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Head and Neck Basaloid Squamous Cell Carcinoma

MedGen UID:
234337
Concept ID:
C1333940
Neoplastic Process
Synonyms: Basaloid Squamous Cell Carcinoma of Head and Neck; Basaloid Squamous Cell Carcinoma of the Head and Neck; Head and Neck Basaloid Carcinoma

Definition

A high-grade, aggressive variant of squamous cell carcinoma that arises from the head and neck region. The most common sites of origin are pyriform sinus, epiglottis, and base of tongue. It is characterized by the presence of small malignant cells with hyperchromatic nuclei and scant amount of cytoplasm forming lobules with peripheral palisading. Comedonecrosis may be present. [from NCI]

Professional guidelines

PubMed

Gootee J, Patel M, Aurit S, Silberstein P
Clin Transl Oncol 2020 Dec;22(12):2264-2274. Epub 2020 May 21 doi: 10.1007/s12094-020-02370-2. PMID: 32440914

Recent clinical studies

Etiology

Rahimi S
J Clin Pathol 2020 Oct;73(10):624-629. Epub 2020 Jun 4 doi: 10.1136/jclinpath-2020-206686. PMID: 32499224
Jumaily M, Faraji F, Zhang D, Walker RJ, Ward GM
Otolaryngol Head Neck Surg 2019 May;160(5):847-854. Epub 2019 Feb 5 doi: 10.1177/0194599818816299. PMID: 30717636
Roy-Chowdhuri S, Krishnamurthy S
Semin Diagn Pathol 2015 Jul;32(4):250-7. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.006. PMID: 25638437
Fritsch VA, Lentsch EJ
J Surg Oncol 2014 May;109(6):616-22. Epub 2014 Jan 24 doi: 10.1002/jso.23536. PMID: 24464879
Cardesa A, Nadal A
Acta Dermatovenerol Alp Pannonica Adriat 2011 Sep;20(3):161-73. PMID: 22131117

Diagnosis

Rahimi S
J Clin Pathol 2020 Oct;73(10):624-629. Epub 2020 Jun 4 doi: 10.1136/jclinpath-2020-206686. PMID: 32499224
Wakely PE Jr
Ann Diagn Pathol 2019 Oct;42:78-86. Epub 2019 Jul 27 doi: 10.1016/j.anndiagpath.2019.07.005. PMID: 31382078
El-Mofty SK
Semin Diagn Pathol 2015 Jan;32(1):23-31. Epub 2015 Feb 25 doi: 10.1053/j.semdp.2015.02.022. PMID: 25804342
Chute DJ, Stelow EB
Diagn Cytopathol 2010 Jan;38(1):65-80. doi: 10.1002/dc.21134. PMID: 19582815
Barnes L, Ferlito A, Altavilla G, MacMillan C, Rinaldo A, Doglioni C
Ann Otol Rhinol Laryngol 1996 Jan;105(1):75-82. doi: 10.1177/000348949610500115. PMID: 8546432

Therapy

Tan E, Mody MD, Saba NF
Oral Oncol 2018 Jul;82:61-68. Epub 2018 May 26 doi: 10.1016/j.oraloncology.2018.05.005. PMID: 29909903
Fritsch VA, Gerry DR, Lentsch EJ
Laryngoscope 2014 Jul;124(7):1573-8. Epub 2014 Apr 29 doi: 10.1002/lary.24384. PMID: 23946211
Boscolo-Rizzo P, Del Mistro A, Bussu F, Lupato V, Baboci L, Almadori G, DA Mosto MC, Paludetti G
Acta Otorhinolaryngol Ital 2013 Apr;33(2):77-87. PMID: 23853396Free PMC Article
Thankappan K
Auris Nasus Larynx 2012 Aug;39(4):397-401. Epub 2011 Aug 24 doi: 10.1016/j.anl.2011.07.018. PMID: 21868181
Cardesa A, Nadal A
Acta Dermatovenerol Alp Pannonica Adriat 2011 Sep;20(3):161-73. PMID: 22131117

Prognosis

Rooper LM, Agaimy A, Dickson BC, Dueber JC, Eberhart CG, Gagan J, Hartmann A, Khararjian A, London NR, MacMillan CM, Palsgrove DN, Nix JS, Sandison A, Stoehr R, Truong T, Weinreb I, Bishop JA
Am J Surg Pathol 2021 Dec 1;45(12):1682-1693. doi: 10.1097/PAS.0000000000001741. PMID: 34049316
El-Mofty SK
Semin Diagn Pathol 2015 Jan;32(1):23-31. Epub 2015 Feb 25 doi: 10.1053/j.semdp.2015.02.022. PMID: 25804342
Roy-Chowdhuri S, Krishnamurthy S
Semin Diagn Pathol 2015 Jul;32(4):250-7. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.006. PMID: 25638437
Thankappan K
Auris Nasus Larynx 2012 Aug;39(4):397-401. Epub 2011 Aug 24 doi: 10.1016/j.anl.2011.07.018. PMID: 21868181
Thariat J, Badoual C, Faure C, Butori C, Marcy PY, Righini CA
J Clin Pathol 2010 Oct;63(10):857-66. doi: 10.1136/jcp.2010.078154. PMID: 20876315

Clinical prediction guides

El-Mofty SK
Semin Diagn Pathol 2015 Jan;32(1):23-31. Epub 2015 Feb 25 doi: 10.1053/j.semdp.2015.02.022. PMID: 25804342
Ylagan LR
Semin Diagn Pathol 2015 Jul;32(4):296-304. Epub 2015 Feb 7 doi: 10.1053/j.semdp.2014.12.011. PMID: 25753530
Roy-Chowdhuri S, Krishnamurthy S
Semin Diagn Pathol 2015 Jul;32(4):250-7. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.006. PMID: 25638437
Jayasooriya PR, Tilakaratne WM, Mendis BR, Lombardi T
Ann Diagn Pathol 2013 Dec;17(6):547-51. Epub 2013 Oct 21 doi: 10.1016/j.anndiagpath.2013.09.001. PMID: 24157420
Krane JF
Acta Cytol 2013;57(2):117-26. Epub 2013 Feb 28 doi: 10.1159/000346715. PMID: 23406782

Recent systematic reviews

Alsavaf MB, Abouammo MD, Bhuskute GS, Sun S, Issa M, Seim NB, VanKoevering KK, Bhateja P, Bonomi M, Carrau RL
Laryngoscope 2024 Sep;134(9):3892-3902. Epub 2024 Apr 23 doi: 10.1002/lary.31426. PMID: 38651346
Zupancic M, Näsman A
Viruses 2021 Sep 17;13(9) doi: 10.3390/v13091861. PMID: 34578442Free PMC Article
Thankappan K
Auris Nasus Larynx 2012 Aug;39(4):397-401. Epub 2011 Aug 24 doi: 10.1016/j.anl.2011.07.018. PMID: 21868181

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