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Childhood Acute Erythroid Leukemia

MedGen UID:
232341
•Concept ID:
C1332937
•
Neoplastic Process
Synonyms: Childhood M6 Leukemia; Pediatric Acute Erythroid Leukemia; Pediatric M6 Leukemia

Definition

An acute erythroid leukemia occurring in children. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChildhood Acute Erythroid Leukemia

Professional guidelines

PubMed

Development of a curative treatment within the AML-BFM studies.
Creutzig U, Zimmermann M, Dworzak MN, Ritter J, Schellong G, Reinhardt D
Klin Padiatr 2013 May;225 Suppl 1:S79-86. Epub 2013 May 22 doi: 10.1055/s-0033-1337968. PMID: 23700063
Treatment refusal and abandonment in childhood acute lymphoblastic leukemia in Indonesia: an analysis of causes and consequences.
Sitaresmi MN, Mostert S, Schook RM; Sutaryo, Veerman AJ
Psychooncology 2010 Apr;19(4):361-7. doi: 10.1002/pon.1578. PMID: 19434599
Adriamycin in the treatment of childhood acute leukemia. A Southwest Oncology Group study.
Ragab AH, Sutow WW, Komp DM, Starling KA, Lyon GM Jr, George S
Cancer 1975 Oct;36(4):1223-6. doi: 10.1002/1097-0142(197510)36:4<1223::aid-cncr2820360407>3.0.co;2-7. PMID: 1058045

Recent clinical studies

Etiology

Integrating RNA-seq and scRNA-seq to explore the biological significance of NAD + metabolism-related genes in the initial diagnosis and relapse of childhood B-cell acute lymphoblastic leukemia.
Lin C, Xu JQ, Zhong GC, Chen H, Xue HM, Yang M, Chen C
Front Immunol 2022;13:1043111. Epub 2022 Nov 11 doi: 10.3389/fimmu.2022.1043111. PMID: 36439178Free PMC Article
Genomic subtyping and therapeutic targeting of acute erythroleukemia.
Iacobucci I, Wen J, Meggendorfer M, Choi JK, Shi L, Pounds SB, Carmichael CL, Masih KE, Morris SM, Lindsley RC, Janke LJ, Alexander TB, Song G, Qu C, Li Y, Payne-Turner D, Tomizawa D, Kiyokawa N, Valentine M, Valentine V, Basso G, Locatelli F, Enemark EJ, Kham SKY, Yeoh AEJ, Ma X, Zhou X, Sioson E, Rusch M, Ries RE, Stieglitz E, Hunger SP, Wei AH, To LB, Lewis ID, D'Andrea RJ, Kile BT, Brown AL, Scott HS, Hahn CN, Marlton P, Pei D, Cheng C, Loh ML, Ebert BL, Meshinchi S, Haferlach T, Mullighan CG
Nat Genet 2019 Apr;51(4):694-704. Epub 2019 Mar 29 doi: 10.1038/s41588-019-0375-1. PMID: 30926971Free PMC Article
Prognostic factors of childhood and adolescent acute myeloid leukemia (AML) survival: evidence from four decades of US population data.
Hossain MJ, Xie L, Caywood EH
Cancer Epidemiol 2015 Oct;39(5):720-6. Epub 2015 Jul 6 doi: 10.1016/j.canep.2015.06.009. PMID: 26159683Free PMC Article
Erythropoietin-induced acute erythroid leukemia-like picture: a potential pitfall.
Moharram L, Kamal N, Al Sukhun S, Sughayer MA
Hematol Oncol Stem Cell Ther 2014 Mar;7(1):50-2. Epub 2013 Nov 14 doi: 10.1016/j.hemonc.2013.09.004. PMID: 24239851
Myeloproliferative diseases in childhood.
Nix WL, Fernbach DJ
Am J Pediatr Hematol Oncol 1981 Winter;3(4):397-407. PMID: 6174053

