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Uveal Spindle Cell Type B Melanoma

MedGen UID:
236839
•Concept ID:
C1336055
•
Neoplastic Process
Synonyms: Spindle Cell Type B Melanoma of the Uvea; Spindle Cell Type B Melanoma of Uvea; Spindle Cell Type B Uveal Melanoma

Definition

A uveal melanoma characterized by the presence of malignant spindle-shaped melanocytes with larger nuclei and distinct nucleoli. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUveal Spindle Cell Type B Melanoma

Professional guidelines

PubMed

Genetic findings in treatment-naïve and proton-beam-radiated iris melanomas.
Krishna Y, Kalirai H, Thornton S, Damato BE, Heimann H, Coupland SE
Br J Ophthalmol 2016 Jul;100(7):1012-1016. Epub 2016 Apr 20 doi: 10.1136/bjophthalmol-2015-308301. PMID: 27098748

Recent clinical studies

Etiology

Clinicopathological Characteristics and Prognosis for Survival after Enucleation of Uveal Melanoma in Chinese Patients: Long-term Follow-up.
Yue H, Qian J, Yuan Y, Zhang R, Bi Y, Meng F, Xuan Y
Curr Eye Res 2017 May;42(5):759-765. Epub 2016 Dec 2 doi: 10.1080/02713683.2016.1245422. PMID: 27911584
Genetic findings in treatment-naïve and proton-beam-radiated iris melanomas.
Krishna Y, Kalirai H, Thornton S, Damato BE, Heimann H, Coupland SE
Br J Ophthalmol 2016 Jul;100(7):1012-1016. Epub 2016 Apr 20 doi: 10.1136/bjophthalmol-2015-308301. PMID: 27098748
Inverse correlation between expression of HLA-B and c-myc in uveal melanoma.
Blom DJ, Mooy CM, Luyten GP, Kerkvliet S, Ouwerkerk I, Zwinderman AH, Schrier PI, Jager MJ
J Pathol 1997 Jan;181(1):75-9. doi: 10.1002/(SICI)1096-9896(199701)181:1<75::AID-PATH724>3.0.CO;2-V. PMID: 9072006
Are most iris "melanomas' really nevi? A clinicopathologic study of 189 lesions.
Jakobiec FA, Silbert G
Arch Ophthalmol 1981 Dec;99(12):2117-32. doi: 10.1001/archopht.1981.03930020993002. PMID: 7305709
Reappraisal of Callender's spindle a type of malignant melanoma of choroid and ciliary body.
McLean IW, Zimmerman LE, Evans RM
Am J Ophthalmol 1978 Oct;86(4):557-64. doi: 10.1016/0002-9394(78)90307-0. PMID: 707604

Diagnosis

Locally advanced choroidal melanoma with favorable molecular prognosis - case report.
Bălăşoiu AT, Ştefănescu-Dima AŞ, Bălăşoiu M, Ciurea RN, Muraru A, Dan AO, Simionescu CE
Rom J Morphol Embryol 2022 Oct-Dec;63(4):645-652. doi: 10.47162/RJME.63.4.07. PMID: 36808200Free PMC Article
Iris Melanoma in a Child Simulating Juvenile Xanthogranuloma.
Shields JA, Shields CL, Lally SE, Milman T, Eagle RC
Middle East Afr J Ophthalmol 2018 Apr-Jun;25(2):115-117. doi: 10.4103/meajo.MEAJO_7_18. PMID: 30122859Free PMC Article
Clinicopathological Characteristics and Prognosis for Survival after Enucleation of Uveal Melanoma in Chinese Patients: Long-term Follow-up.
Yue H, Qian J, Yuan Y, Zhang R, Bi Y, Meng F, Xuan Y
Curr Eye Res 2017 May;42(5):759-765. Epub 2016 Dec 2 doi: 10.1080/02713683.2016.1245422. PMID: 27911584
Cavitary choroidal melanoma.
Becerra EM, Saornil MA, Blanco G, Méndez MC, Muiños Y, Esteban MR
Can J Ophthalmol 2005 Oct;40(5):619-22. doi: 10.1016/S0008-4182(05)80057-2. PMID: 16391628
Immunohistochemical diagnosis of malignant melanoma of the conjunctiva and uvea: comparison of the novel antibody against melan-A with S100 protein and HMB-45.
Heegaard S, Jensen OA, Prause JU
Melanoma Res 2000 Aug;10(4):350-4. doi: 10.1097/00008390-200008000-00006. PMID: 10985669

