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Neoplasm of myocardium

MedGen UID:
266216
•Concept ID:
C1290402
•
Neoplastic Process
Synonyms: Myocardial Neoplasm; myocardial neoplasm; Myocardial Tumor; myocardial tumor; myocardial tumour; myocardium neoplasm; myocardium neoplasm (disease); myocardium tumor; myocardium tumour; Neoplasm of Myocardium; neoplasm of myocardium; Neoplasm of the Myocardium; neoplasm of the myocardium; Tumor of Myocardium; tumor of myocardium; Tumor of the Myocardium; tumor of the myocardium; tumour of myocardium; tumour of the myocardium
SNOMED CT: Neoplasm of myocardium (126732009)
 
Monarch Initiative: MONDO:0021380

Definition

A benign or malignant neoplasm that affects the myocardium. [from NCI]

Professional guidelines

PubMed

MicroRNA in the Diagnosis and Treatment of Doxorubicin-Induced Cardiotoxicity.
Kuang Z, Wu J, Tan Y, Zhu G, Li J, Wu M
Biomolecules 2023 Mar 20;13(3) doi: 10.3390/biom13030568. PMID: 36979503Free PMC Article
Immune Checkpoint Inhibitor Myocarditis: Pathophysiological Characteristics, Diagnosis, and Treatment.
Palaskas N, Lopez-Mattei J, Durand JB, Iliescu C, Deswal A
J Am Heart Assoc 2020 Jan 21;9(2):e013757. doi: 10.1161/JAHA.119.013757. PMID: 31960755Free PMC Article
Cardiac Amyloidosis: Diagnosis and Treatment Strategies.
Tuzovic M, Yang EH, Baas AS, Depasquale EC, Deng MC, Cruz D, Vorobiof G
Curr Oncol Rep 2017 Jul;19(7):46. doi: 10.1007/s11912-017-0607-4. PMID: 28528458

Recent clinical studies

Etiology

Exosomes secreted from cardiomyocytes suppress the sensitivity of tumor ferroptosis in ischemic heart failure.
Yuan Y, Mei Z, Qu Z, Li G, Yu S, Liu Y, Liu K, Shen Z, Pu J, Wang Y, Wang C, Sun Z, Liu Q, Pang X, Wang A, Ren Z, Wang T, Liu Y, Hong J, Xie J, Li X, Wang Z, Du W, Yang B
Signal Transduct Target Ther 2023 Mar 27;8(1):121. doi: 10.1038/s41392-023-01336-4. PMID: 36967385Free PMC Article
The Role of Biomarkers in Cardio-Oncology.
Ananthan K, Lyon AR
J Cardiovasc Transl Res 2020 Jun;13(3):431-450. Epub 2020 Jul 8 doi: 10.1007/s12265-020-10042-3. PMID: 32642841Free PMC Article
Immune Checkpoint Inhibitor Myocarditis: Pathophysiological Characteristics, Diagnosis, and Treatment.
Palaskas N, Lopez-Mattei J, Durand JB, Iliescu C, Deswal A
J Am Heart Assoc 2020 Jan 21;9(2):e013757. doi: 10.1161/JAHA.119.013757. PMID: 31960755Free PMC Article
Multiparametric Echocardiography Scores for the Diagnosis of Cardiac Amyloidosis.
Boldrini M, Cappelli F, Chacko L, Restrepo-Cordoba MA, Lopez-Sainz A, Giannoni A, Aimo A, Baggiano A, Martinez-Naharro A, Whelan C, Quarta C, Passino C, Castiglione V, Chubuchnyi V, Spini V, Taddei C, Vergaro G, Petrie A, Ruiz-Guerrero L, Moñivas V, Mingo-Santos S, Mirelis JG, Dominguez F, Gonzalez-Lopez E, Perlini S, Pontone G, Gillmore J, Hawkins PN, Garcia-Pavia P, Emdin M, Fontana M
JACC Cardiovasc Imaging 2020 Apr;13(4):909-920. Epub 2019 Dec 18 doi: 10.1016/j.jcmg.2019.10.011. PMID: 31864973
Cardioprotective strategies to prevent breast cancer therapy-induced cardiotoxicity.
Padegimas A, Clasen S, Ky B
Trends Cardiovasc Med 2020 Jan;30(1):22-28. Epub 2019 Jan 29 doi: 10.1016/j.tcm.2019.01.006. PMID: 30745071Free PMC Article

