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Breast Ductal Carcinoma In Situ, Intermediate Grade

MedGen UID:
272759
•Concept ID:
C1334206
•
Neoplastic Process
Synonyms: DCIS Grade 2; Ductal Intraepithelial Neoplasia, Grade 2; Intermediate Grade Ductal Breast Carcinoma In Situ; Intermediate-Grade DCIS; Intermediate-Grade Ductal Carcinoma In Situ of Breast

Definition

Breast ductal carcinoma in situ characterized by the presence of monomorphic neoplastic cells that form cribriform, micropapillary, or solid patterns. Intraluminal necrosis is present in some ducts. Ducts that contain neoplastic cells with occasional nucleoli and coarse chromatin may also be present. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast Ductal Carcinoma In Situ, Intermediate Grade

Professional guidelines

PubMed

Management of ductal carcinoma in situ with accelerated partial breast irradiation brachytherapy: Implications for guideline expansion.
Mills MN, Russo NW, Nanda RH, Wilson JP, Altoos TA, Caldwell DL, Stout LL, Dube S, Blumencranz PW, Allen KG, Diaz R
Brachytherapy 2021 Mar-Apr;20(2):345-352. Epub 2020 Dec 11 doi: 10.1016/j.brachy.2020.11.002. PMID: 33317964
Treatment of low-risk ductal carcinoma in situ: is nothing better than something?
Benson JR, Jatoi I, Toi M
Lancet Oncol 2016 Oct;17(10):e442-e451. doi: 10.1016/S1470-2045(16)30367-9. PMID: 27733270
Biology and treatment of ductal carcinoma in situ.
Irvine T, Fentiman IS
Expert Rev Anticancer Ther 2007 Feb;7(2):135-45. doi: 10.1586/14737140.7.2.135. PMID: 17288525

Recent clinical studies

Etiology

Randomized Phase III Trial Evaluating Radiation Following Surgical Excision for Good-Risk Ductal Carcinoma In Situ: Long-Term Report From NRG Oncology/RTOG 9804.
McCormick B, Winter KA, Woodward W, Kuerer HM, Sneige N, Rakovitch E, Smith BL, Germain I, Hartford AC, O'Rourke MA, Walker EM, Strom EA, Hopkins JO, Pierce LJ, Pu AT, Sumida KNM, Vesprini D, Moughan J, White JR
J Clin Oncol 2021 Nov 10;39(32):3574-3582. Epub 2021 Aug 18 doi: 10.1200/JCO.21.01083. PMID: 34406870Free PMC Article
Low-Grade Ductal Carcinoma In Situ.
Alghamdi SA, Krishnamurthy K, Garces Narvaez SA, Algashaamy KJ, Aoun J, Reis IM, Recine MA, Jorda M, Poppiti RJ, Gomez-Fernandez CR
Am J Clin Pathol 2020 Feb 8;153(3):360-367. doi: 10.1093/ajcp/aqz179. PMID: 31769792
Neuroendocrine Tumors of the Breast.
Visscher DW, Yasir S
Endocr Pathol 2017 Jun;28(2):121-127. doi: 10.1007/s12022-017-9477-4. PMID: 28389994
Surgical Excision Without Radiation for Ductal Carcinoma in Situ of the Breast: 12-Year Results From the ECOG-ACRIN E5194 Study.
Solin LJ, Gray R, Hughes LL, Wood WC, Lowen MA, Badve SS, Baehner FL, Ingle JN, Perez EA, Recht A, Sparano JA, Davidson NE
J Clin Oncol 2015 Nov 20;33(33):3938-44. Epub 2015 Sep 14 doi: 10.1200/JCO.2015.60.8588. PMID: 26371148Free PMC Article
RTOG 9804: a prospective randomized trial for good-risk ductal carcinoma in situ comparing radiotherapy with observation.
McCormick B, Winter K, Hudis C, Kuerer HM, Rakovitch E, Smith BL, Sneige N, Moughan J, Shah A, Germain I, Hartford AC, Rashtian A, Walker EM, Yuen A, Strom EA, Wilcox JL, Vallow LA, Small W Jr, Pu AT, Kerlin K, White J
J Clin Oncol 2015 Mar 1;33(7):709-15. Epub 2015 Jan 20 doi: 10.1200/JCO.2014.57.9029. PMID: 25605856Free PMC Article

