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Borderline Ovarian Clear Cell Tumor

MedGen UID:
267394
Concept ID:
C1511261
Neoplastic Process
Synonym: Borderline Ovarian Clear Cell Neoplasm

Definition

An epithelial neoplasm with low malignant potential affecting the ovary. It is characterized by the presence of clear or hobnail cells. In some cases, the cells may display nuclear atypia and prominent nucleoli. When such cells are present, they remain confined to the glands. There is no evidence of stromal invasion. [from NCI]

Professional guidelines

PubMed

Ricotta G, Maulard A, Candiani M, Genestie C, Pautier P, Leary A, Chargari C, Mangili G, Morice P, Gouy S
Ann Surg Oncol 2022 Feb;29(2):1165-1170. Epub 2021 Oct 1 doi: 10.1245/s10434-021-10776-7. PMID: 34596794

Recent clinical studies

Etiology

Wepy C, Nucci MR, Parra-Herran C
Int J Gynecol Pathol 2024 Jan 1;43(1):70-77. Epub 2023 Mar 13 doi: 10.1097/PGP.0000000000000952. PMID: 37043650
Ricotta G, Maulard A, Genestie C, Pautier P, Leary A, Chargari C, Candiani M, Morice P, Gouy S
Ann Surg Oncol 2021 Oct;28(11):6714-6720. Epub 2021 Mar 25 doi: 10.1245/s10434-021-09879-y. PMID: 33768396
Prat J
Best Pract Res Clin Obstet Gynaecol 2017 May;41:15-30. Epub 2016 Oct 3 doi: 10.1016/j.bpobgyn.2016.08.007. PMID: 28277307
La Vecchia C
Eur J Cancer Prev 2017 Jan;26(1):55-62. doi: 10.1097/CEJ.0000000000000217. PMID: 26731563
Kurman RJ, Shih IeM
Am J Surg Pathol 2010 Mar;34(3):433-43. doi: 10.1097/PAS.0b013e3181cf3d79. PMID: 20154587Free PMC Article

Diagnosis

Wepy C, Nucci MR, Parra-Herran C
Int J Gynecol Pathol 2024 Jan 1;43(1):70-77. Epub 2023 Mar 13 doi: 10.1097/PGP.0000000000000952. PMID: 37043650
Armstrong DK, Alvarez RD, Bakkum-Gamez JN, Barroilhet L, Behbakht K, Berchuck A, Chen LM, Cristea M, DeRosa M, Eisenhauer EL, Gershenson DM, Gray HJ, Grisham R, Hakam A, Jain A, Karam A, Konecny GE, Leath CA, Liu J, Mahdi H, Martin L, Matei D, McHale M, McLean K, Miller DS, O'Malley DM, Percac-Lima S, Ratner E, Remmenga SW, Vargas R, Werner TL, Zsiros E, Burns JL, Engh AM
J Natl Compr Canc Netw 2021 Feb 2;19(2):191-226. doi: 10.6004/jnccn.2021.0007. PMID: 33545690
Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974
Prat J
Best Pract Res Clin Obstet Gynaecol 2017 May;41:15-30. Epub 2016 Oct 3 doi: 10.1016/j.bpobgyn.2016.08.007. PMID: 28277307
La Vecchia C
Eur J Cancer Prev 2017 Jan;26(1):55-62. doi: 10.1097/CEJ.0000000000000217. PMID: 26731563

