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t(6;11)(q27;q23)

MedGen UID:
273753
•Concept ID:
C1515779
•
Cell or Molecular Dysfunction
Synonym: t(6;11)(q27;q23.3)

Definition

A cytogenetic abnormality that refers to the translocation of the long arm (q27) of chromosome 6 and the long arm (q23) of chromosome 11. It is associated with the development of de novo acute myeloid leukemia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVt(6;11)(q27;q23)

Professional guidelines

PubMed

Treatment of adult AML with t(6;11)(q27;q23) by allogeneic hematopoietic SCT in the first CR.
Tamai H, Yamaguchi H, Takahashi S, Tojo A, Hamaguchi H, Kobayashi T, Akiyama H, Sakamaki H, Okumura H, Nakao S, Arai A, Miura O, Tajika K, Inokuchi K, Dan K
Bone Marrow Transplant 2008 Oct;42(8):553-4. Epub 2008 Jul 14 doi: 10.1038/bmt.2008.200. PMID: 18622415

Recent clinical studies

Etiology

Outcomes of Childhood Noninfant Acute Lymphoblastic Leukemia With 11q23/KMT2A Rearrangements in a Modern Therapy Era: A Retrospective International Study.
Attarbaschi A, Möricke A, Harrison CJ, Mann G, Baruchel A, De Moerloose B, Conter V, Devidas M, Elitzur S, Escherich G, Hunger SP, Horibe K, Manabe A, Loh ML, Pieters R, Schmiegelow K, Silverman LB, Stary J, Vora A, Pui CH, Schrappe M, Zimmermann M; Ponte-di-Legno Childhood Acute Lymphoblastic Leukemia Working Group
J Clin Oncol 2023 Mar 1;41(7):1404-1422. Epub 2022 Oct 18 doi: 10.1200/JCO.22.01297. PMID: 36256911Free PMC Article
Mutational landscape and clinical outcome of patients with de novo acute myeloid leukemia and rearrangements involving 11q23/KMT2A.
Bill M, Mrózek K, Kohlschmidt J, Eisfeld AK, Walker CJ, Nicolet D, Papaioannou D, Blachly JS, Orwick S, Carroll AJ, Kolitz JE, Powell BL, Stone RM, de la Chapelle A, Byrd JC, Bloomfield CD
Proc Natl Acad Sci U S A 2020 Oct 20;117(42):26340-26346. Epub 2020 Oct 5 doi: 10.1073/pnas.2014732117. PMID: 33020282Free PMC Article
Acute leukaemia and myelodysplastic syndromes with chromosomal rearrangement involving 11q23 locus, but not MLL gene.
Zuo W, Wang SA, DiNardo C, Yabe M, Li S, Medeiros LJ, Tang G
J Clin Pathol 2017 Mar;70(3):244-249. Epub 2016 Aug 5 doi: 10.1136/jclinpath-2016-203831. PMID: 27496968
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793
Novel prognostic subgroups in childhood 11q23/MLL-rearranged acute myeloid leukemia: results of an international retrospective study.
Balgobind BV, Raimondi SC, Harbott J, Zimmermann M, Alonzo TA, Auvrignon A, Beverloo HB, Chang M, Creutzig U, Dworzak MN, Forestier E, Gibson B, Hasle H, Harrison CJ, Heerema NA, Kaspers GJ, Leszl A, Litvinko N, Nigro LL, Morimoto A, Perot C, Pieters R, Reinhardt D, Rubnitz JE, Smith FO, Stary J, Stasevich I, Strehl S, Taga T, Tomizawa D, Webb D, Zemanova Z, Zwaan CM, van den Heuvel-Eibrink MM
Blood 2009 Sep 17;114(12):2489-96. Epub 2009 Jun 15 doi: 10.1182/blood-2009-04-215152. PMID: 19528532Free PMC Article

Diagnosis

Outcomes of Childhood Noninfant Acute Lymphoblastic Leukemia With 11q23/KMT2A Rearrangements in a Modern Therapy Era: A Retrospective International Study.
Attarbaschi A, Möricke A, Harrison CJ, Mann G, Baruchel A, De Moerloose B, Conter V, Devidas M, Elitzur S, Escherich G, Hunger SP, Horibe K, Manabe A, Loh ML, Pieters R, Schmiegelow K, Silverman LB, Stary J, Vora A, Pui CH, Schrappe M, Zimmermann M; Ponte-di-Legno Childhood Acute Lymphoblastic Leukemia Working Group
J Clin Oncol 2023 Mar 1;41(7):1404-1422. Epub 2022 Oct 18 doi: 10.1200/JCO.22.01297. PMID: 36256911Free PMC Article
Association of race and ethnicity with clinical phenotype, genetics, and survival in pediatric acute myeloid leukemia.
Conneely SE, McAtee CL, Gupta R, Lubega J, Scheurer ME, Rau RE
Blood Adv 2021 Dec 14;5(23):4992-5001. doi: 10.1182/bloodadvances.2021004735. PMID: 34619758Free PMC Article
Acute leukaemia and myelodysplastic syndromes with chromosomal rearrangement involving 11q23 locus, but not MLL gene.
Zuo W, Wang SA, DiNardo C, Yabe M, Li S, Medeiros LJ, Tang G
J Clin Pathol 2017 Mar;70(3):244-249. Epub 2016 Aug 5 doi: 10.1136/jclinpath-2016-203831. PMID: 27496968
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793
Novel prognostic subgroups in childhood 11q23/MLL-rearranged acute myeloid leukemia: results of an international retrospective study.
Balgobind BV, Raimondi SC, Harbott J, Zimmermann M, Alonzo TA, Auvrignon A, Beverloo HB, Chang M, Creutzig U, Dworzak MN, Forestier E, Gibson B, Hasle H, Harrison CJ, Heerema NA, Kaspers GJ, Leszl A, Litvinko N, Nigro LL, Morimoto A, Perot C, Pieters R, Reinhardt D, Rubnitz JE, Smith FO, Stary J, Stasevich I, Strehl S, Taga T, Tomizawa D, Webb D, Zemanova Z, Zwaan CM, van den Heuvel-Eibrink MM
Blood 2009 Sep 17;114(12):2489-96. Epub 2009 Jun 15 doi: 10.1182/blood-2009-04-215152. PMID: 19528532Free PMC Article

