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Congenital Melanocytic Nevus

MedGen UID:
272090
•Concept ID:
C1318558
•
Neoplastic Process
Synonyms: Congenital dermal melanocytic nevus; Congenital melanocytic nevus; Congenital melanocytic nevus of skin; Congenital Melanocytic Nevus of Skin; Congenital Melanocytic Nevus of the Skin; Congenital Nevus of Skin; Congenital Nevus of the Skin; Congenital pigmented melanocytic nevus; Congenital pigmented melanocytic nevus of skin; Congenital pigmented nevus; Congenital pigmented nevus of skin; Congenital Pigmented Nevus of Skin; Congenital Pigmented Nevus of the Skin; Congenital Pigmented Skin Nevus; Congenital Skin Nevus
SNOMED CT: Congenital pigmented melanocytic nevus (398696001); Congenital pigmented melanocytic nevus of skin (398943008); Congenital melanocytic nevus (400151006); Congenital melanocytic nevus (398696001); Congenital pigmented nevus (398696001); Congenital dermal melanocytic nevus (398943008); Congenital melanocytic nevus of skin (398943008); Congenital pigmented nevus of skin (398943008)

Definition

A melanocytic nevus that is present at birth. It may present as a small macular, papular, or plaque-like lesion or as a large brown to black hairy skin lesion. [from NCI]

Professional guidelines

PubMed

Comparison of three different surgical approaches for the treatment of large/giant congenital melanocytic nevus.
Cheng X, Wang W, He Y, Bao W, Jia C, Dai T
J Cosmet Dermatol 2022 Oct;21(10):4609-4616. Epub 2022 Jul 19 doi: 10.1111/jocd.15219. PMID: 35810351
Treatment of maxillofacial congenital melanocytic nevus with percutaneous radiofrequency thermal ablation: A case series study.
Wang X, Chen W, Xie H, Jiang T, Weng C, Zhang Z, Lin X, Gao Y
Dermatol Ther 2021 Mar;34(2):e14876. Epub 2021 Feb 21 doi: 10.1111/dth.14876. PMID: 33583124
Laser treatment of congenital melanocytic nevi: a review of the literature.
Bray FN, Shah V, Nouri K
Lasers Med Sci 2016 Jan;31(1):197-204. Epub 2015 Nov 12 doi: 10.1007/s10103-015-1833-3. PMID: 26563957

Recent clinical studies

Etiology

Topical therapy for regression and melanoma prevention of congenital giant nevi.
Choi YS, Erlich TH, von Franque M, Rachmin I, Flesher JL, Schiferle EB, Zhang Y, Pereira da Silva M, Jiang A, Dobry AS, Su M, Germana S, Lacher S, Freund O, Feder E, Cortez JL, Ryu S, Babila Propp T, Samuels YL, Zakka LR, Azin M, Burd CE, Sharpless NE, Liu XS, Meyer C, Austen WG Jr, Bojovic B, Cetrulo CL Jr, Mihm MC, Hoon DS, Demehri S, Hawryluk EB, Fisher DE
Cell 2022 Jun 9;185(12):2071-2085.e12. Epub 2022 May 12 doi: 10.1016/j.cell.2022.04.025. PMID: 35561684Free PMC Article
Imaging of pediatric cutaneous melanoma.
Kaste SC
Pediatr Radiol 2019 Oct;49(11):1476-1487. Epub 2019 Oct 16 doi: 10.1007/s00247-019-04374-9. PMID: 31620848Free PMC Article
Giant congenital melanocytic nevus associated with cerebellar astrocytoma.
Wang X, Luo P, Hanazawa H, Liu J, Li L, Wang M, Jing Z
Eur J Dermatol 2018 Apr 1;28(2):254-255. doi: 10.1684/ejd.2018.3218. PMID: 29619995
Common and not so Common Melanocytic Lesions in Children and Adolescents.
Yang C, Gru AA, Dehner LP
Pediatr Dev Pathol 2018 Mar-Apr;21(2):252-270. doi: 10.1177/1093526617751720. PMID: 29607755
Giant congenital melanocytic nevus.
Viana AC, Gontijo B, Bittencourt FV
An Bras Dermatol 2013 Nov-Dec;88(6):863-78. doi: 10.1590/abd1806-4841.20132233. PMID: 24474093Free PMC Article

Diagnosis

The congenital melanocytic nevus: a rare clinical image.
Kumari D, Lohakare T
Pan Afr Med J 2022;42:250. Epub 2022 Aug 3 doi: 10.11604/pamj.2022.42.250.35727. PMID: 36303818Free PMC Article
A Pigmented Nodule on Congenital Melanocytic Nevus: Challenge.
Sabater-Marco V, Cerveró LN, Losada LO, López NS
Am J Dermatopathol 2022 Oct 1;44(10):e108-e109. doi: 10.1097/DAD.0000000000002265. PMID: 36122342
A Pigmented Nodule on Congenital Melanocytic Nevus: Answer.
Sabater-Marco V, Cerveró LN, Losada LO, López NS
Am J Dermatopathol 2022 Oct 1;44(10):778-779. doi: 10.1097/DAD.0000000000002266. PMID: 36122338
Imaging of pediatric cutaneous melanoma.
Kaste SC
Pediatr Radiol 2019 Oct;49(11):1476-1487. Epub 2019 Oct 16 doi: 10.1007/s00247-019-04374-9. PMID: 31620848Free PMC Article
Bednar Tumor Mimicking Congenital Melanocytic Nevus.
Bernárdez C, Molina-Ruiz AM, Requena L
Actas Dermosifiliogr 2016 Jul-Aug;107(6):523. Epub 2016 Feb 11 doi: 10.1016/j.ad.2015.04.027. PMID: 26875791

