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Ampulla of Vater Adenoma, Intestinal-Type

MedGen UID:
231055
•Concept ID:
C1332244
•
Neoplastic Process
Synonyms: Adenoma of ampulla of Vater; Ampulla of Vater Adenoma; Ampulla of Vater Intestinal-Type Adenoma; Ampullary Adenoma
SNOMED CT: Adenoma of ampulla of Vater (721719006)

Definition

An adenoma that arises from the ampulla of Vater and resembles the adenomas of the small and large intestines. Morphologically, according to the growth pattern, it may be classified as tubular, tubulovillous, or villous. Dysplasia is always present. Jaundice may be an early symptom. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAmpulla of Vater Adenoma, Intestinal-Type

Professional guidelines

PubMed

Indicative value of pathological classification of duodenal papillary adenomas in clinical diagnosis and treatment.
Lv Y, Wang P, Chen J, Zhao L, Chen L, Zhuang Y, Wang L, Zou X
Surg Endosc 2022 Jul;36(7):5183-5197. Epub 2022 Mar 14 doi: 10.1007/s00464-021-08894-0. PMID: 35286472

Recent clinical studies

Etiology

Indicative value of pathological classification of duodenal papillary adenomas in clinical diagnosis and treatment.
Lv Y, Wang P, Chen J, Zhao L, Chen L, Zhuang Y, Wang L, Zou X
Surg Endosc 2022 Jul;36(7):5183-5197. Epub 2022 Mar 14 doi: 10.1007/s00464-021-08894-0. PMID: 35286472
MiR-21 up-regulation in ampullary adenocarcinoma and its pre-invasive lesions.
Saraggi D, Galuppini F, Fanelli GN, Remo A, Urso EDL, Bao RQ, Bacchin D, Guzzardo V, Luchini C, Braconi C, Farinati F, Rugge M, Fassan M
Pathol Res Pract 2018 Jun;214(6):835-839. Epub 2018 May 1 doi: 10.1016/j.prp.2018.04.018. PMID: 29731265
Comparison between the location and the histomorphological/immunohistochemical characteristics of noninvasive neoplasms of the ampulla of Vater.
Yamamoto Y, Nemoto T, Okubo Y, Nihonyanagi Y, Ishiwatari T, Takuma K, Tochigi N, Okano N, Wakayama M, Igarashi Y, Shibuya K
Hum Pathol 2014 Sep;45(9):1910-7. Epub 2014 Jun 12 doi: 10.1016/j.humpath.2014.05.013. PMID: 25081540
The histopathology and staging of carcinoma of the ampulla of Vater.
Talbot IC, Neoptolemos JP, Shaw DE, Carr-Locke D
Histopathology 1988 Feb;12(2):155-65. doi: 10.1111/j.1365-2559.1988.tb01926.x. PMID: 3366434

Diagnosis

Indicative value of pathological classification of duodenal papillary adenomas in clinical diagnosis and treatment.
Lv Y, Wang P, Chen J, Zhao L, Chen L, Zhuang Y, Wang L, Zou X
Surg Endosc 2022 Jul;36(7):5183-5197. Epub 2022 Mar 14 doi: 10.1007/s00464-021-08894-0. PMID: 35286472
Cytological features of mixed adenoneuroendocrine carcinoma of the ampulla of Vater: A case report with immunocytochemical analyses.
Yoshioka S, Ebisu Y, Ishida M, Uemura Y, Yanagimoto H, Satoi S, Tsuta K
Diagn Cytopathol 2018 Jun;46(6):540-546. Epub 2018 Jan 16 doi: 10.1002/dc.23891. PMID: 29341470
Pathogenesis of carcinoma of the papilla of Vater.
Fischer HP, Zhou H
J Hepatobiliary Pancreat Surg 2004;11(5):301-9. doi: 10.1007/s00534-004-0898-3. PMID: 15549428
Total papillectomy for borderline malignant tumor of papilla of Vater.
Moriya T, Kimura W, Hirai I, Sakurai F, Isobe H, Ozawa K, Fuse A
Hepatogastroenterology 2004 May-Jun;51(57):859-61. PMID: 15143934
Diagnosis of duodenal and ampullary epithelial neoplasms by endoscopic biopsy: a clinicopathologic and immunohistochemical study.
Blackman E, Nash SV
Hum Pathol 1985 Sep;16(9):901-10. doi: 10.1016/s0046-8177(85)80129-5. PMID: 4029945