Therapy

Therapy-related Acute Myeloid Leukemia after the Long-term Administration of Low-dose Etoposide for Chronic-type Adult T-cell Leukemia-lymphoma: A Case Report and Literature Review.
Shimada N, Ohno N, Tanosaki R, Fuji S, Suzuki Y, Yuji K, Uchimaru K, Tojo A
Intern Med 2017;56(14):1879-1884. Epub 2017 Jul 15 doi: 10.2169/internalmedicine.56.7763. PMID: 28717086Free PMC Article
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793
Distinct MLL gene rearrangements associated with successive acute monocytic and lymphoblastic leukemias in the same patient.
Jonveaux P, Hillion J, Bernard O, Le Coniat M, Derré J, Flexor M, Larsen CJ, Berger R
Leukemia 1994 Dec;8(12):2224-7. PMID: 7808011

Prognosis

Outcomes of Childhood Noninfant Acute Lymphoblastic Leukemia With 11q23/KMT2A Rearrangements in a Modern Therapy Era: A Retrospective International Study.
Attarbaschi A, Möricke A, Harrison CJ, Mann G, Baruchel A, De Moerloose B, Conter V, Devidas M, Elitzur S, Escherich G, Hunger SP, Horibe K, Manabe A, Loh ML, Pieters R, Schmiegelow K, Silverman LB, Stary J, Vora A, Pui CH, Schrappe M, Zimmermann M; Ponte-di-Legno Childhood Acute Lymphoblastic Leukemia Working Group
J Clin Oncol 2023 Mar 1;41(7):1404-1422. Epub 2022 Oct 18 doi: 10.1200/JCO.22.01297. PMID: 36256911Free PMC Article
Association of race and ethnicity with clinical phenotype, genetics, and survival in pediatric acute myeloid leukemia.
Conneely SE, McAtee CL, Gupta R, Lubega J, Scheurer ME, Rau RE
Blood Adv 2021 Dec 14;5(23):4992-5001. doi: 10.1182/bloodadvances.2021004735. PMID: 34619758Free PMC Article
Mutational landscape and clinical outcome of patients with de novo acute myeloid leukemia and rearrangements involving 11q23/KMT2A.
Bill M, Mrózek K, Kohlschmidt J, Eisfeld AK, Walker CJ, Nicolet D, Papaioannou D, Blachly JS, Orwick S, Carroll AJ, Kolitz JE, Powell BL, Stone RM, de la Chapelle A, Byrd JC, Bloomfield CD
Proc Natl Acad Sci U S A 2020 Oct 20;117(42):26340-26346. Epub 2020 Oct 5 doi: 10.1073/pnas.2014732117. PMID: 33020282Free PMC Article
Lineage switch with t(6;11)(q27;q23) from T-cell lymphoblastic lymphoma to acute monoblastic leukemia at relapse.
Higuchi Y, Tokunaga K, Watanabe Y, Kawakita T, Harada N, Yamaguchi S, Nosaka K, Mitsuya H, Asou N
Cancer Genet 2016 Jun;209(6):267-71. Epub 2016 May 18 doi: 10.1016/j.cancergen.2016.05.070. PMID: 27268298
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793

Clinical prediction guides

Outcomes of Childhood Noninfant Acute Lymphoblastic Leukemia With 11q23/KMT2A Rearrangements in a Modern Therapy Era: A Retrospective International Study.
Attarbaschi A, Möricke A, Harrison CJ, Mann G, Baruchel A, De Moerloose B, Conter V, Devidas M, Elitzur S, Escherich G, Hunger SP, Horibe K, Manabe A, Loh ML, Pieters R, Schmiegelow K, Silverman LB, Stary J, Vora A, Pui CH, Schrappe M, Zimmermann M; Ponte-di-Legno Childhood Acute Lymphoblastic Leukemia Working Group
J Clin Oncol 2023 Mar 1;41(7):1404-1422. Epub 2022 Oct 18 doi: 10.1200/JCO.22.01297. PMID: 36256911Free PMC Article
The role of reciprocal fusions in MLL-r acute leukemia: studying the chromosomal translocation t(6;11).
Kundu A, Kowarz E, Marschalek R
Oncogene 2021 Oct;40(40):5902-5912. Epub 2021 Aug 5 doi: 10.1038/s41388-021-01983-3. PMID: 34354240Free PMC Article
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793
Chronic eosinophilic leukemia with t(6;11)(q27;q23) translocation.
Suzuki S, Chiba K, Toyoshima N, Kurosawa M, Hashino S, Musashi M, Asaka M
Ann Hematol 2001 Sep;80(9):553-6. doi: 10.1007/s002770100327. PMID: 11669308
Analysis of the t(6;11)(q27;q23) in leukemia shows a consistent breakpoint in AF6 in three patients and in the ML-2 cell line.
Tanabe S, Zeleznik-Le NJ, Kobayashi H, Vignon C, Espinosa R 3rd, LeBeau MM, Thirman MJ, Rowley JD
Genes Chromosomes Cancer 1996 Apr;15(4):206-16. doi: 10.1002/(SICI)1098-2264(199604)15:4<206::AID-GCC2>3.0.CO;2-5. PMID: 8703846

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