 9650767
Cytogenetic and age-dependent risk factors associated with uniparental disomy 15.
Robinson WP, Langlois S, Schuffenhauer S, Horsthemke B, Michaelis RC, Christian S, Ledbetter DH, Schinzel A
Prenat Diagn 1996 Sep;16(9):837-44. doi: 10.1002/(SICI)1097-0223(199609)16:9<837::AID-PD956>3.0.CO;2-7. PMID: 8905898

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...