U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Papillary carcinoma of the penis

MedGen UID:
235455
•Concept ID:
C1335322
•
Neoplastic Process
Synonyms: Papillary Carcinoma of Penis; papillary carcinoma of penis; Papillary Carcinoma of the Penis; papillary carcinoma of the penis; Papillary Penile Carcinoma; papillary penile carcinoma; Papillary Penile Squamous Carcinoma; papillary penile squamous carcinoma; Papillary Squamous Carcinoma of Penis; papillary squamous carcinoma of penis; Papillary Squamous Carcinoma of the Penis; papillary squamous carcinoma of the penis; Penile Papillary Carcinoma; penis papillary carcinoma; Squamous Carcinoma of Penis, Papillary Type; squamous carcinoma of penis, papillary type; Squamous Carcinoma of the Penis, Papillary Type; squamous carcinoma of the penis, papillary type
 
Monarch Initiative: MONDO:0004433

Definition

A squamous cell carcinoma that arises from the penis and is characterized by the presence of a papillary growth pattern. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPapillary carcinoma of the penis

Professional guidelines

PubMed

Treatment of urethral recurrence following radical cystectomy and ileal bladder substitution.
Varol C, Thalmann GN, Burkhard FC, Studer UE
J Urol 2004 Sep;172(3):937-42. doi: 10.1097/01.ju.0000135626.91587.c8. PMID: 15311003
Diagnosis and management of superficial bladder cancer.
Amling CL
Curr Probl Cancer 2001 Jul-Aug;25(4):219-78. doi: 10.1067/mcn.2001.117539. PMID: 11514784
The treatment of bladder carcinoma.
Martinez-Piñeiro JA
Eur Urol 1975;1(2):68-70. PMID: 1241895

Recent clinical studies

Etiology

The 2022 revision of the World Health Organization classification of tumors of the urinary system and male genital organs: advances and challenges.
Mohanty SK, Lobo A, Cheng L
Hum Pathol 2023 Jun;136:123-143. Epub 2022 Sep 6 doi: 10.1016/j.humpath.2022.08.006. PMID: 36084769
Tumor lesions of penis and scrotum according to WHO classification 2022.
Michalová K, Beniač P, Kacerovská D
Cesk Patol 2022 Fall;67(4):192-197. PMID: 36513504
Basaloid squamous cell carcinoma of the penis with papillary features: a clinicopathologic study of 12 cases.
Cubilla AL, Lloveras B, Alemany L, Alejo M, Vidal A, Kasamatsu E, Clavero O, Alvarado-Cabrero I, Lynch C, Velasco-Alonso J, Ferrera A, Chaux A, Klaustermeier J, Quint W, de Sanjosé S, Muñoz N, Bosch FX
Am J Surg Pathol 2012 Jun;36(6):869-75. doi: 10.1097/PAS.0b013e318249c6f3. PMID: 22367299
Papillary squamous cell carcinoma, not otherwise specified (NOS) of the penis: clinicopathologic features, differential diagnosis, and outcome of 35 cases.
Chaux A, Soares F, Rodríguez I, Barreto J, Lezcano C, Torres J, Velazquez EF, Cubilla AL
Am J Surg Pathol 2010 Feb;34(2):223-30. doi: 10.1097/PAS.0b013e3181c7666e. PMID: 20061934
Pathologic features of epidermoid carcinoma of the penis. A prospective study of 66 cases.
Cubilla AL, Barreto J, Caballero C, Ayala G, Riveros M
Am J Surg Pathol 1993 Aug;17(8):753-63. doi: 10.1097/00000478-199308000-00001. PMID: 8338190

Diagnosis

Ductal adenocarcinoma of the prostate: histogenesis, biology and clinicopathological features.
Seipel AH, Delahunt B, Samaratunga H, Egevad L
Pathology 2016 Aug;48(5):398-405. Epub 2016 Jun 16 doi: 10.1016/j.pathol.2016.04.001. PMID: 27321992
Cystoscopic findings: a video tutorial.
Lenherr SM, Crosby EC, Cameron AP
Int Urogynecol J 2015 Jun;26(6):921-3. Epub 2015 Jan 27 doi: 10.1007/s00192-014-2614-4. PMID: 25619539Free PMC Article
Diagnostic problems in precancerous lesions and invasive carcinomas of the penis.
Chaux A, Cubilla AL
Semin Diagn Pathol 2012 May;29(2):72-82. doi: 10.1053/j.semdp.2011.08.002. PMID: 22641956
Diagnosis and management of superficial bladder cancer.
Amling CL
Curr Probl Cancer 2001 Jul-Aug;25(4):219-78. doi: 10.1067/mcn.2001.117539. PMID: 11514784
Buschke-Loewenstein tumor: verrucous carcinoma of the penis.
Schwartz RA
J Am Acad Dermatol 1990 Oct;23(4 Pt 1):723-7. doi: 10.1016/0190-9622(90)70281-l. PMID: 2229502