Diagnosis

CBFA2T3::GLIS2 pediatric acute megakaryoblastic leukemia is sensitive to BCL-XL inhibition by navitoclax and DT2216.
Gress V, Roussy M, Boulianne L, Bilodeau M, Cardin S, El-Hachem N, Lisi V, Khakipoor B, Rouette A, Farah A, Théret L, Aubert L, Fatima F, Audemard É, Thibault P, Bonneil É, Chagraoui J, Laramée L, Gendron P, Jouan L, Jammali S, Paré B, Simpson SM, Tran TH, Duval M, Teira P, Bittencourt H, Santiago R, Barabé F, Sauvageau G, Smith MA, Hébert J, Roux PP, Gruber TA, Lavallée VP, Wilhelm BT, Cellot S
Blood Adv 2024 Jan 9;8(1):112-129. doi: 10.1182/bloodadvances.2022008899. PMID: 37729615Free PMC Article
Integrating RNA-seq and scRNA-seq to explore the biological significance of NAD + metabolism-related genes in the initial diagnosis and relapse of childhood B-cell acute lymphoblastic leukemia.
Lin C, Xu JQ, Zhong GC, Chen H, Xue HM, Yang M, Chen C
Front Immunol 2022;13:1043111. Epub 2022 Nov 11 doi: 10.3389/fimmu.2022.1043111. PMID: 36439178Free PMC Article
Genomic subtyping and therapeutic targeting of acute erythroleukemia.
Iacobucci I, Wen J, Meggendorfer M, Choi JK, Shi L, Pounds SB, Carmichael CL, Masih KE, Morris SM, Lindsley RC, Janke LJ, Alexander TB, Song G, Qu C, Li Y, Payne-Turner D, Tomizawa D, Kiyokawa N, Valentine M, Valentine V, Basso G, Locatelli F, Enemark EJ, Kham SKY, Yeoh AEJ, Ma X, Zhou X, Sioson E, Rusch M, Ries RE, Stieglitz E, Hunger SP, Wei AH, To LB, Lewis ID, D'Andrea RJ, Kile BT, Brown AL, Scott HS, Hahn CN, Marlton P, Pei D, Cheng C, Loh ML, Ebert BL, Meshinchi S, Haferlach T, Mullighan CG
Nat Genet 2019 Apr;51(4):694-704. Epub 2019 Mar 29 doi: 10.1038/s41588-019-0375-1. PMID: 30926971Free PMC Article
Erythropoietin-induced acute erythroid leukemia-like picture: a potential pitfall.
Moharram L, Kamal N, Al Sukhun S, Sughayer MA
Hematol Oncol Stem Cell Ther 2014 Mar;7(1):50-2. Epub 2013 Nov 14 doi: 10.1016/j.hemonc.2013.09.004. PMID: 24239851
Plasma leptin and leptin receptor expression in childhood acute lymphoblastic leukemia.
Wex H, Ponelis E, Wex T, Dressendörfer R, Mittler U, Vorwerk P
Int J Hematol 2002 Dec;76(5):446-52. doi: 10.1007/BF02982810. PMID: 12512839

Therapy

Integrating RNA-seq and scRNA-seq to explore the biological significance of NAD + metabolism-related genes in the initial diagnosis and relapse of childhood B-cell acute lymphoblastic leukemia.
Lin C, Xu JQ, Zhong GC, Chen H, Xue HM, Yang M, Chen C
Front Immunol 2022;13:1043111. Epub 2022 Nov 11 doi: 10.3389/fimmu.2022.1043111. PMID: 36439178Free PMC Article
Erythropoietin-induced acute erythroid leukemia-like picture: a potential pitfall.
Moharram L, Kamal N, Al Sukhun S, Sughayer MA
Hematol Oncol Stem Cell Ther 2014 Mar;7(1):50-2. Epub 2013 Nov 14 doi: 10.1016/j.hemonc.2013.09.004. PMID: 24239851
Development of a curative treatment within the AML-BFM studies.
Creutzig U, Zimmermann M, Dworzak MN, Ritter J, Schellong G, Reinhardt D
Klin Padiatr 2013 May;225 Suppl 1:S79-86. Epub 2013 May 22 doi: 10.1055/s-0033-1337968. PMID: 23700063
Abnormal cellular and humoral immunity in childhood acute lymphoblastic leukemia in long-term remission.
Katz J, Walter BN, Bennetts GA, Cairo MS
West J Med 1987 Feb;146(2):179-87. PMID: 3493591Free PMC Article
Myeloproliferative diseases in childhood.
Nix WL, Fernbach DJ
Am J Pediatr Hematol Oncol 1981 Winter;3(4):397-407. PMID: 6174053

