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Gain of Chromosome 19

MedGen UID:
273359
•Concept ID:
C1517398
•
Cell or Molecular Dysfunction

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGain of Chromosome 19

Professional guidelines

PubMed

Exploring the molecular pathogenesis, diagnosis and treatment of fibrolamellar hepatocellular carcinoma: A state of art review of the current literature.
Alshareefy Y, Shen CY, Prekash RJ
Pathol Res Pract 2023 Aug;248:154655. Epub 2023 Jun 26 doi: 10.1016/j.prp.2023.154655. PMID: 37429175
Baseline characteristics, chromosomal alterations, and treatment affecting prognosis of deletion 17p in newly diagnosed myeloma.
Merz M, Hielscher T, Seckinger A, Hose D, Mai EK, Raab MS, Goldschmidt H, Jauch A, Hillengass J
Am J Hematol 2016 Nov;91(11):E473-E477. Epub 2016 Sep 3 doi: 10.1002/ajh.24533. PMID: 27508939
Association of chromosome 19 to lung cancer genotypes and phenotypes.
Wang X, Zhang Y, Nilsson CL, Berven FS, Andrén PE, Carlsohn E, Horvatovich P, Malm J, Fuentes M, Végvári Á, Welinder C, Fehniger TE, Rezeli M, Edula G, Hober S, Nishimura T, Marko-Varga G
Cancer Metastasis Rev 2015 Jun;34(2):217-26. doi: 10.1007/s10555-015-9556-2. PMID: 25982285

Recent clinical studies

Etiology

Multiple-level copy number variations in cell-free DNA for prognostic prediction of HCC with radical treatments.
Wang Y, Zhou K, Wang X, Liu Y, Guo D, Bian Z, Su L, Liu K, Gu X, Guo X, Wang L, Zhang H, Tao K, Xing J
Cancer Sci 2021 Nov;112(11):4772-4784. Epub 2021 Sep 14 doi: 10.1111/cas.15128. PMID: 34490703Free PMC Article
Duplications in 19p13.3 are associated with male infertility.
Singh V, Bala R, Chakraborty A, Rajender S, Trivedi S, Singh K
J Assist Reprod Genet 2019 Oct;36(10):2171-2179. Epub 2019 Aug 16 doi: 10.1007/s10815-019-01547-1. PMID: 31418107Free PMC Article
Molecular profiling of long-term survivors identifies a subgroup of glioblastoma characterized by chromosome 19/20 co-gain.
Geisenberger C, Mock A, Warta R, Rapp C, Schwager C, Korshunov A, Nied AK, Capper D, Brors B, Jungk C, Jones D, Collins VP, Ichimura K, Bäcklund LM, Schnabel E, Mittelbron M, Lahrmann B, Zheng S, Verhaak RG, Grabe N, Pfister SM, Hartmann C, von Deimling A, Debus J, Unterberg A, Abdollahi A, Herold-Mende C
Acta Neuropathol 2015 Sep;130(3):419-34. Epub 2015 May 1 doi: 10.1007/s00401-015-1427-y. PMID: 25931051
Identification of genomic signatures in circulating tumor cells from breast cancer.
Kanwar N, Hu P, Bedard P, Clemons M, McCready D, Done SJ
Int J Cancer 2015 Jul 15;137(2):332-44. Epub 2015 Jan 12 doi: 10.1002/ijc.29399. PMID: 25529931
Crystallization and preliminary crystallographic studies of human kallikrein 7, a serine protease of the multigene kallikrein family.
Fernández IS, Ständker L, Forssmann WG, Giménez-Gallego G, Romero A
Acta Crystallogr Sect F Struct Biol Cryst Commun 2007 Aug 1;63(Pt 8):669-72. Epub 2007 Jul 7 doi: 10.1107/S1744309107031764. PMID: 17671364Free PMC Article

