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Loss of Chromosome 11q

MedGen UID:
274696
•Concept ID:
C1517952
•
Cell or Molecular Dysfunction
Synonyms: 11q Deletion; del(11q)

Definition

A cytogenetic abnormality that refers to the loss of all or part of the long arm of chromosome 11 (11q). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLoss of Chromosome 11q

Professional guidelines

PubMed

Improved clinical utility of preimplantation genetic testing through the integration of ploidy and common pathogenic microdeletions analyses.
Caroselli S, Figliuzzi M, Picchetta L, Cogo F, Zambon P, Pergher I, Girardi L, Patassini C, Poli M, Bakalova D, Cimadomo D, Findikli N, Coban O, Serdarogullari M, Favero F, Bortolato S, Anastasi A, Capodanno F, Gallinelli A, Brancati F, Rienzi L, Ubaldi FM, Jimenez-Almazán J, Blesa-Jarque D, Miravet-Valenciano J, Rubio C, Simòn C, Capalbo A
Hum Reprod 2023 Apr 3;38(4):762-775. doi: 10.1093/humrep/dead033. PMID: 36824049
Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management.
Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Genetic stratification of neuroblastoma for treatment tailoring.
Jeison M, Yaniv I, Ash S
Future Oncol 2011 Sep;7(9):1087-99. doi: 10.2217/fon.11.87. PMID: 21919696

Recent clinical studies

Etiology

Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management.
Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Defining Risk Factors for Chemotherapeutic Intervention in Infants With Stage 4S Neuroblastoma: A Report From Children's Oncology Group Study ANBL0531.
Twist CJ, Naranjo A, Schmidt ML, Tenney SC, Cohn SL, Meany HJ, Mattei P, Adkins ES, Shimada H, London WB, Park JR, Matthay KK, Maris JM
J Clin Oncol 2019 Jan 10;37(2):115-124. Epub 2018 Nov 16 doi: 10.1200/JCO.18.00419. PMID: 30444686Free PMC Article
PRAME as an Independent Biomarker for Metastasis in Uveal Melanoma.
Field MG, Decatur CL, Kurtenbach S, Gezgin G, van der Velden PA, Jager MJ, Kozak KN, Harbour JW
Clin Cancer Res 2016 Mar 1;22(5):1234-42. doi: 10.1158/1078-0432.CCR-15-2071. PMID: 26933176Free PMC Article
Profiling of ileal carcinoids.
Nilsson O
Neuroendocrinology 2013;97(1):7-18. Epub 2012 Nov 2 doi: 10.1159/000343232. PMID: 22986706
Genetic pattern of prostate cancer progression.
Saric T, Brkanac Z, Troyer DA, Padalecki SS, Sarosdy M, Williams K, Abadesco L, Leach RJ, O'Connell P
Int J Cancer 1999 Apr 12;81(2):219-24. doi: 10.1002/(sici)1097-0215(19990412)81:2<219::aid-ijc9>3.0.co;2-3. PMID: 10188722

Diagnosis

Emerging entities: high-grade/large B-cell lymphoma with 11q aberration, large B-cell lymphoma with IRF4 rearrangement, and new molecular subgroups in large B-cell lymphomas. A report of the 2022 EA4HP/SH lymphoma workshop.
Quintanilla-Martinez L, Laurent C, Soma L, Ng SB, Climent F, Ondrejka SL, Zamo A, Wotherspoon A, de Leval L, Dirnhofer S, Leoncini L
Virchows Arch 2023 Sep;483(3):281-298. Epub 2023 Aug 9 doi: 10.1007/s00428-023-03590-x. PMID: 37555980Free PMC Article
Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management.
Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Quantitative assessment of copy number alterations by liquid biopsy for neuroblastoma.
Shirai R, Osumi T, Sato-Otsubo A, Nakabayashi K, Ishiwata K, Yamada Y, Yoshida M, Yoshida K, Shioda Y, Kiyotani C, Terashima K, Tomizawa D, Takasugi N, Takita J, Miyazaki O, Kiyokawa N, Yoneda A, Kanamori Y, Hishiki T, Matsumoto K, Hata K, Yoshioka T, Kato M
Genes Chromosomes Cancer 2022 Nov;61(11):662-669. Epub 2022 Jun 24 doi: 10.1002/gcc.23073. PMID: 35655408
Aggressive mature natural killer cell neoplasms: from epidemiology to diagnosis.
Lima M
Orphanet J Rare Dis 2013 Jul 1;8:95. doi: 10.1186/1750-1172-8-95. PMID: 23816348Free PMC Article
Chromosomal abnormalities of adenocarcinoma of the pancreas: identifying early and late changes.
Kowalski J, Morsberger LA, Blackford A, Hawkins A, Yeo CJ, Hruban RH, Griffin CA
Cancer Genet Cytogenet 2007 Oct 1;178(1):26-35. doi: 10.1016/j.cancergencyto.2007.06.004. PMID: 17889705

