U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pediatric osteosarcoma

MedGen UID:
272464
•Concept ID:
C1332986
•
Neoplastic Process
Synonyms: childhood osteogenic sarcoma; Childhood Osteosarcoma; childhood osteosarcoma; childhood osteosarcoma (disease); osteosarcoma (disease) of childhood; paediatric osteosarcoma (disease); Pediatric Osteosarcoma; pediatric osteosarcoma; pediatric osteosarcoma (disease)
 
Monarch Initiative: MONDO:0002623

Definition

An osteosarcoma that occurs during childhood. [from NCI]

Professional guidelines

PubMed

Pediatric Osteosarcoma: Correlation of Imaging Findings with Histopathologic Features, Treatment, and Outcome.
Nguyen JC, Baghdadi S, Pogoriler J, Guariento A, Rajapakse CS, Arkader A
Radiographics 2022 Jul-Aug;42(4):1196-1213. Epub 2022 May 20 doi: 10.1148/rg.210171. PMID: 35594197
The Clonal Evolution of Metastatic Osteosarcoma as Shaped by Cisplatin Treatment.
Brady SW, Ma X, Bahrami A, Satas G, Wu G, Newman S, Rusch M, Putnam DK, Mulder HL, Yergeau DA, Edmonson MN, Easton J, Alexandrov LB, Chen X, Mardis ER, Wilson RK, Downing JR, Pappo AS, Raphael BJ, Dyer MA, Zhang J
Mol Cancer Res 2019 Apr;17(4):895-906. Epub 2019 Jan 16 doi: 10.1158/1541-7786.MCR-18-0620. PMID: 30651371Free PMC Article
Identification of genetic variants in pharmacokinetic genes associated with Ewing Sarcoma treatment outcome.
Ruiz-Pinto S, Pita G, Patiño-García A, García-Miguel P, Alonso J, Pérez-Martínez A, Sastre A, Gómez-Mariano G, Lissat A, Scotlandi K, Serra M, Ladenstein R, Lapouble E, Pierron G, Kontny U, Picci P, Kovar H, Delattre O, González-Neira A
Ann Oncol 2016 Sep;27(9):1788-93. Epub 2016 Jun 10 doi: 10.1093/annonc/mdw234. PMID: 27287205

Recent clinical studies

Etiology

Pediatric Osteosarcoma: Correlation of Imaging Findings with Histopathologic Features, Treatment, and Outcome.
Nguyen JC, Baghdadi S, Pogoriler J, Guariento A, Rajapakse CS, Arkader A
Radiographics 2022 Jul-Aug;42(4):1196-1213. Epub 2022 May 20 doi: 10.1148/rg.210171. PMID: 35594197
Immune Infiltrate and Tumor Microenvironment Transcriptional Programs Stratify Pediatric Osteosarcoma into Prognostic Groups at Diagnosis.
Marchais A, Marques da Costa ME, Job B, Abbas R, Drubay D, Piperno-Neumann S, Fromigué O, Gomez-Brouchet A, Redini F, Droit R, Lervat C, Entz-Werle N, Pacquement H, Devoldere C, Cupissol D, Bodet D, Gandemer V, Berger M, Marec-Berard P, Jimenez M, Vassal G, Geoerger B, Brugières L, Gaspar N
Cancer Res 2022 Mar 15;82(6):974-985. doi: 10.1158/0008-5472.CAN-20-4189. PMID: 35078815
Late effects of osteosarcoma and its treatment in pediatric patients: A single-center experience.
Nurdan T, Hatice Mine C, Emel U, Handan D, Gulsah T, Incesoy Ozdemir S, Omer K, Yasin Y, Yusuf Y, Basarir K, Gulsan Y
J BUON 2021 May-Jun;26(3):1102-1110. PMID: 34268978
Nanomedicine and drug delivery systems in cancer and regenerative medicine.
Garbayo E, Pascual-Gil S, Rodríguez-Nogales C, Saludas L, Estella-Hermoso de Mendoza A, Blanco-Prieto MJ
Wiley Interdiscip Rev Nanomed Nanobiotechnol 2020 Sep;12(5):e1637. Epub 2020 Apr 29 doi: 10.1002/wnan.1637. PMID: 32351045
miR-200c and phospho-AKT as prognostic factors and mediators of osteosarcoma progression and lung metastasis.
Berlanga P, Muñoz L, Piqueras M, Sirerol JA, Sánchez-Izquierdo MD, Hervás D, Hernández M, Llavador M, Machado I, Llombart-Bosch A, Cañete A, Castel V, Font de Mora J
Mol Oncol 2016 Aug;10(7):1043-53. Epub 2016 Apr 23 doi: 10.1016/j.molonc.2016.04.004. PMID: 27155790Free PMC Article

