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Metastatic Breast Neuroendocrine Tumor G1

MedGen UID:
233179
•Concept ID:
C1334714
•
Neoplastic Process

Definition

A well differentiated neuroendocrine tumor that arises from the breast and has metastasized to other anatomic sites. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Breast Neuroendocrine Tumor G1

Recent clinical studies

Etiology

A phase 2, multicenter, open-label study of anti-LAG-3 ieramilimab in combination with anti-PD-1 spartalizumab in patients with advanced solid malignancies.
Lin CC, Garralda E, Schöffski P, Hong DS, Siu LL, Martin M, Maur M, Hui R, Soo RA, Chiu J, Zhang T, Ma B, Kyi C, Tan DS, Cassier PA, Sarantopoulos J, Weickhardt A, Carvajal RD, Spratlin J, Esaki T, Rolland F, Akerley W, Deschler-Baier B, Rispoli L, Samant TS, Chowdhury NR, Gusenleitner D, Kwak EL, Askoxylakis V, De Braud F
Oncoimmunology 2024;13(1):2290787. Epub 2023 Dec 20 doi: 10.1080/2162402X.2023.2290787. PMID: 38170160Free PMC Article
Changes in survival in de novo metastatic cancer in an era of new medicines.
Luyendijk M, Visser O, Blommestein HM, de Hingh IHJT, Hoebers FJP, Jager A, Sonke GS, de Vries EGE, Uyl-de Groot CA, Siesling S
J Natl Cancer Inst 2023 Jun 8;115(6):628-635. doi: 10.1093/jnci/djad020. PMID: 36978244Free PMC Article
Characteristics, Treatment, Outcomes, and Survival in Neuroendocrine G1 and G2 Pancreatic Tumors: Experiences From a Single Tertiary Referral Center.
Calissendorff J, Bjellerup-Calissendorff F, Bränström R, Juhlin CC, Falhammar H
Front Endocrinol (Lausanne) 2021;12:657698. Epub 2021 Apr 13 doi: 10.3389/fendo.2021.657698. PMID: 33927695Free PMC Article
Capecitabine plus temozolomide in well- or moderately-differentiated primary atypical neuroendocrine tumours - single-centre experience of two cases.
La Salvia A, Brizzi MP, Muratori L, Trevisi E, Di Maio M, Scagliotti GV
Endokrynol Pol 2019;70(4):380-383. Epub 2018 Oct 25 doi: 10.5603/EP.a2018.0076. PMID: 30359462

Diagnosis

Changes in survival in de novo metastatic cancer in an era of new medicines.
Luyendijk M, Visser O, Blommestein HM, de Hingh IHJT, Hoebers FJP, Jager A, Sonke GS, de Vries EGE, Uyl-de Groot CA, Siesling S
J Natl Cancer Inst 2023 Jun 8;115(6):628-635. doi: 10.1093/jnci/djad020. PMID: 36978244Free PMC Article
An analysis of 130 neuroendocrine tumors G3 regarding prevalence, origin, metastasis, and diagnostic features.
Kasajima A, Konukiewitz B, Schlitter AM, Weichert W, Klöppel G
Virchows Arch 2022 Feb;480(2):359-368. Epub 2021 Sep 9 doi: 10.1007/s00428-021-03202-6. PMID: 34499237Free PMC Article
Characteristics, Treatment, Outcomes, and Survival in Neuroendocrine G1 and G2 Pancreatic Tumors: Experiences From a Single Tertiary Referral Center.
Calissendorff J, Bjellerup-Calissendorff F, Bränström R, Juhlin CC, Falhammar H
Front Endocrinol (Lausanne) 2021;12:657698. Epub 2021 Apr 13 doi: 10.3389/fendo.2021.657698. PMID: 33927695Free PMC Article
Capecitabine plus temozolomide in well- or moderately-differentiated primary atypical neuroendocrine tumours - single-centre experience of two cases.
La Salvia A, Brizzi MP, Muratori L, Trevisi E, Di Maio M, Scagliotti GV
Endokrynol Pol 2019;70(4):380-383. Epub 2018 Oct 25 doi: 10.5603/EP.a2018.0076. PMID: 30359462