Diagnosis

Emerging role of PET/MR in the diagnosis and characterization of cardiotoxicity?
Schindler TH, Sivapackiam J, Sharma V
Int J Cardiol 2023 Aug 15;385:82-84. Epub 2023 May 16 doi: 10.1016/j.ijcard.2023.05.022. PMID: 37201611
Cardiac Neoplasms: Radiologic-Pathologic Correlation.
Lichtenberger JP 3rd, Carter BW, Pavio MA, Biko DM
Radiol Clin North Am 2021 Mar;59(2):231-242. Epub 2020 Dec 29 doi: 10.1016/j.rcl.2020.10.002. PMID: 33551084
Immune Checkpoint Inhibitor Myocarditis: Pathophysiological Characteristics, Diagnosis, and Treatment.
Palaskas N, Lopez-Mattei J, Durand JB, Iliescu C, Deswal A
J Am Heart Assoc 2020 Jan 21;9(2):e013757. doi: 10.1161/JAHA.119.013757. PMID: 31960755Free PMC Article
MRI of Cardiotoxicity.
Jordan JH, Hundley WG
Cardiol Clin 2019 Nov;37(4):429-439. Epub 2019 Aug 31 doi: 10.1016/j.ccl.2019.07.007. PMID: 31587784Free PMC Article
Catecholamine-induced cardiomyopathy.
Kassim TA, Clarke DD, Mai VQ, Clyde PW, Mohamed Shakir KM
Endocr Pract 2008 Dec;14(9):1137-49. doi: 10.4158/EP.14.9.1137. PMID: 19158054

Therapy

The Role of Biomarkers in Cardio-Oncology.
Ananthan K, Lyon AR
J Cardiovasc Transl Res 2020 Jun;13(3):431-450. Epub 2020 Jul 8 doi: 10.1007/s12265-020-10042-3. PMID: 32642841Free PMC Article
Immune Checkpoint Inhibitor Myocarditis: Pathophysiological Characteristics, Diagnosis, and Treatment.
Palaskas N, Lopez-Mattei J, Durand JB, Iliescu C, Deswal A
J Am Heart Assoc 2020 Jan 21;9(2):e013757. doi: 10.1161/JAHA.119.013757. PMID: 31960755Free PMC Article
Cardioprotective strategies to prevent breast cancer therapy-induced cardiotoxicity.
Padegimas A, Clasen S, Ky B
Trends Cardiovasc Med 2020 Jan;30(1):22-28. Epub 2019 Jan 29 doi: 10.1016/j.tcm.2019.01.006. PMID: 30745071Free PMC Article
MRI of Cardiotoxicity.
Jordan JH, Hundley WG
Cardiol Clin 2019 Nov;37(4):429-439. Epub 2019 Aug 31 doi: 10.1016/j.ccl.2019.07.007. PMID: 31587784Free PMC Article
Fulminant Myocarditis with Combination Immune Checkpoint Blockade.
Johnson DB, Balko JM, Compton ML, Chalkias S, Gorham J, Xu Y, Hicks M, Puzanov I, Alexander MR, Bloomer TL, Becker JR, Slosky DA, Phillips EJ, Pilkinton MA, Craig-Owens L, Kola N, Plautz G, Reshef DS, Deutsch JS, Deering RP, Olenchock BA, Lichtman AH, Roden DM, Seidman CE, Koralnik IJ, Seidman JG, Hoffman RD, Taube JM, Diaz LA Jr, Anders RA, Sosman JA, Moslehi JJ
N Engl J Med 2016 Nov 3;375(18):1749-1755. doi: 10.1056/NEJMoa1609214. PMID: 27806233Free PMC Article

Prognosis

The Role of Biomarkers in Cardio-Oncology.
Ananthan K, Lyon AR
J Cardiovasc Transl Res 2020 Jun;13(3):431-450. Epub 2020 Jul 8 doi: 10.1007/s12265-020-10042-3. PMID: 32642841Free PMC Article
Multiparametric Echocardiography Scores for the Diagnosis of Cardiac Amyloidosis.
Boldrini M, Cappelli F, Chacko L, Restrepo-Cordoba MA, Lopez-Sainz A, Giannoni A, Aimo A, Baggiano A, Martinez-Naharro A, Whelan C, Quarta C, Passino C, Castiglione V, Chubuchnyi V, Spini V, Taddei C, Vergaro G, Petrie A, Ruiz-Guerrero L, Moñivas V, Mingo-Santos S, Mirelis JG, Dominguez F, Gonzalez-Lopez E, Perlini S, Pontone G, Gillmore J, Hawkins PN, Garcia-Pavia P, Emdin M, Fontana M
JACC Cardiovasc Imaging 2020 Apr;13(4):909-920. Epub 2019 Dec 18 doi: 10.1016/j.jcmg.2019.10.011. PMID: 31864973
Cardioprotective strategies to prevent breast cancer therapy-induced cardiotoxicity.
Padegimas A, Clasen S, Ky B
Trends Cardiovasc Med 2020 Jan;30(1):22-28. Epub 2019 Jan 29 doi: 10.1016/j.tcm.2019.01.006. PMID: 30745071Free PMC Article
Fulminant Myocarditis with Combination Immune Checkpoint Blockade.
Johnson DB, Balko JM, Compton ML, Chalkias S, Gorham J, Xu Y, Hicks M, Puzanov I, Alexander MR, Bloomer TL, Becker JR, Slosky DA, Phillips EJ, Pilkinton MA, Craig-Owens L, Kola N, Plautz G, Reshef DS, Deutsch JS, Deering RP, Olenchock BA, Lichtman AH, Roden DM, Seidman CE, Koralnik IJ, Seidman JG, Hoffman RD, Taube JM, Diaz LA Jr, Anders RA, Sosman JA, Moslehi JJ
N Engl J Med 2016 Nov 3;375(18):1749-1755. doi: 10.1056/NEJMoa1609214. PMID: 27806233Free PMC Article
Spectrum and Degree of CDK Drug Interactions Predicts Clinical Performance.
Chen P, Lee NV, Hu W, Xu M, Ferre RA, Lam H, Bergqvist S, Solowiej J, Diehl W, He YA, Yu X, Nagata A, VanArsdale T, Murray BW
Mol Cancer Ther 2016 Oct;15(10):2273-2281. Epub 2016 Aug 5 doi: 10.1158/1535-7163.MCT-16-0300. PMID: 27496135