Therapy

Metastasis to the penis from a bladder carcinoma invading only the lamina propria: case report and description of the morphological aspects.
Stanimir M, Lorge F, D'Hondt L, Nollevaux MC, Di Gregorio M
Rom J Morphol Embryol 2023 Jan-Mar;64(1):89-94. doi: 10.47162/RJME.64.1.11. PMID: 37128796Free PMC Article
Metastatic squamous cell carcinoma of penis in an HIV-infected man presenting with cutaneous manifestations.
Binny B, Tambe S, Nayak C
Int J STD AIDS 2019 May;30(6):613-616. Epub 2019 Feb 4 doi: 10.1177/0956462418813069. PMID: 31074361
Diagnosis and management of superficial bladder cancer.
Amling CL
Curr Probl Cancer 2001 Jul-Aug;25(4):219-78. doi: 10.1067/mcn.2001.117539. PMID: 11514784
Influence of thiotepa and doxorubicin instillation at time of transurethral surgical treatment of bladder cancer on tumor recurrence: a prospective, randomized, double-blind, controlled trial.
Zincke H, Utz DC, Taylor WF, Myers RP, Leary FJ
J Urol 1983 Mar;129(3):505-9. doi: 10.1016/s0022-5347(17)52205-3. PMID: 6403716
Verrucous carcinoma of the penis: report of a case and review.
Smith RB, Young HH 2nd, Chaffey BT
Br J Urol 1969 Jun;41(3):327-31. doi: 10.1111/j.1464-410x.1969.tb11892.x. PMID: 5784603

Prognosis

Mixed papillary-sarcomatoid carcinoma of the penis: report of an aggressive subtype.
Bovolim G, da Costa WH, Guimaraes GC, Soares FA, da Cunha IW
Virchows Arch 2017 Dec;471(6):815-818. Epub 2017 Jul 8 doi: 10.1007/s00428-017-2191-2. PMID: 28689224
Ductal adenocarcinoma of the prostate: histogenesis, biology and clinicopathological features.
Seipel AH, Delahunt B, Samaratunga H, Egevad L
Pathology 2016 Aug;48(5):398-405. Epub 2016 Jun 16 doi: 10.1016/j.pathol.2016.04.001. PMID: 27321992
Diagnostic problems in precancerous lesions and invasive carcinomas of the penis.
Chaux A, Cubilla AL
Semin Diagn Pathol 2012 May;29(2):72-82. doi: 10.1053/j.semdp.2011.08.002. PMID: 22641956
Basaloid squamous cell carcinoma of the penis with papillary features: a clinicopathologic study of 12 cases.
Cubilla AL, Lloveras B, Alemany L, Alejo M, Vidal A, Kasamatsu E, Clavero O, Alvarado-Cabrero I, Lynch C, Velasco-Alonso J, Ferrera A, Chaux A, Klaustermeier J, Quint W, de Sanjosé S, Muñoz N, Bosch FX
Am J Surg Pathol 2012 Jun;36(6):869-75. doi: 10.1097/PAS.0b013e318249c6f3. PMID: 22367299
Verrucous carcinoma of skin.
Klima M, Kurtis B, Jordan PH Jr
J Cutan Pathol 1980 Apr;7(2):88-98. doi: 10.1111/j.1600-0560.1980.tb01187.x. PMID: 7372883

Clinical prediction guides

High prevalence of p16 staining in malignant tumors.
De Wispelaere N, Rico SD, Bauer M, Luebke AM, Kluth M, Büscheck F, Hube-Magg C, Höflmayer D, Gorbokon N, Weidemann S, Möller K, Fraune C, Bernreuther C, Simon R, Kähler C, Menz A, Hinsch A, Jacobsen F, Lebok P, Clauditz T, Sauter G, Uhlig R, Wilczak W, Steurer S, Burandt E, Krech R, Dum D, Krech T, Marx A, Minner S
PLoS One 2022;17(7):e0262877. Epub 2022 Jul 21 doi: 10.1371/journal.pone.0262877. PMID: 35862385Free PMC Article
Mixed papillary-sarcomatoid carcinoma of the penis: report of an aggressive subtype.
Bovolim G, da Costa WH, Guimaraes GC, Soares FA, da Cunha IW
Virchows Arch 2017 Dec;471(6):815-818. Epub 2017 Jul 8 doi: 10.1007/s00428-017-2191-2. PMID: 28689224
Cystoscopic findings: a video tutorial.
Lenherr SM, Crosby EC, Cameron AP
Int Urogynecol J 2015 Jun;26(6):921-3. Epub 2015 Jan 27 doi: 10.1007/s00192-014-2614-4. PMID: 25619539Free PMC Article
Basaloid squamous cell carcinoma of the penis with papillary features: a clinicopathologic study of 12 cases.
Cubilla AL, Lloveras B, Alemany L, Alejo M, Vidal A, Kasamatsu E, Clavero O, Alvarado-Cabrero I, Lynch C, Velasco-Alonso J, Ferrera A, Chaux A, Klaustermeier J, Quint W, de Sanjosé S, Muñoz N, Bosch FX
Am J Surg Pathol 2012 Jun;36(6):869-75. doi: 10.1097/PAS.0b013e318249c6f3. PMID: 22367299
The contribution of urethrocystoscopy to evaluation of lower urinary tract dysfunction in women.
Cundiff GW, Bent AE
Int Urogynecol J Pelvic Floor Dysfunct 1996;7(6):307-11. doi: 10.1007/BF01901104. PMID: 9203477

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...