U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Liver inflammatory myofibroblastic tumor

MedGen UID:
232275
•Concept ID:
C1333967
•
Neoplastic Process
Synonyms: Hepatic Inflammatory Myofibroblastic Tumor; hepatic inflammatory myofibroblastic tumor; hepatic inflammatory myofibroblastic tumour; Inflammatory pseudotumor of liver; Inflammatory Pseudotumor of Liver; inflammatory pseudotumor of liver; Inflammatory Pseudotumor of the Liver; inflammatory pseudotumor of the liver; Liver Inflammatory Myofibroblastic Tumor; liver inflammatory myofibroblastic tumor; Liver Inflammatory Pseudotumor
SNOMED CT: Inflammatory pseudotumor of liver (717329009)
 
Monarch Initiative: MONDO:0004726

Definition

A rare benign tumour-like lesion. Approximately 140 cases have been reported worldwide, with a higher prevalence for male adults of Asian origin and subjects affected by systemic diseases such as rheumatoid arthritis. There are two clinical presentations. The active form most commonly manifests with abdominal pain, fever and loss of body weight. The second form is usually clinically silent. The aetiopathogenesis remains unclear. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLiver inflammatory myofibroblastic tumor

Professional guidelines

PubMed

Hepatic inflammatory pseudotumor mimicking malignancy: the value of differential diagnosis on contrast enhanced ultrasound.
Kong WT, Wang WP, Shen HY, Xue HY, Liu CR, Huang DQ, Wu M
Med Ultrason 2021 Feb 18;23(1):15-21. Epub 2020 Aug 18 doi: 10.11152/mu-2542. PMID: 32905565
Management of benign liver tumors.
Fuchs J, Warmann SW, Urla C, Schäfer JF, Schmidt A
Semin Pediatr Surg 2020 Aug;29(4):150941. Epub 2020 Jul 24 doi: 10.1016/j.sempedsurg.2020.150941. PMID: 32861445
Diagnosis and management of solid benign liver lesions.
Belghiti J, Cauchy F, Paradis V, Vilgrain V
Nat Rev Gastroenterol Hepatol 2014 Dec;11(12):737-49. Epub 2014 Sep 2 doi: 10.1038/nrgastro.2014.151. PMID: 25178878

Recent clinical studies

Etiology

Combined liver transplant and pancreaticoduodenectomy for inflammatory hilar myofibroblastic tumor: Case report and review of the literature.
Berumen J, McCarty P, Mo J, Newton K, Fairbanks T, Mekeel K, Hemming A
Pediatr Transplant 2017 Mar;21(2) Epub 2016 Dec 20 doi: 10.1111/petr.12846. PMID: 28000317
Retrospective and comparative study of inflammatory myofibroblastic tumor of the liver.
Yang X, Miao R, Yang H, Chi T, Jiang C, Wan X, Xu Y, Xu H, Du S, Lu X, Mao Y, Zhong S, Zhao H, Sang X
J Gastroenterol Hepatol 2015 May;30(5):885-90. doi: 10.1111/jgh.12846. PMID: 25387431
Diagnosis and management of solid benign liver lesions.
Belghiti J, Cauchy F, Paradis V, Vilgrain V
Nat Rev Gastroenterol Hepatol 2014 Dec;11(12):737-49. Epub 2014 Sep 2 doi: 10.1038/nrgastro.2014.151. PMID: 25178878
Inflammatory myofibroblastic tumors.
Kovach SJ, Fischer AC, Katzman PJ, Salloum RM, Ettinghausen SE, Madeb R, Koniaris LG
J Surg Oncol 2006 Oct 1;94(5):385-91. doi: 10.1002/jso.20516. PMID: 16967468
Benign hepatic tumours.
Biecker E, Fischer HP, Strunk H, Sauerbruch T
Z Gastroenterol 2003 Feb;41(2):191-200. doi: 10.1055/s-2003-37316. PMID: 12650132

Diagnosis

Mesenchymal Neoplasms of the Liver.
Papke DJ Jr
Surg Pathol Clin 2023 Sep;16(3):609-634. Epub 2023 Jun 11 doi: 10.1016/j.path.2023.04.013. PMID: 37536892
Inflammatory Pseudotumor of the Liver.
Wang D, Misdraji J
Surg Pathol Clin 2023 Sep;16(3):565-580. Epub 2023 May 31 doi: 10.1016/j.path.2023.04.010. PMID: 37536889
Management of benign liver tumors.
Fuchs J, Warmann SW, Urla C, Schäfer JF, Schmidt A
Semin Pediatr Surg 2020 Aug;29(4):150941. Epub 2020 Jul 24 doi: 10.1016/j.sempedsurg.2020.150941. PMID: 32861445
IgG4-related disease.
Hirabayashi K, Zamboni G
Pathologica 2012 Apr;104(2):43-55. PMID: 22953500
Inflammatory myofibroblastic tumors.
Kovach SJ, Fischer AC, Katzman PJ, Salloum RM, Ettinghausen SE, Madeb R, Koniaris LG
J Surg Oncol 2006 Oct 1;94(5):385-91. doi: 10.1002/jso.20516. PMID: 16967468

