U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Squamous Cell Carcinoma, Clear Cell Type

MedGen UID:
226829
•Concept ID:
C1266006
•
Neoplastic Process
Synonym: Squamous cell carcinoma, clear cell type
SNOMED CT: Squamous cell carcinoma, clear cell type (128635005)

Definition

A squamous cell carcinoma characterized by the presence of malignant cells with clear cytoplasm. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSquamous Cell Carcinoma, Clear Cell Type

Professional guidelines

PubMed

Management of Stage I Squamous Cell Carcinoma of the Anal Canal.
Chai CY, Tran Cao HS, Awad S, Massarweh NN
JAMA Surg 2018 Mar 1;153(3):209-215. doi: 10.1001/jamasurg.2017.3151. PMID: 29049547Free PMC Article
Treatment and Outcomes of Primary Urethra Cancer.
Eng TY, Chen TW, Patel AJ, Vincent JN, Ha CS
Am J Clin Oncol 2018 Sep;41(9):905-908. doi: 10.1097/COC.0000000000000391. PMID: 28537991
New and current preventive treatment options in actinic keratosis.
Arenberger P, Arenbergerova M
J Eur Acad Dermatol Venereol 2017 Sep;31 Suppl 5:13-17. doi: 10.1111/jdv.14375. PMID: 28805940

Recent clinical studies

Etiology

PRAME Updated: Diagnostic, Prognostic, and Therapeutic Role in Skin Cancer.
Cassalia F, Danese A, Tudurachi I, Federico S, Zambello A, Guidotti A, Franceschin L, Bolzon A, Naldi L, Belloni Fortina A
Int J Mol Sci 2024 Jan 27;25(3) doi: 10.3390/ijms25031582. PMID: 38338862Free PMC Article
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Human papillomavirus and cervical cancer.
Okunade KS
J Obstet Gynaecol 2020 Jul;40(5):602-608. Epub 2019 Sep 10 doi: 10.1080/01443615.2019.1634030. PMID: 31500479Free PMC Article
Alcohol and gastrointestinal cancers.
Vanella G, Archibugi L, Stigliano S, Capurso G
Curr Opin Gastroenterol 2019 Mar;35(2):107-113. doi: 10.1097/MOG.0000000000000502. PMID: 30550381
Oropharyngeal cancer.
Psyrri A, Prezas L, Burtness B
Clin Adv Hematol Oncol 2008 Aug;6(8):604-12. PMID: 18820604

Diagnosis

PRAME Updated: Diagnostic, Prognostic, and Therapeutic Role in Skin Cancer.
Cassalia F, Danese A, Tudurachi I, Federico S, Zambello A, Guidotti A, Franceschin L, Bolzon A, Naldi L, Belloni Fortina A
Int J Mol Sci 2024 Jan 27;25(3) doi: 10.3390/ijms25031582. PMID: 38338862Free PMC Article
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Human papillomavirus and cervical cancer.
Okunade KS
J Obstet Gynaecol 2020 Jul;40(5):602-608. Epub 2019 Sep 10 doi: 10.1080/01443615.2019.1634030. PMID: 31500479Free PMC Article
Onycholemmal carcinoma.
Rashid RM, Cutlan JE
Dermatol Online J 2010 Mar 15;16(3):12. PMID: 20233569
Oropharyngeal cancer.
Psyrri A, Prezas L, Burtness B
Clin Adv Hematol Oncol 2008 Aug;6(8):604-12. PMID: 18820604

Therapy

Improving head and neck cancer therapies by immunomodulation of the tumour microenvironment.
Ruffin AT, Li H, Vujanovic L, Zandberg DP, Ferris RL, Bruno TC
Nat Rev Cancer 2023 Mar;23(3):173-188. Epub 2022 Dec 1 doi: 10.1038/s41568-022-00531-9. PMID: 36456755Free PMC Article
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Chang S, Yim S, Park H
Exp Mol Med 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. PMID: 31221981Free PMC Article
Alcohol and gastrointestinal cancers.
Vanella G, Archibugi L, Stigliano S, Capurso G
Curr Opin Gastroenterol 2019 Mar;35(2):107-113. doi: 10.1097/MOG.0000000000000502. PMID: 30550381
Classifying squamous cell carcinoma of the head and neck: prognosis, prediction and implications for therapy.
Weiss J, Hayes DN
Expert Rev Anticancer Ther 2014 Feb;14(2):229-36. Epub 2013 Dec 6 doi: 10.1586/14737140.2014.863154. PMID: 24313652
Gastroesophageal junction adenocarcinoma.
Swisher SG, Pisters PW, Komaki R, Lahoti S, Ajani JA
Curr Treat Options Oncol 2000 Dec;1(5):387-98. doi: 10.1007/s11864-000-0066-1. PMID: 12057146