Therapy

Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management.
Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Lung Neuroendocrine Tumors: How Does Molecular Profiling Help?
Sun TY, Hendifar A, Padda SK
Curr Oncol Rep 2022 Jul;24(7):819-824. Epub 2022 Mar 19 doi: 10.1007/s11912-022-01253-9. PMID: 35305210
Defining Risk Factors for Chemotherapeutic Intervention in Infants With Stage 4S Neuroblastoma: A Report From Children's Oncology Group Study ANBL0531.
Twist CJ, Naranjo A, Schmidt ML, Tenney SC, Cohn SL, Meany HJ, Mattei P, Adkins ES, Shimada H, London WB, Park JR, Matthay KK, Maris JM
J Clin Oncol 2019 Jan 10;37(2):115-124. Epub 2018 Nov 16 doi: 10.1200/JCO.18.00419. PMID: 30444686Free PMC Article
Characteristics of myeloproliferative neoplasms in patients exposed to ionizing radiation following the Chernobyl nuclear accident.
Poluben L, Puligandla M, Neuberg D, Bryke CR, Hsu Y, Shumeiko O, Yuan X, Voznesensky O, Pihan G, Adam M, Fraenkel E, Rasnic R, Linial M, Klymenko S, Balk SP, Fraenkel PG
Am J Hematol 2019 Jan;94(1):62-73. Epub 2018 Oct 31 doi: 10.1002/ajh.25307. PMID: 30295334Free PMC Article
Chromosomal 11 alterations in non-small-cell lung carcinomas in Hong Kong.
Chan AS, Lam WK, Wong MP, Fu KH, Lee J, Yew WW, Chiu SW, Lung ML
Lung Cancer 1996 Aug;15(1):51-65. doi: 10.1016/0169-5002(96)00570-3. PMID: 8865123

Prognosis

Emerging entities: high-grade/large B-cell lymphoma with 11q aberration, large B-cell lymphoma with IRF4 rearrangement, and new molecular subgroups in large B-cell lymphomas. A report of the 2022 EA4HP/SH lymphoma workshop.
Quintanilla-Martinez L, Laurent C, Soma L, Ng SB, Climent F, Ondrejka SL, Zamo A, Wotherspoon A, de Leval L, Dirnhofer S, Leoncini L
Virchows Arch 2023 Sep;483(3):281-298. Epub 2023 Aug 9 doi: 10.1007/s00428-023-03590-x. PMID: 37555980Free PMC Article
Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management.
Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Defining Risk Factors for Chemotherapeutic Intervention in Infants With Stage 4S Neuroblastoma: A Report From Children's Oncology Group Study ANBL0531.
Twist CJ, Naranjo A, Schmidt ML, Tenney SC, Cohn SL, Meany HJ, Mattei P, Adkins ES, Shimada H, London WB, Park JR, Matthay KK, Maris JM
J Clin Oncol 2019 Jan 10;37(2):115-124. Epub 2018 Nov 16 doi: 10.1200/JCO.18.00419. PMID: 30444686Free PMC Article
PRAME as an Independent Biomarker for Metastasis in Uveal Melanoma.
Field MG, Decatur CL, Kurtenbach S, Gezgin G, van der Velden PA, Jager MJ, Kozak KN, Harbour JW
Clin Cancer Res 2016 Mar 1;22(5):1234-42. doi: 10.1158/1078-0432.CCR-15-2071. PMID: 26933176Free PMC Article
New insights into the genetics of neuroblastoma.
Sridhar S, Al-Moallem B, Kamal H, Terrile M, Stallings RL
Mol Diagn Ther 2013 Apr;17(2):63-9. doi: 10.1007/s40291-013-0019-6. PMID: 23329364

Clinical prediction guides

Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management.
Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Genomic and Transcriptomic Tumor Heterogeneity in Bilateral Retinoblastoma.
Winter U, Ganiewich D, Ottaviani D, Zugbi S, Aschero R, Sendoya JM, Cafferata EG, Mena M, Sgroi M, Sampor C, Lubieniecki F, Fandiño A, Abba MC, Doz F, Podhjacer O, Carcaboso AM, Letouzé E, Radvanyi F, Chantada GL, Llera AS, Schaiquevich P
JAMA Ophthalmol 2020 May 1;138(5):569-574. doi: 10.1001/jamaophthalmol.2020.0427. PMID: 32191268Free PMC Article
Defining Risk Factors for Chemotherapeutic Intervention in Infants With Stage 4S Neuroblastoma: A Report From Children's Oncology Group Study ANBL0531.
Twist CJ, Naranjo A, Schmidt ML, Tenney SC, Cohn SL, Meany HJ, Mattei P, Adkins ES, Shimada H, London WB, Park JR, Matthay KK, Maris JM
J Clin Oncol 2019 Jan 10;37(2):115-124. Epub 2018 Nov 16 doi: 10.1200/JCO.18.00419. PMID: 30444686Free PMC Article
PRAME as an Independent Biomarker for Metastasis in Uveal Melanoma.
Field MG, Decatur CL, Kurtenbach S, Gezgin G, van der Velden PA, Jager MJ, Kozak KN, Harbour JW
Clin Cancer Res 2016 Mar 1;22(5):1234-42. doi: 10.1158/1078-0432.CCR-15-2071. PMID: 26933176Free PMC Article
Genetic pattern of prostate cancer progression.
Saric T, Brkanac Z, Troyer DA, Padalecki SS, Sarosdy M, Williams K, Abadesco L, Leach RJ, O'Connell P
Int J Cancer 1999 Apr 12;81(2):219-24. doi: 10.1002/(sici)1097-0215(19990412)81:2<219::aid-ijc9>3.0.co;2-3. PMID: 10188722

Recent systematic reviews

Genetic variation frequencies in Wilms' tumor: A meta-analysis and systematic review.
Deng C, Dai R, Li X, Liu F
Cancer Sci 2016 May;107(5):690-9. Epub 2016 Mar 18 doi: 10.1111/cas.12910. PMID: 26892980Free PMC Article

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