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Adenosquamous colon carcinoma

MedGen UID:
232083
•Concept ID:
C1333082
•
Neoplastic Process
Synonyms: Adenosquamous Carcinoma of Colon; adenosquamous carcinoma of colon; Adenosquamous Carcinoma of the Colon; adenosquamous carcinoma of the colon; Adenosquamous Colon Carcinoma; adenosquamous colon carcinoma; colon adenosquamous cancer; Colon Adenosquamous Carcinoma; colon adenosquamous carcinoma; Colonic Adenosquamous Carcinoma; colonic adenosquamous carcinoma
 
Monarch Initiative: MONDO:0003554

Definition

An unusual colon carcinoma characterized by the presence of glandular and squamous carcinomatous components. The two carcinomatous components may be admixed within the tumor, or the two may appear separately in different areas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdenosquamous colon carcinoma

Professional guidelines

PubMed

Presentation, treatment, and prognosis of colorectal adenosquamous carcinoma: A contemporary analysis of the surveillance, epidemiology, and end results database.
Khan AH, Gao X, Goffredo P, Kahl AR, Utria AF, Charlton ME, Ahad S, Hassan I
Am J Surg 2022 May;223(5):957-962. Epub 2021 Sep 11 doi: 10.1016/j.amjsurg.2021.09.004. PMID: 34530984

Recent clinical studies

Etiology

Characteristics of anal canal squamous cell carcinoma as an HPV-associated cancer in Japan.
Yamada K, Shiraishi K, Takashima A, Takayanagi D, Saiki Y, Takano S, Tanaka M, Fukunaga M, Sugimoto K, Iwasaki Y, Nakamura Y, Kuwahara D, Tsuji Y, Takano M, Sugihara K, Ajioka Y
Int J Clin Oncol 2023 Aug;28(8):990-998. Epub 2023 Apr 28 doi: 10.1007/s10147-023-02339-5. PMID: 37115427
Adenosquamous carcinoma: An aggressive histologic sub-type of colon cancer with poor prognosis.
Nasseri Y, Cox B, Shen W, Zhu R, Stettler I, Cohen J, Artinyan A, Gangi A
Am J Surg 2021 Mar;221(3):649-653. Epub 2020 Aug 22 doi: 10.1016/j.amjsurg.2020.07.038. PMID: 32862977
Population-based evaluation of adenosquamous carcinoma of the colon and rectum.
Masoomi H, Ziogas A, Lin BS, Barleben A, Mills S, Stamos MJ, Zell JA
Dis Colon Rectum 2012 May;55(5):509-14. doi: 10.1097/DCR.0b013e3182420953. PMID: 22513428Free PMC Article
Adenosquamous carcinoma of the colon and rectum.
Petrelli NJ, Valle AA, Weber TK, Rodriguez-Bigas M
Dis Colon Rectum 1996 Nov;39(11):1265-8. doi: 10.1007/BF02055120. PMID: 8918436
Carcinoma of the endometrium.
Cavanagh D, Marsden DE, Ruffolo EH
Obstet Gynecol Annu 1984;13:211-60. PMID: 6371616

Diagnosis

Characteristics of anal canal squamous cell carcinoma as an HPV-associated cancer in Japan.
Yamada K, Shiraishi K, Takashima A, Takayanagi D, Saiki Y, Takano S, Tanaka M, Fukunaga M, Sugimoto K, Iwasaki Y, Nakamura Y, Kuwahara D, Tsuji Y, Takano M, Sugihara K, Ajioka Y
Int J Clin Oncol 2023 Aug;28(8):990-998. Epub 2023 Apr 28 doi: 10.1007/s10147-023-02339-5. PMID: 37115427
A Case Report of Metachronous Multiple Adenosquamous Carcinoma of the Colon Over-expressing PD-L1 and a Literature Review.
Akahoshi S, Yamamura K, Komohara Y, Yoshii D, Oda E, Sato N, Yuki H, Yukimura K, Beppu T
Anticancer Res 2021 Nov;41(11):5847-5854. doi: 10.21873/anticanres.15404. PMID: 34732461
Adenosquamous carcinoma of the right colon with diffuse signet-ring mucinous component.
Di Prete M, Baciorri F, Franceschilli M, Bagaglini G, Sica G, Doldo E, Palmieri G, Orlandi A
Clin J Gastroenterol 2020 Aug;13(4):555-559. Epub 2020 Feb 5 doi: 10.1007/s12328-020-01101-y. PMID: 32026256
Population-based evaluation of adenosquamous carcinoma of the colon and rectum.
Masoomi H, Ziogas A, Lin BS, Barleben A, Mills S, Stamos MJ, Zell JA
Dis Colon Rectum 2012 May;55(5):509-14. doi: 10.1097/DCR.0b013e3182420953. PMID: 22513428Free PMC Article
Carcinoma of the endometrium.
Cavanagh D, Marsden DE, Ruffolo EH
Obstet Gynecol Annu 1984;13:211-60. PMID: 6371616

