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AIDS-Related Pneumocystis Pneumonia

MedGen UID:
231328
•Concept ID:
C1332058
•
Disease or Syndrome
Synonym: AIDS-Related Pneumocystis jirovecii Pneumonia

Definition

A serious AIDS-related opportunistic infection of the lungs, caused by Pneumocystis jirovecii. It is one of the most common AIDS-related illnesses and is a major cause of morbidity in patients with AIDS. Signs and symptoms include cough, fever, dyspnea, and pain or tightness in the chest. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAIDS-Related Pneumocystis Pneumonia

Professional guidelines

PubMed

Management of HIV-infected patients in the intensive care unit.
Barbier F, Mer M, Szychowiak P, Miller RF, Mariotte É, Galicier L, Bouadma L, Tattevin P, Azoulay É
Intensive Care Med 2020 Feb;46(2):329-342. Epub 2020 Feb 3 doi: 10.1007/s00134-020-05945-3. PMID: 32016535Free PMC Article
Pneumocystis infection in humans: diagnosis and treatment.
Calderón EJ, Gutiérrez-Rivero S, Durand-Joly I, Dei-Cas E
Expert Rev Anti Infect Ther 2010 Jun;8(6):683-701. doi: 10.1586/eri.10.42. PMID: 20521896
The results of direct and indirect treatment comparisons in meta-analysis of randomized controlled trials.
Bucher HC, Guyatt GH, Griffith LE, Walter SD
J Clin Epidemiol 1997 Jun;50(6):683-91. doi: 10.1016/s0895-4356(97)00049-8. PMID: 9250266

Recent clinical studies

Etiology

Admission C-Reactive Protein-to-Albumin Ratio Predicts the 180-Day Mortality of AIDS-Related Pneumocystis Pneumonia.
Wang H, Chang Y, Cui ZZ, Liu ZJ, Ma SF
AIDS Res Hum Retroviruses 2020 Sep;36(9):753-761. Epub 2020 Jul 20 doi: 10.1089/AID.2020.0057. PMID: 32580561
Adjunctive steroid in HIV-negative patients with severe Pneumocystis pneumonia.
Lemiale V, Debrumetz A, Delannoy A, Alberti C, Azoulay E
Respir Res 2013 Aug 28;14(1):87. doi: 10.1186/1465-9921-14-87. PMID: 23981859Free PMC Article
Racial variations in care and outcomes for inpatient HIV-related pneumocystis pneumonia.
Parada JP, Yarnold PR, Uphold CR, Chmiel JS, DeHovitz JA, Goetz MB, Weinstein RA, McKoy JM, Chandler KL, Bennett CL
J Health Care Poor Underserved 2010 Feb;21(1):318-33. doi: 10.1353/hpu.0.0249. PMID: 20173272
Abnormal lipid composition of bronchoalveolar lavage fluid obtained from individuals with AIDS-related lung disease.
Rose RM, Catalano PJ, Koziel H, Furlong ST
Am J Respir Crit Care Med 1994 Feb;149(2 Pt 1):332-8. doi: 10.1164/ajrccm.149.2.8306026. PMID: 8306026

Diagnosis

Admission C-Reactive Protein-to-Albumin Ratio Predicts the 180-Day Mortality of AIDS-Related Pneumocystis Pneumonia.
Wang H, Chang Y, Cui ZZ, Liu ZJ, Ma SF
AIDS Res Hum Retroviruses 2020 Sep;36(9):753-761. Epub 2020 Jul 20 doi: 10.1089/AID.2020.0057. PMID: 32580561
AIDS-related Pneumocystis pneumonia complicated by diffuse pneumatocele formation.
Jacob CN, Henein S, Hill AR
N Y State J Med 1992 Jan;92(1):20-1. PMID: 1574227

Therapy

Adjunctive steroid in HIV-negative patients with severe Pneumocystis pneumonia.
Lemiale V, Debrumetz A, Delannoy A, Alberti C, Azoulay E
Respir Res 2013 Aug 28;14(1):87. doi: 10.1186/1465-9921-14-87. PMID: 23981859Free PMC Article
Racial variations in care and outcomes for inpatient HIV-related pneumocystis pneumonia.
Parada JP, Yarnold PR, Uphold CR, Chmiel JS, DeHovitz JA, Goetz MB, Weinstein RA, McKoy JM, Chandler KL, Bennett CL
J Health Care Poor Underserved 2010 Feb;21(1):318-33. doi: 10.1353/hpu.0.0249. PMID: 20173272
AIDS-related Pneumocystis pneumonia complicated by diffuse pneumatocele formation.
Jacob CN, Henein S, Hill AR
N Y State J Med 1992 Jan;92(1):20-1. PMID: 1574227

Prognosis

Admission C-Reactive Protein-to-Albumin Ratio Predicts the 180-Day Mortality of AIDS-Related Pneumocystis Pneumonia.
Wang H, Chang Y, Cui ZZ, Liu ZJ, Ma SF
AIDS Res Hum Retroviruses 2020 Sep;36(9):753-761. Epub 2020 Jul 20 doi: 10.1089/AID.2020.0057. PMID: 32580561
Adjunctive steroid in HIV-negative patients with severe Pneumocystis pneumonia.
Lemiale V, Debrumetz A, Delannoy A, Alberti C, Azoulay E
Respir Res 2013 Aug 28;14(1):87. doi: 10.1186/1465-9921-14-87. PMID: 23981859Free PMC Article
Racial variations in care and outcomes for inpatient HIV-related pneumocystis pneumonia.
Parada JP, Yarnold PR, Uphold CR, Chmiel JS, DeHovitz JA, Goetz MB, Weinstein RA, McKoy JM, Chandler KL, Bennett CL
J Health Care Poor Underserved 2010 Feb;21(1):318-33. doi: 10.1353/hpu.0.0249. PMID: 20173272

Clinical prediction guides

Admission C-Reactive Protein-to-Albumin Ratio Predicts the 180-Day Mortality of AIDS-Related Pneumocystis Pneumonia.
Wang H, Chang Y, Cui ZZ, Liu ZJ, Ma SF
AIDS Res Hum Retroviruses 2020 Sep;36(9):753-761. Epub 2020 Jul 20 doi: 10.1089/AID.2020.0057. PMID: 32580561
Adjunctive steroid in HIV-negative patients with severe Pneumocystis pneumonia.
Lemiale V, Debrumetz A, Delannoy A, Alberti C, Azoulay E
Respir Res 2013 Aug 28;14(1):87. doi: 10.1186/1465-9921-14-87. PMID: 23981859Free PMC Article
Abnormal lipid composition of bronchoalveolar lavage fluid obtained from individuals with AIDS-related lung disease.
Rose RM, Catalano PJ, Koziel H, Furlong ST
Am J Respir Crit Care Med 1994 Feb;149(2 Pt 1):332-8. doi: 10.1164/ajrccm.149.2.8306026. PMID: 8306026

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