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Chondrosarcoma NCI Grade 2

MedGen UID:
272476
•Concept ID:
C1333022
•
Neoplastic Process

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChondrosarcoma NCI Grade 2

Recent clinical studies

Etiology

Characteristics and Long-Term Outcome of Surgically Managed High-Grade Extremity Chondrosarcoma.
Gulbrandsen TR, Skalitzky MK, Russell MD, An Q, Hasan O, Miller BJ
Iowa Orthop J 2023;43(1):71-75. PMID: 37383872Free PMC Article
Pembrolizumab in advanced soft-tissue sarcoma and bone sarcoma (SARC028): a multicentre, two-cohort, single-arm, open-label, phase 2 trial.
Tawbi HA, Burgess M, Bolejack V, Van Tine BA, Schuetze SM, Hu J, D'Angelo S, Attia S, Riedel RF, Priebat DA, Movva S, Davis LE, Okuno SH, Reed DR, Crowley J, Butterfield LH, Salazar R, Rodriguez-Canales J, Lazar AJ, Wistuba II, Baker LH, Maki RG, Reinke D, Patel S
Lancet Oncol 2017 Nov;18(11):1493-1501. Epub 2017 Oct 4 doi: 10.1016/S1470-2045(17)30624-1. PMID: 28988646Free PMC Article
Why do patients with low-grade soft tissue sarcoma die?
Canter RJ, Qin LX, Ferrone CR, Maki RG, Singer S, Brennan MF
Ann Surg Oncol 2008 Dec;15(12):3550-60. Epub 2008 Oct 1 doi: 10.1245/s10434-008-0163-0. PMID: 18830667Free PMC Article
FDG PET imaging for grading and prediction of outcome in chondrosarcoma patients.
Brenner W, Conrad EU, Eary JF
Eur J Nucl Med Mol Imaging 2004 Feb;31(2):189-95. doi: 10.1007/s00259-003-1353-4. PMID: 15129700
Fractionated proton radiation therapy of chordoma and low-grade chondrosarcoma of the base of the skull.
Austin-Seymour M, Munzenrider J, Goitein M, Verhey L, Urie M, Gentry R, Birnbaum S, Ruotolo D, McManus P, Skates S
J Neurosurg 1989 Jan;70(1):13-7. doi: 10.3171/jns.1989.70.1.0013. PMID: 2535872

Diagnosis

Characteristics and Long-Term Outcome of Surgically Managed High-Grade Extremity Chondrosarcoma.
Gulbrandsen TR, Skalitzky MK, Russell MD, An Q, Hasan O, Miller BJ
Iowa Orthop J 2023;43(1):71-75. PMID: 37383872Free PMC Article
Do Patient-derived Spheroid Culture Models Have Relevance in Chondrosarcoma Research?
Ma R, Mandell J, Lu F, Heim T, Schoedel K, Duensing A, Watters RJ, Weiss KR
Clin Orthop Relat Res 2021 Mar 1;479(3):477-490. doi: 10.1097/CORR.0000000000001317. PMID: 32469486Free PMC Article
The role of a monoclonal antibody 11C8B1 as a diagnostic marker of IDH2-mutated sinonasal undifferentiated carcinoma.
Dogan S, Frosina D, Fayad M, de Oliveira TB, Alemar B, Rosenblum M, Tang LH, Hameed M, Xu B, Ghossein RA, Chute DJ, Weigelt B, Jungbluth AA
Mod Pathol 2019 Feb;32(2):205-215. Epub 2018 Sep 11 doi: 10.1038/s41379-018-0126-3. PMID: 30206411Free PMC Article
Cancer-associated isocitrate dehydrogenase mutations induce mitochondrial DNA instability.
Kingsbury JM, Shamaprasad N, Billmyre RB, Heitman J, Cardenas ME
Hum Mol Genet 2016 Aug 15;25(16):3524-3538. Epub 2016 Jul 17 doi: 10.1093/hmg/ddw195. PMID: 27427385Free PMC Article
Why do patients with low-grade soft tissue sarcoma die?
Canter RJ, Qin LX, Ferrone CR, Maki RG, Singer S, Brennan MF
Ann Surg Oncol 2008 Dec;15(12):3550-60. Epub 2008 Oct 1 doi: 10.1245/s10434-008-0163-0. PMID: 18830667Free PMC Article

Therapy

Phase I Study of the Mutant IDH1 Inhibitor Ivosidenib: Safety and Clinical Activity in Patients With Advanced Chondrosarcoma.
Tap WD, Villalobos VM, Cote GM, Burris H, Janku F, Mir O, Beeram M, Wagner AJ, Jiang L, Wu B, Choe S, Yen K, Gliser C, Fan B, Agresta S, Pandya SS, Trent JC
J Clin Oncol 2020 May 20;38(15):1693-1701. Epub 2020 Mar 24 doi: 10.1200/JCO.19.02492. PMID: 32208957Free PMC Article
Pembrolizumab in advanced soft-tissue sarcoma and bone sarcoma (SARC028): a multicentre, two-cohort, single-arm, open-label, phase 2 trial.
Tawbi HA, Burgess M, Bolejack V, Van Tine BA, Schuetze SM, Hu J, D'Angelo S, Attia S, Riedel RF, Priebat DA, Movva S, Davis LE, Okuno SH, Reed DR, Crowley J, Butterfield LH, Salazar R, Rodriguez-Canales J, Lazar AJ, Wistuba II, Baker LH, Maki RG, Reinke D, Patel S
Lancet Oncol 2017 Nov;18(11):1493-1501. Epub 2017 Oct 4 doi: 10.1016/S1470-2045(17)30624-1. PMID: 28988646Free PMC Article
Targeting isocitrate dehydrogenase (IDH) in cancer.
Fujii T, Khawaja MR, DiNardo CD, Atkins JT, Janku F
Discov Med 2016 May;21(117):373-80. PMID: 27355333
Metabolic consequences of oncogenic IDH mutations.
Parker SJ, Metallo CM
Pharmacol Ther 2015 Aug;152:54-62. Epub 2015 May 5 doi: 10.1016/j.pharmthera.2015.05.003. PMID: 25956465Free PMC Article
Why do patients with low-grade soft tissue sarcoma die?
Canter RJ, Qin LX, Ferrone CR, Maki RG, Singer S, Brennan MF
Ann Surg Oncol 2008 Dec;15(12):3550-60. Epub 2008 Oct 1 doi: 10.1245/s10434-008-0163-0. PMID: 18830667Free PMC Article