Therapy

Gjorgoska M, Rizner TL
J Steroid Biochem Mol Biol 2024 May;239:106482. Epub 2024 Feb 17 doi: 10.1016/j.jsbmb.2024.106482. PMID: 38369034
La Vecchia C
Eur J Cancer Prev 2017 Jan;26(1):55-62. doi: 10.1097/CEJ.0000000000000217. PMID: 26731563
Ahmed N, Abubaker K, Findlay J, Quinn M
J Cell Biochem 2013 Jan;114(1):21-34. doi: 10.1002/jcb.24317. PMID: 22887554
Rota M, Pasquali E, Scotti L, Pelucchi C, Tramacere I, Islami F, Negri E, Boffetta P, Bellocco R, Corrao G, La Vecchia C, Bagnardi V
Gynecol Oncol 2012 Jun;125(3):758-63. Epub 2012 Mar 23 doi: 10.1016/j.ygyno.2012.03.031. PMID: 22449732
Kurman RJ, Shih IeM
Int J Gynecol Pathol 2008 Apr;27(2):151-60. doi: 10.1097/PGP.0b013e318161e4f5. PMID: 18317228Free PMC Article

Prognosis

O'Mahony DG, Ramus SJ, Southey MC, Meagher NS, Hadjisavvas A, John EM, Hamann U, Imyanitov EN, Andrulis IL, Sharma P, Daly MB, Hake CR, Weitzel JN, Jakubowska A, Godwin AK, Arason A, Bane A, Simard J, Soucy P, Caligo MA, Mai PL, Claes KBM, Teixeira MR, Chung WK, Lazaro C, Hulick PJ, Toland AE, Pedersen IS; HEBON Investigators, Neuhausen SL, Vega A, de la Hoya M, Nevanlinna H, Dhawan M, Zampiga V, Danesi R, Varesco L, Gismondi V, Vellone VG, James PA, Janavicius R, Nikitina-Zake L, Nielsen FC, van Overeem Hansen T, Pejovic T, Borg A, Rantala J, Offit K, Montagna M, Nathanson KL, Domchek SM, Osorio A, García MJ, Karlan BY; GEMO Study Collaborators, De Fazio A, Bowtell D; AOCS Group, McGuffog L, Leslie G, Parsons MT, Dörk T, Speith LM, Dos Santos ES, da Costa AABA, Radice P, Peterlongo P, Papi L, Engel C, Hahnen E, Schmutzler RK, Wappenschmidt B, Easton DF, Tischkowitz M, Singer CF, Tan YY, Whittemore AS, Sieh W, Brenton JD, Yannoukakos D, Fostira F, Konstantopoulou I, Soukupova J, Vocka M; CZECANCA Consortium, Chenevix-Trench G, Pharoah PDP, Antoniou AC, Goldgar DE, Spurdle AB, Michailidou K; Consortium of Investigators of Modifiers of BRCA1/2; Evidence-based Network for the Interpretation of Germline Mutant Alleles Consortium
Br J Cancer 2023 Jun;128(12):2283-2294. Epub 2023 Apr 19 doi: 10.1038/s41416-023-02263-5. PMID: 37076566Free PMC Article
Ricotta G, Maulard A, Candiani M, Genestie C, Pautier P, Leary A, Chargari C, Mangili G, Morice P, Gouy S
Ann Surg Oncol 2022 Feb;29(2):1165-1170. Epub 2021 Oct 1 doi: 10.1245/s10434-021-10776-7. PMID: 34596794
Ricotta G, Maulard A, Genestie C, Pautier P, Leary A, Chargari C, Candiani M, Morice P, Gouy S
Ann Surg Oncol 2021 Oct;28(11):6714-6720. Epub 2021 Mar 25 doi: 10.1245/s10434-021-09879-y. PMID: 33768396
Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974
Prat J
Best Pract Res Clin Obstet Gynaecol 2017 May;41:15-30. Epub 2016 Oct 3 doi: 10.1016/j.bpobgyn.2016.08.007. PMID: 28277307

