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Sweat gland neoplasm

MedGen UID:
21039
•Concept ID:
C0038987
•
Neoplastic Process
Synonyms: Neoplasm, Sweat Gland; Neoplasms, Sweat Gland; Sweat Gland Neoplasm; Sweat Gland Neoplasms
SNOMED CT: Sweat gland tumor (12933008); Tumor of skin with eccrine differentiation (126490003); Neoplasm of sweat gland (126490003)
 
Monarch Initiative: MONDO:0002381

Definition

A benign or malignant neoplasm arising from the sweat glands. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSweat gland neoplasm

Professional guidelines

PubMed

Current Treatment Options for Cutaneous Adnexal Malignancies.
Goto H
Curr Treat Options Oncol 2022 May;23(5):736-748. Epub 2022 Mar 26 doi: 10.1007/s11864-022-00971-3. PMID: 35347560
Challenges in diagnosis and management of a spiradenocarcinoma: a comprehensive literature review.
Wagner K, Jassal K, Lee JC, Ban EJ, Cameron R, Serpell J
ANZ J Surg 2021 Oct;91(10):1996-2001. Epub 2021 Feb 1 doi: 10.1111/ans.16626. PMID: 33522696
Evaluation and management of the patient with multiple syringomas: A systematic review of the literature.
Williams K, Shinkai K
J Am Acad Dermatol 2016 Jun;74(6):1234-1240.e9. Epub 2016 Feb 3 doi: 10.1016/j.jaad.2015.12.006. PMID: 26850654

Recent clinical studies

Etiology

Porocarcinoma: a review.
Joshy J, Mistry K, Levell NJ, van Bodegraven B, Vernon S, Rajan N, Craig P, Venables ZC
Clin Exp Dermatol 2022 Jun;47(6):1030-1035. Epub 2022 Mar 20 doi: 10.1111/ced.15126. PMID: 35149987
Primary mucinous carcinoma of the skin: the Mayo Clinic experience over the past 2 decades.
Adefusika JA, Pimentel JD, Chavan RN, Brewer JD
Dermatol Surg 2015 Feb;41(2):201-8. doi: 10.1097/DSS.0000000000000198. PMID: 25627628
An immunohistochemical panel to differentiate metastatic breast carcinoma to skin from primary sweat gland carcinomas with a review of the literature.
Rollins-Raval M, Chivukula M, Tseng GC, Jukic D, Dabbs DJ
Arch Pathol Lab Med 2011 Aug;135(8):975-83. doi: 10.5858/2009-0445-OAR2. PMID: 21809988
Papillary eccrine adenoma in association with cutaneous horn.
Blasini W, Hu S, Gugic D, Vincek V
Am J Clin Dermatol 2007;8(3):179-82. doi: 10.2165/00128071-200708030-00005. PMID: 17492846
Aggressive digital papillary adenoma and adenocarcinoma. A clinicopathological study of 57 patients, with histochemical, immunopathological, and ultrastructural observations.
Kao GF, Helwig EB, Graham JH
J Cutan Pathol 1987 Jun;14(3):129-46. doi: 10.1111/j.1600-0560.1987.tb00488.x. PMID: 3301927

Diagnosis

Digital Papillary Adenocarcinoma in Nonacral Skin: Clinicopathologic and Genetic Characterization of 5 Cases.
Kervarrec T, Imbeaud S, Veyer D, Pere H, Puech J, Pekár-Lukacs A, Markiewicz D, Coutts M, Tallet A, Collin C, Berthon P, Bravo IG, Seris A, Jouary T, Macagno N, Touzé A, Cribier B, Battistella M, Calonje E
Am J Surg Pathol 2023 Oct 1;47(10):1077-1084. Epub 2023 Jul 31 doi: 10.1097/PAS.0000000000002096. PMID: 37505796
Porocarcinoma: a review.
Joshy J, Mistry K, Levell NJ, van Bodegraven B, Vernon S, Rajan N, Craig P, Venables ZC
Clin Exp Dermatol 2022 Jun;47(6):1030-1035. Epub 2022 Mar 20 doi: 10.1111/ced.15126. PMID: 35149987
Primary mucinous carcinoma of the skin: the Mayo Clinic experience over the past 2 decades.
Adefusika JA, Pimentel JD, Chavan RN, Brewer JD
Dermatol Surg 2015 Feb;41(2):201-8. doi: 10.1097/DSS.0000000000000198. PMID: 25627628
Apocrine adenomyoepithelioma--a rare but distinctive primary sweat gland neoplasm.
Sabater Marco V
J Cutan Pathol 2012 Jul;39(7):701-6. Epub 2012 May 22 doi: 10.1111/j.1600-0560.2012.01916.x. PMID: 22612240
Apocrine gland carcinoma of the axilla: review of the literature and recommendations for treatment.
Chamberlain RS, Huber K, White JC, Travaglino-Parda R
Am J Clin Oncol 1999 Apr;22(2):131-5. doi: 10.1097/00000421-199904000-00005. PMID: 10199445