Therapy

Fibrohistiocytic Variant of Hepatic Pseudotumor: An Antibiotic Responsive Tumefactive Lesion.
Arora KS, Anderson MA, Neyaz A, Yilmaz O, Pankaj A, Ferrone CR, Zen Y, England J, Deshpande V
Am J Surg Pathol 2021 Oct 1;45(10):1314-1323. doi: 10.1097/PAS.0000000000001767. PMID: 34334689
Aggressive Inflammatory Myofibroblastic Tumor without Anaplastic Lymphoma Kinase Gene Rearrangement in the Rectum with Liver Metastasis.
Shimodaira Y, Sugawara K, Fukuda S, Suzuki Y, Watanabe N, Koizumi S, Ohba R, Hiroshima Y, Matsuhashi T, Nanjo H, Iijima K
Intern Med 2020 Feb 15;59(4):495-499. Epub 2019 Oct 7 doi: 10.2169/internalmedicine.3686-19. PMID: 31588090Free PMC Article
Posttransplant epithelioid inflammatory myofibroblastic sarcoma: A case report.
Garg R, Kaul S, Arora D, Kashyap V
Indian J Pathol Microbiol 2019 Apr-Jun;62(2):303-305. doi: 10.4103/IJPM.IJPM_284_17. PMID: 30971562
Inflammatory myofibroblastic tumors in children.
Dalton BG, Thomas PG, Sharp NE, Manalang MA, Fisher JE, Moir CR, St Peter SD, Iqbal CW
J Pediatr Surg 2016 Apr;51(4):541-4. Epub 2015 Nov 27 doi: 10.1016/j.jpedsurg.2015.11.015. PMID: 26732283
Inflammatory myofibroblastic tumor of the liver following renal transplantation.
Huang YH, Zhong DJ, Tang J, Han JJ, Yu JD, Wang J, Wan YL
Ren Fail 2012;34(6):789-91. doi: 10.3109/0886022X.2012.673446. PMID: 22681584

Prognosis

Combined liver transplant and pancreaticoduodenectomy for inflammatory hilar myofibroblastic tumor: Case report and review of the literature.
Berumen J, McCarty P, Mo J, Newton K, Fairbanks T, Mekeel K, Hemming A
Pediatr Transplant 2017 Mar;21(2) Epub 2016 Dec 20 doi: 10.1111/petr.12846. PMID: 28000317
Retrospective and comparative study of inflammatory myofibroblastic tumor of the liver.
Yang X, Miao R, Yang H, Chi T, Jiang C, Wan X, Xu Y, Xu H, Du S, Lu X, Mao Y, Zhong S, Zhao H, Sang X
J Gastroenterol Hepatol 2015 May;30(5):885-90. doi: 10.1111/jgh.12846. PMID: 25387431
Epithelioid inflammatory myofibroblastic sarcoma: An aggressive intra-abdominal variant of inflammatory myofibroblastic tumor with nuclear membrane or perinuclear ALK.
Mariño-Enríquez A, Wang WL, Roy A, Lopez-Terrada D, Lazar AJ, Fletcher CD, Coffin CM, Hornick JL
Am J Surg Pathol 2011 Jan;35(1):135-44. doi: 10.1097/PAS.0b013e318200cfd5. PMID: 21164297
Inflammatory myofibroblastic tumors.
Kovach SJ, Fischer AC, Katzman PJ, Salloum RM, Ettinghausen SE, Madeb R, Koniaris LG
J Surg Oncol 2006 Oct 1;94(5):385-91. doi: 10.1002/jso.20516. PMID: 16967468
Extrapulmonary inflammatory myofibroblastic tumor: a clinical and pathological survey.
Coffin CM, Humphrey PA, Dehner LP
Semin Diagn Pathol 1998 May;15(2):85-101. PMID: 9606801

Clinical prediction guides

Clinical and Pathological Features of Immune Checkpoint Inhibitor-induced Liver Injury in Comparison with Drug-induced Liver Injury and Autoimmune Hepatitis.
Sunago K, Abe M, Yoshida O, Watanabe T, Nakamura Y, Imai Y, Koizumi Y, Hirooka M, Tokumoto Y, Hiasa Y
J Gastrointestin Liver Dis 2023 Dec 22;32(4):488-496. doi: 10.15403/jgld-5045. PMID: 38147620
Inflammatory myofibroblastic tumor of the heart.
Kato T, Tomita S, Tamaki M, Yutani C, Okawa Y
Heart Vessels 2014 Jan;29(1):123-8. Epub 2013 Apr 11 doi: 10.1007/s00380-013-0344-z. PMID: 23575661
Different imaging findings of inflammatory myofibroblastic tumor of the liver.
Liu XF, He BM, Ou-Yang XH, Wang ZZ, Su JG
World J Gastroenterol 2012 Oct 28;18(40):5821-5. doi: 10.3748/wjg.v18.i40.5821. PMID: 23155327Free PMC Article
Epithelioid inflammatory myofibroblastic sarcoma: An aggressive intra-abdominal variant of inflammatory myofibroblastic tumor with nuclear membrane or perinuclear ALK.
Mariño-Enríquez A, Wang WL, Roy A, Lopez-Terrada D, Lazar AJ, Fletcher CD, Coffin CM, Hornick JL
Am J Surg Pathol 2011 Jan;35(1):135-44. doi: 10.1097/PAS.0b013e318200cfd5. PMID: 21164297
Inflammatory myofibroblastic tumors.
Kovach SJ, Fischer AC, Katzman PJ, Salloum RM, Ettinghausen SE, Madeb R, Koniaris LG
J Surg Oncol 2006 Oct 1;94(5):385-91. doi: 10.1002/jso.20516. PMID: 16967468

Recent systematic reviews

Inflammatory myofibroblastic tumours of the liver - a systematic review.
Li M, Sobnach S, Kotze UK, Zerbini LF, Millis JM, Hampton DA, Bernon MM, Krige JEJ, Jonas EG
S Afr J Surg 2024 May;62(2):23-27. PMID: 38838115

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...