Diagnosis

Screen-detected ductal carcinoma in situ, 2008-2020: An observational study.
Kelly C, Fitzpatrick P, Quinn C, Flanagan F, Connors A, Larke A, Mooney T, Kennedy M, Sheehan M, Bennett MW, Brodie C, O'Doherty A
J Med Screen 2022 Sep;29(3):172-177. Epub 2022 Mar 28 doi: 10.1177/09691413221090739. PMID: 35341364
Low-Grade Ductal Carcinoma In Situ.
Alghamdi SA, Krishnamurthy K, Garces Narvaez SA, Algashaamy KJ, Aoun J, Reis IM, Recine MA, Jorda M, Poppiti RJ, Gomez-Fernandez CR
Am J Clin Pathol 2020 Feb 8;153(3):360-367. doi: 10.1093/ajcp/aqz179. PMID: 31769792
Treatment of low-risk ductal carcinoma in situ: is nothing better than something?
Benson JR, Jatoi I, Toi M
Lancet Oncol 2016 Oct;17(10):e442-e451. doi: 10.1016/S1470-2045(16)30367-9. PMID: 27733270
Ductal carcinoma in situ: a disease entity that merits more recognition.
Dereere E, Papadimitriou K, Tjalma W, Altintas S
Minerva Chir 2015 Aug;70(4):231-9. Epub 2015 Apr 28 PMID: 25916193
RTOG 9804: a prospective randomized trial for good-risk ductal carcinoma in situ comparing radiotherapy with observation.
McCormick B, Winter K, Hudis C, Kuerer HM, Rakovitch E, Smith BL, Sneige N, Moughan J, Shah A, Germain I, Hartford AC, Rashtian A, Walker EM, Yuen A, Strom EA, Wilcox JL, Vallow LA, Small W Jr, Pu AT, Kerlin K, White J
J Clin Oncol 2015 Mar 1;33(7):709-15. Epub 2015 Jan 20 doi: 10.1200/JCO.2014.57.9029. PMID: 25605856Free PMC Article

Therapy

Radiotherapy versus low-dose tamoxifen following breast-conserving surgery for low-risk and estrogen receptor-positive breast ductal carcinoma in situ: an international open-label randomized non-inferiority trial (TBCC-ARO DCIS Trial).
Kuo SH, Tseng LM, Chen ST, Sagara Y, Chang YC, Yeh HT, Kuo YL, Hung CC, Lu TP, Lee YH, Toi M, Huang CS
BMC Cancer 2023 Sep 14;23(1):865. doi: 10.1186/s12885-023-11291-6. PMID: 37710198Free PMC Article
Randomized Phase III Trial Evaluating Radiation Following Surgical Excision for Good-Risk Ductal Carcinoma In Situ: Long-Term Report From NRG Oncology/RTOG 9804.
McCormick B, Winter KA, Woodward W, Kuerer HM, Sneige N, Rakovitch E, Smith BL, Germain I, Hartford AC, O'Rourke MA, Walker EM, Strom EA, Hopkins JO, Pierce LJ, Pu AT, Sumida KNM, Vesprini D, Moughan J, White JR
J Clin Oncol 2021 Nov 10;39(32):3574-3582. Epub 2021 Aug 18 doi: 10.1200/JCO.21.01083. PMID: 34406870Free PMC Article
Surgical Excision Without Radiation for Ductal Carcinoma in Situ of the Breast: 12-Year Results From the ECOG-ACRIN E5194 Study.
Solin LJ, Gray R, Hughes LL, Wood WC, Lowen MA, Badve SS, Baehner FL, Ingle JN, Perez EA, Recht A, Sparano JA, Davidson NE
J Clin Oncol 2015 Nov 20;33(33):3938-44. Epub 2015 Sep 14 doi: 10.1200/JCO.2015.60.8588. PMID: 26371148Free PMC Article
Ductal carcinoma in situ: a disease entity that merits more recognition.
Dereere E, Papadimitriou K, Tjalma W, Altintas S
Minerva Chir 2015 Aug;70(4):231-9. Epub 2015 Apr 28 PMID: 25916193
RTOG 9804: a prospective randomized trial for good-risk ductal carcinoma in situ comparing radiotherapy with observation.
McCormick B, Winter K, Hudis C, Kuerer HM, Rakovitch E, Smith BL, Sneige N, Moughan J, Shah A, Germain I, Hartford AC, Rashtian A, Walker EM, Yuen A, Strom EA, Wilcox JL, Vallow LA, Small W Jr, Pu AT, Kerlin K, White J
J Clin Oncol 2015 Mar 1;33(7):709-15. Epub 2015 Jan 20 doi: 10.1200/JCO.2014.57.9029. PMID: 25605856Free PMC Article

