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Loss of Chromosome 12

MedGen UID:
274697
Concept ID:
C1517954
Cell or Molecular Dysfunction

Definition

A cytogenetic abnormality that refers to loss of all or part of chromosome 12. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLoss of Chromosome 12

Recent clinical studies

Etiology

McGuire Sams C, Shepp K, Pugh J, Bishop MR, Merner ND
BMC Med Genomics 2021 Dec 1;14(1):284. doi: 10.1186/s12920-021-01126-3. PMID: 34852802Free PMC Article
Tilton RK, Wilkens A, Krantz ID, Izumi K
Am J Med Genet A 2014 May;164A(5):1130-5. Epub 2014 Feb 6 doi: 10.1002/ajmg.a.36413. PMID: 24504854
Voz ML, Van de Ven WJ, Kas K
Adv Dent Res 2000 Dec;14:81-3. doi: 10.1177/08959374000140011301. PMID: 11842929
Looijenga LH, de Munnik H, Oosterhuis JW
Int J Cancer 1999 Dec 10;83(6):809-14. doi: 10.1002/(sici)1097-0215(19991210)83:6<809::aid-ijc20>3.0.co;2-0. PMID: 10597200
Cooper GJ, Day AJ, Willis AC, Roberts AN, Reid KB, Leighton B
Biochim Biophys Acta 1989 Dec 14;1014(3):247-58. doi: 10.1016/0167-4889(89)90220-6. PMID: 2690958

Diagnosis

Pepe F, Rassenti LZ, Pekarsky Y, Labanowska J, Nakamura T, Nigita G, Kipps TJ, Balatti V, Croce CM
Proc Natl Acad Sci U S A 2022 Jan 25;119(4) doi: 10.1073/pnas.2118752119. PMID: 35064090Free PMC Article
Basbus FJ, Cremona FA, Lucero Saá F, Chiaradía PA, Francipane L, Menazzi S
Cornea 2022 Apr 1;41(4):491-495. doi: 10.1097/ICO.0000000000002961. PMID: 35044970
Starling CE, Sabra J, Brady B, Horton M, Traweek ST
Diagn Cytopathol 2019 Sep;47(9):930-934. Epub 2019 May 23 doi: 10.1002/dc.24216. PMID: 31120625
Gasparini Y, Montenegro MM, Novo-Filho GM, Ceroni JRM, Honjo RS, Zanardo ÉA, Dias AT, Nascimento AM, Costa TVMM, Madia FA, Chehimi SN, Damasceno JG, Kim CA, Kulikowski LD
Cytogenet Genome Res 2019;157(3):153-157. Epub 2019 Apr 2 doi: 10.1159/000498836. PMID: 30933946
Deng C, Dai R, Li X, Liu F
Cancer Sci 2016 May;107(5):690-9. Epub 2016 Mar 18 doi: 10.1111/cas.12910. PMID: 26892980Free PMC Article

Therapy

Lawlor RT, Mafficini A, Sciammarella C, Cantù C, Rusev BC, Piredda ML, Antonello D, Grimaldi S, Bonizzato G, Sperandio N, Marchegiani G, Malleo G, Pea A, Salvia R, Mombello A, Mazzoleni G, Nottegar A, Hanspeter E, Riva G, Tomezzoli A, Bencivenga M, de Manzoni G, Pedron S, Paolino G, Mattiolo P, Brosens LA, Silvestris N, Fassan M, Cooke SL, Beer PA, Milella M, Adsay VN, Cheng L, Scarpa A, Luchini C
Hum Pathol 2021 Dec;118:30-41. Epub 2021 Sep 22 doi: 10.1016/j.humpath.2021.09.006. PMID: 34562502
Starling CE, Sabra J, Brady B, Horton M, Traweek ST
Diagn Cytopathol 2019 Sep;47(9):930-934. Epub 2019 May 23 doi: 10.1002/dc.24216. PMID: 31120625
Del-Aguila JL, Cooper-DeHoff RM, Chapman AB, Gums JG, Beitelshees AL, Bailey K, Turner ST, Johnson JA, Boerwinkle E
Pharmacogenomics J 2015 Apr;15(2):153-7. Epub 2014 Sep 9 doi: 10.1038/tpj.2014.46. PMID: 25201287Free PMC Article
Voz ML, Van de Ven WJ, Kas K
Adv Dent Res 2000 Dec;14:81-3. doi: 10.1177/08959374000140011301. PMID: 11842929
Jacobsen NJ, Lyons I, Hoogendoorn B, Burge S, Kwok PY, O'Donovan MC, Craddock N, Owen MJ
Hum Mol Genet 1999 Sep;8(9):1631-6. doi: 10.1093/hmg/8.9.1631. PMID: 10441325