Diagnosis

Pediatric Osteosarcoma: Correlation of Imaging Findings with Histopathologic Features, Treatment, and Outcome.
Nguyen JC, Baghdadi S, Pogoriler J, Guariento A, Rajapakse CS, Arkader A
Radiographics 2022 Jul-Aug;42(4):1196-1213. Epub 2022 May 20 doi: 10.1148/rg.210171. PMID: 35594197
In Situ Analysis of mTORC1/C2 and Metabolism-Related Proteins in Pediatric Osteosarcoma.
Mohás A, Krencz I, Váradi Z, Arató G, Felkai L, Kiss DJ, Moldvai D, Sebestyén A, Csóka M
Pathol Oncol Res 2022;28:1610231. Epub 2022 Mar 22 doi: 10.3389/pore.2022.1610231. PMID: 35392503Free PMC Article
Late effects of osteosarcoma and its treatment in pediatric patients: A single-center experience.
Nurdan T, Hatice Mine C, Emel U, Handan D, Gulsah T, Incesoy Ozdemir S, Omer K, Yasin Y, Yusuf Y, Basarir K, Gulsan Y
J BUON 2021 May-Jun;26(3):1102-1110. PMID: 34268978
Novel insights and therapeutic interventions for pediatric osteosarcoma.
Kager L, Tamamyan G, Bielack S
Future Oncol 2017 Feb;13(4):357-368. Epub 2016 Sep 21 doi: 10.2217/fon-2016-0261. PMID: 27651036
Biology and therapeutic advances for pediatric osteosarcoma.
Marina N, Gebhardt M, Teot L, Gorlick R
Oncologist 2004;9(4):422-41. doi: 10.1634/theoncologist.9-4-422. PMID: 15266096

Therapy

Predictors and Treatment Outcomes of Pediatric Osteosarcoma in Diverse Socioeconomic Backgrounds in Southeast Asia: A Retrospective Multicenter Study.
Monsereenusorn C, Alcasabas AP, Loh AHP, Soh SY, Leung KWP, Dhamne C, Blair S, Lam C, Rujkijyanont P, Traivaree C, Photia A, Veerapan P, Puhaindran ME, Oh BLZ, Wang E, Rodriguez-Galindo C
Asian Pac J Cancer Prev 2022 Feb 1;23(2):631-640. doi: 10.31557/APJCP.2022.23.2.631. PMID: 35225476Free PMC Article
Losartan Blocks Osteosarcoma-Elicited Monocyte Recruitment, and Combined With the Kinase Inhibitor Toceranib, Exerts Significant Clinical Benefit in Canine Metastatic Osteosarcoma.
Regan DP, Chow L, Das S, Haines L, Palmer E, Kurihara JN, Coy JW, Mathias A, Thamm DH, Gustafson DL, Dow SW
Clin Cancer Res 2022 Feb 15;28(4):662-676. doi: 10.1158/1078-0432.CCR-21-2105. PMID: 34580111Free PMC Article
Pediatric Osteosarcoma of Extremities: A 15-year Experience From a Tertiary Care Cancer Center in Upper Egypt.
Morsy AM, Abdelgawad MI, Ahmed BM, Rezk KM, Aboelgheit AM, Ramadan IK, Kamel HEM, Fouad DM, Herdan RA, Shabaan SH, Eltyb HA
J Pediatr Hematol Oncol 2019 Aug;41(6):e371-e383. doi: 10.1097/MPH.0000000000001407. PMID: 30629005
Novel insights and therapeutic interventions for pediatric osteosarcoma.
Kager L, Tamamyan G, Bielack S
Future Oncol 2017 Feb;13(4):357-368. Epub 2016 Sep 21 doi: 10.2217/fon-2016-0261. PMID: 27651036
Endothelin-1 gene polymorphisms and risk of chemoresistant pediatric osteosarcoma.
Zhou Y, Liu B, Wang M, Ni J
Pediatr Blood Cancer 2014 Apr;61(4):612-7. Epub 2013 Sep 30 doi: 10.1002/pbc.24790. PMID: 24123836

