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Undifferentiated pancreatic carcinoma

MedGen UID:
237030
•Concept ID:
C1336861
•
Neoplastic Process
Synonyms: pancreas undifferentiated carcinoma; Pancreatic Carcinosarcoma; pancreatic carcinosarcoma; Pancreatic Undifferentiated Carcinoma; Pleomorphic Large Cell Pancreatic Carcinoma; pleomorphic large cell pancreatic carcinoma; Sarcomatoid Pancreatic Carcinoma; sarcomatoid pancreatic carcinoma; Spindle Cell Pancreatic Carcinoma; spindle cell pancreatic carcinoma; UCP; Undifferentiated (Anaplastic) Pancreatic Carcinoma; undifferentiated (anaplastic) pancreatic carcinoma; Undifferentiated Carcinoma of Pancreas; undifferentiated carcinoma of pancreas; Undifferentiated Carcinoma of the Pancreas; undifferentiated carcinoma of the pancreas; Undifferentiated Pancreatic Carcinoma; undifferentiated pancreatic carcinoma
 
Monarch Initiative: MONDO:0006478

Definition

A carcinoma with poor prognosis that arises from the pancreas. It is characterized by the presence of a significant malignant component that does not show differentiation. The malignant cells represent a mixture of large, pleomorphic cells and giant cells, or adenocarcinoma cells and spindle cells, or spindle cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUndifferentiated pancreatic carcinoma

Professional guidelines

PubMed

Radiotherapy in the management of rare gastrointestinal cancers: A systematic review.
Bellefkih FZ, Benchakroun N, Lalya I, Amaoui B, El Kacemi H, Acharki A, El Hfid M, El Mazghi A, Chekrine T, Bouchbika Z, Jouhadi H, Sahraoui S, Tawfiq N, Michalet M
Cancer Radiother 2023 Sep;27(6-7):622-637. Epub 2023 Jul 25 doi: 10.1016/j.canrad.2023.06.010. PMID: 37500390
Comprehensive review of undifferentiated carcinoma of the pancreas: from epidemiology to treatment.
Imaoka H, Ikeda M, Umemoto K, Sunakawa Y, Ueno M, Ueno H, Ozaka M, Kuwahara T, Okano N, Kanai M, Hisano T, Suzuki Y, Asagi A, Shioji K, Todaka A, Tsuji K, Ikezawa K, Miki I, Komatsu Y, Akutsu N, Yamashita T, Okuyama H, Furuse J, Nagano H
Jpn J Clin Oncol 2023 Aug 30;53(9):764-773. doi: 10.1093/jjco/hyad062. PMID: 37325968Free PMC Article
Adjuvant Therapy for Stage II Colon Cancer: ASCO Guideline Update.
Baxter NN, Kennedy EB, Bergsland E, Berlin J, George TJ, Gill S, Gold PJ, Hantel A, Jones L, Lieu C, Mahmoud N, Morris AM, Ruiz-Garcia E, You YN, Meyerhardt JA
J Clin Oncol 2022 Mar 10;40(8):892-910. Epub 2021 Dec 22 doi: 10.1200/JCO.21.02538. PMID: 34936379

Recent clinical studies

Etiology

Long-term survival after resection of sarcomatoid carcinoma of the pancreas: an updated experience.
Blair AB, Burkhart RA, Griffin JF, Miller JA, Weiss MJ, Cameron JL, Wolfgang CL, He J
J Surg Res 2017 Nov;219:238-243. Epub 2017 Jul 3 doi: 10.1016/j.jss.2017.05.065. PMID: 29078888Free PMC Article
Undifferentiated Pancreatic Carcinomas Display Enrichment for Frequency and Extent of PD-L1 Expression by Tumor Cells.
Lehrke HD, Graham RP, McWilliams RR, Lam-Himlin DM, Smyrk TC, Jenkins S, Dong H, Zhang L
Am J Clin Pathol 2017 Nov 2;148(5):441-449. doi: 10.1093/ajcp/aqx092. PMID: 29069274
Expression of L1CAM, COX-2, EGFR, c-KIT and Her2/neu in anaplastic pancreatic cancer: putative therapeutic targets?
Bergmann F, Moldenhauer G, Herpel E, Gaida MM, Strobel O, Werner J, Esposito I, Müerköster SS, Schirmacher P, Kern MA
Histopathology 2010 Mar;56(4):440-8. doi: 10.1111/j.1365-2559.2010.03499.x. PMID: 20459551

Diagnosis

Is pancreatic giant cell tumor resistant to standard chemotherapy?
Çağlayan D, Karakurt Eryilmaz M, Korkmaz M, Karaağaç M, Hendem E, Artaç M
Anticancer Drugs 2022 Sep 1;33(8):758-760. Epub 2022 Aug 10 doi: 10.1097/CAD.0000000000001331. PMID: 35946539
Assessment and management of undifferentiated carcinoma with osteoclastic like giant cells of the pancreas: a case report and revision of literature.
Cavalcanti E, Schena N, Serino G, Lantone G, Armentano R
BMC Gastroenterol 2021 Jun 2;21(1):247. doi: 10.1186/s12876-021-01779-5. PMID: 34078293Free PMC Article
Expression of Calretinin, Marker of Mesothelial Differentiation, in Pancreatic Ductal Adenocarcinoma: A Potential Diagnostic Pitfall.
Askan G, Basturk O
Turk Patoloji Derg 2021;37(2):115-120. doi: 10.5146/tjpath.2020.01519. PMID: 33432559Free PMC Article
Long-term survival after resection of sarcomatoid carcinoma of the pancreas: an updated experience.
Blair AB, Burkhart RA, Griffin JF, Miller JA, Weiss MJ, Cameron JL, Wolfgang CL, He J
J Surg Res 2017 Nov;219:238-243. Epub 2017 Jul 3 doi: 10.1016/j.jss.2017.05.065. PMID: 29078888Free PMC Article
Cytologic features and clinical implications of undifferentiated carcinoma with osteoclastic giant cells of the pancreas: An analysis of 15 cases.
Reid MD, Muraki T, HooKim K, Memis B, Graham RP, Allende D, Shi J, Schaeffer DF, Singh R, Basturk O, Adsay V
Cancer Cytopathol 2017 Jul;125(7):563-575. Epub 2017 Apr 3 doi: 10.1002/cncy.21859. PMID: 28371566

