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Skull base chordoma

MedGen UID:
233448
•Concept ID:
C1335975
•
Neoplastic Process
Synonyms: Chordoma of Skull Base; chordoma of skull base; Chordoma of the Skull Base; chordoma of the skull base; Skull Base Chordoma; skull base chordoma
 
Monarch Initiative: MONDO:0002892

Definition

A chordoma that arises from the base of the skull. [from NCI]

Professional guidelines

PubMed

Skull Base Chordoma and Chondrosarcoma: Neuroradiologist's Guide to Diagnosis, Surgical Management, and Proton Beam Therapy.
Potter GM, Siripurapu R, Herwadkar A, Abdulla S, Ikotun O, Broadhurst P, Woodward M, Bhalla RK, Glancz LJ, Hammerbeck-Ward CL, Rutherford SA, Pathmanaban ON, Roncaroli F, Colaco RJ, Pan S, Whitfield GA
Radiographics 2024 Oct;44(10):e240036. doi: 10.1148/rg.240036. PMID: 39298353
Chordoma: Genetics and Contemporary Management.
Desai R, Pelargos PE, Dunn IF
Int J Mol Sci 2024 May 28;25(11) doi: 10.3390/ijms25115877. PMID: 38892063Free PMC Article
Endoscopic Endonasal Management of Skull Base Chordomas: Surgical Technique, Nuances, and Pitfalls.
Mangussi-Gomes J, Beer-Furlan A, Balsalobre L, Vellutini EA, Stamm AC
Otolaryngol Clin North Am 2016 Feb;49(1):167-82. doi: 10.1016/j.otc.2015.09.011. PMID: 26614836

Recent clinical studies

Etiology

Assessing survival outcomes and complication profiles following surgical excision and radiotherapy as interventions for skull base chordoma: a systematic review of operative margins and surgical approaches.
Brown NJ, Gendreau J, Kuo CC, Nguyen O, Yang C, Catapano JS, Lawton MT
J Neurooncol 2023 Oct;165(1):41-51. Epub 2023 Oct 25 doi: 10.1007/s11060-023-04477-2. PMID: 37880419
The Influence of Facility Volume and Type on Skull Base Chordoma Treatment and Outcomes.
Du AT, Pang JC, Victor R, Tang Meller LL, Torabi SJ, Goshtasbi K, Kim MG, Hsu FPK, Kuan EC
World Neurosurg 2022 Oct;166:e561-e567. Epub 2022 Jul 19 doi: 10.1016/j.wneu.2022.07.064. PMID: 35868508
Skull Base Chordoma: Long-Term Observation and Evaluation of Prognostic Factors after Surgical Resection.
Roy A, Warade A, Jha AK, Misra BK
Neurol India 2021 Nov-Dec;69(6):1608-1612. doi: 10.4103/0028-3886.333474. PMID: 34979650
MR Imaging Grading System for Skull Base Chordoma.
Tian K, Wang L, Ma J, Wang K, Li D, Du J, Jia G, Wu Z, Zhang J
AJNR Am J Neuroradiol 2017 Jun;38(6):1206-1211. Epub 2017 Apr 20 doi: 10.3174/ajnr.A5152. PMID: 28428207Free PMC Article
Skull base chordoma.
Mendenhall WM, Mendenhall CM, Lewis SB, Villaret DB, Mendenhall NP
Head Neck 2005 Feb;27(2):159-65. doi: 10.1002/hed.20144. PMID: 15641104

Diagnosis

Chordoma: Genetics and Contemporary Management.
Desai R, Pelargos PE, Dunn IF
Int J Mol Sci 2024 May 28;25(11) doi: 10.3390/ijms25115877. PMID: 38892063Free PMC Article
Skull-Base Chordoma Mimicking Optic Neuritis.
Ali AA, Dashti F, Behbehani RS
J Neuroophthalmol 2023 Dec 1;43(4):e219-e220. Epub 2023 Jan 18 doi: 10.1097/WNO.0000000000001575. PMID: 36728058
Imaging Review of the Endoscopic Operative Corridor for Clivus Lesions.
Rao D, Stein R, Jenson M, Patel J, Fiester P
Curr Probl Diagn Radiol 2023 Jan-Feb;52(1):66-76. Epub 2022 Jul 30 doi: 10.1067/j.cpradiol.2022.07.005. PMID: 36008190
Genetic aberrations and molecular biology of skull base chordoma and chondrosarcoma.
Kitamura Y, Sasaki H, Yoshida K
Brain Tumor Pathol 2017 Apr;34(2):78-90. Epub 2017 Apr 21 doi: 10.1007/s10014-017-0283-y. PMID: 28432450
Skull base chordoma.
Mendenhall WM, Mendenhall CM, Lewis SB, Villaret DB, Mendenhall NP
Head Neck 2005 Feb;27(2):159-65. doi: 10.1002/hed.20144. PMID: 15641104