Prognosis

Eisenberger T, Di Donato N, Decker C, Delle Vedove A, Neuhaus C, Nürnberg G, Toliat M, Nürnberg P, Mürbe D, Bolz HJ
Genet Med 2018 Jun;20(6):614-621. Epub 2017 Oct 12 doi: 10.1038/gim.2017.155. PMID: 29309402Free PMC Article
Lee JC, Lu TP, Changou CA, Liang CW, Huang HN, Lauria A, Huang HY, Lin CY, Chiang YC, Davidson B, Lin MC, Kuo KT
Mod Pathol 2016 Sep;29(9):1070-82. Epub 2016 Jun 3 doi: 10.1038/modpathol.2016.99. PMID: 27255164
Palmer RD, Foster NA, Vowler SL, Roberts I, Thornton CM, Hale JP, Schneider DT, Nicholson JC, Coleman N
Br J Cancer 2007 Feb 26;96(4):667-76. Epub 2007 Feb 6 doi: 10.1038/sj.bjc.6603602. PMID: 17285132Free PMC Article
Jabber Al-Obaidi MS, Martineau M, Bennett CF, Franklin IM, Goldstone AH, Harewood L, Jalali GR, Prentice HG, Richards SM, Roberts K, Harrison CJ; Medical Research Council Adult Leukaemia Working Party
Leukemia 2002 Apr;16(4):669-74. doi: 10.1038/sj.leu.2402435. PMID: 11960348
Jacobsen NJ, Lyons I, Hoogendoorn B, Burge S, Kwok PY, O'Donovan MC, Craddock N, Owen MJ
Hum Mol Genet 1999 Sep;8(9):1631-6. doi: 10.1093/hmg/8.9.1631. PMID: 10441325

Clinical prediction guides

Eisenberger T, Di Donato N, Decker C, Delle Vedove A, Neuhaus C, Nürnberg G, Toliat M, Nürnberg P, Mürbe D, Bolz HJ
Genet Med 2018 Jun;20(6):614-621. Epub 2017 Oct 12 doi: 10.1038/gim.2017.155. PMID: 29309402Free PMC Article
Cicek MS, Cunningham JM, Fridley BL, Serie DJ, Bamlet WR, Diergaarde B, Haile RW, Le Marchand L, Krontiris TG, Younghusband HB, Gallinger S, Newcomb PA, Hopper JL, Jenkins MA, Casey G, Schumacher F, Chen Z, DeRycke MS, Templeton AS, Winship I, Green RC, Green JS, Macrae FA, Parry S, Young GP, Young JP, Buchanan D, Thomas DC, Bishop DT, Lindor NM, Thibodeau SN, Potter JD, Goode EL; Colon CFR
PLoS One 2012;7(5):e38175. Epub 2012 May 31 doi: 10.1371/journal.pone.0038175. PMID: 22675446Free PMC Article
Whittock NV, Smith FJ, Wan H, Mallipeddi R, Griffiths WA, Dopping-Hepenstal P, Ashton GH, Eady RA, McLean WH, McGrath JA
J Invest Dermatol 2002 May;118(5):838-44. doi: 10.1046/j.1523-1747.2002.01750.x. PMID: 11982762
Voz ML, Van de Ven WJ, Kas K
Adv Dent Res 2000 Dec;14:81-3. doi: 10.1177/08959374000140011301. PMID: 11842929
Looijenga LH, de Munnik H, Oosterhuis JW
Int J Cancer 1999 Dec 10;83(6):809-14. doi: 10.1002/(sici)1097-0215(19991210)83:6<809::aid-ijc20>3.0.co;2-0. PMID: 10597200

Recent systematic reviews

Deng C, Dai R, Li X, Liu F
Cancer Sci 2016 May;107(5):690-9. Epub 2016 Mar 18 doi: 10.1111/cas.12910. PMID: 26892980Free PMC Article

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