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Cholangiolocellular carcinoma

MedGen UID:
273143
•Concept ID:
C1516490
•
Neoplastic Process
Synonyms: cholangiocarcinoma of intralobular bile duct; Cholangiolocellular Carcinoma; cholangiolocellular carcinoma; CLC; intralobular bile duct cholangiocarcinoma
 
Monarch Initiative: MONDO:0004315

Definition

An intrahepatic cholangiocarcinoma that arises from the canals of Hering. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCholangiolocellular carcinoma

Recent clinical studies

Etiology

Minimally invasive liver resection for cholangiolocellular carcinoma: A single-institution experience.
Kihara Y, Takeda Y, Ohmura Y, Katsura Y, Shinke G, Kinoshita M, Aoyama S, Yanagisawa K, Katsuyama S, Ikeshima R, Hiraki M, Sugimura K, Masuzawa T, Hata T, Murata K
Asian J Endosc Surg 2024 Jan;17(1):e13272. doi: 10.1111/ases.13272. PMID: 38212270
Intrahepatic cholangiocarcinoma: typical features, uncommon variants, and controversial related entities.
Zen Y
Hum Pathol 2023 Feb;132:197-207. Epub 2022 Jun 11 doi: 10.1016/j.humpath.2022.06.001. PMID: 35697170
Combined hepatocellular-cholangiocarcinoma: An update.
Beaufrère A, Calderaro J, Paradis V
J Hepatol 2021 May;74(5):1212-1224. Epub 2021 Feb 3 doi: 10.1016/j.jhep.2021.01.035. PMID: 33545267
Mixed hepatocellular cholangiocarcinoma tumors: Cholangiolocellular carcinoma is a distinct molecular entity.
Moeini A, Sia D, Zhang Z, Camprecios G, Stueck A, Dong H, Montal R, Torrens L, Martinez-Quetglas I, Fiel MI, Hao K, Villanueva A, Thung SN, Schwartz ME, Llovet JM
J Hepatol 2017 May;66(5):952-961. Epub 2017 Jan 23 doi: 10.1016/j.jhep.2017.01.010. PMID: 28126467
Intrahepatic cholangiocarcinoma and cholangiolocellular carcinoma in cirrhosis and chronic viral hepatitis.
Ariizumi S, Yamamoto M
Surg Today 2015 Jun;45(6):682-7. Epub 2014 Sep 25 doi: 10.1007/s00595-014-1031-0. PMID: 25253466

Diagnosis

Rare histotypes of epithelial biliary tract tumors: A literature review.
Sapuppo E, Brunetti O, Tessitore D, Brandi G, Di Giovanni N, Fadda G, Luchini C, Martini M, Quaresmini D, Russo A, Santarpia M, Scarpa A, Scartozzi M, Tuccari G, Franchina T, Silvestris N
Crit Rev Oncol Hematol 2023 Jan;181:103892. Epub 2022 Dec 5 doi: 10.1016/j.critrevonc.2022.103892. PMID: 36481306
Intrahepatic cholangiocarcinoma: typical features, uncommon variants, and controversial related entities.
Zen Y
Hum Pathol 2023 Feb;132:197-207. Epub 2022 Jun 11 doi: 10.1016/j.humpath.2022.06.001. PMID: 35697170
Combined hepatocellular-cholangiocarcinoma: An update.
Beaufrère A, Calderaro J, Paradis V
J Hepatol 2021 May;74(5):1212-1224. Epub 2021 Feb 3 doi: 10.1016/j.jhep.2021.01.035. PMID: 33545267
Intrahepatic cholangiocarcinoma.
Nakano M, Ariizumi SI, Yamamoto M
Semin Diagn Pathol 2017 Mar;34(2):160-166. Epub 2017 Jan 5 doi: 10.1053/j.semdp.2016.12.012. PMID: 28094162
Pathogenesis of Cholangiolocellular Carcinoma: Possibility of an Interlobular Duct Origin.
Kondo F, Fukusato T
Intern Med 2015;54(14):1685-94. Epub 2015 Jul 15 doi: 10.2169/internalmedicine.54.3540. PMID: 26179521