Therapy

Heterotransplantation of human uveal melanoma.
Liggett PE, Lo G, Pince KJ, Rao NA, Pascal SG, Kan-Mitchel J
Graefes Arch Clin Exp Ophthalmol 1993;231(1):15-20. doi: 10.1007/BF01681695. PMID: 8428676
Uveal melanomas: correlation of cytologic features with prognosis.
Gamel JW, McLean IW, Foster WD, Zimmerman LE
Cancer 1978 May;41(5):1897-901. doi: 10.1002/1097-0142(197805)41:5<1897::aid-cncr2820410534>3.0.co;2-2. PMID: 647633

Prognosis

Locally advanced choroidal melanoma with favorable molecular prognosis - case report.
Bălăşoiu AT, Ştefănescu-Dima AŞ, Bălăşoiu M, Ciurea RN, Muraru A, Dan AO, Simionescu CE
Rom J Morphol Embryol 2022 Oct-Dec;63(4):645-652. doi: 10.47162/RJME.63.4.07. PMID: 36808200Free PMC Article
Clinicopathological Characteristics and Prognosis for Survival after Enucleation of Uveal Melanoma in Chinese Patients: Long-term Follow-up.
Yue H, Qian J, Yuan Y, Zhang R, Bi Y, Meng F, Xuan Y
Curr Eye Res 2017 May;42(5):759-765. Epub 2016 Dec 2 doi: 10.1080/02713683.2016.1245422. PMID: 27911584
Genetic findings in treatment-naïve and proton-beam-radiated iris melanomas.
Krishna Y, Kalirai H, Thornton S, Damato BE, Heimann H, Coupland SE
Br J Ophthalmol 2016 Jul;100(7):1012-1016. Epub 2016 Apr 20 doi: 10.1136/bjophthalmol-2015-308301. PMID: 27098748
Matrix metalloproteinase-2 (MMP-2) immunoreactive protein--a new prognostic marker in uveal melanoma?
Väisänen A, Kallioinen M, von Dickhoff K, Laatikainen L, Höyhtyä M, Turpeenniemi-Hujanen T
J Pathol 1999 May;188(1):56-62. doi: 10.1002/(SICI)1096-9896(199905)188:1<56::AID-PATH304>3.0.CO;2-B. PMID: 10398141
Reappraisal of Callender's spindle a type of malignant melanoma of choroid and ciliary body.
McLean IW, Zimmerman LE, Evans RM
Am J Ophthalmol 1978 Oct;86(4):557-64. doi: 10.1016/0002-9394(78)90307-0. PMID: 707604

Clinical prediction guides

Clinicopathological Characteristics and Prognosis for Survival after Enucleation of Uveal Melanoma in Chinese Patients: Long-term Follow-up.
Yue H, Qian J, Yuan Y, Zhang R, Bi Y, Meng F, Xuan Y
Curr Eye Res 2017 May;42(5):759-765. Epub 2016 Dec 2 doi: 10.1080/02713683.2016.1245422. PMID: 27911584
Expression and distribution of MMPs and TIMPs in human uveal melanoma.
Lai K, Conway RM, Crouch R, Jager MJ, Madigan MC
Exp Eye Res 2008 Jun;86(6):936-41. Epub 2008 Mar 16 doi: 10.1016/j.exer.2008.03.010. PMID: 18423620
Matrix metalloproteinase-2 (MMP-2) immunoreactive protein--a new prognostic marker in uveal melanoma?
Väisänen A, Kallioinen M, von Dickhoff K, Laatikainen L, Höyhtyä M, Turpeenniemi-Hujanen T
J Pathol 1999 May;188(1):56-62. doi: 10.1002/(SICI)1096-9896(199905)188:1<56::AID-PATH304>3.0.CO;2-B. PMID: 10398141
Inverse correlation between expression of HLA-B and c-myc in uveal melanoma.
Blom DJ, Mooy CM, Luyten GP, Kerkvliet S, Ouwerkerk I, Zwinderman AH, Schrier PI, Jager MJ
J Pathol 1997 Jan;181(1):75-9. doi: 10.1002/(SICI)1096-9896(199701)181:1<75::AID-PATH724>3.0.CO;2-V. PMID: 9072006
Reappraisal of Callender's spindle a type of malignant melanoma of choroid and ciliary body.
McLean IW, Zimmerman LE, Evans RM
Am J Ophthalmol 1978 Oct;86(4):557-64. doi: 10.1016/0002-9394(78)90307-0. PMID: 707604

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