Prognosis

Indicative value of pathological classification of duodenal papillary adenomas in clinical diagnosis and treatment.
Lv Y, Wang P, Chen J, Zhao L, Chen L, Zhuang Y, Wang L, Zou X
Surg Endosc 2022 Jul;36(7):5183-5197. Epub 2022 Mar 14 doi: 10.1007/s00464-021-08894-0. PMID: 35286472
Management of ampullary tumours in children: still a challenge.
Fernandez-Eire P, Vazquez Castelo JL, Herreros Villaraviz M, Fernandez Caamaño B, Gonzalez-Carreró J, Ausania F
Ann R Coll Surg Engl 2017 May;99(5):e139-e141. doi: 10.1308/rcsann.2017.0043. PMID: 28462653Free PMC Article
Pathogenesis of carcinoma of the papilla of Vater.
Fischer HP, Zhou H
J Hepatobiliary Pancreat Surg 2004;11(5):301-9. doi: 10.1007/s00534-004-0898-3. PMID: 15549428
Role of the DPC4 tumor suppressor gene in adenocarcinoma of the ampulla of Vater: analysis of 140 cases.
McCarthy DM, Hruban RH, Argani P, Howe JR, Conlon KC, Brennan MF, Zahurak M, Wilentz RE, Cameron JL, Yeo CJ, Kern SE, Klimstra DS
Mod Pathol 2003 Mar;16(3):272-8. doi: 10.1097/01.MP.0000057246.03448.26. PMID: 12640108
The histopathology and staging of carcinoma of the ampulla of Vater.
Talbot IC, Neoptolemos JP, Shaw DE, Carr-Locke D
Histopathology 1988 Feb;12(2):155-65. doi: 10.1111/j.1365-2559.1988.tb01926.x. PMID: 3366434

Clinical prediction guides

MiR-21 up-regulation in ampullary adenocarcinoma and its pre-invasive lesions.
Saraggi D, Galuppini F, Fanelli GN, Remo A, Urso EDL, Bao RQ, Bacchin D, Guzzardo V, Luchini C, Braconi C, Farinati F, Rugge M, Fassan M
Pathol Res Pract 2018 Jun;214(6):835-839. Epub 2018 May 1 doi: 10.1016/j.prp.2018.04.018. PMID: 29731265
Role of the DPC4 tumor suppressor gene in adenocarcinoma of the ampulla of Vater: analysis of 140 cases.
McCarthy DM, Hruban RH, Argani P, Howe JR, Conlon KC, Brennan MF, Zahurak M, Wilentz RE, Cameron JL, Yeo CJ, Kern SE, Klimstra DS
Mod Pathol 2003 Mar;16(3):272-8. doi: 10.1097/01.MP.0000057246.03448.26. PMID: 12640108
The histopathology and staging of carcinoma of the ampulla of Vater.
Talbot IC, Neoptolemos JP, Shaw DE, Carr-Locke D
Histopathology 1988 Feb;12(2):155-65. doi: 10.1111/j.1365-2559.1988.tb01926.x. PMID: 3366434
Long-term survival after resection of ampullary carcinoma is associated independently with tumor grade and a new staging classification that assesses local invasiveness.
Neoptolemos JP, Talbot IC, Shaw DC, Carr-Locke DL
Cancer 1988 Apr 1;61(7):1403-7. doi: 10.1002/1097-0142(19880401)61:7<1403::aid-cncr2820610721>3.0.co;2-s. PMID: 2449947

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