Therapy

A new schedule of one week on/one week off temozolomide as second-line treatment of advanced neuroendocrine carcinomas (TENEC-TRIAL): a multicenter, open-label, single-arm, phase II trial.
von Arx C, Della Vittoria Scarpati G, Cannella L, Clemente O, Marretta AL, Bracigliano A, Picozzi F, Iervolino D, Granata V, Modica R, Bianco A, Mocerino C, Di Mauro A, Pizzolorusso A, Di Sarno A, Ottaiano A, Tafuto S; ENETs Center of Excellence in Naples, Italy and with the endorsement of the Italian Association for Neuroendocrine Tumor IT.A.NET
ESMO Open 2024 May;9(5):103003. Epub 2024 Apr 13 doi: 10.1016/j.esmoop.2024.103003. PMID: 38615472Free PMC Article
A phase 2, multicenter, open-label study of anti-LAG-3 ieramilimab in combination with anti-PD-1 spartalizumab in patients with advanced solid malignancies.
Lin CC, Garralda E, Schöffski P, Hong DS, Siu LL, Martin M, Maur M, Hui R, Soo RA, Chiu J, Zhang T, Ma B, Kyi C, Tan DS, Cassier PA, Sarantopoulos J, Weickhardt A, Carvajal RD, Spratlin J, Esaki T, Rolland F, Akerley W, Deschler-Baier B, Rispoli L, Samant TS, Chowdhury NR, Gusenleitner D, Kwak EL, Askoxylakis V, De Braud F
Oncoimmunology 2024;13(1):2290787. Epub 2023 Dec 20 doi: 10.1080/2162402X.2023.2290787. PMID: 38170160Free PMC Article
Capecitabine plus temozolomide in well- or moderately-differentiated primary atypical neuroendocrine tumours - single-centre experience of two cases.
La Salvia A, Brizzi MP, Muratori L, Trevisi E, Di Maio M, Scagliotti GV
Endokrynol Pol 2019;70(4):380-383. Epub 2018 Oct 25 doi: 10.5603/EP.a2018.0076. PMID: 30359462
Concurrent irradiation with the anti-programmed cell death ligand-1 immune checkpoint blocker durvalumab: Single centre subset analysis from a phase 1/2 trial.
Levy A, Massard C, Soria JC, Deutsch E
Eur J Cancer 2016 Nov;68:156-162. Epub 2016 Oct 17 doi: 10.1016/j.ejca.2016.09.013. PMID: 27764686
Gold(I) biscarbene complexes derived from vascular-disrupting combretastatin A-4 address different targets and show antimetastatic potential.
Muenzner JK, Biersack B, Kalie H, Andronache IC, Kaps L, Schuppan D, Sasse F, Schobert R
ChemMedChem 2014 Jun;9(6):1195-204. Epub 2014 Mar 19 doi: 10.1002/cmdc.201400049. PMID: 24648184

Prognosis

Changes in survival in de novo metastatic cancer in an era of new medicines.
Luyendijk M, Visser O, Blommestein HM, de Hingh IHJT, Hoebers FJP, Jager A, Sonke GS, de Vries EGE, Uyl-de Groot CA, Siesling S
J Natl Cancer Inst 2023 Jun 8;115(6):628-635. doi: 10.1093/jnci/djad020. PMID: 36978244Free PMC Article
Characteristics, Treatment, Outcomes, and Survival in Neuroendocrine G1 and G2 Pancreatic Tumors: Experiences From a Single Tertiary Referral Center.
Calissendorff J, Bjellerup-Calissendorff F, Bränström R, Juhlin CC, Falhammar H
Front Endocrinol (Lausanne) 2021;12:657698. Epub 2021 Apr 13 doi: 10.3389/fendo.2021.657698. PMID: 33927695Free PMC Article
Concurrent irradiation with the anti-programmed cell death ligand-1 immune checkpoint blocker durvalumab: Single centre subset analysis from a phase 1/2 trial.
Levy A, Massard C, Soria JC, Deutsch E
Eur J Cancer 2016 Nov;68:156-162. Epub 2016 Oct 17 doi: 10.1016/j.ejca.2016.09.013. PMID: 27764686
Umbelliprenin from Ferula szowitsiana inhibits the growth of human M4Beu metastatic pigmented malignant melanoma cells through cell-cycle arrest in G1 and induction of caspase-dependent apoptosis.
Barthomeuf C, Lim S, Iranshahi M, Chollet P
Phytomedicine 2008 Jan;15(1-2):103-11. Epub 2007 Aug 8 doi: 10.1016/j.phymed.2007.04.001. PMID: 17689942

Clinical prediction guides

A new schedule of one week on/one week off temozolomide as second-line treatment of advanced neuroendocrine carcinomas (TENEC-TRIAL): a multicenter, open-label, single-arm, phase II trial.
von Arx C, Della Vittoria Scarpati G, Cannella L, Clemente O, Marretta AL, Bracigliano A, Picozzi F, Iervolino D, Granata V, Modica R, Bianco A, Mocerino C, Di Mauro A, Pizzolorusso A, Di Sarno A, Ottaiano A, Tafuto S; ENETs Center of Excellence in Naples, Italy and with the endorsement of the Italian Association for Neuroendocrine Tumor IT.A.NET
ESMO Open 2024 May;9(5):103003. Epub 2024 Apr 13 doi: 10.1016/j.esmoop.2024.103003. PMID: 38615472Free PMC Article
Changes in survival in de novo metastatic cancer in an era of new medicines.
Luyendijk M, Visser O, Blommestein HM, de Hingh IHJT, Hoebers FJP, Jager A, Sonke GS, de Vries EGE, Uyl-de Groot CA, Siesling S
J Natl Cancer Inst 2023 Jun 8;115(6):628-635. doi: 10.1093/jnci/djad020. PMID: 36978244Free PMC Article
Umbelliprenin from Ferula szowitsiana inhibits the growth of human M4Beu metastatic pigmented malignant melanoma cells through cell-cycle arrest in G1 and induction of caspase-dependent apoptosis.
Barthomeuf C, Lim S, Iranshahi M, Chollet P
Phytomedicine 2008 Jan;15(1-2):103-11. Epub 2007 Aug 8 doi: 10.1016/j.phymed.2007.04.001. PMID: 17689942

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