Prognosis

Characteristics and Long-Term Outcome of Surgically Managed High-Grade Extremity Chondrosarcoma.
Gulbrandsen TR, Skalitzky MK, Russell MD, An Q, Hasan O, Miller BJ
Iowa Orthop J 2023;43(1):71-75. PMID: 37383872Free PMC Article
Distinct IDH1/2-associated Methylation Profile and Enrichment of TP53 and TERT Mutations Distinguish Dedifferentiated Chondrosarcoma from Conventional Chondrosarcoma.
Dermawan JKT, Nafa K, Mohanty A, Xu Y, Rijo I, Casanova J, Villafania L, Benhamida J, Kelly CM, Tap WD, Boland PJ, Fabbri N, Healey JH, Ladanyi M, Lu C, Hameed M
Cancer Res Commun 2023 Mar;3(3):431-443. Epub 2023 Mar 14 doi: 10.1158/2767-9764.CRC-22-0397. PMID: 36926116Free PMC Article
Genomic Profiling Identifies Association of IDH1/IDH2 Mutation with Longer Relapse-Free and Metastasis-Free Survival in High-Grade Chondrosarcoma.
Zhu GG, Nafa K, Agaram N, Zehir A, Benayed R, Sadowska J, Borsu L, Kelly C, Tap WD, Fabbri N, Athanasian E, Boland PJ, Healey JH, Berger MF, Ladanyi M, Hameed M
Clin Cancer Res 2020 Jan 15;26(2):419-427. Epub 2019 Oct 15 doi: 10.1158/1078-0432.CCR-18-4212. PMID: 31615936Free PMC Article
The role of a monoclonal antibody 11C8B1 as a diagnostic marker of IDH2-mutated sinonasal undifferentiated carcinoma.
Dogan S, Frosina D, Fayad M, de Oliveira TB, Alemar B, Rosenblum M, Tang LH, Hameed M, Xu B, Ghossein RA, Chute DJ, Weigelt B, Jungbluth AA
Mod Pathol 2019 Feb;32(2):205-215. Epub 2018 Sep 11 doi: 10.1038/s41379-018-0126-3. PMID: 30206411Free PMC Article
Pembrolizumab in advanced soft-tissue sarcoma and bone sarcoma (SARC028): a multicentre, two-cohort, single-arm, open-label, phase 2 trial.
Tawbi HA, Burgess M, Bolejack V, Van Tine BA, Schuetze SM, Hu J, D'Angelo S, Attia S, Riedel RF, Priebat DA, Movva S, Davis LE, Okuno SH, Reed DR, Crowley J, Butterfield LH, Salazar R, Rodriguez-Canales J, Lazar AJ, Wistuba II, Baker LH, Maki RG, Reinke D, Patel S
Lancet Oncol 2017 Nov;18(11):1493-1501. Epub 2017 Oct 4 doi: 10.1016/S1470-2045(17)30624-1. PMID: 28988646Free PMC Article

Clinical prediction guides

Do Patient-derived Spheroid Culture Models Have Relevance in Chondrosarcoma Research?
Ma R, Mandell J, Lu F, Heim T, Schoedel K, Duensing A, Watters RJ, Weiss KR
Clin Orthop Relat Res 2021 Mar 1;479(3):477-490. doi: 10.1097/CORR.0000000000001317. PMID: 32469486Free PMC Article
Genomic Profiling Identifies Association of IDH1/IDH2 Mutation with Longer Relapse-Free and Metastasis-Free Survival in High-Grade Chondrosarcoma.
Zhu GG, Nafa K, Agaram N, Zehir A, Benayed R, Sadowska J, Borsu L, Kelly C, Tap WD, Fabbri N, Athanasian E, Boland PJ, Healey JH, Berger MF, Ladanyi M, Hameed M
Clin Cancer Res 2020 Jan 15;26(2):419-427. Epub 2019 Oct 15 doi: 10.1158/1078-0432.CCR-18-4212. PMID: 31615936Free PMC Article
The role of a monoclonal antibody 11C8B1 as a diagnostic marker of IDH2-mutated sinonasal undifferentiated carcinoma.
Dogan S, Frosina D, Fayad M, de Oliveira TB, Alemar B, Rosenblum M, Tang LH, Hameed M, Xu B, Ghossein RA, Chute DJ, Weigelt B, Jungbluth AA
Mod Pathol 2019 Feb;32(2):205-215. Epub 2018 Sep 11 doi: 10.1038/s41379-018-0126-3. PMID: 30206411Free PMC Article
Targeting isocitrate dehydrogenase (IDH) in cancer.
Fujii T, Khawaja MR, DiNardo CD, Atkins JT, Janku F
Discov Med 2016 May;21(117):373-80. PMID: 27355333
FDG PET imaging for grading and prediction of outcome in chondrosarcoma patients.
Brenner W, Conrad EU, Eary JF
Eur J Nucl Med Mol Imaging 2004 Feb;31(2):189-95. doi: 10.1007/s00259-003-1353-4. PMID: 15129700

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