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FIGO Stage IV Gestational Trophoblastic Tumor

MedGen UID:
232496
•Concept ID:
C1333563
•
Neoplastic Process

Definition

Gestational trophoblastic tumor in all other metastatic sites. [from NCI]

Professional guidelines

PubMed

Diagnosis and management of gestational trophoblastic disease: 2021 update.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):86-93. doi: 10.1002/ijgo.13877. PMID: 34669197Free PMC Article
Update on the diagnosis and management of gestational trophoblastic disease.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2018 Oct;143 Suppl 2:79-85. doi: 10.1002/ijgo.12615. PMID: 30306586
Treatment of gestational trophoblastic tumors.
Lurain JR
Curr Treat Options Oncol 2002 Apr;3(2):113-24. doi: 10.1007/s11864-002-0057-5. PMID: 12057074

Recent clinical studies

Etiology

Outcomes and prognostic factors of placental-site trophoblastic tumor: a retrospective study of 58 cases.
Liu W, Zhao W, Huang X
Arch Gynecol Obstet 2022 Nov;306(5):1633-1641. Epub 2022 Mar 13 doi: 10.1007/s00404-022-06502-7. PMID: 35279728
Diagnosis and management of gestational trophoblastic disease: 2021 update.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):86-93. doi: 10.1002/ijgo.13877. PMID: 34669197Free PMC Article
Update on the diagnosis and management of gestational trophoblastic disease.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2018 Oct;143 Suppl 2:79-85. doi: 10.1002/ijgo.12615. PMID: 30306586
Pharmacotherapy of gestational trophoblastic disease.
Lurain JR
Expert Opin Pharmacother 2003 Nov;4(11):2005-17. doi: 10.1517/14656566.4.11.2005. PMID: 14596654
Treatment of gestational trophoblastic tumors.
Lurain JR
Curr Treat Options Oncol 2002 Apr;3(2):113-24. doi: 10.1007/s11864-002-0057-5. PMID: 12057074

Diagnosis

Outcomes and prognostic factors of placental-site trophoblastic tumor: a retrospective study of 58 cases.
Liu W, Zhao W, Huang X
Arch Gynecol Obstet 2022 Nov;306(5):1633-1641. Epub 2022 Mar 13 doi: 10.1007/s00404-022-06502-7. PMID: 35279728
Diagnosis and management of gestational trophoblastic disease: 2021 update.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):86-93. doi: 10.1002/ijgo.13877. PMID: 34669197Free PMC Article
Update on the diagnosis and management of gestational trophoblastic disease.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2018 Oct;143 Suppl 2:79-85. doi: 10.1002/ijgo.12615. PMID: 30306586
Gestational trophoblastic neoplasia and human immunodeficiency virus infection: a 10-year review.
Tayib S, van Wijk L, Denny L
Int J Gynecol Cancer 2011 Dec;21(9):1684-91. doi: 10.1097/IGC.0b013e31822d8ffd. PMID: 21997172
Pharmacotherapy of gestational trophoblastic disease.
Lurain JR
Expert Opin Pharmacother 2003 Nov;4(11):2005-17. doi: 10.1517/14656566.4.11.2005. PMID: 14596654

Therapy

Diagnosis and management of gestational trophoblastic disease: 2021 update.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):86-93. doi: 10.1002/ijgo.13877. PMID: 34669197Free PMC Article
Gestational trophoblastic neoplasia and human immunodeficiency virus infection: a 10-year review.
Tayib S, van Wijk L, Denny L
Int J Gynecol Cancer 2011 Dec;21(9):1684-91. doi: 10.1097/IGC.0b013e31822d8ffd. PMID: 21997172
EMA/EP chemotherapy for chemorefractory gestational trophoblastic tumor.
Xiang Y, Sun Z, Wan X, Yang X
J Reprod Med 2004 Jun;49(6):443-6. PMID: 15283051
Pharmacotherapy of gestational trophoblastic disease.
Lurain JR
Expert Opin Pharmacother 2003 Nov;4(11):2005-17. doi: 10.1517/14656566.4.11.2005. PMID: 14596654
Treatment of gestational trophoblastic tumors.
Lurain JR
Curr Treat Options Oncol 2002 Apr;3(2):113-24. doi: 10.1007/s11864-002-0057-5. PMID: 12057074

Prognosis

Outcomes and prognostic factors of placental-site trophoblastic tumor: a retrospective study of 58 cases.
Liu W, Zhao W, Huang X
Arch Gynecol Obstet 2022 Nov;306(5):1633-1641. Epub 2022 Mar 13 doi: 10.1007/s00404-022-06502-7. PMID: 35279728
Management and prognostic analysis of patients with gestational trophoblastic neoplasia (GTN) in FIGO stage IV and its special type.
Wang K, Chen Y
Clin Exp Metastasis 2021 Feb;38(1):47-59. Epub 2020 Nov 20 doi: 10.1007/s10585-020-10064-w. PMID: 33219408Free PMC Article
Update on the diagnosis and management of gestational trophoblastic disease.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2018 Oct;143 Suppl 2:79-85. doi: 10.1002/ijgo.12615. PMID: 30306586
Placental site trophoblastic tumor: analysis of presentation, treatment, and outcome.
Hyman DM, Bakios L, Gualtiere G, Carr C, Grisham RN, Makker V, Sonoda Y, Aghajanian C, Jewell EL
Gynecol Oncol 2013 Apr;129(1):58-62. Epub 2012 Dec 26 doi: 10.1016/j.ygyno.2012.12.029. PMID: 23274560
EMA/EP chemotherapy for chemorefractory gestational trophoblastic tumor.
Xiang Y, Sun Z, Wan X, Yang X
J Reprod Med 2004 Jun;49(6):443-6. PMID: 15283051

Clinical prediction guides

Outcomes and prognostic factors of placental-site trophoblastic tumor: a retrospective study of 58 cases.
Liu W, Zhao W, Huang X
Arch Gynecol Obstet 2022 Nov;306(5):1633-1641. Epub 2022 Mar 13 doi: 10.1007/s00404-022-06502-7. PMID: 35279728
Diagnosis and management of gestational trophoblastic disease: 2021 update.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):86-93. doi: 10.1002/ijgo.13877. PMID: 34669197Free PMC Article
Update on the diagnosis and management of gestational trophoblastic disease.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2018 Oct;143 Suppl 2:79-85. doi: 10.1002/ijgo.12615. PMID: 30306586
Pharmacotherapy of gestational trophoblastic disease.
Lurain JR
Expert Opin Pharmacother 2003 Nov;4(11):2005-17. doi: 10.1517/14656566.4.11.2005. PMID: 14596654
Treatment of gestational trophoblastic tumors.
Lurain JR
Curr Treat Options Oncol 2002 Apr;3(2):113-24. doi: 10.1007/s11864-002-0057-5. PMID: 12057074

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