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Unresponsive to Stimuli

MedGen UID:
208993
•Concept ID:
C0857494
•
Sign or Symptom
Synonym: Unresponsive to stimuli

Definition

An individual whose level of consciousness is such that he is not responsive to any stimulus. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresponsive to Stimuli

Professional guidelines

PubMed

Anesthesia-induced loss of consciousness disrupts auditory responses beyond primary cortex.
Krom AJ, Marmelshtein A, Gelbard-Sagiv H, Tankus A, Hayat H, Hayat D, Matot I, Strauss I, Fahoum F, Soehle M, Boström J, Mormann F, Fried I, Nir Y
Proc Natl Acad Sci U S A 2020 May 26;117(21):11770-11780. Epub 2020 May 12 doi: 10.1073/pnas.1917251117. PMID: 32398367Free PMC Article
Pathogenesis and Management of Pruritus in PBC and PSC.
Kremer AE, Namer B, Bolier R, Fischer MJ, Oude Elferink RP, Beuers U
Dig Dis 2015;33 Suppl 2:164-75. Epub 2015 Dec 7 doi: 10.1159/000440829. PMID: 26641452
Changes in total IgE plasma concentration measured at the third month during anti-IgE treatment predict future exacerbation rates in difficult-to-treat atopic asthma: a pilot study.
Dal Negro RW, Guerriero M, Micheletto C, Tognella S, Visconti M
J Asthma 2011 Jun;48(5):437-41. doi: 10.3109/02770903.2011.578316. PMID: 21599560

Recent clinical studies

Etiology

Physical examination in functional unresponsiveness.
Bacchi S, Slee M
Pract Neurol 2023 Feb;23(1):54-56. Epub 2022 Sep 1 doi: 10.1136/pn-2022-003494. PMID: 36717206
Responses to stimuli in the 'snoezelen' room in unresponsive wakefulness or in minimally responsive state.
Lehrer H, Dayan I, Elkayam K, Kfir A, Bierman U, Front L, Catz A, Aidinoff E
Brain Inj 2022 Jul 29;36(9):1167-1175. Epub 2022 Aug 17 doi: 10.1080/02699052.2022.2110286. PMID: 35978560
Detection of Brain Activation in Unresponsive Patients with Acute Brain Injury.
Claassen J, Doyle K, Matory A, Couch C, Burger KM, Velazquez A, Okonkwo JU, King JR, Park S, Agarwal S, Roh D, Megjhani M, Eliseyev A, Connolly ES, Rohaut B
N Engl J Med 2019 Jun 27;380(26):2497-2505. doi: 10.1056/NEJMoa1812757. PMID: 31242361
Restoring stem cell mobilization to promote vascular repair in diabetes.
Albiero M, Avogaro A, Fadini GP
Vascul Pharmacol 2013 Apr;58(4):253-8. Epub 2013 Jan 29 doi: 10.1016/j.vph.2013.01.003. PMID: 23369723
Neonatal and infantile immune responses to encapsulated bacteria and conjugate vaccines.
Klein Klouwenberg P, Bont L
Clin Dev Immunol 2008;2008:628963. doi: 10.1155/2008/628963. PMID: 18825269Free PMC Article

Diagnosis

Functional coma.
Ludwig L, McWhirter L, Williams S, Derry C, Stone J
Handb Clin Neurol 2016;139:313-327. doi: 10.1016/B978-0-12-801772-2.00028-X. PMID: 27719852
EEG and Coma.
Ardeshna NI
Neurodiagn J 2016 Mar;56(1):1-16. doi: 10.1080/21646821.2015.1114879. PMID: 27180503
Neurally mediated syncope.
Zaqqa M, Massumi A
Tex Heart Inst J 2000;27(3):268-72. PMID: 11093411Free PMC Article
Coma.
Liu GT
Neurosurg Clin N Am 1999 Oct;10(4):579-86, vii-viii. PMID: 10529971
Prevention of prematurity.
Fuchs F
Am J Obstet Gynecol 1976 Dec 1;126(7):809-20. doi: 10.1016/0002-9378(76)90670-0. PMID: 11689

Therapy

Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis.
Ng B, Dong J, D'Agostino G, Viswanathan S, Widjaja AA, Lim WW, Ko NSJ, Tan J, Chothani SP, Huang B, Xie C, Pua CJ, Chacko AM, Guimarães-Camboa N, Evans SM, Byrne AJ, Maher TM, Liang J, Jiang D, Noble PW, Schafer S, Cook SA
Sci Transl Med 2019 Sep 25;11(511) doi: 10.1126/scitranslmed.aaw1237. PMID: 31554736
Role of medicinal plants in HIV/AIDS therapy.
Laila U, Akram M, Shariati MA, Hashmi AM, Akhtar N, Tahir IM, Ghauri AO, Munir N, Riaz M, Akhter N, Shaheen G, Ullah Q, Zahid R, Ahmad S
Clin Exp Pharmacol Physiol 2019 Dec;46(12):1063-1073. Epub 2019 Aug 22 doi: 10.1111/1440-1681.13151. PMID: 31365763
Nicotinic agonists and psychosis.
Simosky JK, Stevens KE, Freedman R
Curr Drug Targets CNS Neurol Disord 2002 Apr;1(2):149-62. doi: 10.2174/1568007024606168. PMID: 12769624
Hypoparathyroidism.
Breslau NA, Pak CY
Metabolism 1979 Dec;28(12):1261-76. doi: 10.1016/0026-0495(79)90141-0. PMID: 390300
Prevention of prematurity.
Fuchs F
Am J Obstet Gynecol 1976 Dec 1;126(7):809-20. doi: 10.1016/0002-9378(76)90670-0. PMID: 11689

