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del(11q25)

MedGen UID:
271835
•Concept ID:
C1515578
•
Cell or Molecular Dysfunction

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVdel(11q25)

Recent clinical studies

Etiology

Silver-Russell syndrome-like features in a child with recombinant chromosome 11 derived from maternal pericentric inversion.
Urzua A, Catena S, Morales P, Lay-Son G
Clin Dysmorphol 2024 Jul 1;33(3):105-109. Epub 2024 May 29 doi: 10.1097/MCD.0000000000000483. PMID: 38818816
Prediction of outcome in newly diagnosed myeloma: a meta-analysis of the molecular profiles of 1905 trial patients.
Shah V, Sherborne AL, Walker BA, Johnson DC, Boyle EM, Ellis S, Begum DB, Proszek PZ, Jones JR, Pawlyn C, Savola S, Jenner MW, Drayson MT, Owen RG, Houlston RS, Cairns DA, Gregory WM, Cook G, Davies FE, Jackson GH, Morgan GJ, Kaiser MF
Leukemia 2018 Jan;32(1):102-110. Epub 2017 Jun 6 doi: 10.1038/leu.2017.179. PMID: 28584253Free PMC Article
An analysis of epilepsy with chromosomal abnormalities.
Yamanouchi H, Imataka G, Nakagawa E, Nitta A, Suzuki N, Hirao J, Suzumura H, Watanabe H, Arisaka O, Eguchi M
Brain Dev 2005 Aug;27(5):370-7. doi: 10.1016/j.braindev.2004.04.012. PMID: 16023555
A complex karyotype involving chromosomes 3, 6, 11, 12, and 22 in adult acute lymphoblastic leukemia.
Shivakumar S, Mathew S, Dalton J, Chandy M, Srivastava A
Leuk Lymphoma 2002 Aug;43(8):1673-7. doi: 10.1080/1042819021000003018. PMID: 12400611
Prognostic significance of secondary cytogenetic changes and nonspecific cross-reacting antigen (NCA) in patients with Ph-positive chronic myeloid leukemia.
Haus O, Noworolska A, Laskowski M, Kuliszkiewicz-Janus M, Kozłowska J, Harłozińska-Szmyrka A, Jagielski J, Kotlarek-Haus S
Exp Mol Pathol 1990 Apr;52(2):235-42. doi: 10.1016/0014-4800(90)90008-2. PMID: 2332039

Diagnosis

Silver-Russell syndrome-like features in a child with recombinant chromosome 11 derived from maternal pericentric inversion.
Urzua A, Catena S, Morales P, Lay-Son G
Clin Dysmorphol 2024 Jul 1;33(3):105-109. Epub 2024 May 29 doi: 10.1097/MCD.0000000000000483. PMID: 38818816
A novel homozygous variant in JAM3 gene causing hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts (HDBSCC) with neonatal onset.
De Rose DU, Gallini F, Battaglia DI, Tiberi E, Gaudino S, Contaldo I, Veredice C, Romeo DM, Massimi L, Asaro A, Cereda C, Vento G, Mercuri EM
Neurol Sci 2021 Nov;42(11):4759-4765. Epub 2021 Jul 22 doi: 10.1007/s10072-021-05480-z. PMID: 34292449Free PMC Article
Prediction of outcome in newly diagnosed myeloma: a meta-analysis of the molecular profiles of 1905 trial patients.
Shah V, Sherborne AL, Walker BA, Johnson DC, Boyle EM, Ellis S, Begum DB, Proszek PZ, Jones JR, Pawlyn C, Savola S, Jenner MW, Drayson MT, Owen RG, Houlston RS, Cairns DA, Gregory WM, Cook G, Davies FE, Jackson GH, Morgan GJ, Kaiser MF
Leukemia 2018 Jan;32(1):102-110. Epub 2017 Jun 6 doi: 10.1038/leu.2017.179. PMID: 28584253Free PMC Article
Molecular cytogenetic characterization of Jacobsen syndrome (11q23.3-q25 deletion) in a fetus associated with double outlet right ventricle, hypoplastic left heart syndrome and ductus venosus agenesis on prenatal ultrasound.
Chen CP, Wang LK, Wu PC, Chang TY, Chern SR, Wu PS, Chen YN, Chen SW, Lee CC, Yang CW, Wang W
Taiwan J Obstet Gynecol 2017 Feb;56(1):102-105. doi: 10.1016/j.tjog.2016.12.004. PMID: 28254208
An analysis of epilepsy with chromosomal abnormalities.
Yamanouchi H, Imataka G, Nakagawa E, Nitta A, Suzuki N, Hirao J, Suzumura H, Watanabe H, Arisaka O, Eguchi M
Brain Dev 2005 Aug;27(5):370-7. doi: 10.1016/j.braindev.2004.04.012. PMID: 16023555

