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Hypercellular bone marrow

MedGen UID:
235183
•Concept ID:
C1334068
•
Finding
Synonym: Hypercellular Bone Marrow

Definition

An abnormal finding in a bone marrow aspirate or biopsy specimen indicating increased cellularity. It can result from hyperplasia of one or more hematopoietic cell lines or malignant neoplasms that affect the bone marrow. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHypercellular bone marrow

Professional guidelines

PubMed

Chronic neutrophilic leukemia and atypical chronic myeloid leukemia: 2024 update on diagnosis, genetics, risk stratification, and management.
Szuber N, Orazi A, Tefferi A
Am J Hematol 2024 Jul;99(7):1360-1387. Epub 2024 Apr 21 doi: 10.1002/ajh.27321. PMID: 38644693
Atypical chronic myeloid leukemia: a rare entity with management challenges.
Dhakal P, Gundabolu K, Amador C, Rayamajhi S, Bhatt VR
Future Oncol 2018 Jan;14(2):177-185. Epub 2017 Dec 11 doi: 10.2217/fon-2017-0334. PMID: 29226717
Treatment strategies and issues in low/intermediate-1-risk myelodysplastic syndrome (MDS) patients.
Bowen DT
Semin Oncol 2005 Aug;32(4 Suppl 5):S16-23. doi: 10.1053/j.seminoncol.2005.06.017. PMID: 16085013

Recent clinical studies

Therapy

Modified Giemsa Stain: A solution to improve the quality of hypercellular bone marrow smears.
Gunawardena D, Priyankara I, Jayamanne H, Suresh S
Int J Lab Hematol 2022 Jun;44(3):504-509. Epub 2022 Apr 5 doi: 10.1111/ijlh.13824. PMID: 35384335
Atypical chronic myeloid leukemia: a rare entity with management challenges.
Dhakal P, Gundabolu K, Amador C, Rayamajhi S, Bhatt VR
Future Oncol 2018 Jan;14(2):177-185. Epub 2017 Dec 11 doi: 10.2217/fon-2017-0334. PMID: 29226717
Molecular Testing in Patients with Suspected Myelodysplastic Syndromes.
Moyo TK, Savona MR
Curr Hematol Malig Rep 2016 Dec;11(6):441-448. doi: 10.1007/s11899-016-0356-8. PMID: 27734261
Immunosuppressive therapy for myelodysplastic syndromes.
Dobbelstein C, Ganser A
Curr Pharm Des 2012;18(22):3184-9. doi: 10.2174/1381612811209023184. PMID: 22571697
Pancytopenia with hypercellular bone marrow secondary to cytomegalovirus after cardiac transplant.
Elkhateeb O, Jackson S, Schlech WF, Storm K, Howlett J
J Heart Lung Transplant 2009 Jul;28(7):749-50. Epub 2009 May 13 doi: 10.1016/j.healun.2009.04.007. PMID: 19560708

Prognosis

Molecular Testing in Patients with Suspected Myelodysplastic Syndromes.
Moyo TK, Savona MR
Curr Hematol Malig Rep 2016 Dec;11(6):441-448. doi: 10.1007/s11899-016-0356-8. PMID: 27734261
Cellularity, characteristics of hematopoietic parameters and prognosis in myelodysplastic syndromes.
Schemenau J, Baldus S, Anlauf M, Reinecke P, Braunstein S, Blum S, Nachtkamp K, Neukirchen J, Strup C, Aul C, Haas R, Gattermann N, Germing U
Eur J Haematol 2015 Sep;95(3):181-9. Epub 2015 May 15 doi: 10.1111/ejh.12512. PMID: 25600827
Pediatric myelodysplastic syndromes: they do exist!
Glaubach T, Robinson LJ, Corey SJ
J Pediatr Hematol Oncol 2014 Jan;36(1):1-7. doi: 10.1097/MPH.0000000000000046. PMID: 24345881
The relationship between bone marrow characteristics and the clinical prognosis of antithyroid drug-induced agranulocytosis.
Yang J, Zhong J, Xiao XH, Zhou LZ, Chen YJ, Liu JH, Cao RX, Wen GB
Endocr J 2013;60(2):185-9. Epub 2012 Oct 27 doi: 10.1507/endocrj.ej12-0332. PMID: 23117149
Immunosuppressive therapy for myelodysplastic syndromes.
Dobbelstein C, Ganser A
Curr Pharm Des 2012;18(22):3184-9. doi: 10.2174/1381612811209023184. PMID: 22571697

Clinical prediction guides

Tissue methylation and demethylation influence translesion synthesis DNA polymerases (TLS) contributing to the genesis of chromosomal abnormalities in myelodysplastic syndrome.
Cavalcante GM, Borges DP, de Oliveira RTG, Furtado CLM, Alves APNN, Sousa AM, de Paula DS, Filho FDR, Magalhães SMM, Ribeiro-Jr HL, Pinheiro RF
J Clin Pathol 2022 Feb;75(2):85-93. Epub 2020 Nov 24 doi: 10.1136/jclinpath-2020-207131. PMID: 33234697
DNA repair gene expressions are related to bone marrow cellularity in myelodysplastic syndrome.
Ribeiro HL Jr, Maia ARS, de Oliveira RTG, Costa MB, Farias IR, de Paula Borges D, de Sousa JC, Magalhães SMM, Pinheiro RF
J Clin Pathol 2017 Nov;70(11):970-980. Epub 2017 May 29 doi: 10.1136/jclinpath-2016-204269. PMID: 28554891
Prognostic impact of blast cell counts in dysplastic bone marrow disorders (MDS and CMML I) with concomitant fibrosis.
Machherndl-Spandl S, Sega W, Bösmüller H, Germing U, Gruber Ch, Nachtkamp K, Reinecke P, Sperr WR, Wimazal F, Müllauer L, Sotlar K, Horny HP, Tüchler H, Valent P, Krieger O
Ann Hematol 2014 Jan;93(1):57-64. Epub 2013 Nov 17 doi: 10.1007/s00277-013-1945-4. PMID: 24241126
Treatment strategies and issues in low/intermediate-1-risk myelodysplastic syndrome (MDS) patients.
Bowen DT
Semin Oncol 2005 Aug;32(4 Suppl 5):S16-23. doi: 10.1053/j.seminoncol.2005.06.017. PMID: 16085013
The role of bone marrow study in diagnosis and prognosis of myelodysplastic syndrome.
Saad ST, Vassallo J, Arruda VA, Lorand-Metze I
Pathologica 1994 Feb;86(1):47-51. PMID: 8072801

Recent systematic reviews

CSF3R-mutant chronic myelomonocytic leukemia is a distinct clinically subset with abysmal prognosis: a case report and systematic review of the literature.
Guastafierro V, Ubezio M, Manes N, Milanesi C, Della Porta M, Bonometti A
Leuk Lymphoma 2023 Sep;64(9):1566-1573. Epub 2023 Jul 3 doi: 10.1080/10428194.2023.2227750. PMID: 37395413

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