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Ovarian large-cell neuroendocrine carcinoma

MedGen UID:
233809
•Concept ID:
C1335174
•
Neoplastic Process
Synonyms: Large Cell Neuroendocrine Carcinoma of Ovary; large cell neuroendocrine carcinoma of ovary; Large Cell Neuroendocrine Carcinoma of the Ovary; large cell neuroendocrine carcinoma of the ovary; Large-Cell Neuroendocrine Carcinoma of Ovary; large-cell neuroendocrine carcinoma of ovary; Large-Cell Neuroendocrine Carcinoma of the Ovary; large-cell neuroendocrine carcinoma of the ovary; Non-Small-Cell Type Neuroendocrine Carcinoma of Ovary; non-small-cell type neuroendocrine carcinoma of ovary; Non-Small-Cell Type Neuroendocrine Carcinoma of the Ovary; non-small-cell type neuroendocrine carcinoma of the ovary; Ovarian Large Cell NEC; ovarian large cell NEC; Ovarian Large Cell Neuroendocrine Carcinoma; ovarian large cell neuroendocrine carcinoma; ovarian large-cell neuroendocrine carcinoma; Ovarian Non-Small-Cell Type Neuroendocrine Carcinoma; ovarian non-small-cell type neuroendocrine carcinoma; ovary large cell neuroendocrine carcinoma
 
Monarch Initiative: MONDO:0003049

Definition

A carcinoma that arises from the ovary and is characterized by the presence of large malignant cells exhibiting neuroendocrine differentiation. The prognosis is poor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOvarian large-cell neuroendocrine carcinoma

Professional guidelines

PubMed

Clinicopathologic feature and treatment progress of high-grade ovarian neuroendocrine tumors.
He Q, Wang C, Huang D, Shen J, Liu R, Guan Y, Zhou J
Med Oncol 2024 Nov 14;42(1):2. doi: 10.1007/s12032-024-02544-w. PMID: 39541042
The value of SOX2 in the differential diagnosis of SMARCA4 (BRG1)-deficient uterine neoplasms.
Zheng L, Zhang L, Wang XI, Katz G, Tandon N, Zhao B, Lucci J, Ding J, Zhang S
Hum Pathol 2022 Jun;124:45-55. Epub 2022 Mar 22 doi: 10.1016/j.humpath.2022.03.009. PMID: 35331811
Immune Checkpoint Inhibitors in the Treatment of Patients with Neuroendocrine Neoplasia.
Weber MM, Fottner C
Oncol Res Treat 2018;41(5):306-312. Epub 2018 Apr 26 doi: 10.1159/000488996. PMID: 29742518

Recent clinical studies

Diagnosis

Primary pure large cell neuroendocrine carcinoma of the ovary: A rare case report and review of literature.
Peng X, Wang H
Medicine (Baltimore) 2020 Dec 4;99(49):e22474. doi: 10.1097/MD.0000000000022474. PMID: 33285672Free PMC Article
Pathological features, clinical presentations and prognostic factors of ovarian large cell neuroendocrine carcinoma: a case report and review of published literature.
Yang X, Chen J, Dong R
J Ovarian Res 2019 Jul 25;12(1):69. doi: 10.1186/s13048-019-0543-z. PMID: 31345245Free PMC Article
Ovarian large cell neuroendocrine carcinoma in the youngest woman.
Kwon YS, Im KS, Choi DI
Eur J Gynaecol Oncol 2016;37(2):244-6. PMID: 27172753
Ovarian large cell neuroendocrine carcinoma.
Tsuji T, Togami S, Shintomo N, Fukamachi N, Douchi T, Taguchi S
J Obstet Gynaecol Res 2008 Aug;34(4 Pt 2):726-30. doi: 10.1111/j.1447-0756.2008.00916.x. PMID: 18840191
Large cell neuroendocrine carcinoma of the ovary.
Lindboe CF
APMIS 2007 Feb;115(2):169-76. doi: 10.1111/j.1600-0463.2007.apm_570.x. PMID: 17295684

Therapy

Primary pure large cell neuroendocrine carcinoma of the ovary: A rare case report and review of literature.
Peng X, Wang H
Medicine (Baltimore) 2020 Dec 4;99(49):e22474. doi: 10.1097/MD.0000000000022474. PMID: 33285672Free PMC Article
Pathological features, clinical presentations and prognostic factors of ovarian large cell neuroendocrine carcinoma: a case report and review of published literature.
Yang X, Chen J, Dong R
J Ovarian Res 2019 Jul 25;12(1):69. doi: 10.1186/s13048-019-0543-z. PMID: 31345245Free PMC Article
Ovarian large cell neuroendocrine carcinoma in the youngest woman.
Kwon YS, Im KS, Choi DI
Eur J Gynaecol Oncol 2016;37(2):244-6. PMID: 27172753
Mixed ovarian large cell neuroendocrine carcinoma, mucinous adenocarcinoma, and teratoma: a report of two cases and review of the literature.
Chênevert J, Bessette P, Plante M, Têtu B, Dubé V
Pathol Res Pract 2009;205(9):657-61. Epub 2009 Jul 3 doi: 10.1016/j.prp.2009.01.013. PMID: 19577382
Large cell neuroendocrine carcinoma of the ovary.
Lindboe CF
APMIS 2007 Feb;115(2):169-76. doi: 10.1111/j.1600-0463.2007.apm_570.x. PMID: 17295684

Prognosis

Primary pure large cell neuroendocrine carcinoma of the ovary: A rare case report and review of literature.
Peng X, Wang H
Medicine (Baltimore) 2020 Dec 4;99(49):e22474. doi: 10.1097/MD.0000000000022474. PMID: 33285672Free PMC Article
Pathological features, clinical presentations and prognostic factors of ovarian large cell neuroendocrine carcinoma: a case report and review of published literature.
Yang X, Chen J, Dong R
J Ovarian Res 2019 Jul 25;12(1):69. doi: 10.1186/s13048-019-0543-z. PMID: 31345245Free PMC Article
Ovarian large cell neuroendocrine carcinoma in the youngest woman.
Kwon YS, Im KS, Choi DI
Eur J Gynaecol Oncol 2016;37(2):244-6. PMID: 27172753
Mixed ovarian large cell neuroendocrine carcinoma, mucinous adenocarcinoma, and teratoma: a report of two cases and review of the literature.
Chênevert J, Bessette P, Plante M, Têtu B, Dubé V
Pathol Res Pract 2009;205(9):657-61. Epub 2009 Jul 3 doi: 10.1016/j.prp.2009.01.013. PMID: 19577382
Ovarian large cell neuroendocrine carcinoma.
Tsuji T, Togami S, Shintomo N, Fukamachi N, Douchi T, Taguchi S
J Obstet Gynaecol Res 2008 Aug;34(4 Pt 2):726-30. doi: 10.1111/j.1447-0756.2008.00916.x. PMID: 18840191

Clinical prediction guides

Ovarian large cell neuroendocrine carcinoma.
Tsuji T, Togami S, Shintomo N, Fukamachi N, Douchi T, Taguchi S
J Obstet Gynaecol Res 2008 Aug;34(4 Pt 2):726-30. doi: 10.1111/j.1447-0756.2008.00916.x. PMID: 18840191

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