U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Germ cell benign neoplasm

MedGen UID:
272358
Concept ID:
C1332505
Neoplastic Process
Synonyms: Benign germ cell neoplasm; Benign Germ Cell Neoplasm; Benign Germ Cell Tumor; Benign Neoplasm of Germ Cell; Benign Neoplasm of the Germ Cell; Benign Tumor of Germ Cell; Benign Tumor of the Germ Cell; germ cell benign neoplasm
SNOMED CT: Benign germ cell neoplasm (713588001)
 
Monarch Initiative: MONDO:0850144

Definition

A germ cell tumor without evidence of atypia and metastatic potential. [from NCI]

Professional guidelines

PubMed

Saleh M, Bhosale P, Menias CO, Ramalingam P, Jensen C, Iyer R, Ganeshan D
Abdom Radiol (NY) 2021 Jun;46(6):2293-2307. Epub 2021 Jan 4 doi: 10.1007/s00261-020-02873-0. PMID: 33394097
Smith ZL, Werntz RP, Eggener SE
Med Clin North Am 2018 Mar;102(2):251-264. Epub 2017 Dec 21 doi: 10.1016/j.mcna.2017.10.003. PMID: 29406056
Brioude F, Kalish JM, Mussa A, Foster AC, Bliek J, Ferrero GB, Boonen SE, Cole T, Baker R, Bertoletti M, Cocchi G, Coze C, De Pellegrin M, Hussain K, Ibrahim A, Kilby MD, Krajewska-Walasek M, Kratz CP, Ladusans EJ, Lapunzina P, Le Bouc Y, Maas SM, Macdonald F, Õunap K, Peruzzi L, Rossignol S, Russo S, Shipster C, Skórka A, Tatton-Brown K, Tenorio J, Tortora C, Grønskov K, Netchine I, Hennekam RC, Prawitt D, Tümer Z, Eggermann T, Mackay DJG, Riccio A, Maher ER
Nat Rev Endocrinol 2018 Apr;14(4):229-249. Epub 2018 Jan 29 doi: 10.1038/nrendo.2017.166. PMID: 29377879Free PMC Article

Recent clinical studies

Etiology

Leiendecker L, Neumann T, Jung PS, Cronin SM, Steinacker TL, Schleiffer A, Schutzbier M, Mechtler K, Kervarrec T, Laurent E, Bachiri K, Coyaud E, Murali R, Busam KJ, Itzinger-Monshi B, Kirnbauer R, Cerroni L, Calonje E, Rütten A, Stubenrauch F, Griewank KG, Wiesner T, Obenauf AC
Cancer Discov 2023 Jan 9;13(1):70-84. doi: 10.1158/2159-8290.CD-22-0489. PMID: 36213965Free PMC Article
Yang Y, Zhang G, Hu C, Luo W, Jiang H, Liu S, Yang H
BMC Urol 2022 Nov 30;22(1):196. doi: 10.1186/s12894-022-01141-1. PMID: 36451132Free PMC Article
Li P, Brown S, Williams M, White T, Xie W, Cui W, Peker D, Lei L, Kunder CA, Wang HY, Murray SS, Vagher J, Kovacsovics T, Patel JL
Blood 2022 Aug 18;140(7):716-755. doi: 10.1182/blood.2021015135. PMID: 35671390Free PMC Article
Guindalini RSC, Viana DV, Kitajima JPFW, Rocha VM, López RVM, Zheng Y, Freitas É, Monteiro FPM, Valim A, Schlesinger D, Kok F, Olopade OI, Folgueira MAAK
Sci Rep 2022 Mar 9;12(1):4190. doi: 10.1038/s41598-022-07383-1. PMID: 35264596Free PMC Article
Al-Obaidy KI, Idrees MT
Adv Anat Pathol 2021 Jul 1;28(4):258-275. doi: 10.1097/PAP.0000000000000302. PMID: 33871428

