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Malignant childhood germ cell neoplasm

MedGen UID:: 233150
•Concept ID:: C1334574
•: Neoplastic Process

Synonyms:	Childhood Malignant Germ Cell Tumor; Malignant Childhood Germ Cell Neoplasm; malignant childhood germ cell neoplasm; malignant childhood germ cell tumor; malignant childhood germ cell tumour; malignant paediatric germ cell neoplasm; malignant paediatric germ cell tumour; Malignant Pediatric Germ Cell Neoplasm; malignant pediatric germ cell neoplasm; Malignant Pediatric Germ Cell Tumor; malignant pediatric germ cell tumor

Monarch Initiative:	MONDO:0004479

Definition

A malignant germ cell tumor that occurs during childhood. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVMalignant childhood germ cell neoplasm

Pathological process
- Disease
  - Neoplasm
    - Neoplasm by Special Category
      - Childhood neoplasm
        Childhood germ cell tumor
        Malignant childhood germ cell neoplasm
        Childhood Choriocarcinoma
        Childhood choriocarcinoma of the ovary
        Childhood testicular choriocarcinoma
        Pediatric CNS choriocarcinoma
        Childhood Embryonal Carcinoma
        Childhood central nervous system embryonal carcinoma
        Childhood embryonal testis carcinoma
        Childhood ovarian embryonal carcinoma
        Childhood endodermal sinus tumor
        Central nervous system endodermal sinus tumor
        Childhood ovarian yolk sac tumor
        Childhood Testicular Yolk Sac Tumor
        Childhood Extragonadal Malignant Germ Cell Tumor
        Childhood central nervous system germinoma
        Childhood brain germinoma
        Childhood central nervous system mixed germ cell tumor
        Childhood Malignant Ovarian Germ Cell Tumor
        Childhood Ovarian Mixed Germ Cell Tumor
        Pediatric ovarian dysgerminoma
        Childhood Malignant Testicular Germ Cell Tumor
        Childhood testicular mixed germ cell cancer
        Childhood testicular mixed embryonal carcinoma and teratoma
        Childhood Mixed Germ Cell Tumor
        Childhood Seminoma
        Recurrent Childhood Malignant Germ Cell Tumor
        Refractory Childhood Malignant Germ Cell Tumor

Professional guidelines

PubMed

National UK guidelines for the management of paediatric craniopharyngioma.

Gan HW, Morillon P, Albanese A, Aquilina K, Chandler C, Chang YC, Drimtzias E, Farndon S, Jacques TS, Korbonits M, Kuczynski A, Limond J, Robinson L, Simmons I, Thomas N, Thomas S, Thorp N, Vargha-Khadem F, Warren D, Zebian B, Mallucci C, Spoudeas HA
Lancet Diabetes Endocrinol 2023 Sep;11(9):694-706. Epub 2023 Aug 4 doi: 10.1016/S2213-8587(23)00162-6. PMID: 37549682

Modern treatment of retinoblastoma: A 2020 review.

Ancona-Lezama D, Dalvin LA, Shields CL
Indian J Ophthalmol 2020 Nov;68(11):2356-2365. doi: 10.4103/ijo.IJO_721_20. PMID: 33120616 Free PMC Article

Updates in Diagnosis, Management, and Treatment of Neuroblastoma.

Swift CC, Eklund MJ, Kraveka JM, Alazraki AL
Radiographics 2018 Mar-Apr;38(2):566-580. doi: 10.1148/rg.2018170132. PMID: 29528815

See all (512)

Recent clinical studies

Etiology

Wilms Tumor.

Saltzman AF, Cost NG, Romao RLP
Urol Clin North Am 2023 Aug;50(3):455-464. Epub 2023 May 18 doi: 10.1016/j.ucl.2023.04.008. PMID: 37385707

Melanoma in children: A systematic review and individual patient meta-analysis.

Pampena R, Piccolo V, Muscianese M, Kyrgidis A, Lai M, Russo T, Briatico G, Di Brizzi EV, Cascone G, Pellerone S, Longo C, Moscarella E, Argenziano G
J Eur Acad Dermatol Venereol 2023 Sep;37(9):1758-1776. Epub 2023 Jun 2 doi: 10.1111/jdv.19220. PMID: 37210654

Mediastinal neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: Pathology review and diagnostic approach.

