U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

T-cell immunodeficiency

MedGen UID:
226894
Concept ID:
C1274233
Disease or Syndrome
Synonyms: T lymphocyte deficiency; T-Cell Immunodeficiency; T-lymphocyte deficiency (finding); T-lymphocyte immunodeficiency
SNOMED CT: T-lymphocyte immunodeficiency (402792003)
 
Monarch Initiative: MONDO:0003780

Definition

A broad classification of disorders that affect the cell-mediated aspect of the immune response. Circulating numbers of T lymphocytes are decreased or ineffective. [from NCI]

Professional guidelines

PubMed

Patrawala M, Kobrynski L
Curr Opin Allergy Clin Immunol 2019 Dec;19(6):586-593. doi: 10.1097/ACI.0000000000000586. PMID: 31490207
Galal N, Ohida M, Meshaal S, Elaziz DA, Elhawary I
Afr Health Sci 2019 Mar;19(1):1449-1459. doi: 10.4314/ahs.v19i1.18. PMID: 31148972Free PMC Article
Kneyber MC, Moll HA, de Groot R
Eur J Pediatr 2000 Jun;159(6):399-411. doi: 10.1007/s004310051296. PMID: 10867843

Recent clinical studies

Etiology

Armanios M
Annu Rev Genomics Hum Genet 2022 Aug 31;23:363-381. Epub 2022 Jun 24 doi: 10.1146/annurev-genom-010422-091101. PMID: 35609925Free PMC Article
Urschel D, Hernandez-Trujillo VP
Clin Rev Allergy Immunol 2022 Aug;63(1):99-105. Epub 2022 Feb 8 doi: 10.1007/s12016-022-08927-z. PMID: 35133619
Azizi G, Ghanavatinejad A, Abolhassani H, Yazdani R, Rezaei N, Mirshafiey A, Aghamohammadi A
Expert Rev Clin Immunol 2016 Sep;12(9):989-1006. Epub 2016 Apr 28 doi: 10.1080/1744666X.2016.1177458. PMID: 27063703
Roifman CM, Somech R, Kavadas F, Pires L, Nahum A, Dalal I, Grunebaum E
J Allergy Clin Immunol 2012 Jul;130(1):177-83. Epub 2012 Jun 2 doi: 10.1016/j.jaci.2012.04.029. PMID: 22664165
Edgar JD
J Clin Pathol 2008 Sep;61(9):988-93. doi: 10.1136/jcp.2007.051144. PMID: 18755723

Diagnosis

Alder JK, Armanios M
Physiol Rev 2022 Oct 1;102(4):1703-1720. Epub 2022 May 9 doi: 10.1152/physrev.00046.2021. PMID: 35532056Free PMC Article
Takeuchi Y, Hirota K, Sakaguchi S
Immunol Rev 2020 Mar;294(1):164-176. Epub 2020 Jan 16 doi: 10.1111/imr.12841. PMID: 31944330
Ji J, Shen L, Bootwalla M, Quindipan C, Tatarinova T, Maglinte DT, Buckley J, Raca G, Saitta SC, Biegel JA, Gai X
Cold Spring Harb Mol Case Stud 2019 Apr;5(2) Epub 2019 Apr 1 doi: 10.1101/mcs.a003756. PMID: 30755392Free PMC Article
Roifman CM, Somech R, Kavadas F, Pires L, Nahum A, Dalal I, Grunebaum E
J Allergy Clin Immunol 2012 Jul;130(1):177-83. Epub 2012 Jun 2 doi: 10.1016/j.jaci.2012.04.029. PMID: 22664165
Edgar JD
J Clin Pathol 2008 Sep;61(9):988-93. doi: 10.1136/jcp.2007.051144. PMID: 18755723