Clinical prediction guides

O'Mahony DG, Ramus SJ, Southey MC, Meagher NS, Hadjisavvas A, John EM, Hamann U, Imyanitov EN, Andrulis IL, Sharma P, Daly MB, Hake CR, Weitzel JN, Jakubowska A, Godwin AK, Arason A, Bane A, Simard J, Soucy P, Caligo MA, Mai PL, Claes KBM, Teixeira MR, Chung WK, Lazaro C, Hulick PJ, Toland AE, Pedersen IS; HEBON Investigators, Neuhausen SL, Vega A, de la Hoya M, Nevanlinna H, Dhawan M, Zampiga V, Danesi R, Varesco L, Gismondi V, Vellone VG, James PA, Janavicius R, Nikitina-Zake L, Nielsen FC, van Overeem Hansen T, Pejovic T, Borg A, Rantala J, Offit K, Montagna M, Nathanson KL, Domchek SM, Osorio A, García MJ, Karlan BY; GEMO Study Collaborators, De Fazio A, Bowtell D; AOCS Group, McGuffog L, Leslie G, Parsons MT, Dörk T, Speith LM, Dos Santos ES, da Costa AABA, Radice P, Peterlongo P, Papi L, Engel C, Hahnen E, Schmutzler RK, Wappenschmidt B, Easton DF, Tischkowitz M, Singer CF, Tan YY, Whittemore AS, Sieh W, Brenton JD, Yannoukakos D, Fostira F, Konstantopoulou I, Soukupova J, Vocka M; CZECANCA Consortium, Chenevix-Trench G, Pharoah PDP, Antoniou AC, Goldgar DE, Spurdle AB, Michailidou K; Consortium of Investigators of Modifiers of BRCA1/2; Evidence-based Network for the Interpretation of Germline Mutant Alleles Consortium
Br J Cancer 2023 Jun;128(12):2283-2294. Epub 2023 Apr 19 doi: 10.1038/s41416-023-02263-5. PMID: 37076566Free PMC Article
Ricotta G, Maulard A, Candiani M, Genestie C, Pautier P, Leary A, Chargari C, Mangili G, Morice P, Gouy S
Ann Surg Oncol 2022 Feb;29(2):1165-1170. Epub 2021 Oct 1 doi: 10.1245/s10434-021-10776-7. PMID: 34596794
Ricotta G, Maulard A, Genestie C, Pautier P, Leary A, Chargari C, Candiani M, Morice P, Gouy S
Ann Surg Oncol 2021 Oct;28(11):6714-6720. Epub 2021 Mar 25 doi: 10.1245/s10434-021-09879-y. PMID: 33768396
Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974
Schuijer M, Berns EM
Hum Mutat 2003 Mar;21(3):285-91. doi: 10.1002/humu.10181. PMID: 12619114

Recent systematic reviews

Bercow A, Nitecki R, Brady PC, Rauh-Hain JA
J Minim Invasive Gynecol 2021 Mar;28(3):527-536.e1. Epub 2020 Aug 26 doi: 10.1016/j.jmig.2020.08.018. PMID: 32861046
Santucci C, Bosetti C, Peveri G, Liu X, Bagnardi V, Specchia C, Gallus S, Lugo A
Cancer Causes Control 2019 Sep;30(9):1023-1032. Epub 2019 Jun 24 doi: 10.1007/s10552-019-01198-8. PMID: 31236793
Bentivegna E, Gouy S, Maulard A, Pautier P, Leary A, Colombo N, Morice P
Ann Oncol 2016 Nov;27(11):1994-2004. Epub 2016 Aug 8 doi: 10.1093/annonc/mdw311. PMID: 27502723
Daraï E, Fauvet R, Uzan C, Gouy S, Duvillard P, Morice P
Hum Reprod Update 2013 Mar-Apr;19(2):151-66. Epub 2012 Dec 12 doi: 10.1093/humupd/dms047. PMID: 23242913
Rota M, Pasquali E, Scotti L, Pelucchi C, Tramacere I, Islami F, Negri E, Boffetta P, Bellocco R, Corrao G, La Vecchia C, Bagnardi V
Gynecol Oncol 2012 Jun;125(3):758-63. Epub 2012 Mar 23 doi: 10.1016/j.ygyno.2012.03.031. PMID: 22449732

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