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Unresectable Pancreatic Carcinoma

MedGen UID:
208908
•Concept ID:
C0854776
•
Neoplastic Process
Synonyms: Non-Resectable Carcinoma of Pancreas; Non-Resectable Carcinoma of the Pancreas; Non-Resectable Pancreas Carcinoma; Non-Resectable Pancreatic Carcinoma; Pancreatic Carcinoma, Non-Resectable; Unresectable Pancreatic Cancer

Definition

Carcinoma of the pancreas that is not amenable to surgical removal. [from NCI]

Professional guidelines

PubMed

Potential risk of residual cancer cells in the surgical treatment of initially unresectable pancreatic carcinoma after chemoradiotherapy.
Takano H, Tsuchikawa T, Nakamura T, Okamura K, Shichinohe T, Hirano S
World J Surg Oncol 2015 Jun 26;13:209. doi: 10.1186/s12957-015-0617-3. PMID: 26113164Free PMC Article
Endoscopic ultrasonography-guided interstitial implantation of iodine 125-seeds combined with chemotherapy in the treatment of unresectable pancreatic carcinoma: a prospective pilot study.
Jin Z, Du Y, Li Z, Jiang Y, Chen J, Liu Y
Endoscopy 2008 Apr;40(4):314-20. Epub 2008 Feb 19 doi: 10.1055/s-2007-995476. PMID: 18283622
Surgical treatment of pancreatic carcinoma.
Zhou J, Li CL, Zhang GW
Hepatobiliary Pancreat Dis Int 2003 Feb;2(1):139-41. PMID: 14607667

Recent clinical studies

Etiology

Percutaneous stenting and chemotherapy for unresectable pancreatic cancer: Comparison of irradiation stents vs conventional metal stents.
Wang W, Li P, Wang Y, Liu B, Li Y
Pancreatology 2019 Oct;19(7):957-962. Epub 2019 Sep 18 doi: 10.1016/j.pan.2019.09.006. PMID: 31551162
Diagnostic and therapeutic approach to pancreatic cancer-associated gastroparesis: literature review and our experience.
Leung J, Silverman W
Dig Dis Sci 2009 Feb;54(2):401-5. Epub 2008 Jul 10 doi: 10.1007/s10620-008-0354-3. PMID: 18618259
Surgical palliation for unresectable pancreatic carcinoma.
Hussain D, Khan MR, Azami R
J Pak Med Assoc 2004 Dec;54(12):601-4. PMID: 16104485
Other risk factors for pancreatic cancer: hormonal aspects.
Andrén-Sandberg A, Hoem D, Bäckman PL
Ann Oncol 1999;10 Suppl 4:131-5. PMID: 10436805
Surgical palliation of unresectable pancreatic carcinoma.
Lillemoe KD, Barnes SA
Surg Clin North Am 1995 Oct;75(5):953-68. doi: 10.1016/s0039-6109(16)46739-3. PMID: 7544919

Diagnosis

The investigation of 125I seed implantation as a salvage modality for unresectable pancreatic carcinoma.
Wang H, Wang J, Jiang Y, Li J, Tian S, Ran W, Xiu D, Gao Y
J Exp Clin Cancer Res 2013 Dec 27;32(1):106. doi: 10.1186/1756-9966-32-106. PMID: 24370348Free PMC Article
Intraoperative ultrasound-guided iodine-125 seed implantation for unresectable pancreatic carcinoma.
Wang J, Jiang Y, Li J, Tian S, Ran W, Xiu D
J Exp Clin Cancer Res 2009 Jun 23;28(1):88. doi: 10.1186/1756-9966-28-88. PMID: 19545454Free PMC Article
Diagnostic and therapeutic approach to pancreatic cancer-associated gastroparesis: literature review and our experience.
Leung J, Silverman W
Dig Dis Sci 2009 Feb;54(2):401-5. Epub 2008 Jul 10 doi: 10.1007/s10620-008-0354-3. PMID: 18618259
Endoscopic pancreatic stenting in pancreatic cancer.
Costamagna G, Alevras P, Palladino F, Rainoldi F, Mutignani M, Morganti A
Can J Gastroenterol 1999 Jul-Aug;13(6):481-7. doi: 10.1155/1999/123210. PMID: 10464348
Pancreatic and ampullary carcinoma. Ultrasound, computed tomography, magnetic resonance imaging and angiography.
Brambs HJ, Claussen CD
Endoscopy 1993 Jan;25(1):58-68. doi: 10.1055/s-2007-1009126. PMID: 8453928