Choi JH, Ro JY
Semin Diagn Pathol 2022 Mar;39(2):120-130. Epub 2021 Jun 15 doi: 10.1053/j.semdp.2021.06.007. PMID: 34167847

Understanding medulloblastoma.

Quinlan A, Rizzolo D
JAAPA 2017 Oct;30(10):30-36. doi: 10.1097/01.JAA.0000524717.71084.50. PMID: 28953021

Neuroblastoma imaging.

Ley S, Ley-Zaporozhan J, Günther P, Deubzer HE, Witt O, Schenk JP
Rofo 2011 Mar;183(3):217-25. Epub 2010 Dec 17 doi: 10.1055/s-0029-1245903. PMID: 21170823

See all (3483)

Diagnosis

Wilms Tumor.

Saltzman AF, Cost NG, Romao RLP
Urol Clin North Am 2023 Aug;50(3):455-464. Epub 2023 May 18 doi: 10.1016/j.ucl.2023.04.008. PMID: 37385707

Mediastinal neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: Pathology review and diagnostic approach.

Choi JH, Ro JY
Semin Diagn Pathol 2022 Mar;39(2):120-130. Epub 2021 Jun 15 doi: 10.1053/j.semdp.2021.06.007. PMID: 34167847

Pediatric Brain Tumors.

Udaka YT, Packer RJ
Neurol Clin 2018 Aug;36(3):533-556. doi: 10.1016/j.ncl.2018.04.009. PMID: 30072070

Understanding medulloblastoma.

Quinlan A, Rizzolo D
JAAPA 2017 Oct;30(10):30-36. doi: 10.1097/01.JAA.0000524717.71084.50. PMID: 28953021

Retinoblastoma.

Rao R, Honavar SG
Indian J Pediatr 2017 Dec;84(12):937-944. Epub 2017 Jun 16 doi: 10.1007/s12098-017-2395-0. PMID: 28620731

See all (3698)

Therapy

Childhood sunburn and risk of melanoma and non-melanoma skin cancer: a Mendelian randomization study.

Li Y, Wu J, Cao Z
Environ Sci Pollut Res Int 2023 Dec;30(58):122011-122023. Epub 2023 Nov 14 doi: 10.1007/s11356-023-30535-3. PMID: 37962759 Free PMC Article

Efficacy and Safety of Trametinib Monotherapy or in Combination With Dabrafenib in Pediatric BRAF V600-Mutant Low-Grade Glioma.

Bouffet E, Geoerger B, Moertel C, Whitlock JA, Aerts I, Hargrave D, Osterloh L, Tan E, Choi J, Russo M, Fox E
J Clin Oncol 2023 Jan 20;41(3):664-674. Epub 2022 Nov 14 doi: 10.1200/JCO.22.01000. PMID: 36375115 Free PMC Article

Serial assessment of measurable residual disease in medulloblastoma liquid biopsies.

Liu APY, Smith KS, Kumar R, Paul L, Bihannic L, Lin T, Maass KK, Pajtler KW, Chintagumpala M, Su JM, Bouffet E, Fisher MJ, Gururangan S, Cohn R, Hassall T, Hansford JR, Klimo P Jr, Boop FA, Stewart CF, Harreld JH, Merchant TE, Tatevossian RG, Neale G, Lear M, Klco JM, Orr BA, Ellison DW, Gilbertson RJ, Onar-Thomas A, Gajjar A, Robinson GW, Northcott PA
Cancer Cell 2021 Nov 8;39(11):1519-1530.e4. Epub 2021 Oct 21 doi: 10.1016/j.ccell.2021.09.012. PMID: 34678152 Free PMC Article

Craniopharyngioma.

Müller HL
Handb Clin Neurol 2014;124:235-53. doi: 10.1016/B978-0-444-59602-4.00016-2. PMID: 25248591

Craniopharyngioma.

Müller HL
Endocr Rev 2014 Jun;35(3):513-43. Epub 2014 Jan 27 doi: 10.1210/er.2013-1115. PMID: 24467716

See all (1734)

Prognosis

Childhood-onset Craniopharyngioma.