Diagnosis

Germline PRKACA amplification-associated primary pigmented nodular adrenocortical disease: a case report and literature review.
Yang WR, Liang XH, Qin YF, Yang HY, He SZ, Huang ZX, Liu YP, Luo ZJ
Arch Endocrinol Metab 2023 Nov 17;68:e220491. doi: 10.20945/2359-4292-2022-0491. PMID: 37988664Free PMC Article
Overcoming the Odds: Toward a Molecular Profile of Long-Term Survival in Glioblastoma.
Richardson TE, Kumar A, Xing C, Hatanpaa KJ, Walker JM
J Neuropathol Exp Neurol 2020 Oct 1;79(10):1031-1037. doi: 10.1093/jnen/nlaa102. PMID: 32954439
"High-grade oncocytic renal tumor": morphologic, immunohistochemical, and molecular genetic study of 14 cases.
He H, Trpkov K, Martinek P, Isikci OT, Maggi-Galuzzi C, Alaghehbandan R, Gill AJ, Tretiakova M, Lopez JI, Williamson SR, Montiel DP, Sperga M, Comperat E, Brimo F, Yilmaz A, Pivovarcikova K, Michalova K, Slouka D, Prochazkova K, Hora M, Bonert M, Michal M, Hes O
Virchows Arch 2018 Dec;473(6):725-738. Epub 2018 Sep 19 doi: 10.1007/s00428-018-2456-4. PMID: 30232607
Estimation of copy number aberrations: Comparison of exome sequencing data with SNP microarrays identifies homozygous deletions of 19q13.2 and CIC in neuroblastoma.
Fransson S, Östensson M, Djos A, Javanmardi N, Kogner P, Martinsson T
Int J Oncol 2016 Mar;48(3):1103-16. Epub 2016 Jan 19 doi: 10.3892/ijo.2016.3349. PMID: 26794043
Molecular profiling of long-term survivors identifies a subgroup of glioblastoma characterized by chromosome 19/20 co-gain.
Geisenberger C, Mock A, Warta R, Rapp C, Schwager C, Korshunov A, Nied AK, Capper D, Brors B, Jungk C, Jones D, Collins VP, Ichimura K, Bäcklund LM, Schnabel E, Mittelbron M, Lahrmann B, Zheng S, Verhaak RG, Grabe N, Pfister SM, Hartmann C, von Deimling A, Debus J, Unterberg A, Abdollahi A, Herold-Mende C
Acta Neuropathol 2015 Sep;130(3):419-34. Epub 2015 May 1 doi: 10.1007/s00401-015-1427-y. PMID: 25931051

Therapy

Germline PRKACA amplification-associated primary pigmented nodular adrenocortical disease: a case report and literature review.
Yang WR, Liang XH, Qin YF, Yang HY, He SZ, Huang ZX, Liu YP, Luo ZJ
Arch Endocrinol Metab 2023 Nov 17;68:e220491. doi: 10.20945/2359-4292-2022-0491. PMID: 37988664Free PMC Article
Recurrent oligodendroglioma with changed 1p/19q status.
Barresi V, Mafficini A, Calicchia M, Piredda ML, Musumeci A, Ghimenton C, Scarpa A
Neuropathology 2022 Apr;42(2):160-166. Epub 2022 Feb 10 doi: 10.1111/neup.12789. PMID: 35144313Free PMC Article
Distribution of segmental chromosomal alterations in neuroblastoma.
Juan Ribelles A, Gargallo P, Ferriol C, Segura V, Yáñez Y, Juan B, Cañada AJ, Font de Mora J, Cañete A, Castel V
Clin Transl Oncol 2021 Jun;23(6):1096-1104. Epub 2020 Sep 18 doi: 10.1007/s12094-020-02497-2. PMID: 32948984
Whole genome and biomarker analysis of patients with recurrent glioblastoma on bevacizumab: A subset analysis of the CABARET trial.
Olafson LR, Siddell AH, Field KM, Byrnes M, Rapkins RW, Ng B, Nixdorf S, Barnes EH, Johns TG, Yip S, Simes J, Nowak AK, Rosenthal MA, McDonald KL
J Clin Neurosci 2019 Dec;70:157-163. Epub 2019 Sep 30 doi: 10.1016/j.jocn.2019.08.044. PMID: 31582283
Relationship between chromatin structure, DNA damage and repair following X-irradiation of human lymphocytes.
Mosesso P, Palitti F, Pepe G, Piñero J, Bellacima R, Ahnstrom G, Natarajan AT
Mutat Res 2010 Aug 14;701(1):86-91. Epub 2010 Mar 16 doi: 10.1016/j.mrgentox.2010.03.005. PMID: 20298805

