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Grade 4 Malignant Neoplasm

MedGen UID:
232250
•Concept ID:
C1333854
•
Neoplastic Process

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 4 Malignant Neoplasm

Professional guidelines

PubMed

Recommendations from the 2023 international evidence-based guideline for the assessment and management of polycystic ovary syndrome.
Teede HJ, Tay CT, Laven JJE, Dokras A, Moran LJ, Piltonen TT, Costello MF, Boivin J, Redman LM, Boyle JA, Norman RJ, Mousa A, Joham AE; International PCOS Network
Eur J Endocrinol 2023 Aug 2;189(2):G43-G64. doi: 10.1093/ejendo/lvad096. PMID: 37580861
European Society of Endocrinology clinical practice guidelines on the management of adrenal incidentalomas, in collaboration with the European Network for the Study of Adrenal Tumors.
Fassnacht M, Tsagarakis S, Terzolo M, Tabarin A, Sahdev A, Newell-Price J, Pelsma I, Marina L, Lorenz K, Bancos I, Arlt W, Dekkers OM
Eur J Endocrinol 2023 Jul 20;189(1):G1-G42. doi: 10.1093/ejendo/lvad066. PMID: 37318239
Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline.
Brahmer JR, Lacchetti C, Schneider BJ, Atkins MB, Brassil KJ, Caterino JM, Chau I, Ernstoff MS, Gardner JM, Ginex P, Hallmeyer S, Holter Chakrabarty J, Leighl NB, Mammen JS, McDermott DF, Naing A, Nastoupil LJ, Phillips T, Porter LD, Puzanov I, Reichner CA, Santomasso BD, Seigel C, Spira A, Suarez-Almazor ME, Wang Y, Weber JS, Wolchok JD, Thompson JA; National Comprehensive Cancer Network
J Clin Oncol 2018 Jun 10;36(17):1714-1768. Epub 2018 Feb 14 doi: 10.1200/JCO.2017.77.6385. PMID: 29442540Free PMC Article

Recent clinical studies

Etiology

Risk of Carcinoma in Pleomorphic Adenomas of the Parotid.
Levyn H, Subramanian T, Eagan A, Katabi N, Lin O, Badillo ND, Martinez G, Scholfield DW, Wong RJ, Shah JP, Givi B, Morris LGT, Ganly I, Patel SG
JAMA Otolaryngol Head Neck Surg 2023 Nov 1;149(11):1034-1041. doi: 10.1001/jamaoto.2023.3212. PMID: 37824134Free PMC Article
The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part B: Prostate and Bladder Tumours.
Humphrey PA, Moch H, Cubilla AL, Ulbright TM, Reuter VE
Eur Urol 2016 Jul;70(1):106-119. Epub 2016 Mar 17 doi: 10.1016/j.eururo.2016.02.028. PMID: 26996659
Pathological grading for predicting metastasis in phaeochromocytoma and paraganglioma.
Kimura N, Takayanagi R, Takizawa N, Itagaki E, Katabami T, Kakoi N, Rakugi H, Ikeda Y, Tanabe A, Nigawara T, Ito S, Kimura I, Naruse M; Phaeochromocytoma Study Group in Japan
Endocr Relat Cancer 2014 Jun;21(3):405-14. Epub 2014 May 6 doi: 10.1530/ERC-13-0494. PMID: 24521857
Fourth-ventricular immature teratoma.
Furtado SV, Ghosal N, Rokade VB, Hegde AS
J Clin Neurosci 2011 Feb;18(2):296-8. Epub 2010 Oct 27 doi: 10.1016/j.jocn.2010.03.061. PMID: 21030259
Bladder cancer: epidemiology, staging and grading, and diagnosis.
Kirkali Z, Chan T, Manoharan M, Algaba F, Busch C, Cheng L, Kiemeney L, Kriegmair M, Montironi R, Murphy WM, Sesterhenn IA, Tachibana M, Weider J
Urology 2005 Dec;66(6 Suppl 1):4-34. doi: 10.1016/j.urology.2005.07.062. PMID: 16399414