Therapy

Assessing survival outcomes and complication profiles following surgical excision and radiotherapy as interventions for skull base chordoma: a systematic review of operative margins and surgical approaches.
Brown NJ, Gendreau J, Kuo CC, Nguyen O, Yang C, Catapano JS, Lawton MT
J Neurooncol 2023 Oct;165(1):41-51. Epub 2023 Oct 25 doi: 10.1007/s11060-023-04477-2. PMID: 37880419
The incidence of brainstem toxicity following high-dose conformal proton therapy for adult skull-base malignancies.
Holtzman AL, Rutenberg MS, De Leo AN, Rao D, Patel J, Morris CG, Indelicato DJ, Mendenhall WM
Acta Oncol 2022 Aug;61(8):1026-1031. Epub 2022 Jul 27 doi: 10.1080/0284186X.2022.2101900. PMID: 35897132
Vision loss following high-dose proton-based radiotherapy for skull-base chordoma and chondrosarcoma.
De Leo AN, Holtzman AL, Ho MW, Morris CG, Rutenberg MS, Rotondo RL, Bates JE, Indelicato DJ, Rao D, Asa Hasan M, Mendenhall WM
Radiother Oncol 2021 May;158:125-130. Epub 2021 Feb 19 doi: 10.1016/j.radonc.2021.02.012. PMID: 33610625
Long-term outcomes of skull base chordoma treated with high-dose carbon-ion radiotherapy.
Koto M, Ikawa H, Kaneko T, Hagiwara Y, Hayashi K, Tsuji H
Head Neck 2020 Sep;42(9):2607-2613. Epub 2020 May 30 doi: 10.1002/hed.26307. PMID: 32472716Free PMC Article
Iatrogenic seeding of skull base chordoma following endoscopic endonasal surgery.
Fernandes Cabral DT, Zenonos GA, Fernandez-Miranda JC, Wang EW, Gardner PA
J Neurosurg 2018 Oct;129(4):947-953. Epub 2017 Dec 22 doi: 10.3171/2017.6.JNS17111. PMID: 29271711

Prognosis

Proteogenomic characterization of skull-base chordoma.
Zhang Q, Xu Z, Han R, Wang Y, Ye Z, Zhu J, Cai Y, Zhang F, Zhao J, Yao B, Qin Z, Qiao N, Huang R, Feng J, Wang Y, Rui W, He F, Zhao Y, Ding C
Nat Commun 2024 Sep 27;15(1):8338. doi: 10.1038/s41467-024-52285-7. PMID: 39333076Free PMC Article
Chordoma: Genetics and Contemporary Management.
Desai R, Pelargos PE, Dunn IF
Int J Mol Sci 2024 May 28;25(11) doi: 10.3390/ijms25115877. PMID: 38892063Free PMC Article
Prognostic Factors in Skull Base Chordoma: A Systematic Literature Review and Meta-Analysis.
Zou MX, Lv GH, Zhang QS, Wang SF, Li J, Wang XB
World Neurosurg 2018 Jan;109:307-327. Epub 2017 Oct 16 doi: 10.1016/j.wneu.2017.10.010. PMID: 29045855
Genetic aberrations and molecular biology of skull base chordoma and chondrosarcoma.
Kitamura Y, Sasaki H, Yoshida K
Brain Tumor Pathol 2017 Apr;34(2):78-90. Epub 2017 Apr 21 doi: 10.1007/s10014-017-0283-y. PMID: 28432450
Skull base chordoma.
Mendenhall WM, Mendenhall CM, Lewis SB, Villaret DB, Mendenhall NP
Head Neck 2005 Feb;27(2):159-65. doi: 10.1002/hed.20144. PMID: 15641104

