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Infiltrate of cornea

MedGen UID:
208880
•Concept ID:
C0853336
•
Pathologic Function
Synonyms: Corneal Infiltrate; Corneal Infiltration
SNOMED CT: Infiltrate of cornea (440027000)

Definition

Discrete, small lesions present in the cornea as a result of corneal inflammation and, in some cases, after soft contact lens wear especially extended-wear lenses. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInfiltrate of cornea

Professional guidelines

PubMed

Management of descemetocele: Our experience and a simplified treatment algorithm.
Shankar S, Agarwal R, Nagpal R, Maharana PK, Goel S, Sinha R, Agarwal T, Titiyal JS, Sharma N
Indian J Ophthalmol 2022 May;70(5):1564-1570. doi: 10.4103/ijo.IJO_3070_21. PMID: 35502027Free PMC Article
Consensus Recommendations for the Diagnosis of Vitreoretinal Lymphoma.
Carbonell D, Mahajan S, Chee SP, Sobolewska B, Agrawal R, Bülow T, Gupta V, Jones NP, Accorinti M, Agarwal M, Batchelor T, Biswas J, Cimino L, tenDam-van Loon NH, de-la-Torre A, Frenkel S, Pe'er J, Kramer M, Miserocchi E, Mochizuki M, Ness T, Rosenbaum JT, Sen HN, Simion M (VRL patient), Sitter H, Vasconcelos-Santos DV, Habot-Wilner Z, Coupland SE, Pulido JS, Smith J, Thorne JE, Zierhut M; Study Group for Vitreoretinal Lymphoma Diagnostics
Ocul Immunol Inflamm 2021 Apr 3;29(3):507-520. Epub 2021 May 19 doi: 10.1080/09273948.2021.1878233. PMID: 34009095
Symptomatic Treatment of Subepithelial Infiltrates after Viral Conjunctivitis: Loteprednol or Dexamethasone?
Koçluk Y, Sukgen EA, Cevher S, Mat E
Ocul Immunol Inflamm 2017 Oct;25(5):649-653. Epub 2016 Mar 25 doi: 10.3109/09273948.2016.1149593. PMID: 27015587

Recent clinical studies

Etiology

Contact Lens-Associated Keratitis-an Often Underestimated Risk.
Maier P, Betancor PK, Reinhard T
Dtsch Arztebl Int 2022 Oct 7;119(40):669-674. doi: 10.3238/arztebl.m2022.0281. PMID: 35912449Free PMC Article
The Acanthamoeba-Fungal Keratitis Study.
Raghavan A, Baidwal S, Venkatapathy N, Rammohan R
Am J Ophthalmol 2019 May;201:31-36. Epub 2019 Feb 2 doi: 10.1016/j.ajo.2019.01.024. PMID: 30721687
Fungal keratitis.
Bourcier T, Sauer A, Dory A, Denis J, Sabou M
J Fr Ophtalmol 2017 Nov;40(9):e307-e313. Epub 2017 Oct 4 doi: 10.1016/j.jfo.2017.08.001. PMID: 28987448
Curvularia keratitis.
Wilhelmus KR, Jones DB
Trans Am Ophthalmol Soc 2001;99:111-30; discussion 130-2. PMID: 11797300Free PMC Article
Acanthamoeba keratitis.
Illingworth CD, Cook SD
Surv Ophthalmol 1998 May-Jun;42(6):493-508. doi: 10.1016/s0039-6257(98)00004-6. PMID: 9635900

Diagnosis

Contact Lens-Associated Keratitis-an Often Underestimated Risk.
Maier P, Betancor PK, Reinhard T
Dtsch Arztebl Int 2022 Oct 7;119(40):669-674. doi: 10.3238/arztebl.m2022.0281. PMID: 35912449Free PMC Article
Pythium insidiosum keratitis - A review.
Gurnani B, Kaur K, Venugopal A, Srinivasan B, Bagga B, Iyer G, Christy J, Prajna L, Vanathi M, Garg P, Narayana S, Agarwal S, Sahu S
Indian J Ophthalmol 2022 Apr;70(4):1107-1120. doi: 10.4103/ijo.IJO_1534_21. PMID: 35325996Free PMC Article
The Acanthamoeba-Fungal Keratitis Study.
Raghavan A, Baidwal S, Venkatapathy N, Rammohan R
Am J Ophthalmol 2019 May;201:31-36. Epub 2019 Feb 2 doi: 10.1016/j.ajo.2019.01.024. PMID: 30721687
Curvularia keratitis.
Wilhelmus KR, Jones DB
Trans Am Ophthalmol Soc 2001;99:111-30; discussion 130-2. PMID: 11797300Free PMC Article
Acanthamoeba keratitis.
Illingworth CD, Cook SD
Surv Ophthalmol 1998 May-Jun;42(6):493-508. doi: 10.1016/s0039-6257(98)00004-6. PMID: 9635900