Prognosis

Immune Infiltrate and Tumor Microenvironment Transcriptional Programs Stratify Pediatric Osteosarcoma into Prognostic Groups at Diagnosis.
Marchais A, Marques da Costa ME, Job B, Abbas R, Drubay D, Piperno-Neumann S, Fromigué O, Gomez-Brouchet A, Redini F, Droit R, Lervat C, Entz-Werle N, Pacquement H, Devoldere C, Cupissol D, Bodet D, Gandemer V, Berger M, Marec-Berard P, Jimenez M, Vassal G, Geoerger B, Brugières L, Gaspar N
Cancer Res 2022 Mar 15;82(6):974-985. doi: 10.1158/0008-5472.CAN-20-4189. PMID: 35078815
Late effects of osteosarcoma and its treatment in pediatric patients: A single-center experience.
Nurdan T, Hatice Mine C, Emel U, Handan D, Gulsah T, Incesoy Ozdemir S, Omer K, Yasin Y, Yusuf Y, Basarir K, Gulsan Y
J BUON 2021 May-Jun;26(3):1102-1110. PMID: 34268978
Novel insights and therapeutic interventions for pediatric osteosarcoma.
Kager L, Tamamyan G, Bielack S
Future Oncol 2017 Feb;13(4):357-368. Epub 2016 Sep 21 doi: 10.2217/fon-2016-0261. PMID: 27651036
Personalized care of pediatric cancer patients.
Rabin K, Man TK, Lau CC
Nestle Nutr Workshop Ser Pediatr Program 2008;62:173-85; discussion 185-8. doi: 10.1159/000146259. PMID: 18626200
Biology and therapeutic advances for pediatric osteosarcoma.
Marina N, Gebhardt M, Teot L, Gorlick R
Oncologist 2004;9(4):422-41. doi: 10.1634/theoncologist.9-4-422. PMID: 15266096

Clinical prediction guides

Comparative Analysis of Skip Metastasis in Pediatric Osteosarcoma: Clinical Features and Outcomes.
Halalsheh H, Amer S, Omari Z, Shawagfeh M, Boheisi M, Sultan I
J Pediatr Hematol Oncol 2024 Apr 1;46(3):154-158. Epub 2024 Feb 19 doi: 10.1097/MPH.0000000000002831. PMID: 38408127Free PMC Article
In Situ Analysis of mTORC1/C2 and Metabolism-Related Proteins in Pediatric Osteosarcoma.
Mohás A, Krencz I, Váradi Z, Arató G, Felkai L, Kiss DJ, Moldvai D, Sebestyén A, Csóka M
Pathol Oncol Res 2022;28:1610231. Epub 2022 Mar 22 doi: 10.3389/pore.2022.1610231. PMID: 35392503Free PMC Article
Immune Infiltrate and Tumor Microenvironment Transcriptional Programs Stratify Pediatric Osteosarcoma into Prognostic Groups at Diagnosis.
Marchais A, Marques da Costa ME, Job B, Abbas R, Drubay D, Piperno-Neumann S, Fromigué O, Gomez-Brouchet A, Redini F, Droit R, Lervat C, Entz-Werle N, Pacquement H, Devoldere C, Cupissol D, Bodet D, Gandemer V, Berger M, Marec-Berard P, Jimenez M, Vassal G, Geoerger B, Brugières L, Gaspar N
Cancer Res 2022 Mar 15;82(6):974-985. doi: 10.1158/0008-5472.CAN-20-4189. PMID: 35078815
Losartan Blocks Osteosarcoma-Elicited Monocyte Recruitment, and Combined With the Kinase Inhibitor Toceranib, Exerts Significant Clinical Benefit in Canine Metastatic Osteosarcoma.
Regan DP, Chow L, Das S, Haines L, Palmer E, Kurihara JN, Coy JW, Mathias A, Thamm DH, Gustafson DL, Dow SW
Clin Cancer Res 2022 Feb 15;28(4):662-676. doi: 10.1158/1078-0432.CCR-21-2105. PMID: 34580111Free PMC Article
Personalized care of pediatric cancer patients.
Rabin K, Man TK, Lau CC
Nestle Nutr Workshop Ser Pediatr Program 2008;62:173-85; discussion 185-8. doi: 10.1159/000146259. PMID: 18626200

Recent systematic reviews

Prognostic factors in high-grade pediatric osteosarcoma among children and young adults: Greek Nationwide Registry for Childhood Hematological Malignancies and Solid Tumors (NARECHEM-ST) data along with a systematic review and meta-analysis.
Papakonstantinou E, Athanasiadou KI, Markozannes G, Tzotzola V, Bouka E, Baka M, Moschovi M, Polychronopoulou S, Hatzipantelis E, Galani V, Stefanaki K, Strantzia K, Vousvouki M, Kourou P, Magkou E, Nikita M, Zambakides C, Michelarakis J, Alexopoulou A, Gavra M, Malama A, Ntzani EE, Petridou ET
Cancer Epidemiol 2024 Jun;90:102551. Epub 2024 Mar 5 doi: 10.1016/j.canep.2024.102551. PMID: 38447251
Elevated expression of miR-210 predicts poor survival of cancer patients: a systematic review and meta-analysis.
Wang J, Zhao J, Shi M, Ding Y, Sun H, Yuan F, Zou Z
PLoS One 2014;9(2):e89223. Epub 2014 Feb 20 doi: 10.1371/journal.pone.0089223. PMID: 24586608Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...