Clinical prediction guides

The Role of Biomarkers in Cardio-Oncology.
Ananthan K, Lyon AR
J Cardiovasc Transl Res 2020 Jun;13(3):431-450. Epub 2020 Jul 8 doi: 10.1007/s12265-020-10042-3. PMID: 32642841Free PMC Article
Multiparametric Echocardiography Scores for the Diagnosis of Cardiac Amyloidosis.
Boldrini M, Cappelli F, Chacko L, Restrepo-Cordoba MA, Lopez-Sainz A, Giannoni A, Aimo A, Baggiano A, Martinez-Naharro A, Whelan C, Quarta C, Passino C, Castiglione V, Chubuchnyi V, Spini V, Taddei C, Vergaro G, Petrie A, Ruiz-Guerrero L, Moñivas V, Mingo-Santos S, Mirelis JG, Dominguez F, Gonzalez-Lopez E, Perlini S, Pontone G, Gillmore J, Hawkins PN, Garcia-Pavia P, Emdin M, Fontana M
JACC Cardiovasc Imaging 2020 Apr;13(4):909-920. Epub 2019 Dec 18 doi: 10.1016/j.jcmg.2019.10.011. PMID: 31864973
Spectrum and Degree of CDK Drug Interactions Predicts Clinical Performance.
Chen P, Lee NV, Hu W, Xu M, Ferre RA, Lam H, Bergqvist S, Solowiej J, Diehl W, He YA, Yu X, Nagata A, VanArsdale T, Murray BW
Mol Cancer Ther 2016 Oct;15(10):2273-2281. Epub 2016 Aug 5 doi: 10.1158/1535-7163.MCT-16-0300. PMID: 27496135
Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity.
Burridge PW, Li YF, Matsa E, Wu H, Ong SG, Sharma A, Holmström A, Chang AC, Coronado MJ, Ebert AD, Knowles JW, Telli ML, Witteles RM, Blau HM, Bernstein D, Altman RB, Wu JC
Nat Med 2016 May;22(5):547-56. Epub 2016 Apr 18 doi: 10.1038/nm.4087. PMID: 27089514Free PMC Article
Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma.
Linette GP, Stadtmauer EA, Maus MV, Rapoport AP, Levine BL, Emery L, Litzky L, Bagg A, Carreno BM, Cimino PJ, Binder-Scholl GK, Smethurst DP, Gerry AB, Pumphrey NJ, Bennett AD, Brewer JE, Dukes J, Harper J, Tayton-Martin HK, Jakobsen BK, Hassan NJ, Kalos M, June CH
Blood 2013 Aug 8;122(6):863-71. Epub 2013 Jun 14 doi: 10.1182/blood-2013-03-490565. PMID: 23770775Free PMC Article

Recent systematic reviews

MRI-derived extracellular volume as a biomarker of cancer therapy cardiotoxicity: systematic review and meta-analysis.
Folco G, Monti CB, Zanardo M, Silletta F, Capra D, Secchi F, Sardanelli F
Eur Radiol 2024 Apr;34(4):2699-2710. Epub 2023 Oct 12 doi: 10.1007/s00330-023-10260-8. PMID: 37823922Free PMC Article
The benign nature and rare occurrence of cardiac myxoma as a possible consequence of the limited cardiac proliferative/ regenerative potential: a systematic review.
Shafi O, Siddiqui G, Jaffry HA
BMC Cancer 2023 Dec 18;23(1):1245. doi: 10.1186/s12885-023-11723-3. PMID: 38110859Free PMC Article
Hamartoma of mature cardiac myocytes: systematic review.
Techasatian W, Gozun M, Morihara C, Pham A, Benavente K, Nagamine T, Nishimura Y
Cardiovasc Pathol 2023 Jul-Aug;65:107538. Epub 2023 Apr 7 doi: 10.1016/j.carpath.2023.107538. PMID: 37031829
AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review.
Višnjić D, Lalić H, Dembitz V, Tomić B, Smoljo T
Cells 2021 May 4;10(5) doi: 10.3390/cells10051095. PMID: 34064363Free PMC Article
From pathogenesis to treatment, a systemic review of cardiac lipoma.
Shu S, Wang J, Zheng C
J Cardiothorac Surg 2021 Jan 6;16(1):1. doi: 10.1186/s13019-020-01379-6. PMID: 33407682Free PMC Article

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