Therapy

Rare NUP98::PRRX1 fusion transcript in a therapy-related acute myeloid leukemia associated with del(7q) following chemotherapy for diffuse large B-cell lymphoma.
Wang Y, Zhang Z, Wang L, Wang H, Dong F
Cancer Genet 2024 Jun;284-285:12-15. Epub 2024 Mar 12 doi: 10.1016/j.cancergen.2024.03.004. PMID: 38493578
Prediction of outcome in newly diagnosed myeloma: a meta-analysis of the molecular profiles of 1905 trial patients.
Shah V, Sherborne AL, Walker BA, Johnson DC, Boyle EM, Ellis S, Begum DB, Proszek PZ, Jones JR, Pawlyn C, Savola S, Jenner MW, Drayson MT, Owen RG, Houlston RS, Cairns DA, Gregory WM, Cook G, Davies FE, Jackson GH, Morgan GJ, Kaiser MF
Leukemia 2018 Jan;32(1):102-110. Epub 2017 Jun 6 doi: 10.1038/leu.2017.179. PMID: 28584253Free PMC Article

Prognosis

Rare NUP98::PRRX1 fusion transcript in a therapy-related acute myeloid leukemia associated with del(7q) following chemotherapy for diffuse large B-cell lymphoma.
Wang Y, Zhang Z, Wang L, Wang H, Dong F
Cancer Genet 2024 Jun;284-285:12-15. Epub 2024 Mar 12 doi: 10.1016/j.cancergen.2024.03.004. PMID: 38493578
Prediction of outcome in newly diagnosed myeloma: a meta-analysis of the molecular profiles of 1905 trial patients.
Shah V, Sherborne AL, Walker BA, Johnson DC, Boyle EM, Ellis S, Begum DB, Proszek PZ, Jones JR, Pawlyn C, Savola S, Jenner MW, Drayson MT, Owen RG, Houlston RS, Cairns DA, Gregory WM, Cook G, Davies FE, Jackson GH, Morgan GJ, Kaiser MF
Leukemia 2018 Jan;32(1):102-110. Epub 2017 Jun 6 doi: 10.1038/leu.2017.179. PMID: 28584253Free PMC Article
A complex karyotype involving chromosomes 3, 6, 11, 12, and 22 in adult acute lymphoblastic leukemia.
Shivakumar S, Mathew S, Dalton J, Chandy M, Srivastava A
Leuk Lymphoma 2002 Aug;43(8):1673-7. doi: 10.1080/1042819021000003018. PMID: 12400611
Prognostic significance of secondary cytogenetic changes and nonspecific cross-reacting antigen (NCA) in patients with Ph-positive chronic myeloid leukemia.
Haus O, Noworolska A, Laskowski M, Kuliszkiewicz-Janus M, Kozłowska J, Harłozińska-Szmyrka A, Jagielski J, Kotlarek-Haus S
Exp Mol Pathol 1990 Apr;52(2):235-42. doi: 10.1016/0014-4800(90)90008-2. PMID: 2332039

Clinical prediction guides

Prediction of outcome in newly diagnosed myeloma: a meta-analysis of the molecular profiles of 1905 trial patients.
Shah V, Sherborne AL, Walker BA, Johnson DC, Boyle EM, Ellis S, Begum DB, Proszek PZ, Jones JR, Pawlyn C, Savola S, Jenner MW, Drayson MT, Owen RG, Houlston RS, Cairns DA, Gregory WM, Cook G, Davies FE, Jackson GH, Morgan GJ, Kaiser MF
Leukemia 2018 Jan;32(1):102-110. Epub 2017 Jun 6 doi: 10.1038/leu.2017.179. PMID: 28584253Free PMC Article

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