Prognosis

Variability in grading of ductal carcinoma in situ among an international group of pathologists.
van Seijen M, Jóźwiak K, Pinder SE, Hall A, Krishnamurthy S, Thomas JS, Collins LC, Bijron J, Bart J, Cohen D, Ng W, Bouybayoune I, Stobart H, Hudecek J, Schaapveld M, Thompson A, Lips EH, Wesseling J; Grand Challenge PRECISION consortium.
J Pathol Clin Res 2021 May;7(3):233-242. Epub 2021 Feb 23 doi: 10.1002/cjp2.201. PMID: 33620141Free PMC Article
Neuroendocrine Tumors of the Breast.
Visscher DW, Yasir S
Endocr Pathol 2017 Jun;28(2):121-127. doi: 10.1007/s12022-017-9477-4. PMID: 28389994
Treatment of low-risk ductal carcinoma in situ: is nothing better than something?
Benson JR, Jatoi I, Toi M
Lancet Oncol 2016 Oct;17(10):e442-e451. doi: 10.1016/S1470-2045(16)30367-9. PMID: 27733270
Surgical Excision Without Radiation for Ductal Carcinoma in Situ of the Breast: 12-Year Results From the ECOG-ACRIN E5194 Study.
Solin LJ, Gray R, Hughes LL, Wood WC, Lowen MA, Badve SS, Baehner FL, Ingle JN, Perez EA, Recht A, Sparano JA, Davidson NE
J Clin Oncol 2015 Nov 20;33(33):3938-44. Epub 2015 Sep 14 doi: 10.1200/JCO.2015.60.8588. PMID: 26371148Free PMC Article
Ductal carcinoma in situ: a disease entity that merits more recognition.
Dereere E, Papadimitriou K, Tjalma W, Altintas S
Minerva Chir 2015 Aug;70(4):231-9. Epub 2015 Apr 28 PMID: 25916193

Clinical prediction guides

Screen-detected ductal carcinoma in situ, 2008-2020: An observational study.
Kelly C, Fitzpatrick P, Quinn C, Flanagan F, Connors A, Larke A, Mooney T, Kennedy M, Sheehan M, Bennett MW, Brodie C, O'Doherty A
J Med Screen 2022 Sep;29(3):172-177. Epub 2022 Mar 28 doi: 10.1177/09691413221090739. PMID: 35341364
Randomized Phase III Trial Evaluating Radiation Following Surgical Excision for Good-Risk Ductal Carcinoma In Situ: Long-Term Report From NRG Oncology/RTOG 9804.
McCormick B, Winter KA, Woodward W, Kuerer HM, Sneige N, Rakovitch E, Smith BL, Germain I, Hartford AC, O'Rourke MA, Walker EM, Strom EA, Hopkins JO, Pierce LJ, Pu AT, Sumida KNM, Vesprini D, Moughan J, White JR
J Clin Oncol 2021 Nov 10;39(32):3574-3582. Epub 2021 Aug 18 doi: 10.1200/JCO.21.01083. PMID: 34406870Free PMC Article
Low-Grade Ductal Carcinoma In Situ.
Alghamdi SA, Krishnamurthy K, Garces Narvaez SA, Algashaamy KJ, Aoun J, Reis IM, Recine MA, Jorda M, Poppiti RJ, Gomez-Fernandez CR
Am J Clin Pathol 2020 Feb 8;153(3):360-367. doi: 10.1093/ajcp/aqz179. PMID: 31769792
Treatment of low-risk ductal carcinoma in situ: is nothing better than something?
Benson JR, Jatoi I, Toi M
Lancet Oncol 2016 Oct;17(10):e442-e451. doi: 10.1016/S1470-2045(16)30367-9. PMID: 27733270
RTOG 9804: a prospective randomized trial for good-risk ductal carcinoma in situ comparing radiotherapy with observation.
McCormick B, Winter K, Hudis C, Kuerer HM, Rakovitch E, Smith BL, Sneige N, Moughan J, Shah A, Germain I, Hartford AC, Rashtian A, Walker EM, Yuen A, Strom EA, Wilcox JL, Vallow LA, Small W Jr, Pu AT, Kerlin K, White J
J Clin Oncol 2015 Mar 1;33(7):709-15. Epub 2015 Jan 20 doi: 10.1200/JCO.2014.57.9029. PMID: 25605856Free PMC Article

Recent systematic reviews

Systematic review and meta-analysis of prognostic characteristics for breast cancers in populations with digital vs film mammography indicate the transition may have increased both early detection and overdiagnosis.
Farber R, Marinovich ML, Pinna A, Houssami N, McGeechan K, Barratt A, Bell KJL
J Clin Epidemiol 2024 Jul;171:111339. Epub 2024 Apr 2 doi: 10.1016/j.jclinepi.2024.111339. PMID: 38570078
Is sentinel lymph node biopsy indicated in patients with a diagnosis of ductal carcinoma in situ? A systematic literature review and meta-analysis.
El Hage Chehade H, Headon H, Wazir U, Abtar H, Kasem A, Mokbel K
Am J Surg 2017 Jan;213(1):171-180. Epub 2016 Sep 6 doi: 10.1016/j.amjsurg.2016.04.019. PMID: 27773373

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