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Thrombocytopenic purpura

MedGen UID:
208992
Concept ID:
C0857305
Disease or Syndrome
Synonyms: Purpura, Thrombocytopenic; Purpura, Thrombopenic; Purpuras, Thrombocytopenic; Purpuras, Thrombopenic; Thrombocytopenic Purpura; Thrombocytopenic Purpuras; Thrombopenic Purpura; Thrombopenic Purpuras
SNOMED CT: Thrombocytopenic purpura (302873008)
 
Monarch Initiative: MONDO:0043768

Definition

Purpura associated with a reduction in circulating blood platelets which can result from a variety of factors. [from NCI]

Professional guidelines

PubMed

Thompson GL, Kavanagh D
Int J Lab Hematol 2022 Sep;44 Suppl 1(Suppl 1):101-113. doi: 10.1111/ijlh.13954. PMID: 36074708Free PMC Article
Zheng XL, Vesely SK, Cataland SR, Coppo P, Geldziler B, Iorio A, Matsumoto M, Mustafa RA, Pai M, Rock G, Russell L, Tarawneh R, Valdes J, Peyvandi F
J Thromb Haemost 2020 Oct;18(10):2496-2502. Epub 2020 Sep 11 doi: 10.1111/jth.15010. PMID: 32914526Free PMC Article
Chey WD, Leontiadis GI, Howden CW, Moss SF
Am J Gastroenterol 2017 Feb;112(2):212-239. Epub 2017 Jan 10 doi: 10.1038/ajg.2016.563. PMID: 28071659

Recent clinical studies

Etiology

Nusrat S, Beg K, Khan O, Sinha A, George J
Genes (Basel) 2023 Oct 18;14(10) doi: 10.3390/genes14101956. PMID: 37895305Free PMC Article
Subhan M, Scully M
Blood Rev 2022 Sep;55:100945. Epub 2022 Feb 17 doi: 10.1016/j.blre.2022.100945. PMID: 35216839
Onisâi M, Vlădăreanu AM, Spînu A, Găman M, Bumbea H
Rom J Intern Med 2019 Dec 1;57(4):273-283. doi: 10.2478/rjim-2019-0014. PMID: 31199777
Lambert MP, Gernsheimer TB
Blood 2017 May 25;129(21):2829-2835. Epub 2017 Apr 17 doi: 10.1182/blood-2017-03-754119. PMID: 28416506Free PMC Article
Rodeghiero F, Stasi R, Gernsheimer T, Michel M, Provan D, Arnold DM, Bussel JB, Cines DB, Chong BH, Cooper N, Godeau B, Lechner K, Mazzucconi MG, McMillan R, Sanz MA, Imbach P, Blanchette V, Kühne T, Ruggeri M, George JN
Blood 2009 Mar 12;113(11):2386-93. Epub 2008 Nov 12 doi: 10.1182/blood-2008-07-162503. PMID: 19005182

Diagnosis

Onisâi M, Vlădăreanu AM, Spînu A, Găman M, Bumbea H
Rom J Intern Med 2019 Dec 1;57(4):273-283. doi: 10.2478/rjim-2019-0014. PMID: 31199777
Joly BS, Coppo P, Veyradier A
Expert Rev Hematol 2019 Jun;12(6):383-395. Epub 2019 May 20 doi: 10.1080/17474086.2019.1611423. PMID: 31107120
Despotovic JM, Grimes AB
Hematology Am Soc Hematol Educ Program 2018 Nov 30;2018(1):405-411. doi: 10.1182/asheducation-2018.1.405. PMID: 30504339Free PMC Article
Kistangari G, McCrae KR
Hematol Oncol Clin North Am 2013 Jun;27(3):495-520. doi: 10.1016/j.hoc.2013.03.001. PMID: 23714309Free PMC Article
Rodeghiero F, Stasi R, Gernsheimer T, Michel M, Provan D, Arnold DM, Bussel JB, Cines DB, Chong BH, Cooper N, Godeau B, Lechner K, Mazzucconi MG, McMillan R, Sanz MA, Imbach P, Blanchette V, Kühne T, Ruggeri M, George JN
Blood 2009 Mar 12;113(11):2386-93. Epub 2008 Nov 12 doi: 10.1182/blood-2008-07-162503. PMID: 19005182

Therapy

Rodeghiero F
Int J Hematol 2023 Mar;117(3):316-330. Epub 2023 Jan 9 doi: 10.1007/s12185-022-03527-1. PMID: 36622549
Bussel JB, Soff G, Balduzzi A, Cooper N, Lawrence T, Semple JW
Drug Des Devel Ther 2021;15:2243-2268. Epub 2021 May 26 doi: 10.2147/DDDT.S299591. PMID: 34079225Free PMC Article
Miltiadous O, Hou M, Bussel JB
Blood 2020 Feb 13;135(7):472-490. doi: 10.1182/blood.2019003599. PMID: 31756253Free PMC Article
Ghanima W, Cooper N, Rodeghiero F, Godeau B, Bussel JB
Haematologica 2019 Jun;104(6):1112-1123. Epub 2019 May 9 doi: 10.3324/haematol.2018.212845. PMID: 31073079Free PMC Article
Scully M, Cataland SR, Peyvandi F, Coppo P, Knöbl P, Kremer Hovinga JA, Metjian A, de la Rubia J, Pavenski K, Callewaert F, Biswas D, De Winter H, Zeldin RK; HERCULES Investigators
N Engl J Med 2019 Jan 24;380(4):335-346. Epub 2019 Jan 9 doi: 10.1056/NEJMoa1806311. PMID: 30625070