Therapy

Percutaneous stenting and chemotherapy for unresectable pancreatic cancer: Comparison of irradiation stents vs conventional metal stents.
Wang W, Li P, Wang Y, Liu B, Li Y
Pancreatology 2019 Oct;19(7):957-962. Epub 2019 Sep 18 doi: 10.1016/j.pan.2019.09.006. PMID: 31551162
Other risk factors for pancreatic cancer: hormonal aspects.
Andrén-Sandberg A, Hoem D, Bäckman PL
Ann Oncol 1999;10 Suppl 4:131-5. PMID: 10436805
Endoscopic palliation for unresectable pancreatic carcinoma.
Lichtenstein DR, Carr-Locke DL
Surg Clin North Am 1995 Oct;75(5):969-88. doi: 10.1016/s0039-6109(16)46740-x. PMID: 7544920
Neoadjuvant therapy for unresectable pancreatic adenocarcinoma.
Jessup JM, Steele G Jr, Mayer RJ, Posner M, Busse P, Cady B, Stone M, Jenkins R, Osteen R
Arch Surg 1993 May;128(5):559-64. doi: 10.1001/archsurg.1993.01420170093014. PMID: 8098206
Is adjuvant intra-operative radiotherapy (IORT) for resectable and unresectable pancreatic carcinoma worthwhile?
Heijmans HJ, Hoekstra HJ, Mehta DM
Hepatogastroenterology 1989 Dec;36(6):474-7. PMID: 2515137

Prognosis

The role of seed implantation in patients with unresectable pancreatic carcinoma after relief of obstructive jaundice using ERCP.
Li W, Wang X, Wang Z, Zhang T, Cai F, Tang P, Meng J, Du H, Wang H, Li M, Li S
Brachytherapy 2020 Jan-Feb;19(1):97-103. Epub 2019 Sep 26 doi: 10.1016/j.brachy.2019.08.010. PMID: 31564517
The investigation of 125I seed implantation as a salvage modality for unresectable pancreatic carcinoma.
Wang H, Wang J, Jiang Y, Li J, Tian S, Ran W, Xiu D, Gao Y
J Exp Clin Cancer Res 2013 Dec 27;32(1):106. doi: 10.1186/1756-9966-32-106. PMID: 24370348Free PMC Article
Chemoradiation of unresectable pancreatic carcinoma: impact of pretreatment hemoglobin level on patterns of failure.
Morganti AG, Forni F, Macchia G, Valentini V, Smaniotto D, Trodella L, Balducci M, Cellini N
Strahlenther Onkol 2003 Feb;179(2):87-92. doi: 10.1007/s00066-003-1043-y. PMID: 12590318
Surgical palliation of unresectable pancreatic carcinoma.
Lillemoe KD, Barnes SA
Surg Clin North Am 1995 Oct;75(5):953-68. doi: 10.1016/s0039-6109(16)46739-3. PMID: 7544919
Neoadjuvant therapy for unresectable pancreatic adenocarcinoma.
Jessup JM, Steele G Jr, Mayer RJ, Posner M, Busse P, Cady B, Stone M, Jenkins R, Osteen R
Arch Surg 1993 May;128(5):559-64. doi: 10.1001/archsurg.1993.01420170093014. PMID: 8098206

Clinical prediction guides

The role of seed implantation in patients with unresectable pancreatic carcinoma after relief of obstructive jaundice using ERCP.
Li W, Wang X, Wang Z, Zhang T, Cai F, Tang P, Meng J, Du H, Wang H, Li M, Li S
Brachytherapy 2020 Jan-Feb;19(1):97-103. Epub 2019 Sep 26 doi: 10.1016/j.brachy.2019.08.010. PMID: 31564517
The investigation of 125I seed implantation as a salvage modality for unresectable pancreatic carcinoma.
Wang H, Wang J, Jiang Y, Li J, Tian S, Ran W, Xiu D, Gao Y
J Exp Clin Cancer Res 2013 Dec 27;32(1):106. doi: 10.1186/1756-9966-32-106. PMID: 24370348Free PMC Article
Chemoradiation of unresectable pancreatic carcinoma: impact of pretreatment hemoglobin level on patterns of failure.
Morganti AG, Forni F, Macchia G, Valentini V, Smaniotto D, Trodella L, Balducci M, Cellini N
Strahlenther Onkol 2003 Feb;179(2):87-92. doi: 10.1007/s00066-003-1043-y. PMID: 12590318
Feasibility and efficacy of high dose conformal radiotherapy for patients with locally advanced pancreatic carcinoma.
Ceha HM, van Tienhoven G, Gouma DJ, Veenhof CH, Schneider CJ, Rauws EA, Phoa SS, González González D
Cancer 2000 Dec 1;89(11):2222-9. doi: 10.1002/1097-0142(20001201)89:11<2222::aid-cncr10>3.0.co;2-v. PMID: 11147592
Surgical palliation of unresectable pancreatic carcinoma.
Lillemoe KD, Barnes SA
Surg Clin North Am 1995 Oct;75(5):953-68. doi: 10.1016/s0039-6109(16)46739-3. PMID: 7544919

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