Therapy

Cholangiolocellular Carcinoma in a Young Patient Who Showed Sustained Virological Response after Treatment for Hepatitis C Virus Infection.
Osawa M, Saitoh S, Fujiyama S, Kawamura Y, Sezaki H, Hosaka T, Akuta N, Kobayashi M, Suzuki Y, Suzuki F, Ikeda K, Kinowaki K, Fujii T, Fukusato T, Kondo F, Kumada H
Intern Med 2017 Nov 15;56(22):3033-3040. Epub 2017 Sep 25 doi: 10.2169/internalmedicine.9021-17. PMID: 28943584Free PMC Article
Repeated Hepatectomy for Recurrent Intrahepatic Cholangiolocellular Carcinoma: Report of a Case.
Tomioku M, Yazawa N, Furukawa D, Izumi H, Mashiko T, Ozawa S, Sadahiro S, Yasuda S, Hirabayashi K, Nakagohri T
Tokai J Exp Clin Med 2016 Jun 20;41(2):92-6. PMID: 27345000
Repeat hepatectomy for intrahepatic recurrence of cholangiolocellular carcinoma.
Maeda T, Hashimoto K, Ishida T, Yamashita Y, Saeki H, Kawanaka H, Uchiyama H, Ikeda T, Tsujitani S, Maehara Y
Fukuoka Igaku Zasshi 2013 Dec;104(12):564-8. PMID: 24693685
Morphometric and immunohistochemical study of cholangiolocellular carcinoma: comparison with non-neoplastic cholangiole, interlobular duct and septal duct.
Maeno S, Kondo F, Sano K, Takada T, Asano T
J Hepatobiliary Pancreat Sci 2012 May;19(3):289-96. doi: 10.1007/s00534-011-0483-5. PMID: 22179577Free PMC Article
Allelotypic characteristics of thorotrast-induced intrahepatic cholangiocarcinoma: comparison to liver cancers not associated with thorotrast.
Liu D, Wada I, Tateno H, Ogino D, Suzuki M, Li L, Lu W, Kojiro M, Fukayama M, Okabe H, Fukumoto M
Radiat Res 2004 Feb;161(2):235-43. doi: 10.1667/rr3118. PMID: 14731065

Prognosis

Combined hepatocellular-cholangiocarcinoma: An update.
Beaufrère A, Calderaro J, Paradis V
J Hepatol 2021 May;74(5):1212-1224. Epub 2021 Feb 3 doi: 10.1016/j.jhep.2021.01.035. PMID: 33545267
Clinical features and diagnostic imaging of cholangiolocellular carcinoma compared with other primary liver cancers: a surgical perspective.
Takamura H, Gabata R, Obatake Y, Nakanuma S, Hayashi H, Kozaka K, Sasaki M, Okazaki M, Yamaguchi T, Shimbashi H, Terai S, Okamoto K, Makino I, Kinoshita J, Nakamura K, Miyashita T, Tajima H, Ninomiya I, Fushida S, Kitao A, Kitahara M, Arai K, Yamashita T, Yamashita T, Ikeda H, Satoh Y, Harada K, Kaneko S, Gabata T, Kosaka T, Ohta T
Technol Cancer Res Treat 2020 Jan-Dec;19:1533033820948141. doi: 10.1177/1533033820948141. PMID: 33073719Free PMC Article
Intrahepatic cholangiocarcinoma.
Nakano M, Ariizumi SI, Yamamoto M
Semin Diagn Pathol 2017 Mar;34(2):160-166. Epub 2017 Jan 5 doi: 10.1053/j.semdp.2016.12.012. PMID: 28094162
Mutational landscape of combined hepatocellular carcinoma and cholangiocarcinoma, and its clinicopathological significance.
Sasaki M, Sato Y, Nakanuma Y
Histopathology 2017 Feb;70(3):423-434. Epub 2016 Nov 15 doi: 10.1111/his.13084. PMID: 27634656
Intrahepatic cholangiocarcinoma and cholangiolocellular carcinoma in cirrhosis and chronic viral hepatitis.
Ariizumi S, Yamamoto M
Surg Today 2015 Jun;45(6):682-7. Epub 2014 Sep 25 doi: 10.1007/s00595-014-1031-0. PMID: 25253466

Clinical prediction guides

Intrahepatic cholangiocarcinoma: typical features, uncommon variants, and controversial related entities.
Zen Y
Hum Pathol 2023 Feb;132:197-207. Epub 2022 Jun 11 doi: 10.1016/j.humpath.2022.06.001. PMID: 35697170
Combined hepatocellular-cholangiocarcinoma: An update.
Beaufrère A, Calderaro J, Paradis V
J Hepatol 2021 May;74(5):1212-1224. Epub 2021 Feb 3 doi: 10.1016/j.jhep.2021.01.035. PMID: 33545267
Mutational landscape of combined hepatocellular carcinoma and cholangiocarcinoma, and its clinicopathological significance.
Sasaki M, Sato Y, Nakanuma Y
Histopathology 2017 Feb;70(3):423-434. Epub 2016 Nov 15 doi: 10.1111/his.13084. PMID: 27634656
Immunostaining for polycomb group protein EZH2 and senescent marker p16INK4a may be useful to differentiate cholangiolocellular carcinoma from ductular reaction and bile duct adenoma.
Sasaki M, Matsubara T, Kakuda Y, Sato Y, Nakanuma Y
Am J Surg Pathol 2014 Mar;38(3):364-9. doi: 10.1097/PAS.0000000000000125. PMID: 24487593
Clinicopathological study on cholangiolocellular carcinoma suggesting hepatic progenitor cell origin.
Komuta M, Spee B, Vander Borght S, De Vos R, Verslype C, Aerts R, Yano H, Suzuki T, Matsuda M, Fujii H, Desmet VJ, Kojiro M, Roskams T
Hepatology 2008 May;47(5):1544-56. doi: 10.1002/hep.22238. PMID: 18393293

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