Prognosis

Scully M, de la Rubia J, Pavenski K, Metjian A, Knöbl P, Peyvandi F, Cataland S, Coppo P, Kremer Hovinga JA, Minkue Mi Edou J, De Passos Sousa R, Callewaert F, Gunawardena S, Lin J
J Thromb Haemost 2022 Dec;20(12):2810-2822. Epub 2022 Oct 21 doi: 10.1111/jth.15892. PMID: 36138517Free PMC Article
Kohli R, Chaturvedi S
Hamostaseologie 2019 Aug;39(3):238-249. Epub 2019 Mar 13 doi: 10.1055/s-0039-1683416. PMID: 30868551
Bayer G, von Tokarski F, Thoreau B, Bauvois A, Barbet C, Cloarec S, Mérieau E, Lachot S, Garot D, Bernard L, Gyan E, Perrotin F, Pouplard C, Maillot F, Gatault P, Sautenet B, Rusch E, Buchler M, Vigneau C, Fakhouri F, Halimi JM
Clin J Am Soc Nephrol 2019 Apr 5;14(4):557-566. Epub 2019 Mar 12 doi: 10.2215/CJN.11470918. PMID: 30862697Free PMC Article
Mansouri Taleghani M, von Krogh AS, Fujimura Y, George JN, Hrachovinová I, Knöbl PN, Quist-Paulsen P, Schneppenheim R, Lämmle B, Kremer Hovinga JA
Hamostaseologie 2013 May 29;33(2):138-43. doi: 10.5482/HAMO-13-04-0026. PMID: 23715103
Aster RH, Bougie DW
N Engl J Med 2007 Aug 9;357(6):580-7. doi: 10.1056/NEJMra066469. PMID: 17687133

Clinical prediction guides

Akwaa F, Antun A, Cataland SR
Blood 2022 Aug 4;140(5):438-444. doi: 10.1182/blood.2021014514. PMID: 35667044
DeSouza S, Angelini D
Cleve Clin J Med 2021 Dec 2;88(12):664-668. doi: 10.3949/ccjm.88a.20201. PMID: 34857604
Chiasakul T, Cuker A
Hematology Am Soc Hematol Educ Program 2018 Nov 30;2018(1):530-538. doi: 10.1182/asheducation-2018.1.530. PMID: 30504354Free PMC Article
Gupta M, Feinberg BB, Burwick RM
Pregnancy Hypertens 2018 Apr;12:29-34. Epub 2018 Feb 16 doi: 10.1016/j.preghy.2018.02.007. PMID: 29674195
Rodeghiero F, Stasi R, Gernsheimer T, Michel M, Provan D, Arnold DM, Bussel JB, Cines DB, Chong BH, Cooper N, Godeau B, Lechner K, Mazzucconi MG, McMillan R, Sanz MA, Imbach P, Blanchette V, Kühne T, Ruggeri M, George JN
Blood 2009 Mar 12;113(11):2386-93. Epub 2008 Nov 12 doi: 10.1182/blood-2008-07-162503. PMID: 19005182

Recent systematic reviews

Bidari A, Asgarian S, Pour Mohammad A, Naderi D, Anaraki SR, Gholizadeh Mesgarha M, Naderkhani M
Eur J Haematol 2023 Apr;110(4):335-353. Epub 2022 Dec 30 doi: 10.1111/ejh.13917. PMID: 36562217Free PMC Article
Di Pietrantonj C, Rivetti A, Marchione P, Debalini MG, Demicheli V
Cochrane Database Syst Rev 2020 Apr 20;4(4):CD004407. doi: 10.1002/14651858.CD004407.pub4. PMID: 32309885Free PMC Article
Mithoowani S, Gregory-Miller K, Goy J, Miller MC, Wang G, Noroozi N, Kelton JG, Arnold DM
Lancet Haematol 2016 Oct;3(10):e489-e496. Epub 2016 Sep 16 doi: 10.1016/S2352-3026(16)30109-0. PMID: 27658982
Al-Nouri ZL, Reese JA, Terrell DR, Vesely SK, George JN
Blood 2015 Jan 22;125(4):616-8. Epub 2014 Nov 20 doi: 10.1182/blood-2014-11-611335. PMID: 25414441Free PMC Article
Gkegkes ID, Mourtarakos S, Iavazzo C
JSLS 2014 Jul-Sep;18(3) doi: 10.4293/JSLS.2014.00350. PMID: 25392670Free PMC Article

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