Diagnosis

Li P, Brown S, Williams M, White T, Xie W, Cui W, Peker D, Lei L, Kunder CA, Wang HY, Murray SS, Vagher J, Kovacsovics T, Patel JL
Blood 2022 Aug 18;140(7):716-755. doi: 10.1182/blood.2021015135. PMID: 35671390Free PMC Article
Marx A, Chan JKC, Chalabreysse L, Dacic S, Detterbeck F, French CA, Hornick JL, Inagaki H, Jain D, Lazar AJ, Marino M, Marom EM, Moreira AL, Nicholson AG, Noguchi M, Nonaka D, Papotti MG, Porubsky S, Sholl LM, Tateyama H, Thomas de Montpréville V, Travis WD, Rajan A, Roden AC, Ströbel P
J Thorac Oncol 2022 Feb;17(2):200-213. Epub 2021 Oct 22 doi: 10.1016/j.jtho.2021.10.010. PMID: 34695605
El-Zaatari ZM, Ro JY
Adv Anat Pathol 2021 Sep 1;28(5):335-350. doi: 10.1097/PAP.0000000000000304. PMID: 34029275
Al-Obaidy KI, Idrees MT
Adv Anat Pathol 2021 Jul 1;28(4):258-275. doi: 10.1097/PAP.0000000000000302. PMID: 33871428
Huang L, Ma F, Chapman A, Lu S, Xie XS
Annu Rev Genomics Hum Genet 2015;16:79-102. Epub 2015 Jun 11 doi: 10.1146/annurev-genom-090413-025352. PMID: 26077818

Therapy

Geyer CE Jr, Garber JE, Gelber RD, Yothers G, Taboada M, Ross L, Rastogi P, Cui K, Arahmani A, Aktan G, Armstrong AC, Arnedos M, Balmaña J, Bergh J, Bliss J, Delaloge S, Domchek SM, Eisen A, Elsafy F, Fein LE, Fielding A, Ford JM, Friedman S, Gelmon KA, Gianni L, Gnant M, Hollingsworth SJ, Im SA, Jager A, Jóhannsson ÓÞ, Lakhani SR, Janni W, Linderholm B, Liu TW, Loman N, Korde L, Loibl S, Lucas PC, Marmé F, Martinez de Dueñas E, McConnell R, Phillips KA, Piccart M, Rossi G, Schmutzler R, Senkus E, Shao Z, Sharma P, Singer CF, Španić T, Stickeler E, Toi M, Traina TA, Viale G, Zoppoli G, Park YH, Yerushalmi R, Yang H, Pang D, Jung KH, Mailliez A, Fan Z, Tennevet I, Zhang J, Nagy T, Sonke GS, Sun Q, Parton M, Colleoni MA, Schmidt M, Brufsky AM, Razaq W, Kaufman B, Cameron D, Campbell C, Tutt ANJ; OlympiA Clinical Trial Steering Committee and Investigators
Ann Oncol 2022 Dec;33(12):1250-1268. Epub 2022 Oct 10 doi: 10.1016/j.annonc.2022.09.159. PMID: 36228963Free PMC Article
Kindler HL, Hammel P, Reni M, Van Cutsem E, Macarulla T, Hall MJ, Park JO, Hochhauser D, Arnold D, Oh DY, Reinacher-Schick A, Tortora G, Algül H, O'Reilly EM, Bordia S, McGuinness D, Cui K, Locker GY, Golan T
J Clin Oncol 2022 Dec 1;40(34):3929-3939. Epub 2022 Jul 14 doi: 10.1200/JCO.21.01604. PMID: 35834777Free PMC Article
Litton JK, Hurvitz SA, Mina LA, Rugo HS, Lee KH, Gonçalves A, Diab S, Woodward N, Goodwin A, Yerushalmi R, Roché H, Im YH, Eiermann W, Quek RGW, Usari T, Lanzalone S, Czibere A, Blum JL, Martin M, Ettl J
Ann Oncol 2020 Nov;31(11):1526-1535. Epub 2020 Aug 20 doi: 10.1016/j.annonc.2020.08.2098. PMID: 32828825Free PMC Article
Einhorn LH, Williams SD, Chamness A, Brames MJ, Perkins SM, Abonour R
N Engl J Med 2007 Jul 26;357(4):340-8. doi: 10.1056/NEJMoa067749. PMID: 17652649
Schlatt S
Mol Cell Endocrinol 2002 Jan 25;186(2):163-7. doi: 10.1016/s0303-7207(01)00661-x. PMID: 11900891