Diagnosis

Risk of Carcinoma in Pleomorphic Adenomas of the Parotid.
Levyn H, Subramanian T, Eagan A, Katabi N, Lin O, Badillo ND, Martinez G, Scholfield DW, Wong RJ, Shah JP, Givi B, Morris LGT, Ganly I, Patel SG
JAMA Otolaryngol Head Neck Surg 2023 Nov 1;149(11):1034-1041. doi: 10.1001/jamaoto.2023.3212. PMID: 37824134Free PMC Article
Grading of renal cell carcinoma.
Delahunt B, Eble JN, Egevad L, Samaratunga H
Histopathology 2019 Jan;74(1):4-17. doi: 10.1111/his.13735. PMID: 30565310
Pathological grading for predicting metastasis in phaeochromocytoma and paraganglioma.
Kimura N, Takayanagi R, Takizawa N, Itagaki E, Katabami T, Kakoi N, Rakugi H, Ikeda Y, Tanabe A, Nigawara T, Ito S, Kimura I, Naruse M; Phaeochromocytoma Study Group in Japan
Endocr Relat Cancer 2014 Jun;21(3):405-14. Epub 2014 May 6 doi: 10.1530/ERC-13-0494. PMID: 24521857
The International Society of Urological Pathology (ISUP) grading system for renal cell carcinoma and other prognostic parameters.
Delahunt B, Cheville JC, Martignoni G, Humphrey PA, Magi-Galluzzi C, McKenney J, Egevad L, Algaba F, Moch H, Grignon DJ, Montironi R, Srigley JR; Members of the ISUP Renal Tumor Panel
Am J Surg Pathol 2013 Oct;37(10):1490-504. doi: 10.1097/PAS.0b013e318299f0fb. PMID: 24025520
Bladder cancer: epidemiology, staging and grading, and diagnosis.
Kirkali Z, Chan T, Manoharan M, Algaba F, Busch C, Cheng L, Kiemeney L, Kriegmair M, Montironi R, Murphy WM, Sesterhenn IA, Tachibana M, Weider J
Urology 2005 Dec;66(6 Suppl 1):4-34. doi: 10.1016/j.urology.2005.07.062. PMID: 16399414

Therapy

Organ Preservation and Survival by Clinical Response Grade in Patients With Rectal Cancer Treated With Total Neoadjuvant Therapy: A Secondary Analysis of the OPRA Randomized Clinical Trial.
Thompson HM, Omer DM, Lin S, Kim JK, Yuval JB, Verheij FS, Qin LX, Gollub MJ, Wu AJ, Lee M, Patil S, Hezel AF, Marcet JE, Cataldo PA, Polite BN, Herzig DO, Liska D, Oommen S, Friel CM, Ternent CA, Coveler AL, Hunt SR, Garcia-Aguilar J; OPRA Consortium
JAMA Netw Open 2024 Jan 2;7(1):e2350903. doi: 10.1001/jamanetworkopen.2023.50903. PMID: 38194231Free PMC Article
Subcutaneous epcoritamab monotherapy in Japanese adults with relapsed/refractory diffuse large B-cell lymphoma.
Izutsu K, Kumode T, Yuda J, Nagai H, Mishima Y, Suehiro Y, Yamamoto K, Fujisaki T, Ishitsuka K, Ishizawa K, Ikezoe T, Nishikori M, Akahane D, Fujita J, Dinh M, Soong D, Noguchi H, Buchbjerg JK, Favaro E, Fukuhara N
Cancer Sci 2023 Dec;114(12):4643-4653. Epub 2023 Nov 3 doi: 10.1111/cas.15996. PMID: 37921363Free PMC Article
Geriatric Assessment-Driven Intervention (GAIN) on Chemotherapy-Related Toxic Effects in Older Adults With Cancer: A Randomized Clinical Trial.
Li D, Sun CL, Kim H, Soto-Perez-de-Celis E, Chung V, Koczywas M, Fakih M, Chao J, Cabrera Chien L, Charles K, Hughes SFDS, Katheria V, Trent M, Roberts E, Jayani R, Moreno J, Kelly C, Sedrak MS, Dale W
JAMA Oncol 2021 Nov 1;7(11):e214158. Epub 2021 Nov 18 doi: 10.1001/jamaoncol.2021.4158. PMID: 34591080Free PMC Article
The management of menopause in women with a history of endometriosis: a systematic review.
Gemmell LC, Webster KE, Kirtley S, Vincent K, Zondervan KT, Becker CM
Hum Reprod Update 2017 Jul 1;23(4):481-500. doi: 10.1093/humupd/dmx011. PMID: 28498913Free PMC Article
Interventions for treating oral leukoplakia to prevent oral cancer.
Lodi G, Franchini R, Warnakulasuriya S, Varoni EM, Sardella A, Kerr AR, Carrassi A, MacDonald LC, Worthington HV
Cochrane Database Syst Rev 2016 Jul 29;7(7):CD001829. doi: 10.1002/14651858.CD001829.pub4. PMID: 27471845Free PMC Article