Therapy

Undifferentiated Carcinoma of the Pancreas - a Case Report.
Kašperová B, Jurišová S, Macúch J, Bumberová M, Janega P, Dolinský J, Mego M
Klin Onkol 2018 Winter;31(6):453-456. doi: 10.14735/amko2018453. PMID: 31035768
Expression of L1CAM, COX-2, EGFR, c-KIT and Her2/neu in anaplastic pancreatic cancer: putative therapeutic targets?
Bergmann F, Moldenhauer G, Herpel E, Gaida MM, Strobel O, Werner J, Esposito I, Müerköster SS, Schirmacher P, Kern MA
Histopathology 2010 Mar;56(4):440-8. doi: 10.1111/j.1365-2559.2010.03499.x. PMID: 20459551
UCN-01 (7-hydroxystaurosporine) enhances 5-fluorouracil cytotoxicity through down-regulation of thymidylate synthetase messenger RNA.
Abe S, Kubota T, Otani Y, Furukawa T, Watanabe M, Kumai K, Kitajima M
Jpn J Cancer Res 2000 Nov;91(11):1192-8. doi: 10.1111/j.1349-7006.2000.tb00904.x. PMID: 11092986Free PMC Article

Prognosis

Is pancreatic giant cell tumor resistant to standard chemotherapy?
Çağlayan D, Karakurt Eryilmaz M, Korkmaz M, Karaağaç M, Hendem E, Artaç M
Anticancer Drugs 2022 Sep 1;33(8):758-760. Epub 2022 Aug 10 doi: 10.1097/CAD.0000000000001331. PMID: 35946539
Assessment and management of undifferentiated carcinoma with osteoclastic like giant cells of the pancreas: a case report and revision of literature.
Cavalcanti E, Schena N, Serino G, Lantone G, Armentano R
BMC Gastroenterol 2021 Jun 2;21(1):247. doi: 10.1186/s12876-021-01779-5. PMID: 34078293Free PMC Article
Undifferentiated Pancreatic Carcinoma with Osteoclast-like Giant Cells: a Review and Case Report Analysis.
Kharkhach A, Bouhout T, Serji B, El Harroudi T
J Gastrointest Cancer 2021 Sep;52(3):1106-1113. Epub 2021 Jan 14 doi: 10.1007/s12029-021-00583-4. PMID: 33447945
Expression of Calretinin, Marker of Mesothelial Differentiation, in Pancreatic Ductal Adenocarcinoma: A Potential Diagnostic Pitfall.
Askan G, Basturk O
Turk Patoloji Derg 2021;37(2):115-120. doi: 10.5146/tjpath.2020.01519. PMID: 33432559Free PMC Article
Cytologic features and clinical implications of undifferentiated carcinoma with osteoclastic giant cells of the pancreas: An analysis of 15 cases.
Reid MD, Muraki T, HooKim K, Memis B, Graham RP, Allende D, Shi J, Schaeffer DF, Singh R, Basturk O, Adsay V
Cancer Cytopathol 2017 Jul;125(7):563-575. Epub 2017 Apr 3 doi: 10.1002/cncy.21859. PMID: 28371566

Clinical prediction guides

Assessment and management of undifferentiated carcinoma with osteoclastic like giant cells of the pancreas: a case report and revision of literature.
Cavalcanti E, Schena N, Serino G, Lantone G, Armentano R
BMC Gastroenterol 2021 Jun 2;21(1):247. doi: 10.1186/s12876-021-01779-5. PMID: 34078293Free PMC Article
Metastatic Infiltration of Anaplastic Carcinoma of the Pancreas Into the Portal Venous System: A Masquerading Cause of Expansive Portal Venous Thrombosis.
Hirakawa Y, Tago M, Katsuki NE, Makio S, Yamashita SI
Am J Case Rep 2021 Mar 26;22:e929678. doi: 10.12659/AJCR.929678. PMID: 33767127Free PMC Article
Expression of Calretinin, Marker of Mesothelial Differentiation, in Pancreatic Ductal Adenocarcinoma: A Potential Diagnostic Pitfall.
Askan G, Basturk O
Turk Patoloji Derg 2021;37(2):115-120. doi: 10.5146/tjpath.2020.01519. PMID: 33432559Free PMC Article
Undifferentiated Carcinoma of the Pancreas - a Case Report.
Kašperová B, Jurišová S, Macúch J, Bumberová M, Janega P, Dolinský J, Mego M
Klin Onkol 2018 Winter;31(6):453-456. doi: 10.14735/amko2018453. PMID: 31035768
Cytologic features and clinical implications of undifferentiated carcinoma with osteoclastic giant cells of the pancreas: An analysis of 15 cases.
Reid MD, Muraki T, HooKim K, Memis B, Graham RP, Allende D, Shi J, Schaeffer DF, Singh R, Basturk O, Adsay V
Cancer Cytopathol 2017 Jul;125(7):563-575. Epub 2017 Apr 3 doi: 10.1002/cncy.21859. PMID: 28371566

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