Prognosis

Oing C, Seidel C, Bokemeyer C
Expert Rev Anticancer Ther 2018 Apr;18(4):389-397. Epub 2018 Mar 12 doi: 10.1080/14737140.2018.1450630. PMID: 29516750
Sandoval JA, Williams RF
Curr Pediatr Rev 2015;11(3):205-15. doi: 10.2174/1573396311666150714105531. PMID: 26168938
Chieffi P
Int Rev Cell Mol Biol 2014;312:79-100. doi: 10.1016/B978-0-12-800178-3.00003-8. PMID: 25262239
Looijenga LH
Pediatr Endocrinol Rev 2014 Feb;11 Suppl 2:251-62. PMID: 24683949
Einhorn LH, Williams SD, Chamness A, Brames MJ, Perkins SM, Abonour R
N Engl J Med 2007 Jul 26;357(4):340-8. doi: 10.1056/NEJMoa067749. PMID: 17652649

Clinical prediction guides

Hu C, Huang H, Na J, Lumby C, Abozaid M, Holdren MA, Rao TJ, Karam R, Pesaran T, Weyandt JD, Csuy CM, Seelaus CA, Young CC, Fulk K, Heidari Z, Morais Lyra PC Jr, Couch RE, Persons B, Polley EC, Gnanaolivu RD, Boddicker NJ, Monteiro ANA, Yadav S, Domchek SM, Richardson ME, Couch FJ
Am J Hum Genet 2024 Mar 7;111(3):584-593. Epub 2024 Feb 27 doi: 10.1016/j.ajhg.2024.02.002. PMID: 38417439Free PMC Article
Darst BF, Saunders E, Dadaev T, Sheng X, Wan P, Pooler L, Xia LY, Chanock S, Berndt SI, Wang Y, Patel AV, Albanes D, Weinstein SJ, Gnanapragasam V, Huff C, Couch FJ, Wolk A, Giles GG, Nguyen-Dumont T, Milne RL, Pomerantz MM, Schmidt JA, Travis RC, Key TJ, Stopsack KH, Mucci LA, Catalona WJ, Marosy B, Hetrick KN, Doheny KF, MacInnis RJ, Southey MC, Eeles RA, Wiklund F, Conti DV, Kote-Jarai Z, Haiman CA
JAMA Oncol 2023 Nov 1;9(11):1514-1524. doi: 10.1001/jamaoncol.2023.3482. PMID: 37733366Free PMC Article
Garcia-Pelaez J, Barbosa-Matos R, Lobo S, Dias A, Garrido L, Castedo S, Sousa S, Pinheiro H, Sousa L, Monteiro R, Maqueda JJ, Fernandes S, Carneiro F, Pinto N, Lemos C, Pinto C, Teixeira MR, Aretz S, Bajalica-Lagercrantz S, Balmaña J, Blatnik A, Benusiglio PR, Blanluet M, Bours V, Brems H, Brunet J, Calistri D, Capellá G, Carrera S, Colas C, Dahan K, de Putter R, Desseignés C, Domínguez-Garrido E, Egas C, Evans DG, Feret D, Fewings E, Fitzgerald RC, Coulet F, Garcia-Barcina M, Genuardi M, Golmard L, Hackmann K, Hanson H, Holinski-Feder E, Hüneburg R, Krajc M, Lagerstedt-Robinson K, Lázaro C, Ligtenberg MJL, Martínez-Bouzas C, Merino S, Michils G, Novaković S, Patiño-García A, Ranzani GN, Schröck E, Silva I, Silveira C, Soto JL, Spier I, Steinke-Lange V, Tedaldi G, Tejada MI, Woodward ER, Tischkowitz M, Hoogerbrugge N, Oliveira C