Therapy

Contact Lens-Associated Keratitis-an Often Underestimated Risk.
Maier P, Betancor PK, Reinhard T
Dtsch Arztebl Int 2022 Oct 7;119(40):669-674. doi: 10.3238/arztebl.m2022.0281. PMID: 35912449Free PMC Article
Pathophysiology and Treatment of Diffuse Lamellar Keratitis.
Wilson SE, de Oliveira RC
J Refract Surg 2020 Feb 1;36(2):124-130. doi: 10.3928/1081597X-20200114-01. PMID: 32032434
Host defense at the ocular surface.
Pearlman E, Sun Y, Roy S, Karmakar M, Hise AG, Szczotka-Flynn L, Ghannoum M, Chinnery HR, McMenamin PG, Rietsch A
Int Rev Immunol 2013 Feb;32(1):4-18. doi: 10.3109/08830185.2012.749400. PMID: 23360155Free PMC Article
Curvularia keratitis.
Wilhelmus KR, Jones DB
Trans Am Ophthalmol Soc 2001;99:111-30; discussion 130-2. PMID: 11797300Free PMC Article
Acanthamoeba keratitis.
Illingworth CD, Cook SD
Surv Ophthalmol 1998 May-Jun;42(6):493-508. doi: 10.1016/s0039-6257(98)00004-6. PMID: 9635900

Prognosis

Clinical Characteristics and Therapeutic Outcomes of Pediatric Blepharokeratoconjunctivitis.
Moon J, Lee J, Kim MK, Hyon JY, Jeon HS, Oh JY
Cornea 2023 May 1;42(5):578-583. Epub 2022 Aug 24 doi: 10.1097/ICO.0000000000003120. PMID: 36036680
Fungal keratitis.
Bourcier T, Sauer A, Dory A, Denis J, Sabou M
J Fr Ophtalmol 2017 Nov;40(9):e307-e313. Epub 2017 Oct 4 doi: 10.1016/j.jfo.2017.08.001. PMID: 28987448
Microsporidia infection of the cornea--a unique and challenging disease.
Garg P
Cornea 2013 Nov;32 Suppl 1:S33-8. doi: 10.1097/ICO.0b013e3182a2c91f. PMID: 24104931
Atypical fungal sclerokeratitis.
Amiel H, Chohan AB, Snibson GR, Vajpayee R
Cornea 2008 Apr;27(3):382-3. doi: 10.1097/ICO.0b013e31815e9298. PMID: 18362676
Acanthamoeba keratitis.
Illingworth CD, Cook SD
Surv Ophthalmol 1998 May-Jun;42(6):493-508. doi: 10.1016/s0039-6257(98)00004-6. PMID: 9635900

Clinical prediction guides

Clinical Characteristics and Therapeutic Outcomes of Pediatric Blepharokeratoconjunctivitis.
Moon J, Lee J, Kim MK, Hyon JY, Jeon HS, Oh JY
Cornea 2023 May 1;42(5):578-583. Epub 2022 Aug 24 doi: 10.1097/ICO.0000000000003120. PMID: 36036680
Role of MyD88 in adenovirus keratitis.
Zhou X, Ramke M, Chintakuntlawar AV, Lee JY, Rajaiya J, Chodosh J
Immunol Cell Biol 2017 Jan;95(1):108-116. Epub 2016 Aug 16 doi: 10.1038/icb.2016.73. PMID: 27528076Free PMC Article
LASIK interface complications: etiology, management, and outcomes.
Randleman JB, Shah RD
J Refract Surg 2012 Aug;28(8):575-86. doi: 10.3928/1081597X-20120722-01. PMID: 22869235Free PMC Article
Rethinking contact lens associated keratitis.
Efron N, Morgan PB
Clin Exp Optom 2006 Sep;89(5):280-98. doi: 10.1111/j.1444-0938.2006.00069.x. PMID: 16907666
Contact lens-associated corneal infiltrates.
Robboy MW, Comstock TL, Kalsow CM
Eye Contact Lens 2003 Jul;29(3):146-54. doi: 10.1097/01.ICL.0000072830.41886.1E. PMID: 12861108

Recent systematic reviews

A systematic review and meta-analysis on the efficacy of topical povidone iodine in adenoviral conjunctivitis.
González Martín-Moro J, Zarallo-Gallardo J, Guzmán-Almagro E, Antón Rodríguez C
Cont Lens Anterior Eye 2023 Oct;46(5):101873. Epub 2023 Jun 26 doi: 10.1016/j.clae.2023.101873. PMID: 37380515
Topical Omega-3 Fatty Acids Eyedrops in the Treatment of Dry Eye and Ocular Surface Disease: A Systematic Review.
Paik B, Tong L
Int J Mol Sci 2022 Oct 29;23(21) doi: 10.3390/ijms232113156. PMID: 36361942Free PMC Article
Role of Neutrophils on the Ocular Surface.
Mun Y, Hwang JS, Shin YJ
Int J Mol Sci 2021 Sep 27;22(19) doi: 10.3390/ijms221910386. PMID: 34638724Free PMC Article
Transepithelial versus epithelium-off corneal crosslinking for progressive keratoconus.
Ng SM, Ren M, Lindsley KB, Hawkins BS, Kuo IC
Cochrane Database Syst Rev 2021 Mar 23;3(3):CD013512. doi: 10.1002/14651858.CD013512.pub2. PMID: 33765359Free PMC Article
Corneal collagen cross-linking for treating keratoconus.
Sykakis E, Karim R, Evans JR, Bunce C, Amissah-Arthur KN, Patwary S, McDonnell PJ, Hamada S
Cochrane Database Syst Rev 2015 Mar 24;2015(3):CD010621. doi: 10.1002/14651858.CD010621.pub2. PMID: 25803325Free PMC Article

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