Prognosis

Late mortality and chronic health conditions in long-term survivors of early-adolescent and young adult cancers: a retrospective cohort analysis from the Childhood Cancer Survivor Study.
Suh E, Stratton KL, Leisenring WM, Nathan PC, Ford JS, Freyer DR, McNeer JL, Stock W, Stovall M, Krull KR, Sklar CA, Neglia JP, Armstrong GT, Oeffinger KC, Robison LL, Henderson TO
Lancet Oncol 2020 Mar;21(3):421-435. Epub 2020 Feb 14 doi: 10.1016/S1470-2045(19)30800-9. PMID: 32066543Free PMC Article
Effects of sodium thiosulfate versus observation on development of cisplatin-induced hearing loss in children with cancer (ACCL0431): a multicentre, randomised, controlled, open-label, phase 3 trial.
Freyer DR, Chen L, Krailo MD, Knight K, Villaluna D, Bliss B, Pollock BH, Ramdas J, Lange B, Van Hoff D, VanSoelen ML, Wiernikowski J, Neuwelt EA, Sung L
Lancet Oncol 2017 Jan;18(1):63-74. Epub 2016 Dec 1 doi: 10.1016/S1470-2045(16)30625-8. PMID: 27914822Free PMC Article
Pathological grading for predicting metastasis in phaeochromocytoma and paraganglioma.
Kimura N, Takayanagi R, Takizawa N, Itagaki E, Katabami T, Kakoi N, Rakugi H, Ikeda Y, Tanabe A, Nigawara T, Ito S, Kimura I, Naruse M; Phaeochromocytoma Study Group in Japan
Endocr Relat Cancer 2014 Jun;21(3):405-14. Epub 2014 May 6 doi: 10.1530/ERC-13-0494. PMID: 24521857
Predicting chemotherapy toxicity in older adults with cancer: a prospective multicenter study.
Hurria A, Togawa K, Mohile SG, Owusu C, Klepin HD, Gross CP, Lichtman SM, Gajra A, Bhatia S, Katheria V, Klapper S, Hansen K, Ramani R, Lachs M, Wong FL, Tew WP
J Clin Oncol 2011 Sep 1;29(25):3457-65. Epub 2011 Aug 1 doi: 10.1200/JCO.2011.34.7625. PMID: 21810685Free PMC Article
Bladder cancer: epidemiology, staging and grading, and diagnosis.
Kirkali Z, Chan T, Manoharan M, Algaba F, Busch C, Cheng L, Kiemeney L, Kriegmair M, Montironi R, Murphy WM, Sesterhenn IA, Tachibana M, Weider J
Urology 2005 Dec;66(6 Suppl 1):4-34. doi: 10.1016/j.urology.2005.07.062. PMID: 16399414

