U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Benign ovarian mucinous tumor

MedGen UID:
267038
•Concept ID:
C1511100
•
Neoplastic Process
Synonyms: Benign Ovarian Mucinous Neoplasm; benign ovarian mucinous neoplasm; Benign Ovarian Mucinous Tumor; benign ovarian mucinous tumor; ovarian mucinous neoplasm, benign
 
Monarch Initiative: MONDO:0036915

Definition

A non-metastasizing neoplasm that arises from the ovary and is characterized by the presence of neoplastic epithelium that resembles the epithelium of the endocervix or gastrointestinal tract. There is no evidence of atypia. It includes mucinous adenofibroma, mucinous cystadenofibroma, and mucinous cystadenoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign ovarian mucinous tumor

Professional guidelines

PubMed

Retrospective Study of the Epidemiology, Pathology, and Therapeutic Management in Patients With Mucinous Ovarian Tumors.
Zhang Y, Li C, Luo S, Su Y, Gang X, Chu P, Zhang J, Wu H, Liu G
Technol Cancer Res Treat 2020 Jan-Dec;19:1533033820946423. doi: 10.1177/1533033820946423. PMID: 32783505Free PMC Article

Recent clinical studies

Etiology

Mucinous Ovarian Tumors.
Mills AM, Shanes ED
Surg Pathol Clin 2019 Jun;12(2):565-585. doi: 10.1016/j.path.2019.01.008. PMID: 31097115
Recent Insights into Mucinous Ovarian Carcinoma.
Ricci F, Affatato R, Carrassa L, Damia G
Int J Mol Sci 2018 May 24;19(6) doi: 10.3390/ijms19061569. PMID: 29795040Free PMC Article
Pathology of borderline and invasive cancers.
Prat J
Best Pract Res Clin Obstet Gynaecol 2017 May;41:15-30. Epub 2016 Oct 3 doi: 10.1016/j.bpobgyn.2016.08.007. PMID: 28277307
The Dualistic Model of Ovarian Carcinogenesis: Revisited, Revised, and Expanded.
Kurman RJ, Shih IeM
Am J Pathol 2016 Apr;186(4):733-47. doi: 10.1016/j.ajpath.2015.11.011. PMID: 27012190Free PMC Article
The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory.
Kurman RJ, Shih IeM
Am J Surg Pathol 2010 Mar;34(3):433-43. doi: 10.1097/PAS.0b013e3181cf3d79. PMID: 20154587Free PMC Article

Diagnosis

Mucinous Ovarian Tumors.
Mills AM, Shanes ED
Surg Pathol Clin 2019 Jun;12(2):565-585. doi: 10.1016/j.path.2019.01.008. PMID: 31097115
Recent Insights into Mucinous Ovarian Carcinoma.
Ricci F, Affatato R, Carrassa L, Damia G
Int J Mol Sci 2018 May 24;19(6) doi: 10.3390/ijms19061569. PMID: 29795040Free PMC Article
Mucinous epithelial ovarian carcinoma.
Perren TJ
Ann Oncol 2016 Apr;27 Suppl 1:i53-i57. doi: 10.1093/annonc/mdw087. PMID: 27141073
Pathology of the adnexal mass.
Bennett JA, Oliva E
Clin Obstet Gynecol 2015 Mar;58(1):3-27. doi: 10.1097/GRF.0000000000000082. PMID: 25608250
Mucinous tumors of the ovary: current thoughts on diagnosis and management.
Brown J, Frumovitz M
Curr Oncol Rep 2014 Jun;16(6):389. doi: 10.1007/s11912-014-0389-x. PMID: 24777667Free PMC Article

Therapy

Mucinous epithelial ovarian carcinoma.
Perren TJ
Ann Oncol 2016 Apr;27 Suppl 1:i53-i57. doi: 10.1093/annonc/mdw087. PMID: 27141073
Clinical outcomes in patients with isolated serous tubal intraepithelial carcinoma (STIC): A comprehensive review.
Patrono MG, Iniesta MD, Malpica A, Lu KH, Fernandez RO, Salvo G, Ramirez PT
Gynecol Oncol 2015 Dec;139(3):568-72. Epub 2015 Sep 25 doi: 10.1016/j.ygyno.2015.09.018. PMID: 26407480
Intraoperative rupture of benign mucinous cystadenoma does not increase its recurrence rate.
Mizrachi Y, Weiner E, Keidar R, Kerner R, Golan A, Sagiv R
Arch Gynecol Obstet 2015 May;291(5):1135-9. Epub 2014 Nov 12 doi: 10.1007/s00404-014-3543-7. PMID: 25388920
Mucinous tumors of the ovary: current thoughts on diagnosis and management.
Brown J, Frumovitz M
Curr Oncol Rep 2014 Jun;16(6):389. doi: 10.1007/s11912-014-0389-x. PMID: 24777667Free PMC Article
Oral contraceptive and benign ovarian tumors.
Westhoff C, Britton JA, Gammon MD, Wright T, Kelsey JL
Am J Epidemiol 2000 Aug 1;152(3):242-6. doi: 10.1093/aje/152.3.242. PMID: 10933271