Prognosis

Exploring the molecular pathogenesis, diagnosis and treatment of fibrolamellar hepatocellular carcinoma: A state of art review of the current literature.
Alshareefy Y, Shen CY, Prekash RJ
Pathol Res Pract 2023 Aug;248:154655. Epub 2023 Jun 26 doi: 10.1016/j.prp.2023.154655. PMID: 37429175
Multiple-level copy number variations in cell-free DNA for prognostic prediction of HCC with radical treatments.
Wang Y, Zhou K, Wang X, Liu Y, Guo D, Bian Z, Su L, Liu K, Gu X, Guo X, Wang L, Zhang H, Tao K, Xing J
Cancer Sci 2021 Nov;112(11):4772-4784. Epub 2021 Sep 14 doi: 10.1111/cas.15128. PMID: 34490703Free PMC Article
Overcoming the Odds: Toward a Molecular Profile of Long-Term Survival in Glioblastoma.
Richardson TE, Kumar A, Xing C, Hatanpaa KJ, Walker JM
J Neuropathol Exp Neurol 2020 Oct 1;79(10):1031-1037. doi: 10.1093/jnen/nlaa102. PMID: 32954439
Molecular profiling of long-term survivors identifies a subgroup of glioblastoma characterized by chromosome 19/20 co-gain.
Geisenberger C, Mock A, Warta R, Rapp C, Schwager C, Korshunov A, Nied AK, Capper D, Brors B, Jungk C, Jones D, Collins VP, Ichimura K, Bäcklund LM, Schnabel E, Mittelbron M, Lahrmann B, Zheng S, Verhaak RG, Grabe N, Pfister SM, Hartmann C, von Deimling A, Debus J, Unterberg A, Abdollahi A, Herold-Mende C
Acta Neuropathol 2015 Sep;130(3):419-34. Epub 2015 May 1 doi: 10.1007/s00401-015-1427-y. PMID: 25931051
Identification of genomic signatures in circulating tumor cells from breast cancer.
Kanwar N, Hu P, Bedard P, Clemons M, McCready D, Done SJ
Int J Cancer 2015 Jul 15;137(2):332-44. Epub 2015 Jan 12 doi: 10.1002/ijc.29399. PMID: 25529931

Clinical prediction guides

Exploring the molecular pathogenesis, diagnosis and treatment of fibrolamellar hepatocellular carcinoma: A state of art review of the current literature.
Alshareefy Y, Shen CY, Prekash RJ
Pathol Res Pract 2023 Aug;248:154655. Epub 2023 Jun 26 doi: 10.1016/j.prp.2023.154655. PMID: 37429175
Distribution of segmental chromosomal alterations in neuroblastoma.
Juan Ribelles A, Gargallo P, Ferriol C, Segura V, Yáñez Y, Juan B, Cañada AJ, Font de Mora J, Cañete A, Castel V
Clin Transl Oncol 2021 Jun;23(6):1096-1104. Epub 2020 Sep 18 doi: 10.1007/s12094-020-02497-2. PMID: 32948984
Baseline characteristics, chromosomal alterations, and treatment affecting prognosis of deletion 17p in newly diagnosed myeloma.
Merz M, Hielscher T, Seckinger A, Hose D, Mai EK, Raab MS, Goldschmidt H, Jauch A, Hillengass J
Am J Hematol 2016 Nov;91(11):E473-E477. Epub 2016 Sep 3 doi: 10.1002/ajh.24533. PMID: 27508939
Comprehensive analysis of 19q12 amplicon in human gastric cancers.
Leung SY, Ho C, Tu IP, Li R, So S, Chu KM, Yuen ST, Chen X
Mod Pathol 2006 Jun;19(6):854-63. doi: 10.1038/modpathol.3800593. PMID: 16575401
Mutation of human short tandem repeats.
Weber JL, Wong C
Hum Mol Genet 1993 Aug;2(8):1123-8. doi: 10.1093/hmg/2.8.1123. PMID: 8401493

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