Clinical prediction guides

The New Realization About Cribriform Prostate Cancer.
Iczkowski KA, Paner GP, Van der Kwast T
Adv Anat Pathol 2018 Jan;25(1):31-37. doi: 10.1097/PAP.0000000000000168. PMID: 28820750
Contemporary Gleason grading and novel Grade Groups in clinical practice.
Magi-Galluzzi C, Montironi R, Epstein JI
Curr Opin Urol 2016 Sep;26(5):488-92. doi: 10.1097/MOU.0000000000000320. PMID: 27308734
The 2014 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma: Definition of Grading Patterns and Proposal for a New Grading System.
Epstein JI, Egevad L, Amin MB, Delahunt B, Srigley JR, Humphrey PA; Grading Committee
Am J Surg Pathol 2016 Feb;40(2):244-52. doi: 10.1097/PAS.0000000000000530. PMID: 26492179
A Contemporary Prostate Cancer Grading System: A Validated Alternative to the Gleason Score.
Epstein JI, Zelefsky MJ, Sjoberg DD, Nelson JB, Egevad L, Magi-Galluzzi C, Vickers AJ, Parwani AV, Reuter VE, Fine SW, Eastham JA, Wiklund P, Han M, Reddy CA, Ciezki JP, Nyberg T, Klein EA
Eur Urol 2016 Mar;69(3):428-35. Epub 2015 Jul 10 doi: 10.1016/j.eururo.2015.06.046. PMID: 26166626Free PMC Article
Predicting chemotherapy toxicity in older adults with cancer: a prospective multicenter study.
Hurria A, Togawa K, Mohile SG, Owusu C, Klepin HD, Gross CP, Lichtman SM, Gajra A, Bhatia S, Katheria V, Klapper S, Hansen K, Ramani R, Lachs M, Wong FL, Tew WP
J Clin Oncol 2011 Sep 1;29(25):3457-65. Epub 2011 Aug 1 doi: 10.1200/JCO.2011.34.7625. PMID: 21810685Free PMC Article

Recent systematic reviews

Therapy for Diffuse Astrocytic and Oligodendroglial Tumors in Adults: ASCO-SNO Guideline.
Mohile NA, Messersmith H, Gatson NT, Hottinger AF, Lassman A, Morton J, Ney D, Nghiemphu PL, Olar A, Olson J, Perry J, Portnow J, Schiff D, Shannon A, Shih HA, Strowd R, van den Bent M, Ziu M, Blakeley J
J Clin Oncol 2022 Feb 1;40(4):403-426. Epub 2021 Dec 13 doi: 10.1200/JCO.21.02036. PMID: 34898238
A Systematic Review of the Evidence for the Decipher Genomic Classifier in Prostate Cancer.
Jairath NK, Dal Pra A, Vince R Jr, Dess RT, Jackson WC, Tosoian JJ, McBride SM, Zhao SG, Berlin A, Mahal BA, Kishan AU, Den RB, Freedland SJ, Salami SS, Kaffenberger SD, Pollack A, Tran P, Mehra R, Morgan TM, Weiner AB, Mohamad O, Carroll PR, Cooperberg MR, Karnes RJ, Nguyen PL, Michalski JM, Tward JD, Feng FY, Schaeffer EM, Spratt DE
Eur Urol 2021 Mar;79(3):374-383. Epub 2020 Dec 5 doi: 10.1016/j.eururo.2020.11.021. PMID: 33293078
Early palliative care for adults with advanced cancer.
Haun MW, Estel S, Rücker G, Friederich HC, Villalobos M, Thomas M, Hartmann M
Cochrane Database Syst Rev 2017 Jun 12;6(6):CD011129. doi: 10.1002/14651858.CD011129.pub2. PMID: 28603881Free PMC Article
The management of menopause in women with a history of endometriosis: a systematic review.
Gemmell LC, Webster KE, Kirtley S, Vincent K, Zondervan KT, Becker CM
Hum Reprod Update 2017 Jul 1;23(4):481-500. doi: 10.1093/humupd/dmx011. PMID: 28498913Free PMC Article
Diagnosis and Treatment of Non-Muscle Invasive Bladder Cancer: AUA/SUO Guideline.
Chang SS, Boorjian SA, Chou R, Clark PE, Daneshmand S, Konety BR, Pruthi R, Quale DZ, Ritch CR, Seigne JD, Skinner EC, Smith ND, McKiernan JM
J Urol 2016 Oct;196(4):1021-9. Epub 2016 Jun 16 doi: 10.1016/j.juro.2016.06.049. PMID: 27317986

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    Practice guidelines

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