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Vaginal adenosarcoma

MedGen UID:
274378
•Concept ID:
C1519914
•
Neoplastic Process
Synonyms: adenosarcoma of vagina; vagina adenosarcoma; Vaginal Adenosarcoma; vaginal adenosarcoma; Vaginal Mullerian Adenosarcoma; vaginal Mullerian adenosarcoma; Vaginal Müllerian Adenosarcoma; vaginal Müllerian adenosarcoma
 
Monarch Initiative: MONDO:0002881

Definition

A malignant mixed epithelial and mesenchymal neoplasm that arises from the vagina and is characterized by the presence of a malignant mesenchymal component and a benign or atypical mullerian-type epithelial component. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVaginal adenosarcoma

Professional guidelines

PubMed

Embryonal Rhabdomyosarcoma of the Uterine Cervix: A Clinicopathologic Study of 94 Cases Emphasizing Issues in Differential Diagnosis Staging, and Prognostic Factors.
Devins KM, Young RH, Ghioni M, Burandt E, Bennett JA, Oliva E
Am J Surg Pathol 2022 Nov 1;46(11):1477-1489. Epub 2022 Aug 9 doi: 10.1097/PAS.0000000000001933. PMID: 35941719
DICER1-associated embryonal rhabdomyosarcoma and adenosarcoma of the gynecologic tract: Pathology, molecular genetics, and indications for molecular testing.
Apellaniz-Ruiz M, McCluggage WG, Foulkes WD
Genes Chromosomes Cancer 2021 Mar;60(3):217-233. Epub 2020 Nov 19 doi: 10.1002/gcc.22913. PMID: 33135284
Diagnosis and management of Müllerian adenosarcoma of the uterine cervix.
Chin PS, Chia YN, Lim YK, Yam KL
Int J Gynaecol Obstet 2013 Jun;121(3):229-32. Epub 2013 Mar 13 doi: 10.1016/j.ijgo.2012.12.015. PMID: 23490428

Recent clinical studies

Diagnosis

Primary extra-uterine and extra-ovarian mullerian adenosarcoma: case report and literature review.
Mandato VD, Torricelli F, Mastrofilippo V, Valli R, Aguzzoli L, La Sala GB
BMC Cancer 2018 Feb 5;18(1):134. doi: 10.1186/s12885-018-4037-y. PMID: 29402239Free PMC Article
Primary Vaginal Adenosarcoma With Sarcomatous Overgrowth Arising in Recurrent Endometriosis: Feasibility of Laparoscopic Treatment and Review of the Literature.
Pontrelli G, Cozzolino M, Stepniewska A, Bruni F, Pesci A, Ceccaroni M
J Minim Invasive Gynecol 2016 Jul-Aug;23(5):833-8. Epub 2016 Mar 31 doi: 10.1016/j.jmig.2016.03.019. PMID: 27041653
Primary vaginal adenosarcoma with sarcomatous overgrowth.
Toyoshima M, Akahira J, Moriya T, Hayakawa S, Yaegashi N
Gynecol Oncol 2004 Dec;95(3):759-61. doi: 10.1016/j.ygyno.2004.08.004. PMID: 15582000
Adenosarcoma in a patient with vaginal endometriosis.
Anderson J, Behbakht K, De Geest K, Bitterman P
Obstet Gynecol 2001 Nov;98(5 Pt 2):964-6. doi: 10.1016/s0029-7844(01)01545-9. PMID: 11704223
Vaginal adenosarcoma arising from endometriosis.
Judson PL, Temple AM, Fowler WC Jr, Novotny DB, Funkhouser WK Jr
Gynecol Oncol 2000 Jan;76(1):123-5. doi: 10.1006/gyno.1999.5617. PMID: 10620454

Therapy

Vaginal adenosarcoma arising from refractory endometriosis: a case report.
Han X, Leng J, Guo L, Xiang Y, Lang J
Aust N Z J Obstet Gynaecol 2010 Dec;50(6):574-6. Epub 2010 Sep 1 doi: 10.1111/j.1479-828X.2010.01213.x. PMID: 21133871
Primary vaginal adenosarcoma with sarcomatous overgrowth.
Toyoshima M, Akahira J, Moriya T, Hayakawa S, Yaegashi N
Gynecol Oncol 2004 Dec;95(3):759-61. doi: 10.1016/j.ygyno.2004.08.004. PMID: 15582000

Prognosis

Primary extra-uterine and extra-ovarian mullerian adenosarcoma: case report and literature review.
Mandato VD, Torricelli F, Mastrofilippo V, Valli R, Aguzzoli L, La Sala GB
BMC Cancer 2018 Feb 5;18(1):134. doi: 10.1186/s12885-018-4037-y. PMID: 29402239Free PMC Article
Primary vaginal adenosarcoma with sarcomatous overgrowth.
Toyoshima M, Akahira J, Moriya T, Hayakawa S, Yaegashi N
Gynecol Oncol 2004 Dec;95(3):759-61. doi: 10.1016/j.ygyno.2004.08.004. PMID: 15582000
Vaginal adenosarcoma arising from endometriosis.
Judson PL, Temple AM, Fowler WC Jr, Novotny DB, Funkhouser WK Jr
Gynecol Oncol 2000 Jan;76(1):123-5. doi: 10.1006/gyno.1999.5617. PMID: 10620454

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