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Rectum leiomyosarcoma

MedGen UID:
233391
•Concept ID:
C1335683
•
Neoplastic Process
Synonyms: Leiomyosarcoma of rectum; Leiomyosarcoma of Rectum; leiomyosarcoma of rectum; Leiomyosarcoma of the Rectum; leiomyosarcoma of the rectum; Rectal Leiomyosarcoma; rectal leiomyosarcoma; rectum leiomyosarcoma
SNOMED CT: Leiomyosarcoma of rectum (1156783003)
 
Monarch Initiative: MONDO:0003379

Definition

An aggressive malignant smooth muscle neoplasm that arises from the rectum. It is characterized by a proliferation of neoplastic spindle cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRectum leiomyosarcoma

Professional guidelines

PubMed

Management of less common tumors of the colon, rectum, and anus.
Cuffy M, Abir F, Longo WE
Clin Colorectal Cancer 2006 Jan;5(5):327-37. doi: 10.3816/CCC.2006.n.002. PMID: 16512991
Gastrointestinal stromal tumors--definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis.
Miettinen M, Lasota J
Virchows Arch 2001 Jan;438(1):1-12. doi: 10.1007/s004280000338. PMID: 11213830
Benign and malignant neoplasms of colon and rectum. Diagnosis and management.
Stearns MW Jr
Surg Clin North Am 1978 Jun;58(3):605-18. doi: 10.1016/s0039-6109(16)41542-2. PMID: 354056

Recent clinical studies

Etiology

Computed tomography and magnetic resonance imaging findings in dogs with vaginal leiomyoma and leiomyosarcoma.
Tanaka T, Noguchi S, Wada Y, Yamazaki H, Nishida H, Akiyoshi H
Vet Med Sci 2022 Nov;8(6):2337-2344. Epub 2022 Sep 5 doi: 10.1002/vms3.930. PMID: 36063539Free PMC Article
Unusual evolution of leiomyosarcoma of the rectum: a case report and review of the literature.
Sahli N, Khmou M, Khalil J, Elmajjaoui S, El Khannoussi B, Kebdani T, Elkacemi H, Benjaafar N
J Med Case Rep 2016 Sep 15;10(1):249. doi: 10.1186/s13256-016-1047-8. PMID: 27633779Free PMC Article
Benign and malignant tumors of the rectum and perirectal region.
Purysko AS, Coppa CP, Kalady MF, Pai RK, Leão Filho HM, Thupili CR, Remer EM
Abdom Imaging 2014 Aug;39(4):824-52. doi: 10.1007/s00261-014-0119-8. PMID: 24663381
Epidemiology of AIDS-related malignancies an international perspective.
Mbulaiteye SM, Parkin DM, Rabkin CS
Hematol Oncol Clin North Am 2003 Jun;17(3):673-96, v. doi: 10.1016/s0889-8588(03)00048-0. PMID: 12852650
Gastrointestinal stromal tumors.
Suster S
Semin Diagn Pathol 1996 Nov;13(4):297-313. PMID: 8946608

Diagnosis

Giant multilocular prostatic cystadenoma.
Nakamura Y, Shida D, Shibayama T, Yoshida A, Matsui Y, Shinoda Y, Iwata S, Kanemitsu Y
World J Surg Oncol 2019 Feb 26;17(1):42. doi: 10.1186/s12957-019-1579-7. PMID: 30808350Free PMC Article
Benign and malignant tumors of the rectum and perirectal region.
Purysko AS, Coppa CP, Kalady MF, Pai RK, Leão Filho HM, Thupili CR, Remer EM
Abdom Imaging 2014 Aug;39(4):824-52. doi: 10.1007/s00261-014-0119-8. PMID: 24663381
Tumors of the rectum and anal canal.
Hatch KF, Blanchard DK, Hatch GF 3rd, Wertheimer-Hatch L, Davis GB, Foster RS Jr, Skandalakis JE
World J Surg 2000 Apr;24(4):437-43. doi: 10.1007/s002689910069. PMID: 10706916
Gastrointestinal stromal tumors.
Suster S
Semin Diagn Pathol 1996 Nov;13(4):297-313. PMID: 8946608
Benign and malignant neoplasms of colon and rectum. Diagnosis and management.
Stearns MW Jr
Surg Clin North Am 1978 Jun;58(3):605-18. doi: 10.1016/s0039-6109(16)41542-2. PMID: 354056

