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Tic

MedGen UID:
21556
•Concept ID:
C0040188
•
Mental or Behavioral Dysfunction
Synonyms: Tic Disorder; Tic Disorders
SNOMED CT: Tic (386783003); Tics (386783003); Tic disorder (568005)

Definition

Disorders characterized by recurrent TICS that may interfere with speech and other activities. Tics are sudden, rapid, nonrhythmic, stereotyped motor movements or vocalizations which may be exacerbated by stress and are generally attenuated during absorbing activities. Tic disorders are distinguished from conditions which feature other types of abnormal movements that may accompany another another condition. (From DSM-IV, 1994) [from MeSH]

Professional guidelines

PubMed

Tourette Syndrome Treatment Updates: a Review and Discussion of the Current and Upcoming Literature.
Frey J, Malaty IA
Curr Neurol Neurosci Rep 2022 Feb;22(2):123-142. Epub 2022 Feb 2 doi: 10.1007/s11910-022-01177-8. PMID: 35107785Free PMC Article
European clinical guidelines for Tourette syndrome and other tic disorders-version 2.0. Part I: assessment.
Szejko N, Robinson S, Hartmann A, Ganos C, Debes NM, Skov L, Haas M, Rizzo R, Stern J, Münchau A, Czernecki V, Dietrich A, Murphy TL, Martino D, Tarnok Z, Hedderly T, Müller-Vahl KR, Cath DC
Eur Child Adolesc Psychiatry 2022 Mar;31(3):383-402. Epub 2021 Oct 18 doi: 10.1007/s00787-021-01842-2. PMID: 34661764Free PMC Article
Treatment of Tourette syndrome with cannabinoids.
Müller-Vahl KR
Behav Neurol 2013;27(1):119-24. doi: 10.3233/BEN-120276. PMID: 23187140Free PMC Article

Recent clinical studies

Etiology

Pathophysiology of Trauma-Induced Coagulopathy.
Schöchl H, Schmitt FCF, Maegele M
Hamostaseologie 2024 Feb;44(1):31-39. Epub 2024 Feb 28 doi: 10.1055/a-2215-8936. PMID: 38417803
Trauma-informed abortion care.
Cahill EP, Doyle A
Curr Opin Obstet Gynecol 2021 Dec 1;33(6):453-457. doi: 10.1097/GCO.0000000000000749. PMID: 34747881
Trauma-induced coagulopathy.
Moore EE, Moore HB, Kornblith LZ, Neal MD, Hoffman M, Mutch NJ, Schöchl H, Hunt BJ, Sauaia A
Nat Rev Dis Primers 2021 Apr 29;7(1):30. doi: 10.1038/s41572-021-00264-3. PMID: 33927200Free PMC Article
Tics and functional tic-like movements: Can we tell them apart?
Ganos C, Martino D, Espay AJ, Lang AE, Bhatia KP, Edwards MJ
Neurology 2019 Oct 22;93(17):750-758. Epub 2019 Sep 24 doi: 10.1212/WNL.0000000000008372. PMID: 31551261
Pharmacological treatment for attention deficit hyperactivity disorder (ADHD) in children with comorbid tic disorders.
Osland ST, Steeves TD, Pringsheim T
Cochrane Database Syst Rev 2018 Jun 26;6(6):CD007990. doi: 10.1002/14651858.CD007990.pub3. PMID: 29944175Free PMC Article

Diagnosis

Tic Disorders.
Vermilion J, Mink JW
Pediatr Rev 2023 May 1;44(5):294-296. doi: 10.1542/pir.2022-005566. PMID: 37122042
Trauma-induced coagulopathy.
Moore EE, Moore HB, Kornblith LZ, Neal MD, Hoffman M, Mutch NJ, Schöchl H, Hunt BJ, Sauaia A
Nat Rev Dis Primers 2021 Apr 29;7(1):30. doi: 10.1038/s41572-021-00264-3. PMID: 33927200Free PMC Article
Tics and Tourette Syndrome.
Singer HS
Continuum (Minneap Minn) 2019 Aug;25(4):936-958. doi: 10.1212/CON.0000000000000752. PMID: 31356288
Trauma-Induced Coagulopathy.
Petros S
Hamostaseologie 2019 Feb;39(1):20-27. Epub 2019 Jan 31 doi: 10.1055/s-0039-1677853. PMID: 30703820
Viscoelastic Testing in Trauma.
Wirtz MR, Baumann HM, Klinkspoor JH, Goslings JC, Juffermans NP
Semin Thromb Hemost 2017 Jun;43(4):375-385. Epub 2017 Apr 1 doi: 10.1055/s-0037-1598057. PMID: 28364737

Therapy

Comparative efficacy, tolerability, and acceptability of pharmacological interventions for the treatment of children, adolescents, and young adults with Tourette's syndrome: a systematic review and network meta-analysis.
Farhat LC, Behling E, Landeros-Weisenberger A, Levine JLS, Macul Ferreira de Barros P, Wang Z, Bloch MH
Lancet Child Adolesc Health 2023 Feb;7(2):112-126. Epub 2022 Dec 14 doi: 10.1016/S2352-4642(22)00316-9. PMID: 36528030
Use of Nutritional Supplements Based on L-Theanine and Vitamin B6 in Children with Tourette Syndrome, with Anxiety Disorders: A Pilot Study.
Rizzo R, Prato A, Scerbo M, Saia F, Barone R, Curatolo P
Nutrients 2022 Feb 18;14(4) doi: 10.3390/nu14040852. PMID: 35215501Free PMC Article
Trauma-informed abortion care.
Cahill EP, Doyle A
Curr Opin Obstet Gynecol 2021 Dec 1;33(6):453-457. doi: 10.1097/GCO.0000000000000749. PMID: 34747881
Pharmacological treatment for attention deficit hyperactivity disorder (ADHD) in children with comorbid tic disorders.
Osland ST, Steeves TD, Pringsheim T
Cochrane Database Syst Rev 2018 Jun 26;6(6):CD007990. doi: 10.1002/14651858.CD007990.pub3. PMID: 29944175Free PMC Article
Biotin for the treatment of nail disease: what is the evidence?
Lipner SR, Scher RK
J Dermatolog Treat 2018 Jun;29(4):411-414. Epub 2017 Nov 9 doi: 10.1080/09546634.2017.1395799. PMID: 29057689

