U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Malignant gastric granular cell tumor

MedGen UID:
233664
•Concept ID:
C1334585
•
Neoplastic Process
Synonyms: Malignant Gastric Granular Cell Neoplasm; malignant gastric granular cell neoplasm; Malignant Gastric Granular Cell Tumor; malignant gastric granular cell tumor; Malignant Granular Cell Neoplasm of Stomach; malignant granular cell neoplasm of stomach; Malignant Granular Cell Neoplasm of the Stomach; malignant granular cell neoplasm of the stomach; Malignant Granular Cell Stomach Neoplasm; malignant granular cell stomach neoplasm; Malignant Granular Cell Stomach Tumor; malignant granular cell stomach tumor; malignant granular cell stomach tumour; Malignant Granular Cell Tumor of Stomach; malignant granular cell tumor of stomach; Malignant Granular Cell Tumor of the Stomach; malignant granular cell tumor of the stomach; malignant granular cell tumour of stomach; malignant granular cell tumour of the stomach
 
Monarch Initiative: MONDO:0001057

Definition

A metastasizing granular cell tumor that arises from the stomach. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant gastric granular cell tumor

Professional guidelines

PubMed

Endoscopic management of subepithelial lesions including neuroendocrine neoplasms: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.
Deprez PH, Moons LMG, OʼToole D, Gincul R, Seicean A, Pimentel-Nunes P, Fernández-Esparrach G, Polkowski M, Vieth M, Borbath I, Moreels TG, Nieveen van Dijkum E, Blay JY, van Hooft JE
Endoscopy 2022 Apr;54(4):412-429. Epub 2022 Feb 18 doi: 10.1055/a-1751-5742. PMID: 35180797

Recent clinical studies

Etiology

Gastrointestinal Tract Granular Cell Tumor in the Pediatric Population: A Multicenter Experience.
Shaheen M, Wilkins BJ, Shenoy A, Byrnes K, Zhang XT, González IA
Pediatr Dev Pathol 2024 May-Jun;27(3):211-217. Epub 2024 Jan 5 doi: 10.1177/10935266231220472. PMID: 38179814
Early Immune Changes Support Signet Ring Cell Dormancy in CDH1-Driven Hereditary Diffuse Gastric Carcinogenesis.
Green BL, Gamble LA, Diggs LP, Nousome D, Patterson JC, Joughin BA, Gasmi B, Lux SC, Samaranayake SG, Miettinen M, Quezado M, Hernandez JM, Yaffe MB, Davis JL
Mol Cancer Res 2023 Dec 1;21(12):1356-1365. doi: 10.1158/1541-7786.MCR-23-0122. PMID: 37707375Free PMC Article
Endoscopic management of subepithelial lesions including neuroendocrine neoplasms: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.
Deprez PH, Moons LMG, OʼToole D, Gincul R, Seicean A, Pimentel-Nunes P, Fernández-Esparrach G, Polkowski M, Vieth M, Borbath I, Moreels TG, Nieveen van Dijkum E, Blay JY, van Hooft JE
Endoscopy 2022 Apr;54(4):412-429. Epub 2022 Feb 18 doi: 10.1055/a-1751-5742. PMID: 35180797
GP73 is down-regulated in gastric cancer and associated with tumor differentiation.
Chen LG, Wang HJ, Yao HB, Guan TP, Wu F, He XJ, Ma YY, Tao HQ, Ye ZY
World J Surg Oncol 2013 Jun 7;11:132. doi: 10.1186/1477-7819-11-132. PMID: 23742050Free PMC Article
PNA: a marker of neoplastic progression and differentiation in the gastro-intestinal tract.
Grigolato P, Benetti A, Berenzi A, Villanacci V, Tardanico R
Int J Biol Markers 1990 Apr-Jun;5(2):81-4. PMID: 2283482