Therapy

Bertaina A, Grimm PC, Weinberg K, Parkman R, Kristovich KM, Barbarito G, Lippner E, Dhamdhere G, Ramachandran V, Spatz JM, Fathallah-Shaykh S, Atkinson TP, Al-Uzri A, Aubert G, van der Elst K, Green SG, Agarwal R, Slepicka PF, Shah AJ, Roncarolo MG, Gallo A, Concepcion W, Lewis DB
N Engl J Med 2022 Jun 16;386(24):2295-2302. doi: 10.1056/NEJMoa2117028. PMID: 35704481Free PMC Article
Pan J, Tan Y, Wang G, Deng B, Ling Z, Song W, Seery S, Zhang Y, Peng S, Xu J, Duan J, Wang Z, Yu X, Zheng Q, Xu X, Yuan Y, Yan F, Tian Z, Tang K, Zhang J, Chang AH, Feng X
J Clin Oncol 2021 Oct 20;39(30):3340-3351. Epub 2021 Jul 29 doi: 10.1200/JCO.21.00389. PMID: 34324392
Fischer A, Hacein-Bey-Abina S
J Exp Med 2020 Jan 6;217(2) doi: 10.1084/jem.20190607. PMID: 31826240Free PMC Article
Joshua D, Suen H, Brown R, Bryant C, Ho PJ, Hart D, Gibson J
Clin Lymphoma Myeloma Leuk 2016 Oct;16(10):537-542. Epub 2016 Aug 10 doi: 10.1016/j.clml.2016.08.003. PMID: 27601001
Edgar JD
J Clin Pathol 2008 Sep;61(9):988-93. doi: 10.1136/jcp.2007.051144. PMID: 18755723

Prognosis

Gamliel A, Lee YN, Lev A, AbuZaitun O, Rechavi E, Levy S, Simon AJ, Somech R
J Investig Allergol Clin Immunol 2023 Jul 27;33(4):263-270. Epub 2022 Feb 15 doi: 10.18176/jiaci.0792. PMID: 35166674
Alder JK, Armanios M
Physiol Rev 2022 Oct 1;102(4):1703-1720. Epub 2022 May 9 doi: 10.1152/physrev.00046.2021. PMID: 35532056Free PMC Article
Pan J, Tan Y, Wang G, Deng B, Ling Z, Song W, Seery S, Zhang Y, Peng S, Xu J, Duan J, Wang Z, Yu X, Zheng Q, Xu X, Yuan Y, Yan F, Tian Z, Tang K, Zhang J, Chang AH, Feng X
J Clin Oncol 2021 Oct 20;39(30):3340-3351. Epub 2021 Jul 29 doi: 10.1200/JCO.21.00389. PMID: 34324392
Worth AJ, Houldcroft CJ, Booth C
Br J Haematol 2016 Nov;175(4):559-576. Epub 2016 Oct 17 doi: 10.1111/bjh.14339. PMID: 27748521
Nucci M, Anaissie E
Clin Microbiol Rev 2007 Oct;20(4):695-704. doi: 10.1128/CMR.00014-07. PMID: 17934079Free PMC Article

Clinical prediction guides

Singh J, Mohtashami M, Anderson G, Zúñiga-Pflücker JC
Front Immunol 2020;11:1850. Epub 2020 Aug 18 doi: 10.3389/fimmu.2020.01850. PMID: 32973763Free PMC Article
Fischer A, Hacein-Bey-Abina S
J Exp Med 2020 Jan 6;217(2) doi: 10.1084/jem.20190607. PMID: 31826240Free PMC Article
Roifman CM, Somech R, Kavadas F, Pires L, Nahum A, Dalal I, Grunebaum E
J Allergy Clin Immunol 2012 Jul;130(1):177-83. Epub 2012 Jun 2 doi: 10.1016/j.jaci.2012.04.029. PMID: 22664165
Mackall CL
Stem Cells 2000;18(1):10-8. doi: 10.1634/stemcells.18-1-10. PMID: 10661568
Mackall CL
Oncologist 1999;4(5):370-8. PMID: 10551553

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...