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Loss of Chromosome 14

MedGen UID:
274698
Concept ID:
C1517959
Cell or Molecular Dysfunction
Synonym: del(14)

Definition

A cytogenetic abnormality that refers to loss of all or part of chromosome 14. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLoss of Chromosome 14

Professional guidelines

PubMed

Pekarsky Y, Balatti V, Croce CM
Cell Death Differ 2018 Jan;25(1):21-26. Epub 2017 Oct 6 doi: 10.1038/cdd.2017.159. PMID: 28984869Free PMC Article
Freedman A
Am J Hematol 2014 Apr;89(4):429-36. doi: 10.1002/ajh.23674. PMID: 24687887
Freedman A
Am J Hematol 2012 Oct;87(10):988-95. doi: 10.1002/ajh.23313. PMID: 23001911

Recent clinical studies

Etiology

Yoshikawa Y, Yamada Y, Emi M, Atanesyan L, Smout J, de Groot K, Savola S, Nakanishi-Shinkai Y, Kanematsu A, Nojima M, Ohmuraya M, Hashimoto-Tamaoki T, Yamamoto S
Cancer Sci 2022 Jan;113(1):297-307. Epub 2021 Nov 3 doi: 10.1111/cas.15170. PMID: 34687579Free PMC Article
De Coninck S, Berx G, Taghon T, Van Vlierberghe P, Goossens S
Adv Biol Regul 2019 Dec;74:100639. Epub 2019 Jul 27 doi: 10.1016/j.jbior.2019.100639. PMID: 31383581
Turajlic S, Xu H, Litchfield K, Rowan A, Chambers T, Lopez JI, Nicol D, O'Brien T, Larkin J, Horswell S, Stares M, Au L, Jamal-Hanjani M, Challacombe B, Chandra A, Hazell S, Eichler-Jonsson C, Soultati A, Chowdhury S, Rudman S, Lynch J, Fernando A, Stamp G, Nye E, Jabbar F, Spain L, Lall S, Guarch R, Falzon M, Proctor I, Pickering L, Gore M, Watkins TBK, Ward S, Stewart A, DiNatale R, Becerra MF, Reznik E, Hsieh JJ, Richmond TA, Mayhew GF, Hill SM, McNally CD, Jones C, Rosenbaum H, Stanislaw S, Burgess DL, Alexander NR, Swanton C; PEACE; TRACERx Renal Consortium
Cell 2018 Apr 19;173(3):581-594.e12. Epub 2018 Apr 12 doi: 10.1016/j.cell.2018.03.057. PMID: 29656895Free PMC Article
Renbaum P, Kellerman E, Jaron R, Geiger D, Segel R, Lee M, King MC, Levy-Lahad E
Am J Hum Genet 2009 Aug;85(2):281-9. Epub 2009 Jul 30 doi: 10.1016/j.ajhg.2009.07.006. PMID: 19646678Free PMC Article
Brion JP
Acta Clin Belg 1996;51(2):80-90. doi: 10.1080/17843286.1996.11718490. PMID: 8693872

Diagnosis

Sobh A, Encinas E, Patel A, Surapaneni G, Bonilla E, Kaestner C, Poullard J, Clerio M, Vasan K, Freeman T, Lv D, Dupéré-Richer D, Riva A, Barwick BG, Zhou D, Boise LH, Mitsiades CS, Kim B, Bennett RL, Chandel NS, Licht JD
Blood 2024 Jul 18;144(3):283-295. doi: 10.1182/blood.2023022859. PMID: 38598835
El-Asrag ME, Corton M, McKibbin M, Avila-Fernandez A, Mohamed MD, Blanco-Kelly F, Toomes C, Inglehearn CF, Ayuso C, Ali M
Mol Vis 2022;28:48-56. Epub 2022 May 17 PMID: 35693422Free PMC Article
Pan CC, Epstein JI
Mod Pathol 2013 Nov;26(11):1536-43. Epub 2013 Jun 14 doi: 10.1038/modpathol.2013.99. PMID: 23765249
Engels H, Eggermann T, Caliebe A, Jelska A, Schubert R, Schüler HM, Panasiuk B, Zaremba J, Latos-Bieleńska A, Jakubowski L, Zerres KP, Schwanitz G, Midro AT
Am J Med Genet A 2008 Oct 15;146A(20):2611-6. doi: 10.1002/ajmg.a.32500. PMID: 18798317
Rosário F, Marques AR, Roque L, Rodrigues R, Ferreira TC, Limbert E, Sobrinho L, Leite V
Clin Nucl Med 2005 Feb;30(2):79-82. doi: 10.1097/00003072-200502000-00001. PMID: 15647670