Prognosis

Genomic subtyping and therapeutic targeting of acute erythroleukemia.
Iacobucci I, Wen J, Meggendorfer M, Choi JK, Shi L, Pounds SB, Carmichael CL, Masih KE, Morris SM, Lindsley RC, Janke LJ, Alexander TB, Song G, Qu C, Li Y, Payne-Turner D, Tomizawa D, Kiyokawa N, Valentine M, Valentine V, Basso G, Locatelli F, Enemark EJ, Kham SKY, Yeoh AEJ, Ma X, Zhou X, Sioson E, Rusch M, Ries RE, Stieglitz E, Hunger SP, Wei AH, To LB, Lewis ID, D'Andrea RJ, Kile BT, Brown AL, Scott HS, Hahn CN, Marlton P, Pei D, Cheng C, Loh ML, Ebert BL, Meshinchi S, Haferlach T, Mullighan CG
Nat Genet 2019 Apr;51(4):694-704. Epub 2019 Mar 29 doi: 10.1038/s41588-019-0375-1. PMID: 30926971Free PMC Article
Prognostic factors of childhood and adolescent acute myeloid leukemia (AML) survival: evidence from four decades of US population data.
Hossain MJ, Xie L, Caywood EH
Cancer Epidemiol 2015 Oct;39(5):720-6. Epub 2015 Jul 6 doi: 10.1016/j.canep.2015.06.009. PMID: 26159683Free PMC Article
Erythropoietin-induced acute erythroid leukemia-like picture: a potential pitfall.
Moharram L, Kamal N, Al Sukhun S, Sughayer MA
Hematol Oncol Stem Cell Ther 2014 Mar;7(1):50-2. Epub 2013 Nov 14 doi: 10.1016/j.hemonc.2013.09.004. PMID: 24239851
Development of a curative treatment within the AML-BFM studies.
Creutzig U, Zimmermann M, Dworzak MN, Ritter J, Schellong G, Reinhardt D
Klin Padiatr 2013 May;225 Suppl 1:S79-86. Epub 2013 May 22 doi: 10.1055/s-0033-1337968. PMID: 23700063
Promotion and maintenance of leukemia by ERG.
Tsuzuki S, Taguchi O, Seto M
Blood 2011 Apr 7;117(14):3858-68. Epub 2011 Feb 14 doi: 10.1182/blood-2010-11-320515. PMID: 21321361

Clinical prediction guides

Sex disparity in childhood and young adult acute myeloid leukemia (AML) survival: Evidence from US population data.
Hossain MJ, Xie L
Cancer Epidemiol 2015 Dec;39(6):892-900. Epub 2015 Nov 9 doi: 10.1016/j.canep.2015.10.020. PMID: 26520618Free PMC Article
Natural history of GATA1 mutations in Down syndrome.
Ahmed M, Sternberg A, Hall G, Thomas A, Smith O, O'Marcaigh A, Wynn R, Stevens R, Addison M, King D, Stewart B, Gibson B, Roberts I, Vyas P
Blood 2004 Apr 1;103(7):2480-9. Epub 2003 Dec 4 doi: 10.1182/blood-2003-10-3383. PMID: 14656875
Elevated dihydrofolate reductase and impaired methotrexate transport as elements in methotrexate resistance in childhood acute lymphoblastic leukemia.
Matherly LH, Taub JW, Ravindranath Y, Proefke SA, Wong SC, Gimotty P, Buck S, Wright JE, Rosowsky A
Blood 1995 Jan 15;85(2):500-9. PMID: 7812005
Acute myeloid leukaemia in childhood: clinical features and prognosis.
Chessells JM, O'Callaghan U, Hardisty RM
Br J Haematol 1986 Jul;63(3):555-64. doi: 10.1111/j.1365-2141.1986.tb07533.x. PMID: 3460625
Adriamycin in the treatment of childhood acute leukemia. A Southwest Oncology Group study.
Ragab AH, Sutow WW, Komp DM, Starling KA, Lyon GM Jr, George S
Cancer 1975 Oct;36(4):1223-6. doi: 10.1002/1097-0142(197510)36:4<1223::aid-cncr2820360407>3.0.co;2-7. PMID: 1058045

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