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Central nervous system leiomyosarcoma

MedGen UID:
235254
•Concept ID:
C1334385
•
Neoplastic Process
Synonyms: Central Nervous System Leiomyosarcoma; central nervous system leiomyosarcoma; CNS Leiomyosarcoma; CNS leiomyosarcoma; Leiomyosarcoma of Central Nervous System; leiomyosarcoma of central nervous system; Leiomyosarcoma of CNS; leiomyosarcoma of CNS; Leiomyosarcoma of the Central Nervous System; leiomyosarcoma of the central nervous system; Leiomyosarcoma of the CNS; leiomyosarcoma of the CNS
 
Monarch Initiative: MONDO:0003349

Definition

An aggressive malignant smooth muscle neoplasm, arising from the central nervous system. It is characterized by a proliferation of neoplastic spindle cells. [from NCI]

Professional guidelines

PubMed

Surgical management and long-term outcomes of primary intracranial leiomyosarcoma: a case series and review of literature.
Zhang GJ, Weng JC, Huo XL, Ma JP, Wang B, Wang L, Li H, Li D, Zhang JT, Wu Z
Neurosurg Rev 2021 Aug;44(4):2319-2328. Epub 2020 Oct 24 doi: 10.1007/s10143-020-01422-z. PMID: 33099713
Establishment and operation of a Good Manufacturing Practice-compliant allogeneic Epstein-Barr virus (EBV)-specific cytotoxic cell bank for the treatment of EBV-associated lymphoproliferative disease.
Vickers MA, Wilkie GM, Robinson N, Rivera N, Haque T, Crawford DH, Barry J, Fraser N, Turner DM, Robertson V, Dyer P, Flanagan P, Newlands HR, Campbell J, Turner ML
Br J Haematol 2014 Nov;167(3):402-10. Epub 2014 Jul 26 doi: 10.1111/bjh.13051. PMID: 25066775Free PMC Article
Sarcoma metastatic to the brain: results of surgical treatment.
Bindal RK, Sawaya RE, Leavens ME, Taylor SH, Guinee VF
Neurosurgery 1994 Aug;35(2):185-90; discussion 190-1. doi: 10.1227/00006123-199408000-00002. PMID: 7969824

Recent clinical studies

Etiology

Surgical management and long-term outcomes of primary intracranial leiomyosarcoma: a case series and review of literature.
Zhang GJ, Weng JC, Huo XL, Ma JP, Wang B, Wang L, Li H, Li D, Zhang JT, Wu Z
Neurosurg Rev 2021 Aug;44(4):2319-2328. Epub 2020 Oct 24 doi: 10.1007/s10143-020-01422-z. PMID: 33099713
Recommendations for Long-Term Follow-up of Adults with Heritable Retinoblastoma.
Tonorezos ES, Friedman DN, Barnea D, Bosscha MI, Chantada G, Dommering CJ, de Graaf P, Dunkel IJ, Fabius AWM, Francis JH, Greer MC, Kleinerman RA, Kors WA, Laughlin S, Moll AC, Morton LM, Temming P, Tucker MA, van Leeuwen FE, Walsh MF, Oeffinger KC, Abramson DH
Ophthalmology 2020 Nov;127(11):1549-1557. Epub 2020 May 15 doi: 10.1016/j.ophtha.2020.05.024. PMID: 32422154Free PMC Article
DNA methylation-based profiling of uterine neoplasms: a novel tool to improve gynecologic cancer diagnostics.
Kommoss FKF, Stichel D, Schrimpf D, Kriegsmann M, Tessier-Cloutier B, Talhouk A, McAlpine JN, Chang KTE, Sturm D, Pfister SM, Romero-Pérez L, Kirchner T, Grünewald TGP, Buslei R, Sinn HP, Mechtersheimer G, Schirmacher P, Schmidt D, Lehr HA, Sahm F, Huntsman DG, Gilks CB, Kommoss F, von Deimling A, Koelsche C
J Cancer Res Clin Oncol 2020 Jan;146(1):97-104. Epub 2019 Nov 25 doi: 10.1007/s00432-019-03093-w. PMID: 31768620
Risk of Soft-Tissue Sarcoma Among 69 460 Five-Year Survivors of Childhood Cancer in Europe.
Bright CJ, Hawkins MM, Winter DL, Alessi D, Allodji RS, Bagnasco F, Bárdi E, Bautz A, Byrne J, Feijen EAM, Fidler MM, Garwicz S, Grabow D, Gudmundsdottir T, Guha J, Haddy N, Jankovic M, Kaatsch P, Kaiser M, Kuehni CE, Linge H, Øfstaas H, Ronckers CM, Skinner R, Teepen JC, Terenziani M, Vu-Bezin G, Wesenberg F, Wiebe T, Sacerdote C, Jakab Z, Haupt R, Lähteenmäki P, Zaletel LZ, Kuonen R, Winther JF, de Vathaire F, Kremer LC, Hjorth L, Reulen RC; PanCareSurFup Consortium
J Natl Cancer Inst 2018 Jun 1;110(6):649-660. doi: 10.1093/jnci/djx235. PMID: 29165710Free PMC Article
Cancers in children with HIV infection.
McClain KL, Joshi VV, Murphy SB
Hematol Oncol Clin North Am 1996 Oct;10(5):1189-201. doi: 10.1016/s0889-8588(05)70393-2. PMID: 8880205