Diagnosis

Endoscopic management of subepithelial lesions including neuroendocrine neoplasms: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.
Deprez PH, Moons LMG, OʼToole D, Gincul R, Seicean A, Pimentel-Nunes P, Fernández-Esparrach G, Polkowski M, Vieth M, Borbath I, Moreels TG, Nieveen van Dijkum E, Blay JY, van Hooft JE
Endoscopy 2022 Apr;54(4):412-429. Epub 2022 Feb 18 doi: 10.1055/a-1751-5742. PMID: 35180797
Benign esophageal lesions: endoscopic and pathologic features.
Tsai SJ, Lin CC, Chang CW, Hung CY, Shieh TY, Wang HY, Shih SC, Chen MJ
World J Gastroenterol 2015 Jan 28;21(4):1091-8. doi: 10.3748/wjg.v21.i4.1091. PMID: 25632181Free PMC Article
A laterally-spreading tumor in a colonic interposition treated by endoscopic submucosal dissection.
Bando H, Ikematsu H, Fu KI, Oono Y, Kojima T, Minashi K, Yano T, Matsuda T, Saito Y, Kaneko K, Ohtsu A
World J Gastroenterol 2010 Jan 21;16(3):392-4. doi: 10.3748/wjg.v16.i3.392. PMID: 20082488Free PMC Article
Abrikosoff's tumor of the esophagus: case report and review of literature.
Harikumar R, Simikumar, Aravindan SK, Thomas V
Trop Gastroenterol 2006 Jan-Mar;27(1):52-3. PMID: 16910065
Oncocytic and oncocytoid tumors of the exocrine pancreas, liver, and gastrointestinal tract.
Papotti M, Cassoni P, Taraglio S, Bussolati G
Semin Diagn Pathol 1999 May;16(2):126-34. PMID: 10452578

Therapy

Over-the-scope clip-assisted method for resection of full-thickness submucosal lesions of the gastrointestinal tract.
Sarker S, Gutierrez JP, Council L, Brazelton JD, Kyanam Kabir Baig KR, Mönkemüller K
Endoscopy 2014 Sep;46(9):758-61. Epub 2014 May 15 doi: 10.1055/s-0034-1365513. PMID: 24830398
Submucosal tumors of the esophagogastric junction originating from the muscularis propria layer: a large study of endoscopic submucosal dissection (with video).
Li QL, Yao LQ, Zhou PH, Xu MD, Chen SY, Zhong YS, Zhang YQ, Chen WF, Ma LL, Qin WZ
Gastrointest Endosc 2012 Jun;75(6):1153-8. Epub 2012 Mar 28 doi: 10.1016/j.gie.2012.01.037. PMID: 22459663
Preliminary studies on anti-tumor activity of 2',4'-dihydroxychalcone isolated from Herba Oxytropis in human gastric cancer MGC-803 cells.
Lou C, Wang M, Yang G, Cai H, Li Y, Zhao F, Yang H, Tong L, Cai B
Toxicol In Vitro 2009 Aug;23(5):906-10. Epub 2009 May 18 doi: 10.1016/j.tiv.2009.05.002. PMID: 19457454
Immunohistochemical evaluation of thymidylate synthase in gastric carcinoma using a new polyclonal antibody: the clinical role of thymidylate synthase as a prognostic indicator and its therapeutic usefulness.
Kuniyasu T, Nakamura T, Tabuchi Y, Kuroda Y
Cancer 1998 Oct 1;83(7):1300-6. doi: 10.1002/(sici)1097-0142(19981001)83:7<1300::aid-cncr5>3.0.co;2-m. PMID: 9762929
Regression of superficial gastric MALT lymphoma with unsuccessful eradication therapy for Helicobacter pylori infection.
Yoshikane H, Yokoi T, Hidano H, Sakakibara A, Niwa Y, Goto H
J Gastroenterol 1997 Dec;32(6):812-6. doi: 10.1007/BF02936960. PMID: 9430022