Therapy

Immunological Overkilling Followed by Cellular Replenishment: A Novel 2-Step Treatment for Halo Congenital Melanocytic Nevus.
Gupta V, Pangti R, Gupta S
Dermatol Surg 2021 Oct 1;47(10):1404-1405. doi: 10.1097/DSS.0000000000003156. PMID: 34417395
Congenital Melanocytic Nevus of the Nose Removed Using Dermabrasion, Hydroquinone, and Serial Excision.
Hassanein AH, Greene AK
J Craniofac Surg 2015 Oct;26(7):2216-7. doi: 10.1097/SCS.0000000000002120. PMID: 26413965
Pediatric melanoma, moles, and sun safety.
Hawryluk EB, Liang MG
Pediatr Clin North Am 2014 Apr;61(2):279-91. Epub 2014 Jan 28 doi: 10.1016/j.pcl.2013.11.004. PMID: 24636646
Infantile giant congenital melanocytic nevus: report of three unusual cases.
Thapa R, Ghosh A, Dhar S
Int J Dermatol 2009 Nov;48(11):1209-12. doi: 10.1111/j.1365-4632.2009.04125.x. PMID: 20064178
Cutaneous lesions: benign and malignant.
Padgett JK
Facial Plast Surg Clin North Am 2005 May;13(2):195-202, v. doi: 10.1016/j.fsc.2004.11.006. PMID: 15817400

Prognosis

Melanoma on congenital melanocytic nevi.
Alos L, Carrasco A, Teixidó C, Szumera-Ciećkiewicz A, Vicente A, Massi D, Carrera C
Pathol Res Pract 2024 Apr;256:155262. Epub 2024 Mar 11 doi: 10.1016/j.prp.2024.155262. PMID: 38518732
Giant congenital melanocytic nevus associated with cerebellar astrocytoma.
Wang X, Luo P, Hanazawa H, Liu J, Li L, Wang M, Jing Z
Eur J Dermatol 2018 Apr 1;28(2):254-255. doi: 10.1684/ejd.2018.3218. PMID: 29619995
Common and not so Common Melanocytic Lesions in Children and Adolescents.
Yang C, Gru AA, Dehner LP
Pediatr Dev Pathol 2018 Mar-Apr;21(2):252-270. doi: 10.1177/1093526617751720. PMID: 29607755
Alveolar rhabdomyosarcoma arising in a giant congenital melanocytic nevus in an adult--case report with review of literature.
Chikhalkar S, Gutte R, Holmukhe S, Khopkar U, Desai S, Gupta S
Int J Dermatol 2013 Nov;52(11):1372-5. Epub 2013 Mar 3 doi: 10.1111/j.1365-4632.2011.05448.x. PMID: 23451914
Congenital melanocytic nevi.
Zayour M, Lazova R
Clin Lab Med 2011 Jun;31(2):267-80. doi: 10.1016/j.cll.2011.03.004. PMID: 21549240

Clinical prediction guides

Congenital melanocytic nevus syndrome: An association between congenital melanocytic nevi and neurological abnormalities.
Ruth J
Semin Pediatr Neurol 2024 Oct;51:101153. Epub 2024 Sep 13 doi: 10.1016/j.spen.2024.101153. PMID: 39389659
Newborn Skin: Part II. Birthmarks.
Snyder KAM, Voelckers AD
Am Fam Physician 2024 Mar;109(3):217-221. PMID: 38574211
Spitzoid proliferative nodules arising in a congenital melanocytic naevus: A case report with clinical, dermoscopic and histologic correlation.
Amat-Samaranch V, Yélamos O, Agut-Busquet E, Dalmau J, Mozos A, López S, Roé E
Australas J Dermatol 2022 Aug;63(3):e251-e254. Epub 2022 May 5 doi: 10.1111/ajd.13861. PMID: 35510363
Lower and upper extremity atrophy associated with a giant congenital melanocytic nevus.
Itin PH, Lautenschlager S
Pediatr Dermatol 1998 Jul-Aug;15(4):287-9. doi: 10.1046/j.1525-1470.1998.1998015287.x. PMID: 9720694
Giant congenital melanocytic nevus with placental involvement: long-term follow-up of a case and review of the literature.
Jauniaux E, de Meeus MC, Verellen G, Lachapelle JM, Hustin J
Pediatr Pathol 1993 Nov-Dec;13(6):717-21. doi: 10.3109/15513819309048258. PMID: 8108291

Recent systematic reviews

Treatments of palpebral congenital melanocytic nevus: a systematic review.
Camargo CP, Saliba M, Saad EA, Milan M, Caldera JM
Acta Cir Bras 2023;38:e384823. Epub 2023 Dec 1 doi: 10.1590/acb384823. PMID: 38055392Free PMC Article

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