Diagnosis

Lessons from Epstein-Barr virus DNA detection in cerebrospinal fluid as a diagnostic tool for EBV-induced central nervous system dysfunction among HIV-positive patients.
Wang Y, Yang J, Wen Y
Biomed Pharmacother 2022 Jan;145:112392. Epub 2021 Nov 12 doi: 10.1016/j.biopha.2021.112392. PMID: 34781140
Recommendations for Long-Term Follow-up of Adults with Heritable Retinoblastoma.
Tonorezos ES, Friedman DN, Barnea D, Bosscha MI, Chantada G, Dommering CJ, de Graaf P, Dunkel IJ, Fabius AWM, Francis JH, Greer MC, Kleinerman RA, Kors WA, Laughlin S, Moll AC, Morton LM, Temming P, Tucker MA, van Leeuwen FE, Walsh MF, Oeffinger KC, Abramson DH
Ophthalmology 2020 Nov;127(11):1549-1557. Epub 2020 May 15 doi: 10.1016/j.ophtha.2020.05.024. PMID: 32422154Free PMC Article
DNA methylation-based profiling of uterine neoplasms: a novel tool to improve gynecologic cancer diagnostics.
Kommoss FKF, Stichel D, Schrimpf D, Kriegsmann M, Tessier-Cloutier B, Talhouk A, McAlpine JN, Chang KTE, Sturm D, Pfister SM, Romero-Pérez L, Kirchner T, Grünewald TGP, Buslei R, Sinn HP, Mechtersheimer G, Schirmacher P, Schmidt D, Lehr HA, Sahm F, Huntsman DG, Gilks CB, Kommoss F, von Deimling A, Koelsche C
J Cancer Res Clin Oncol 2020 Jan;146(1):97-104. Epub 2019 Nov 25 doi: 10.1007/s00432-019-03093-w. PMID: 31768620
Dural lesions mimicking meningiomas.
Johnson MD, Powell SZ, Boyer PJ, Weil RJ, Moots PL
Hum Pathol 2002 Dec;33(12):1211-26. doi: 10.1053/hupa.2002.129200. PMID: 12514791
Cancers in children with HIV infection.
McClain KL, Joshi VV, Murphy SB
Hematol Oncol Clin North Am 1996 Oct;10(5):1189-201. doi: 10.1016/s0889-8588(05)70393-2. PMID: 8880205

Therapy

Leiomyosarcoma After Liver Transplantation Is Unrelated to Epstein-Barr Virus: A Case Report.
Zhang J, Sun Y, Gao YJ, Zhou S
Transplant Proc 2020 Nov;52(9):2809-2812. Epub 2020 Jul 13 doi: 10.1016/j.transproceed.2020.06.023. PMID: 32674859
Lung metastases from benign uterine leiomyoma: does 18-FDG-PET/CT have a role to play?
Abu Saadeh F, Riain CO, Cormack CM, Gleeson N
Ir J Med Sci 2019 May;188(2):619-624. Epub 2018 Aug 3 doi: 10.1007/s11845-018-1876-0. PMID: 30074141
Additional diverse findings expand the clinical presentation of DOCK8 deficiency.
Sanal O, Jing H, Ozgur T, Ayvaz D, Strauss-Albee DM, Ersoy-Evans S, Tezcan I, Turkkani G, Matthews HF, Haliloglu G, Yuce A, Yalcin B, Gokoz O, Oguz KK, Su HC
J Clin Immunol 2012 Aug;32(4):698-708. Epub 2012 Apr 4 doi: 10.1007/s10875-012-9664-5. PMID: 22476911Free PMC Article
Gemcitabine-induced posterior reversible encephalopathy syndrome: a case report.
Cioffi P, Laudadio L, Nuzzo A, Belfiglio M, Petrelli F, Grappasonni I
J Oncol Pharm Pract 2012 Jun;18(2):299-302. Epub 2011 Nov 7 doi: 10.1177/1078155211424628. PMID: 22065198
Second malignant neoplasms in long-term survivors of osteosarcoma: Memorial Sloan-Kettering Cancer Center Experience.
Aung L, Gorlick RG, Shi W, Thaler H, Shorter NA, Healey JH, Huvos AG, Meyers PA
Cancer 2002 Oct 15;95(8):1728-34. doi: 10.1002/cncr.10861. PMID: 12365021