Prognosis

Evoked and Event-Related Potentials as Biomarkers of Consciousness State and Recovery.
Pruvost-Robieux E, Marchi A, Martinelli I, Bouchereau E, Gavaret M
J Clin Neurophysiol 2022 Jan 1;39(1):22-31. doi: 10.1097/WNP.0000000000000762. PMID: 34474424Free PMC Article
Detection of Brain Activation in Unresponsive Patients with Acute Brain Injury.
Claassen J, Doyle K, Matory A, Couch C, Burger KM, Velazquez A, Okonkwo JU, King JR, Park S, Agarwal S, Roh D, Megjhani M, Eliseyev A, Connolly ES, Rohaut B
N Engl J Med 2019 Jun 27;380(26):2497-2505. doi: 10.1056/NEJMoa1812757. PMID: 31242361
EEG and Coma.
Ardeshna NI
Neurodiagn J 2016 Mar;56(1):1-16. doi: 10.1080/21646821.2015.1114879. PMID: 27180503
Pathogenesis and Management of Pruritus in PBC and PSC.
Kremer AE, Namer B, Bolier R, Fischer MJ, Oude Elferink RP, Beuers U
Dig Dis 2015;33 Suppl 2:164-75. Epub 2015 Dec 7 doi: 10.1159/000440829. PMID: 26641452
Clinical neurophysiology in acute coma and disorders of consciousness.
Koenig MA, Kaplan PW
Semin Neurol 2013 Apr;33(2):121-32. Epub 2013 Jul 25 doi: 10.1055/s-0033-1348962. PMID: 23888396

Clinical prediction guides

Evoked and Event-Related Potentials as Biomarkers of Consciousness State and Recovery.
Pruvost-Robieux E, Marchi A, Martinelli I, Bouchereau E, Gavaret M
J Clin Neurophysiol 2022 Jan 1;39(1):22-31. doi: 10.1097/WNP.0000000000000762. PMID: 34474424Free PMC Article
Role of medicinal plants in HIV/AIDS therapy.
Laila U, Akram M, Shariati MA, Hashmi AM, Akhtar N, Tahir IM, Ghauri AO, Munir N, Riaz M, Akhter N, Shaheen G, Ullah Q, Zahid R, Ahmad S
Clin Exp Pharmacol Physiol 2019 Dec;46(12):1063-1073. Epub 2019 Aug 22 doi: 10.1111/1440-1681.13151. PMID: 31365763
Pathogenesis and Management of Pruritus in PBC and PSC.
Kremer AE, Namer B, Bolier R, Fischer MJ, Oude Elferink RP, Beuers U
Dig Dis 2015;33 Suppl 2:164-75. Epub 2015 Dec 7 doi: 10.1159/000440829. PMID: 26641452
Nicotinic agonists and psychosis.
Simosky JK, Stevens KE, Freedman R
Curr Drug Targets CNS Neurol Disord 2002 Apr;1(2):149-62. doi: 10.2174/1568007024606168. PMID: 12769624
Clindamycin-induced neuromuscular blockade.
al Ahdal O, Bevan DR
Can J Anaesth 1995 Jul;42(7):614-7. doi: 10.1007/BF03011880. PMID: 7553999

Recent systematic reviews

Residual implicit and explicit language abilities in patients with disorders of consciousness: A systematic review.
Aubinet C, Chatelle C, Gosseries O, Carrière M, Laureys S, Majerus S
Neurosci Biobehav Rev 2022 Jan;132:391-409. Epub 2021 Dec 2 doi: 10.1016/j.neubiorev.2021.12.001. PMID: 34864003
Can Salient Stimuli Enhance Responses in Disorders of Consciousness? A Systematic Review.
Magliacano A, De Bellis F, Galvao-Carmona A, Estraneo A, Trojano L
Curr Neurol Neurosci Rep 2019 Nov 26;19(12):98. doi: 10.1007/s11910-019-1018-8. PMID: 31773300
Comprehensive Systematic Review Update Summary: Disorders of Consciousness: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology; the American Congress of Rehabilitation Medicine; and the National Institute on Disability, Independent Living, and Rehabilitation Research.
Giacino JT, Katz DI, Schiff ND, Whyte J, Ashman EJ, Ashwal S, Barbano R, Hammond FM, Laureys S, Ling GSF, Nakase-Richardson R, Seel RT, Yablon S, Getchius TSD, Gronseth GS, Armstrong MJ
Arch Phys Med Rehabil 2018 Sep;99(9):1710-1719. Epub 2018 Aug 8 doi: 10.1016/j.apmr.2018.07.002. PMID: 30098792
Comprehensive systematic review update summary: Disorders of consciousness: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology; the American Congress of Rehabilitation Medicine; and the National Institute on Disability, Independent Living, and Rehabilitation Research.
Giacino JT, Katz DI, Schiff ND, Whyte J, Ashman EJ, Ashwal S, Barbano R, Hammond FM, Laureys S, Ling GSF, Nakase-Richardson R, Seel RT, Yablon S, Getchius TSD, Gronseth GS, Armstrong MJ
Neurology 2018 Sep 4;91(10):461-470. Epub 2018 Aug 8 doi: 10.1212/WNL.0000000000005928. PMID: 30089617Free PMC Article

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