Therapy

Canton APM, Krepischi ACV, Montenegro LR, Costa S, Rosenberg C, Steunou V, Sobrier ML, Santana L, Honjo RS, Kim CA, de Zegher F, Idkowiak J, Gilligan LC, Arlt W, Funari MFA, Jorge AAL, Mendonca BB, Netchine I, Brito VN, Latronico AC
Hum Reprod 2021 Jan 25;36(2):506-518. doi: 10.1093/humrep/deaa306. PMID: 33313884
Pekarsky Y, Balatti V, Croce CM
Cell Death Differ 2018 Jan;25(1):21-26. Epub 2017 Oct 6 doi: 10.1038/cdd.2017.159. PMID: 28984869Free PMC Article
Freedman A
Am J Hematol 2014 Apr;89(4):429-36. doi: 10.1002/ajh.23674. PMID: 24687887
Rosário F, Marques AR, Roque L, Rodrigues R, Ferreira TC, Limbert E, Sobrinho L, Leite V
Clin Nucl Med 2005 Feb;30(2):79-82. doi: 10.1097/00003072-200502000-00001. PMID: 15647670
Ha CS, Tucker SL, Lee MS, McLaughlin P, Cabanillas F, Cox JD
Int J Radiat Oncol Biol Phys 2001 Mar 1;49(3):727-32. doi: 10.1016/s0360-3016(00)01416-4. PMID: 11172955

Prognosis

El-Asrag ME, Corton M, McKibbin M, Avila-Fernandez A, Mohamed MD, Blanco-Kelly F, Toomes C, Inglehearn CF, Ayuso C, Ali M
Mol Vis 2022;28:48-56. Epub 2022 May 17 PMID: 35693422Free PMC Article
Yoshikawa Y, Yamada Y, Emi M, Atanesyan L, Smout J, de Groot K, Savola S, Nakanishi-Shinkai Y, Kanematsu A, Nojima M, Ohmuraya M, Hashimoto-Tamaoki T, Yamamoto S
Cancer Sci 2022 Jan;113(1):297-307. Epub 2021 Nov 3 doi: 10.1111/cas.15170. PMID: 34687579Free PMC Article
Nakano N, Utsunomiya A, Matsuo K, Yoshida N, Seto M, Ohshima K, Fujiwara H, Fuji S, Takatsuka Y, Ito A, Miyamoto T, Suehiro Y, Nakamae H, Sawayama Y, Yuasa M, Miyazaki Y, Ota S, Imada K, Fukuda T, Ichinohe T, Atsuta Y, Kato K
Blood Adv 2021 Jan 26;5(2):475-486. doi: 10.1182/bloodadvances.2020003639. PMID: 33496743Free PMC Article
Kannabiran C
Ophthalmic Genet 2020 Dec;41(6):513-517. Epub 2020 Aug 17 doi: 10.1080/13816810.2020.1807025. PMID: 32799588
Chase A, Leung W, Tapper W, Jones AV, Knoops L, Rasi C, Forsberg LA, Guglielmelli P, Zoi K, Hall V, Chiecchio L, Eder-Azanza L, Bryant C, Lannfelt L, Docherty L, White HE, Score J, Mackay DJ, Vannucchi AM, Dumanski JP, Cross NC
Leukemia 2015 Oct;29(10):2069-74. Epub 2015 May 20 doi: 10.1038/leu.2015.130. PMID: 26114957Free PMC Article

Clinical prediction guides

El-Asrag ME, Corton M, McKibbin M, Avila-Fernandez A, Mohamed MD, Blanco-Kelly F, Toomes C, Inglehearn CF, Ayuso C, Ali M
Mol Vis 2022;28:48-56. Epub 2022 May 17 PMID: 35693422Free PMC Article
Kannabiran C
Ophthalmic Genet 2020 Dec;41(6):513-517. Epub 2020 Aug 17 doi: 10.1080/13816810.2020.1807025. PMID: 32799588
Turajlic S, Xu H, Litchfield K, Rowan A, Chambers T, Lopez JI, Nicol D, O'Brien T, Larkin J, Horswell S, Stares M, Au L, Jamal-Hanjani M, Challacombe B, Chandra A, Hazell S, Eichler-Jonsson C, Soultati A, Chowdhury S, Rudman S, Lynch J, Fernando A, Stamp G, Nye E, Jabbar F, Spain L, Lall S, Guarch R, Falzon M, Proctor I, Pickering L, Gore M, Watkins TBK, Ward S, Stewart A, DiNatale R, Becerra MF, Reznik E, Hsieh JJ, Richmond TA, Mayhew GF, Hill SM, McNally CD, Jones C, Rosenbaum H, Stanislaw S, Burgess DL, Alexander NR, Swanton C; PEACE; TRACERx Renal Consortium
Cell 2018 Apr 19;173(3):581-594.e12. Epub 2018 Apr 12 doi: 10.1016/j.cell.2018.03.057. PMID: 29656895Free PMC Article
Smol T, Daudignon A
Cytogenet Genome Res 2017;153(1):18-21. Epub 2017 Oct 18 doi: 10.1159/000481523. PMID: 29040969
Ladanyi M, Parsa NZ, Offit K, Wachtel MS, Filippa DA, Jhanwar SC
Genes Chromosomes Cancer 1991 Jul;3(4):294-9. doi: 10.1002/gcc.2870030408. PMID: 1958594

Recent systematic reviews

Och W, Szmuda T, Sikorska B, Springer J, Jaskólski D, Zakrzewska M, Liberski PP
Neurol Neurochir Pol 2016 Nov-Dec;50(6):439-448. Epub 2016 Aug 20 doi: 10.1016/j.pjnns.2016.08.003. PMID: 27575681

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