Therapy

Aggressive Digital Papillary Adenocarcinoma With Multiple Organ Metastases: A Case Report and Review of the Literature.
Kobayashi T, Hiura A, Oishi K, Maeda S, Le Pavoux AJ, Ohara K, Uruga H
Am J Dermatopathol 2016 Dec;38(12):910-914. doi: 10.1097/DAD.0000000000000703. PMID: 27870729Free PMC Article

Prognosis

Porocarcinoma: a review.
Joshy J, Mistry K, Levell NJ, van Bodegraven B, Vernon S, Rajan N, Craig P, Venables ZC
Clin Exp Dermatol 2022 Jun;47(6):1030-1035. Epub 2022 Mar 20 doi: 10.1111/ced.15126. PMID: 35149987
Aggressive Digital Papillary Adenocarcinoma With Multiple Organ Metastases: A Case Report and Review of the Literature.
Kobayashi T, Hiura A, Oishi K, Maeda S, Le Pavoux AJ, Ohara K, Uruga H
Am J Dermatopathol 2016 Dec;38(12):910-914. doi: 10.1097/DAD.0000000000000703. PMID: 27870729Free PMC Article
An immunohistochemical panel to differentiate metastatic breast carcinoma to skin from primary sweat gland carcinomas with a review of the literature.
Rollins-Raval M, Chivukula M, Tseng GC, Jukic D, Dabbs DJ
Arch Pathol Lab Med 2011 Aug;135(8):975-83. doi: 10.5858/2009-0445-OAR2. PMID: 21809988
Papillary eccrine adenoma. A light microscopic and immunohistochemical study.
Sexton M, Maize JC
J Am Acad Dermatol 1988 May;18(5 Pt 1):1114-20. PMID: 3290282
Aggressive digital papillary adenoma and adenocarcinoma. A clinicopathological study of 57 patients, with histochemical, immunopathological, and ultrastructural observations.
Kao GF, Helwig EB, Graham JH
J Cutan Pathol 1987 Jun;14(3):129-46. doi: 10.1111/j.1600-0560.1987.tb00488.x. PMID: 3301927

Clinical prediction guides

Primary cutaneous cribriform tumor: A case report and literature review.
Jiang D, Tian Y, Tian J, Liu H, Guan Y
J Cutan Pathol 2025 Jan;52(1):9-15. Epub 2024 Sep 23 doi: 10.1111/cup.14723. PMID: 39313825
An immunohistochemical panel to differentiate metastatic breast carcinoma to skin from primary sweat gland carcinomas with a review of the literature.
Rollins-Raval M, Chivukula M, Tseng GC, Jukic D, Dabbs DJ
Arch Pathol Lab Med 2011 Aug;135(8):975-83. doi: 10.5858/2009-0445-OAR2. PMID: 21809988
Mucinous carcinoma of the skin: evaluation of lymphatic invasion with D2-40.
Paradela S, Castiñeiras I, Cuevas J, Almagro M, del Pozo J, Fonseca E
Am J Dermatopathol 2008 Oct;30(5):504-8. doi: 10.1097/DAD.0b013e318170c3cf. PMID: 18806501
'Nuclear grooves' in nodular hidradenoma: frequency and significance of an unrecognized histopatological feature.
Khurshid A, Yaqoob N, Devan HA, Pervez S
J Cutan Pathol 2007 Nov;34(11):871-5. doi: 10.1111/j.1600-0560.2007.00743.x. PMID: 17944729
Aggressive digital papillary adenoma and adenocarcinoma. A clinicopathological study of 57 patients, with histochemical, immunopathological, and ultrastructural observations.
Kao GF, Helwig EB, Graham JH
J Cutan Pathol 1987 Jun;14(3):129-46. doi: 10.1111/j.1600-0560.1987.tb00488.x. PMID: 3301927

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