Otte A, Müller HL
J Clin Endocrinol Metab 2021 Sep 27;106(10):e3820-e3836. doi: 10.1210/clinem/dgab397. PMID: 34086900

Primary mediastinal germ cell tumors.

Rosti G, Secondino S, Necchi A, Fornarini G, Pedrazzoli P
Semin Oncol 2019 Apr;46(2):107-111. Epub 2019 Apr 24 doi: 10.1053/j.seminoncol.2019.04.001. PMID: 31076171

The management of retinoblastoma.

Fabian ID, Onadim Z, Karaa E, Duncan C, Chowdhury T, Scheimberg I, Ohnuma SI, Reddy MA, Sagoo MS
Oncogene 2018 Mar;37(12):1551-1560. Epub 2018 Jan 11 doi: 10.1038/s41388-017-0050-x. PMID: 29321667

Obesity and craniopharyngioma.

Iughetti L, Bruzzi P
Ital J Pediatr 2011 Aug 16;37:38. doi: 10.1186/1824-7288-37-38. PMID: 21846381 Free PMC Article

Childhood medulloblastoma.

Massimino M, Giangaspero F, Garrè ML, Gandola L, Poggi G, Biassoni V, Gatta G, Rutkowski S
Crit Rev Oncol Hematol 2011 Jul;79(1):65-83. Epub 2010 Dec 3 doi: 10.1016/j.critrevonc.2010.07.010. PMID: 21129995

See all (2967)

Clinical prediction guides

Childhood sunburn and risk of melanoma and non-melanoma skin cancer: a Mendelian randomization study.

Li Y, Wu J, Cao Z
Environ Sci Pollut Res Int 2023 Dec;30(58):122011-122023. Epub 2023 Nov 14 doi: 10.1007/s11356-023-30535-3. PMID: 37962759 Free PMC Article

Childhood-onset Craniopharyngioma.

Otte A, Müller HL
J Clin Endocrinol Metab 2021 Sep 27;106(10):e3820-e3836. doi: 10.1210/clinem/dgab397. PMID: 34086900

Congenital Neuroblastoma.

Minakova E, Lang J
Neoreviews 2020 Nov;21(11):e716-e727. doi: 10.1542/neo.21-11-e716. PMID: 33139509

Biological and Genetic Features of Neuroblastoma and Their Clinical Importance.

Aygun N
Curr Pediatr Rev 2018;14(2):73-90. doi: 10.2174/1573396314666180129101627. PMID: 29380702

Childhood medulloblastoma.

See all (1739)

Recent systematic reviews

Agricultural exposures and risk of childhood neuroblastoma: a systematic review and meta-analysis.

Hymel E, Degarege A, Fritch J, Farazi E, Napit K, Coulter D, Schmidt C, Watanabe-Galloway S
Environ Sci Pollut Res Int 2023 Nov;30(53):113193-113204. Epub 2023 Oct 19 doi: 10.1007/s11356-023-30315-z. PMID: 37858025

Melanoma in children: A systematic review and individual patient meta-analysis.

Maternal smoking during pregnancy and risk of childhood neuroblastoma: Systematic review and meta-analysis.

Chu P, Wang H, Han S, Jin Y, Lu J, Han W, Shi J, Guo Y, Ni X
J Cancer Res Ther 2016 Apr-Jun;12(2):999-1005. doi: 10.4103/0973-1482.171367. PMID: 27461688

Malignant melanoma as second malignant neoplasm in long-term childhood cancer survivors: a systematic review.

Braam KI, Overbeek A, Kaspers GJ, Ronckers CM, Schouten-van Meeteren AY, Van Dulmen-Den Broeder E, Veening MA
Pediatr Blood Cancer 2012 May;58(5):665-74. Epub 2012 Jan 9 doi: 10.1002/pbc.24023. PMID: 22232079

Breast-feeding and childhood cancer: A systematic review with metaanalysis.

Martin RM, Gunnell D, Owen CG, Smith GD
Int J Cancer 2005 Dec 20;117(6):1020-31. doi: 10.1002/ijc.21274. PMID: 15986434

See all (65)

MedGen

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Malignant childhood germ cell neoplasm

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

Recent activity