Therapy

Radiation-induced leiomyosarcoma of the rectum after cervical cancer treatment.
Garcia-Ortega DY, Reyes-Garcia N, Martinez-Said H, Caro-Sanchez CHS, Cuellar-Hubbe M
Rev Gastroenterol Mex (Engl Ed) 2018 Oct-Dec;83(4):465-467. Epub 2018 Feb 10 doi: 10.1016/j.rgmx.2017.06.001. PMID: 29439826
Rectal leiomyosarcoma: a rare and long-term complication of radiation therapy.
Futuri S, Donohoe K, Spaccavento C, Yudelman I
BMJ Case Rep 2014 Oct 14;2014 doi: 10.1136/bcr-2014-205240. PMID: 25315801Free PMC Article
Sphincter preservation of leiomyosarcoma of the rectum and anus with local excision and brachytherapy.
Grann A, Paty PB, Guillem JG, Cohen AM, Minsky BD
Dis Colon Rectum 1999 Oct;42(10):1296-9. doi: 10.1007/BF02234218. PMID: 10528767
Conservative management of anal leiomyosarcoma.
Minsky BD, Cohen AM, Hajdu SI
Cancer 1991 Oct 1;68(7):1640-3. doi: 10.1002/1097-0142(19911001)68:7<1640::aid-cncr2820680729>3.0.co;2-6. PMID: 1893364
Synchronous leiomyosarcoma and ameboma of the rectum: report of a case.
Adekunle OO, Abioye A
Dis Colon Rectum 1978 Mar;21(2):123-5. doi: 10.1007/BF02586457. PMID: 648289

Prognosis

Schwannoma of the colon and rectum: a systematic literature review.
Bohlok A, El Khoury M, Bormans A, Galdon MG, Vouche M, El Nakadi I, Donckier V, Liberale G
World J Surg Oncol 2018 Jul 3;16(1):125. doi: 10.1186/s12957-018-1427-1. PMID: 29970075Free PMC Article
Unusual evolution of leiomyosarcoma of the rectum: a case report and review of the literature.
Sahli N, Khmou M, Khalil J, Elmajjaoui S, El Khannoussi B, Kebdani T, Elkacemi H, Benjaafar N
J Med Case Rep 2016 Sep 15;10(1):249. doi: 10.1186/s13256-016-1047-8. PMID: 27633779Free PMC Article
Management of less common tumors of the colon, rectum, and anus.
Cuffy M, Abir F, Longo WE
Clin Colorectal Cancer 2006 Jan;5(5):327-37. doi: 10.3816/CCC.2006.n.002. PMID: 16512991
Leiomyosarcoma of the rectum. A report of two cases and review of the literature.
Zbar AP, Sokolowsky N, Sandiford N, Prussia PR
West Indian Med J 2004 Mar;53(2):122-5. PMID: 15199725
Gastrointestinal stromal tumors.
Suster S
Semin Diagn Pathol 1996 Nov;13(4):297-313. PMID: 8946608

Clinical prediction guides

Endoscopic ultrasound-guided fine-needle aspiration cytology in the diagnosis of leiomyomas of the gastrointestinal tract.
Val-Bernal JF, Martino M, Terán A, Yllera E, Castro-Senosiain B
Rev Esp Patol 2019 Jul-Sep;52(3):154-162. Epub 2018 Dec 4 doi: 10.1016/j.patol.2018.09.003. PMID: 31213256
Outcomes of Primary Colorectal Sarcoma: A National Cancer Data Base (NCDB) Review.
Thiels CA, Bergquist JR, Krajewski AC, Lee HE, Nelson H, Mathis KL, Habermann EB, Cima RR
J Gastrointest Surg 2017 Mar;21(3):560-568. Epub 2017 Jan 17 doi: 10.1007/s11605-016-3347-0. PMID: 28097468
Leiomyosarcoma of the rectum. A report of two cases and review of the literature.
Zbar AP, Sokolowsky N, Sandiford N, Prussia PR
West Indian Med J 2004 Mar;53(2):122-5. PMID: 15199725
Histologic analysis of the irradiated anal sphincter.
Da Silva GM, Berho M, Wexner SD, Efron J, Weiss EG, Nogueras JJ, Vernava AM 3rd, Connor JT, Gervaz P
Dis Colon Rectum 2003 Nov;46(11):1492-7. doi: 10.1007/s10350-004-6800-1. PMID: 14605568
Novel immunohistochemical localization of 28,000 molecular-weight (Mr) calcium binding protein (calbindin-D28k) in enterochromaffin cells of the human appendix and neuroendocrine tumors (carcinoids and small-cell carcinomas) of the midgut and foregut.
Katsetos CD, Jami MM, Krishna L, Jackson R, Patchefsky AS, Cooper HS
Arch Pathol Lab Med 1994 Jun;118(6):633-9. PMID: 8204010

Recent systematic reviews

Leiomyosarcoma of the rectum: A systematic review of recent literature.
Annicchiarico A, Montali F, Baldinu M, Casali L, Virgilio E, Costi R
J Surg Oncol 2024 Feb;129(2):365-380. Epub 2023 Oct 10 doi: 10.1002/jso.27481. PMID: 37814590

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