Prognosis

Gastrointestinal Tract Granular Cell Tumor in the Pediatric Population: A Multicenter Experience.
Shaheen M, Wilkins BJ, Shenoy A, Byrnes K, Zhang XT, González IA
Pediatr Dev Pathol 2024 May-Jun;27(3):211-217. Epub 2024 Jan 5 doi: 10.1177/10935266231220472. PMID: 38179814
Early Immune Changes Support Signet Ring Cell Dormancy in CDH1-Driven Hereditary Diffuse Gastric Carcinogenesis.
Green BL, Gamble LA, Diggs LP, Nousome D, Patterson JC, Joughin BA, Gasmi B, Lux SC, Samaranayake SG, Miettinen M, Quezado M, Hernandez JM, Yaffe MB, Davis JL
Mol Cancer Res 2023 Dec 1;21(12):1356-1365. doi: 10.1158/1541-7786.MCR-23-0122. PMID: 37707375Free PMC Article
Recent developments in gastroesophageal mesenchymal tumours.
Papke DJ Jr, Hornick JL
Histopathology 2021 Jan;78(1):171-186. doi: 10.1111/his.14164. PMID: 33382494
Granular Cell Tumor: Report of 13 Cases in a Veterans Administration Hospital.
Jobrack AD, Goel S, Cotlar AM
Mil Med 2018 Sep 1;183(9-10):e589-e593. doi: 10.1093/milmed/usx237. PMID: 29548015
Benign esophageal lesions: endoscopic and pathologic features.
Tsai SJ, Lin CC, Chang CW, Hung CY, Shieh TY, Wang HY, Shih SC, Chen MJ
World J Gastroenterol 2015 Jan 28;21(4):1091-8. doi: 10.3748/wjg.v21.i4.1091. PMID: 25632181Free PMC Article

Clinical prediction guides

Early Immune Changes Support Signet Ring Cell Dormancy in CDH1-Driven Hereditary Diffuse Gastric Carcinogenesis.
Green BL, Gamble LA, Diggs LP, Nousome D, Patterson JC, Joughin BA, Gasmi B, Lux SC, Samaranayake SG, Miettinen M, Quezado M, Hernandez JM, Yaffe MB, Davis JL
Mol Cancer Res 2023 Dec 1;21(12):1356-1365. doi: 10.1158/1541-7786.MCR-23-0122. PMID: 37707375Free PMC Article
Mast Cell Interaction with Neutrophils in Human Gastric Carcinomas: Ultrastructural Observations.
Ieni A, Barresi V, Branca G, Alberto Caruso R, Tuccari G
Anal Cell Pathol (Amst) 2016;2016:6891971. Epub 2016 Nov 2 doi: 10.1155/2016/6891971. PMID: 27882290Free PMC Article
Granular cell tumor of the gastrointestinal tract: histologic and immunohistochemical analysis of 98 cases.
An S, Jang J, Min K, Kim MS, Park H, Park YS, Kim J, Lee JH, Song HJ, Kim KJ, Yu E, Hong SM
Hum Pathol 2015 Jun;46(6):813-9. Epub 2015 Feb 26 doi: 10.1016/j.humpath.2015.02.005. PMID: 25882927
Benign esophageal lesions: endoscopic and pathologic features.
Tsai SJ, Lin CC, Chang CW, Hung CY, Shieh TY, Wang HY, Shih SC, Chen MJ
World J Gastroenterol 2015 Jan 28;21(4):1091-8. doi: 10.3748/wjg.v21.i4.1091. PMID: 25632181Free PMC Article
Endoscopic resection of granular cell tumors in the gastrointestinal tract: a single center experience.
Kahng DH, Kim GH, Park DY, Jeon MS, Yi JW, Choi YY, Song GA
Surg Endosc 2013 Sep;27(9):3228-36. Epub 2013 Mar 12 doi: 10.1007/s00464-013-2899-2. PMID: 23479255

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...