Lancet Oncol 2023 Jan;24(1):91-106. Epub 2022 Nov 24 doi: 10.1016/S1470-2045(22)00643-X. PMID: 36436516Free PMC Article
Makishima H, Saiki R, Nannya Y, Korotev S, Gurnari C, Takeda J, Momozawa Y, Best S, Krishnamurthy P, Yoshizato T, Atsuta Y, Shiozawa Y, Iijima-Yamashita Y, Yoshida K, Shiraishi Y, Nagata Y, Kakiuchi N, Onizuka M, Chiba K, Tanaka H, Kon A, Ochi Y, Nakagawa MM, Okuda R, Mori T, Yoda A, Itonaga H, Miyazaki Y, Sanada M, Ishikawa T, Chiba S, Tsurumi H, Kasahara S, Müller-Tidow C, Takaori-Kondo A, Ohyashiki K, Kiguchi T, Matsuda F, Jansen JH, Polprasert C, Blombery P, Kamatani Y, Miyano S, Malcovati L, Haferlach T, Kubo M, Cazzola M, Kulasekararaj AG, Godley LA, Maciejewski JP, Ogawa S
Blood 2023 Feb 2;141(5):534-549. doi: 10.1182/blood.2022018221. PMID: 36322930Free PMC Article
Kindler HL, Hammel P, Reni M, Van Cutsem E, Macarulla T, Hall MJ, Park JO, Hochhauser D, Arnold D, Oh DY, Reinacher-Schick A, Tortora G, Algül H, O'Reilly EM, Bordia S, McGuinness D, Cui K, Locker GY, Golan T
J Clin Oncol 2022 Dec 1;40(34):3929-3939. Epub 2022 Jul 14 doi: 10.1200/JCO.21.01604. PMID: 35834777Free PMC Article

Recent systematic reviews

Fraison E, Huberlant S, Labrune E, Cavalieri M, Montagut M, Brugnon F, Courbiere B
Hum Reprod 2023 Mar 1;38(3):489-502. doi: 10.1093/humrep/deac249. PMID: 36421038Free PMC Article
Nijsten K, Jansen LAW, Limpens J, Finken MJJ, Koot MH, Grooten IJ, Roseboom TJ, Painter RC
Am J Obstet Gynecol 2022 Sep;227(3):414-429.e17. Epub 2022 Mar 30 doi: 10.1016/j.ajog.2022.03.052. PMID: 35367190
Konstantinopoulos PA, Norquist B, Lacchetti C, Armstrong D, Grisham RN, Goodfellow PJ, Kohn EC, Levine DA, Liu JF, Lu KH, Sparacio D, Annunziata CM
J Clin Oncol 2020 Apr 10;38(11):1222-1245. Epub 2020 Jan 27 doi: 10.1200/JCO.19.02960. PMID: 31986064Free PMC Article
Ghasemiesfe M, Barrow B, Leonard S, Keyhani S, Korenstein D
JAMA Netw Open 2019 Nov 1;2(11):e1916318. doi: 10.1001/jamanetworkopen.2019.16318. PMID: 31774524Free PMC Article
Pilarski R, Burt R, Kohlman W, Pho L, Shannon KM, Swisher E
J Natl Cancer Inst 2013 Nov 6;105(21):1607-16. Epub 2013 Oct 17 doi: 10.1093/jnci/djt277. PMID: 24136893

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...