Prognosis

The molecular origin and taxonomy of mucinous ovarian carcinoma.
Cheasley D, Wakefield MJ, Ryland GL, Allan PE, Alsop K, Amarasinghe KC, Ananda S, Anglesio MS, Au-Yeung G, Böhm M, Bowtell DDL, Brand A, Chenevix-Trench G, Christie M, Chiew YE, Churchman M, DeFazio A, Demeo R, Dudley R, Fairweather N, Fedele CG, Fereday S, Fox SB, Gilks CB, Gourley C, Hacker NF, Hadley AM, Hendley J, Ho GY, Hughes S, Hunstman DG, Hunter SM, Jobling TW, Kalli KR, Kaufmann SH, Kennedy CJ, Köbel M, Le Page C, Li J, Lupat R, McNally OM, McAlpine JN, Mes-Masson AM, Mileshkin L, Provencher DM, Pyman J, Rahimi K, Rowley SM, Salazar C, Samimi G, Saunders H, Semple T, Sharma R, Sharpe AJ, Stephens AN, Thio N, Torres MC, Traficante N, Xing Z, Zethoven M, Antill YC, Scott CL, Campbell IG, Gorringe KL
Nat Commun 2019 Sep 2;10(1):3935. doi: 10.1038/s41467-019-11862-x. PMID: 31477716Free PMC Article
Low-grade Serous Neoplasia of the Female Genital Tract.
Folkins AK, Longacre TA
Surg Pathol Clin 2019 Jun;12(2):481-513. doi: 10.1016/j.path.2019.02.006. PMID: 31097112
Pathology of borderline and invasive cancers.
Prat J
Best Pract Res Clin Obstet Gynaecol 2017 May;41:15-30. Epub 2016 Oct 3 doi: 10.1016/j.bpobgyn.2016.08.007. PMID: 28277307
Mucinous epithelial ovarian carcinoma.
Perren TJ
Ann Oncol 2016 Apr;27 Suppl 1:i53-i57. doi: 10.1093/annonc/mdw087. PMID: 27141073
TP53 and ovarian cancer.
Schuijer M, Berns EM
Hum Mutat 2003 Mar;21(3):285-91. doi: 10.1002/humu.10181. PMID: 12619114

Clinical prediction guides

Characterization and clinical significance of the CADM1/HER2/STAT3 axis in serous ovarian tumors.
Wu D, Lei Y, Liu Q, Hu H, Li H, Xie L, Zhou J
Medicine (Baltimore) 2021 Feb 26;100(8):e23777. doi: 10.1097/MD.0000000000023777. PMID: 33663040Free PMC Article
Ovarian tumors: a survey of selected advances of note during the life of this journal.
Young RH
Hum Pathol 2020 Jan;95:169-206. Epub 2019 Oct 22 doi: 10.1016/j.humpath.2019.09.002. PMID: 31654691
Clinical and ultrasound features of benign, borderline, and malignant invasive mucinous ovarian tumors.
Pascual A, Guerriero S, Rams N, Juez L, Ajossa S, Graupera B, Hereter L, Cappai A, Pero M, Perniciano M, Errasti T, Parra J, Solis M, Alcázar JL
Eur J Gynaecol Oncol 2017;38(3):382-386. PMID: 29693878
Ovarian needle aspiration in the diagnosis and management of ovarian masses.
Nagamine K, Kondo J, Kaneshiro R, Tauchi-Nishi P, Terada K
J Gynecol Oncol 2017 Jul;28(4):e40. doi: 10.3802/jgo.2017.28.e40. PMID: 28541632Free PMC Article
Metachronous benign ovarian tumors are not uncommon in children.
Taskinen S, Urtane A, Fagerholm R, Lohi J, Taskinen M
J Pediatr Surg 2014 Apr;49(4):543-5. Epub 2013 Oct 3 doi: 10.1016/j.jpedsurg.2013.09.019. PMID: 24726109

Recent systematic reviews

Simple mucinous cyst: another potential cancer precursor in the pancreas? Case report with molecular characterization and systematic review of the literature.
Milanetto AC, Tonello AS, Valotto G, Munari G, Luchini C, Fassan M, Pasquali C
Virchows Arch 2021 Jul;479(1):179-189. Epub 2021 Jan 28 doi: 10.1007/s00428-021-03029-1. PMID: 33511431Free PMC Article
Role of Imaging Tools for the Diagnosis of Borderline Ovarian Tumors: A Systematic Review and Meta-Analysis.
Borrelli GM, de Mattos LA, Andres MP, Gonçalves MO, Kho RM, Abrão MS
J Minim Invasive Gynecol 2017 Mar-Apr;24(3):353-363. Epub 2016 Dec 24 doi: 10.1016/j.jmig.2016.12.012. PMID: 28027973
Accuracy of serum human epididymis protein 4 in ovarian cancer diagnosis: a systematic review and meta-analysis.
Macedo AC, da Rosa MI, Lumertz S, Medeiros LR
Int J Gynecol Cancer 2014 Sep;24(7):1222-31. doi: 10.1097/IGC.0000000000000192. PMID: 25078339
A systematic review of papers examining the use of intraoperative frozen section in predicting the final diagnosis of ovarian lesions.
Heatley MK
Int J Gynecol Pathol 2012 Mar;31(2):111-5. doi: 10.1097/PGP.0b013e318226043b. PMID: 22317865

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...