Prognosis

Pathophysiology of Trauma-Induced Coagulopathy.
Schöchl H, Schmitt FCF, Maegele M
Hamostaseologie 2024 Feb;44(1):31-39. Epub 2024 Feb 28 doi: 10.1055/a-2215-8936. PMID: 38417803
Tourette syndrome and other tic disorders of childhood.
Nilles C, Hartmann A, Roze E, Martino D, Pringsheim T
Handb Clin Neurol 2023;196:457-474. doi: 10.1016/B978-0-323-98817-9.00002-8. PMID: 37620085
Viscoelastic Testing in Trauma.
Wirtz MR, Baumann HM, Klinkspoor JH, Goslings JC, Juffermans NP
Semin Thromb Hemost 2017 Jun;43(4):375-385. Epub 2017 Apr 1 doi: 10.1055/s-0037-1598057. PMID: 28364737
Trauma-associated hyperfibrinolysis.
Schöchl H, Voelckel W, Maegele M, Solomon C
Hamostaseologie 2012;32(1):22-7. Epub 2011 Oct 19 doi: 10.5482/ha-1178. PMID: 22009115
Tics in childhood.
Golden GS
Pediatr Ann 1983 Nov;12(11):821-4. doi: 10.3928/0090-4481-19831101-05. PMID: 6359039

Clinical prediction guides

Trauma-induced coagulopathy: What you need to know.
Buzzard L, Schreiber M
J Trauma Acute Care Surg 2024 Feb 1;96(2):179-185. Epub 2023 Oct 13 doi: 10.1097/TA.0000000000004170. PMID: 37828662
Tetrahydrocannabinol and Cannabidiol in Tourette Syndrome.
Mosley PE, Webb L, Suraev A, Hingston L, Turnbull T, Foster K, Ballard E, Gomes L, Mohan A, Sachdev PS, Kevin R, Gordon R, Benson M, McGregor IS
NEJM Evid 2023 Sep;2(9):EVIDoa2300012. Epub 2023 Jun 7 doi: 10.1056/EVIDoa2300012. PMID: 38320199
The tic douloureux of Alexis Pujol (1739-1804).
Walusinski O
Rev Neurol (Paris) 2023 Mar;179(3):128-136. Epub 2022 Sep 20 doi: 10.1016/j.neurol.2022.05.008. PMID: 36150938
Trauma Providers' Knowledge, Views, and Practice of Trauma-Informed Care.
Bruce MM, Kassam-Adams N, Rogers M, Anderson KM, Sluys KP, Richmond TS
J Trauma Nurs 2018 Mar/Apr;25(2):131-138. doi: 10.1097/JTN.0000000000000356. PMID: 29521782Free PMC Article
Voluntary inhibitory motor control over involuntary tic movements.
Ganos C, Rothwell J, Haggard P
Mov Disord 2018 Jul;33(6):937-946. Epub 2018 Mar 6 doi: 10.1002/mds.27346. PMID: 29508917

Recent systematic reviews

Comparative efficacy, tolerability, and acceptability of pharmacological interventions for the treatment of children, adolescents, and young adults with Tourette's syndrome: a systematic review and network meta-analysis.
Farhat LC, Behling E, Landeros-Weisenberger A, Levine JLS, Macul Ferreira de Barros P, Wang Z, Bloch MH
Lancet Child Adolesc Health 2023 Feb;7(2):112-126. Epub 2022 Dec 14 doi: 10.1016/S2352-4642(22)00316-9. PMID: 36528030
The relationship between allergic diseases and tic disorders: A systematic review and meta-analysis.
Huang J, Li R, Li L, Song Y, Jin L
Neurosci Biobehav Rev 2022 Jan;132:362-377. Epub 2021 Dec 6 doi: 10.1016/j.neubiorev.2021.12.004. PMID: 34883165
Tics in patients with encephalitis.
Badenoch J, Searle T, Watson I, Cavanna AE
Neurol Sci 2021 Apr;42(4):1311-1323. Epub 2021 Jan 23 doi: 10.1007/s10072-021-05065-w. PMID: 33486621Free PMC Article
Comprehensive systematic review summary: Treatment of tics in people with Tourette syndrome and chronic tic disorders.
Pringsheim T, Holler-Managan Y, Okun MS, Jankovic J, Piacentini J, Cavanna AE, Martino D, Müller-Vahl K, Woods DW, Robinson M, Jarvie E, Roessner V, Oskoui M
Neurology 2019 May 7;92(19):907-915. doi: 10.1212/WNL.0000000000007467. PMID: 31061209Free PMC Article
Pharmacological treatment for attention deficit hyperactivity disorder (ADHD) in children with comorbid tic disorders.
Osland ST, Steeves TD, Pringsheim T
Cochrane Database Syst Rev 2018 Jun 26;6(6):CD007990. doi: 10.1002/14651858.CD007990.pub3. PMID: 29944175Free PMC Article

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