Clinical prediction guides

Proteogenomic characterization of skull-base chordoma.
Zhang Q, Xu Z, Han R, Wang Y, Ye Z, Zhu J, Cai Y, Zhang F, Zhao J, Yao B, Qin Z, Qiao N, Huang R, Feng J, Wang Y, Rui W, He F, Zhao Y, Ding C
Nat Commun 2024 Sep 27;15(1):8338. doi: 10.1038/s41467-024-52285-7. PMID: 39333076Free PMC Article
Revisitation of imaging features of skull base chondrosarcoma in comparison to chordoma.
Hasegawa H, Shin M, Niwa R, Koizumi S, Yoshimoto S, Shono N, Shinya Y, Takami H, Tanaka S, Umekawa M, Amemiya S, Kin T, Saito N
J Neurooncol 2022 Sep;159(3):581-590. Epub 2022 Jul 26 doi: 10.1007/s11060-022-04097-2. PMID: 35882753
Skull Base Chordoma: Long-Term Observation and Evaluation of Prognostic Factors after Surgical Resection.
Roy A, Warade A, Jha AK, Misra BK
Neurol India 2021 Nov-Dec;69(6):1608-1612. doi: 10.4103/0028-3886.333474. PMID: 34979650
Prognostic Factors in Skull Base Chordoma: A Systematic Literature Review and Meta-Analysis.
Zou MX, Lv GH, Zhang QS, Wang SF, Li J, Wang XB
World Neurosurg 2018 Jan;109:307-327. Epub 2017 Oct 16 doi: 10.1016/j.wneu.2017.10.010. PMID: 29045855
Genomic and transcriptomic characterization of skull base chordoma.
Sa JK, Lee IH, Hong SD, Kong DS, Nam DH
Oncotarget 2017 Jan 3;8(1):1321-1328. doi: 10.18632/oncotarget.13616. PMID: 27901492Free PMC Article

Recent systematic reviews

Anatomical determinants of occipitocervical fusion in skull base chordoma resection: a systematic review of the literature with illustrative cases.
Golub D, Küffer AF, Garrel S, Zandpazandi S, McBriar JD, Modi S, Papadimitriou K, Costantino PD, Sciubba DM, Dehdashti AR
Neurosurg Focus 2024 May;56(5):E8. doi: 10.3171/2024.3.FOCUS248. PMID: 38691866
Optimizing radiotherapy strategies for skull base chordoma: a comprehensive meta-analysis and systematic review of treatment modalities and outcomes.
Palavani LB, Borges P, Andreão FF, Borges J, Batista S, Oliveira LB, Ferreira MY, Reis PCA, Pontes J, Negri H, Beer-Furlan A, Krishna C, Bertani R, Rassi MS
Neurosurg Focus 2024 May;56(5):E11. doi: 10.3171/2024.2.FOCUS2413. PMID: 38691862
Assessing survival outcomes and complication profiles following surgical excision and radiotherapy as interventions for skull base chordoma: a systematic review of operative margins and surgical approaches.
Brown NJ, Gendreau J, Kuo CC, Nguyen O, Yang C, Catapano JS, Lawton MT
J Neurooncol 2023 Oct;165(1):41-51. Epub 2023 Oct 25 doi: 10.1007/s11060-023-04477-2. PMID: 37880419
Adjuvant stereotactic radiosurgery with or without postoperative fractionated radiation therapy in adults with skull base chordomas: a systematic review.
Bin-Alamer O, Mallela AN, Palmisciano P, Gersey ZC, Elarjani T, Labib MA, Zenonos GA, Dehdashti AR, Sheehan JP, Couldwell WT, Lunsford LD, Abou-Al-Shaar H
Neurosurg Focus 2022 Nov;53(5):E5. doi: 10.3171/2022.8.FOCUS22239. PMID: 36321281
Prognostic Factors in Skull Base Chordoma: A Systematic Literature Review and Meta-Analysis.
Zou MX, Lv GH, Zhang QS, Wang SF, Li J, Wang XB
World Neurosurg 2018 Jan;109:307-327. Epub 2017 Oct 16 doi: 10.1016/j.wneu.2017.10.010. PMID: 29045855

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