Prognosis

PRAME Updated: Diagnostic, Prognostic, and Therapeutic Role in Skin Cancer.
Cassalia F, Danese A, Tudurachi I, Federico S, Zambello A, Guidotti A, Franceschin L, Bolzon A, Naldi L, Belloni Fortina A
Int J Mol Sci 2024 Jan 27;25(3) doi: 10.3390/ijms25031582. PMID: 38338862Free PMC Article
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Systematic Pan-Cancer Analysis Identifies TREM2 as an Immunological and Prognostic Biomarker.
Cheng X, Wang X, Nie K, Cheng L, Zhang Z, Hu Y, Peng W
Front Immunol 2021;12:646523. Epub 2021 Feb 17 doi: 10.3389/fimmu.2021.646523. PMID: 33679809Free PMC Article
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Chang S, Yim S, Park H
Exp Mol Med 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. PMID: 31221981Free PMC Article
Classifying squamous cell carcinoma of the head and neck: prognosis, prediction and implications for therapy.
Weiss J, Hayes DN
Expert Rev Anticancer Ther 2014 Feb;14(2):229-36. Epub 2013 Dec 6 doi: 10.1586/14737140.2014.863154. PMID: 24313652

Clinical prediction guides

Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
Zhang X, Wang Y, A G, Qu C, Chen J
Front Immunol 2021;12:721030. Epub 2021 Aug 31 doi: 10.3389/fimmu.2021.721030. PMID: 34531868Free PMC Article
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Chang S, Yim S, Park H
Exp Mol Med 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. PMID: 31221981Free PMC Article
Genomic and Epigenomic Aberrations in Esophageal Squamous Cell Carcinoma and Implications for Patients.
Lin DC, Wang MR, Koeffler HP
Gastroenterology 2018 Jan;154(2):374-389. Epub 2017 Jul 27 doi: 10.1053/j.gastro.2017.06.066. PMID: 28757263Free PMC Article
Classifying squamous cell carcinoma of the head and neck: prognosis, prediction and implications for therapy.
Weiss J, Hayes DN
Expert Rev Anticancer Ther 2014 Feb;14(2):229-36. Epub 2013 Dec 6 doi: 10.1586/14737140.2014.863154. PMID: 24313652
Skin precancer.
Brash DE, Pontén J
Cancer Surv 1998;32:69-113. PMID: 10489624

Recent systematic reviews

The Role of Glucose Transporters in Oral Squamous Cell Carcinoma.
Botha H, Farah CS, Koo K, Cirillo N, McCullough M, Paolini R, Celentano A
Biomolecules 2021 Jul 21;11(8) doi: 10.3390/biom11081070. PMID: 34439735Free PMC Article
Exfoliative cytology for diagnosing basal cell carcinoma and other skin cancers in adults.
Ferrante di Ruffano L, Dinnes J, Chuchu N, Bayliss SE, Takwoingi Y, Davenport C, Matin RN, O'Sullivan C, Roskell D, Deeks JJ, Williams HC; Cochrane Skin Cancer Diagnostic Test Accuracy Group
Cochrane Database Syst Rev 2018 Dec 4;12(12):CD013187. doi: 10.1002/14651858.CD013187. PMID: 30521689Free PMC Article
Annexin A2 and cancer: A systematic review.
Christensen MV, Høgdall CK, Jochumsen KM, Høgdall EVS
Int J Oncol 2018 Jan;52(1):5-18. Epub 2017 Nov 8 doi: 10.3892/ijo.2017.4197. PMID: 29115416
Smoking Cessation and Risk of Esophageal Cancer by Histological Type: Systematic Review and Meta-analysis.
Wang QL, Xie SH, Li WT, Lagergren J
J Natl Cancer Inst 2017 Dec 1;109(12) doi: 10.1093/jnci/djx115. PMID: 29933436
A systematic review of p53 as a prognostic factor of survival in squamous cell carcinoma of the four main anatomical subsites of the head and neck.
Tandon S, Tudur-Smith C, Riley RD, Boyd MT, Jones TM
Cancer Epidemiol Biomarkers Prev 2010 Feb;19(2):574-87. doi: 10.1158/1055-9965.EPI-09-0981. PMID: 20142252Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...