Prognosis

Surgical management and long-term outcomes of primary intracranial leiomyosarcoma: a case series and review of literature.
Zhang GJ, Weng JC, Huo XL, Ma JP, Wang B, Wang L, Li H, Li D, Zhang JT, Wu Z
Neurosurg Rev 2021 Aug;44(4):2319-2328. Epub 2020 Oct 24 doi: 10.1007/s10143-020-01422-z. PMID: 33099713
Recommendations for Long-Term Follow-up of Adults with Heritable Retinoblastoma.
Tonorezos ES, Friedman DN, Barnea D, Bosscha MI, Chantada G, Dommering CJ, de Graaf P, Dunkel IJ, Fabius AWM, Francis JH, Greer MC, Kleinerman RA, Kors WA, Laughlin S, Moll AC, Morton LM, Temming P, Tucker MA, van Leeuwen FE, Walsh MF, Oeffinger KC, Abramson DH
Ophthalmology 2020 Nov;127(11):1549-1557. Epub 2020 May 15 doi: 10.1016/j.ophtha.2020.05.024. PMID: 32422154Free PMC Article
Primary Intracranial Leiomyosarcoma with Intratumoral Hemorrhage: Case Report and Review of Literature.
Torihashi K, Chin M, Yoshida K, Narumi O, Yamagata S
World Neurosurg 2018 Aug;116:169-173. Epub 2018 May 16 doi: 10.1016/j.wneu.2018.05.004. PMID: 29753901
Risk of Soft-Tissue Sarcoma Among 69 460 Five-Year Survivors of Childhood Cancer in Europe.
Bright CJ, Hawkins MM, Winter DL, Alessi D, Allodji RS, Bagnasco F, Bárdi E, Bautz A, Byrne J, Feijen EAM, Fidler MM, Garwicz S, Grabow D, Gudmundsdottir T, Guha J, Haddy N, Jankovic M, Kaatsch P, Kaiser M, Kuehni CE, Linge H, Øfstaas H, Ronckers CM, Skinner R, Teepen JC, Terenziani M, Vu-Bezin G, Wesenberg F, Wiebe T, Sacerdote C, Jakab Z, Haupt R, Lähteenmäki P, Zaletel LZ, Kuonen R, Winther JF, de Vathaire F, Kremer LC, Hjorth L, Reulen RC; PanCareSurFup Consortium
J Natl Cancer Inst 2018 Jun 1;110(6):649-660. doi: 10.1093/jnci/djx235. PMID: 29165710Free PMC Article
Primary intracranial leiomyosarcoma: review of the literature and presentation of a case.
Zhang H, Dong L, Huang Y, Zhang B, Ma H, Zhou Y, Shu C, Cheng G
Onkologie 2012;35(10):609-16. Epub 2012 Sep 18 doi: 10.1159/000342676. PMID: 23038237

Clinical prediction guides

DNA methylation-based profiling of uterine neoplasms: a novel tool to improve gynecologic cancer diagnostics.
Kommoss FKF, Stichel D, Schrimpf D, Kriegsmann M, Tessier-Cloutier B, Talhouk A, McAlpine JN, Chang KTE, Sturm D, Pfister SM, Romero-Pérez L, Kirchner T, Grünewald TGP, Buslei R, Sinn HP, Mechtersheimer G, Schirmacher P, Schmidt D, Lehr HA, Sahm F, Huntsman DG, Gilks CB, Kommoss F, von Deimling A, Koelsche C
J Cancer Res Clin Oncol 2020 Jan;146(1):97-104. Epub 2019 Nov 25 doi: 10.1007/s00432-019-03093-w. PMID: 31768620
Intractable Repeated Intracerebral Hemorrhage Due to Primary Dural Leiomyosarcoma: Case Report and Literature Review.
Saito A, Ninomiya A, Ishida T, Inoue T, Inoue T, Suzuki S, Ezura M, Uenohara H
World Neurosurg 2019 Feb;122:116-122. Epub 2018 Nov 1 doi: 10.1016/j.wneu.2018.10.132. PMID: 30391601
Primary gliosarcoma of the brain: radiologic and histopathologic features.
Romero-Rojas AE, Diaz-Perez JA, Ariza-Serrano LM, Amaro D, Lozano-Castillo A
Neuroradiol J 2013 Dec;26(6):639-48. Epub 2013 Dec 18 doi: 10.1177/197140091302600606. PMID: 24355182Free PMC Article
The expression and localization of Prune2 mRNA in the central nervous system.
Li S, Itoh M, Ohta K, Ueda M, Mizuno A, Ohta E, Hida Y, Wang MX, Takeuchi K, Nakagawa T
Neurosci Lett 2011 Oct 10;503(3):208-14. Epub 2011 Aug 26 doi: 10.1016/j.neulet.2011.08.037. PMID: 21893162
Epithelioid leiomyosarcoma with rhabdoid features.
Yorulmaz G, Erdogan G, Pestereli HE, Savas B, Karaveli FS
Wien Klin Wochenschr 2007;119(17-18):557-60. doi: 10.1007/s00508-007-0822-3. PMID: 17943409

Recent systematic reviews

Surgically Treated Brain Metastases from Uterine Origin: A Case Series and Systematic Review.
Eatz T, Levy A, Merenzon M, Bystrom L, Berry K, Morell A, Bhatia S, Daggubati L, Higgins D, Schlumbrecht M, Komotar RJ, Shah AH, Ivan ME
World Neurosurg 2023 May;173:e91-e108. Epub 2023 Feb 11 doi: 10.1016/j.wneu.2023.02.007. PMID: 36775238

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