Therapy

Application of colon interposition among the esophageal cancer patients with partial gastrectomy.
Chen Q, Mao W, Yu H, Liang Y, Wang J, Chen G
J Cancer Res Ther 2016 Dec;12(Supplement):C212-C216. doi: 10.4103/0973-1482.200602. PMID: 28230019
The prognostic significance of pretreatment leukocytosis in patients with anal cancer treated with radical chemoradiotherapy or radiotherapy.
Banerjee R, Roxin G, Eliasziw M, Joseph K, Maclean A, Buie WD, Doll C
Dis Colon Rectum 2013 Sep;56(9):1036-42. doi: 10.1097/DCR.0b013e31829ab0d4. PMID: 23929012
Adenosquamous carcinoma of the rectum showing endocrine-cell differentiation: report of a case.
Kono T, Yamamoto Y, Kakisaka A, Tokusasi Y, Miyokawa N, Kasai S
Dis Colon Rectum 1999 Aug;42(8):1089-92. doi: 10.1007/BF02236710. PMID: 10458137
Squamous-cell carcinoma of the colon responsive to combination chemotherapy: report of two cases and review of the literature.
Juturi JV, Francis B, Koontz PW, Wilkes JD
Dis Colon Rectum 1999 Jan;42(1):102-9. doi: 10.1007/BF02235191. PMID: 10211528
Carcinoma of the endometrium.
Cavanagh D, Marsden DE, Ruffolo EH
Obstet Gynecol Annu 1984;13:211-60. PMID: 6371616

Prognosis

Epidemiology and survival outcomes in adenosquamous carcinoma: a population-based study.
Cheng C, Luo Z, Xiong W, Shi Z, Tan H
Int J Colorectal Dis 2022 Jul;37(7):1581-1592. Epub 2022 Jun 9 doi: 10.1007/s00384-022-04198-4. PMID: 35678851
Presentation, treatment, and prognosis of colorectal adenosquamous carcinoma: A contemporary analysis of the surveillance, epidemiology, and end results database.
Khan AH, Gao X, Goffredo P, Kahl AR, Utria AF, Charlton ME, Ahad S, Hassan I
Am J Surg 2022 May;223(5):957-962. Epub 2021 Sep 11 doi: 10.1016/j.amjsurg.2021.09.004. PMID: 34530984
Adenosquamous carcinoma: An aggressive histologic sub-type of colon cancer with poor prognosis.
Nasseri Y, Cox B, Shen W, Zhu R, Stettler I, Cohen J, Artinyan A, Gangi A
Am J Surg 2021 Mar;221(3):649-653. Epub 2020 Aug 22 doi: 10.1016/j.amjsurg.2020.07.038. PMID: 32862977
Adenosquamous carcinoma of the right colon with diffuse signet-ring mucinous component.
Di Prete M, Baciorri F, Franceschilli M, Bagaglini G, Sica G, Doldo E, Palmieri G, Orlandi A
Clin J Gastroenterol 2020 Aug;13(4):555-559. Epub 2020 Feb 5 doi: 10.1007/s12328-020-01101-y. PMID: 32026256
Population-based evaluation of adenosquamous carcinoma of the colon and rectum.
Masoomi H, Ziogas A, Lin BS, Barleben A, Mills S, Stamos MJ, Zell JA
Dis Colon Rectum 2012 May;55(5):509-14. doi: 10.1097/DCR.0b013e3182420953. PMID: 22513428Free PMC Article

Clinical prediction guides

Epidemiology and survival outcomes in adenosquamous carcinoma: a population-based study.
Cheng C, Luo Z, Xiong W, Shi Z, Tan H
Int J Colorectal Dis 2022 Jul;37(7):1581-1592. Epub 2022 Jun 9 doi: 10.1007/s00384-022-04198-4. PMID: 35678851
Adenosquamous carcinoma of the right colon with diffuse signet-ring mucinous component.
Di Prete M, Baciorri F, Franceschilli M, Bagaglini G, Sica G, Doldo E, Palmieri G, Orlandi A
Clin J Gastroenterol 2020 Aug;13(4):555-559. Epub 2020 Feb 5 doi: 10.1007/s12328-020-01101-y. PMID: 32026256
Intestinal adenosquamous carcinoma with a synchronous skin metastasis: a immunohistochemical and molecular analysis.
Parente P, Covelli C, Parrella P, Latiano TP, Fiordelisi F, Pellico MT, Maiello E, Graziano P
Int J Colorectal Dis 2020 Feb;35(2):337-341. Epub 2019 Dec 10 doi: 10.1007/s00384-019-03464-2. PMID: 31823050
Colonic adenosquamous carcinoma and mucinous adenocarcinoma with microsatellite instability.
Parra-Medina R, Lopez-Correa P, Gutierrez V, Polo F
Malays J Pathol 2018 Aug;40(2):199-202. PMID: 30173239
Colorectal cancer: prognostic values.
Manxhuka-Kerliu S, Telaku S, Ahmetaj H, Baruti A, Loxha S, Kerliu A
Bosn J Basic Med Sci 2009 Feb;9(1):19-24. doi: 10.17305/bjbms.2009.2851. PMID: 19284390Free PMC Article

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